Cassine (BioDeep_00000007898)

   

natural product


代谢物信息卡片


(-)-Cassine

化学式: C18H35NO2 (297.2668)
中文名称:
谱图信息: 最多检出来源 Laoying Hawk Eagle China Tea(plant) 100%

分子结构信息

SMILES: CC(=O)CCCCCCCCCCC1CCC(O)C(C)N1
InChI: InChI=1S/C18H35NO2/c1-15(20)11-9-7-5-3-4-6-8-10-12-17-13-14-18(21)16(2)19-17/h16-19,21H,3-14H2,1-2H3/t16-,17+,18-/m1/s1

描述信息

同义名列表

4 个代谢物同义名

Cassine; (-)-Cassine; Cassine; Cassine



数据库引用编号

15 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

16 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 3 ARG1, CCND1, PTGS2
Peripheral membrane protein 2 ACHE, PTGS2
Endoplasmic reticulum membrane 1 PTGS2
Nucleus 4 ACHE, ARG1, CCND1, MPO
cytosol 2 ARG1, CCND1
centrosome 1 CCND1
nucleoplasm 2 CCND1, MPO
Cell membrane 3 ACHE, TRPA1, TRPV1
Cytoplasmic granule 1 ARG1
Multi-pass membrane protein 2 TRPA1, TRPV1
Synapse 1 ACHE
cell surface 1 ACHE
Golgi apparatus 2 ACHE, ATRN
neuromuscular junction 1 ACHE
neuronal cell body 1 TRPV1
Lysosome 1 MPO
plasma membrane 4 ACHE, ATRN, TRPA1, TRPV1
Membrane 3 ACHE, TRPA1, TRPV1
caveola 1 PTGS2
extracellular exosome 2 ATRN, MPO
endoplasmic reticulum 1 PTGS2
extracellular space 6 ACHE, ARG1, ATRN, IL6, LPA, MPO
perinuclear region of cytoplasm 1 ACHE
bicellular tight junction 1 CCND1
protein-containing complex 1 PTGS2
intracellular membrane-bounded organelle 1 MPO
Microsome membrane 1 PTGS2
Single-pass type I membrane protein 1 ATRN
Secreted 2 ACHE, IL6
extracellular region 5 ACHE, ARG1, IL6, LPA, MPO
[Isoform 2]: Secreted 1 ATRN
Extracellular side 1 ACHE
Nucleus membrane 1 CCND1
nuclear membrane 1 CCND1
external side of plasma membrane 1 TRPV1
postsynaptic membrane 1 TRPV1
GABA-ergic synapse 1 TRPV1
basement membrane 1 ACHE
secretory granule 1 MPO
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
Postsynaptic cell membrane 1 TRPV1
Cell projection, neuron projection 1 TRPV1
neuron projection 1 PTGS2
stereocilium bundle 1 TRPA1
Lipid-anchor, GPI-anchor 1 ACHE
[Isoform 3]: Secreted 1 ATRN
side of membrane 1 ACHE
azurophil granule 1 MPO
endoplasmic reticulum lumen 2 IL6, PTGS2
transcription repressor complex 1 CCND1
specific granule lumen 1 ARG1
azurophil granule lumen 2 ARG1, MPO
phagocytic vesicle lumen 1 MPO
synaptic cleft 1 ACHE
[Isoform 1]: Cell membrane 1 ATRN
Cell projection, dendritic spine membrane 1 TRPV1
dendritic spine membrane 1 TRPV1
cyclin-dependent protein kinase holoenzyme complex 1 CCND1
interleukin-6 receptor complex 1 IL6
plasma lipoprotein particle 1 LPA
cyclin D1-CDK4 complex 1 CCND1
[Isoform H]: Cell membrane 1 ACHE
cyclin D1-CDK6 complex 1 CCND1


文献列表

  • Wiwied Ekasari, Dewi Resty Basuki, Heny Arwati, Tutik Sri Wahyuni. Antiplasmodial activity of Ethanolic extract of Cassia spectabilis DC leaf and its inhibition effect in Heme detoxification. BMC complementary medicine and therapies. 2021 Feb; 21(1):71. doi: 10.1186/s12906-021-03239-9. [PMID: 33607987]
  • Rosimeire Borges Moreira Lacerda, Thamires Rodrigues Freitas, Mário Machado Martins, Thaise Lara Teixeira, Cláudio Vieira da Silva, Pamela Aparecida Candido, Ronaldo Junio de Oliveira, Claudio Viegas Júnior, Vanderlan da Silva Bolzani, Amanda Danuello, Marcos Pivatto. Isolation, leishmanicidal evaluation and molecular docking simulations of piperidine alkaloids from Senna spectabilis. Bioorganic & medicinal chemistry. 2018 12; 26(22):5816-5823. doi: 10.1016/j.bmc.2018.10.032. [PMID: 30413343]
  • Andreísa Teixeira de Castro, Aline Pereira Castro, Matheus Siqueira Silva, Isabella Maria Monteiro de Souza, Raquel Lopes Martins-Souza, Daniela Aparecida Chagas-Paula, Luiz Felipe Leomil Coelho, Vanderlan da Silva Bolzani, Marcos Pivatto, Claudio Viegas, Marcos José Marques. In vitro evaluation of the schistosomicidal effect of the extracts, fractions and major 3-hydroxy-2,6-dialkyl-substituted piperidine alkaloids from the flowers of Senna spectabilis (Fabaceae). Bioorganic & medicinal chemistry letters. 2016 09; 26(17):4197-204. doi: 10.1016/j.bmcl.2016.07.058. [PMID: 27491706]
  • Rodrigo Machado Pereira, Guilherme Álvaro Ferreira-Silva, Marcos Pivatto, Luciana de Ávila Santos, Vanderlan da Silva Bolzani, Daniela Aparecida Chagas de Paula, Jaqueline Carvalho de Oliveira, Cláudio Viegas Júnior, Marisa Ionta. Alkaloids derived from flowers of Senna spectabilis, (-)-cassine and (-)-spectaline, have antiproliferative activity on HepG2 cells for inducing cell cycle arrest in G1/S transition through ERK inactivation and downregulation of cyclin D1 expression. Toxicology in vitro : an international journal published in association with BIBRA. 2016 Mar; 31(?):86-92. doi: 10.1016/j.tiv.2015.11.018. [PMID: 26616281]
  • Ningy S Mthethwa, Bola A O Oyedeji, Larry C Obi, Olayinka A Aiyegoro. Anti-staphylococcal, anti-HIV and cytotoxicity studies of four South African medicinal plants and isolation of bioactive compounds from Cassine transvaalensis (Burtt. Davy) codd. BMC complementary and alternative medicine. 2014 Dec; 14(?):512. doi: 10.1186/1472-6882-14-512. [PMID: 25522685]
  • Gabriela Muniz de Albuquerque Melo, Marcela Campelo Rodrigues Silva, Thaís Pereira Guimarães, Kátia Mantovani Pinheiro, Carolina Barbosa Brito da Matta, Aline Cavalcanti de Queiroz, Marcos Pivatto, Vanderlan da Silva Bolzani, Magna Suzana Alexandre-Moreira, Claudio Viegas. Leishmanicidal activity of the crude extract, fractions and major piperidine alkaloids from the flowers of Senna spectabilis. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2014 Feb; 21(3):277-81. doi: 10.1016/j.phymed.2013.09.024. [PMID: 24188737]
  • Kathryn A B S da Silva, Marianne Neves Manjavachi, Ana Flávia Paszcuk, Marcos Pivatto, Claudio Viegas, Vanderlan S Bolzani, João B Calixto. Plant derived alkaloid (-)-cassine induces anti-inflammatory and anti-hyperalgesics effects in both acute and chronic inflammatory and neuropathic pain models. Neuropharmacology. 2012 Feb; 62(2):967-77. doi: 10.1016/j.neuropharm.2011.10.002. [PMID: 22032869]
  • Fábio de Oliveira Silva, Maria Goretti de Vasconcelos Silva, Dejiang Feng, Rivelilson Mendes de Freitas. Evaluation of central nervous system effects of iso-6-cassine isolated from Senna spectabilis var. excelsa (Schrad) in mice. Fitoterapia. 2011 Mar; 82(2):255-9. doi: 10.1016/j.fitote.2010.10.007. [PMID: 20940032]
  • Rosa E Moo-Puc, Gonzalo J Mena-Rejon, Leovigildo Quijano, Roberto Cedillo-Rivera. Antiprotozoal activity of Senna racemosa. Journal of ethnopharmacology. 2007 Jun; 112(2):415-6. doi: 10.1016/j.jep.2007.03.028. [PMID: 17481835]
  • P Sansores-Peraza, M Rosado-Vallado, W Brito-Loeza, G J Mena-Rejón, L Quijano. Cassine, an antimicrobial alkaloid from Senna racemosa. Fitoterapia. 2000 Dec; 71(6):690-2. doi: 10.1016/s0367-326x(00)00152-0. [PMID: 11077177]