Zaluzanin C (BioDeep_00000007489)

   

PANOMIX_OTCML-2023 natural product


代谢物信息卡片


Zaluzanin C

化学式: C15H18O3 (246.1256)
中文名称:
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 95.12%

分子结构信息

SMILES: C=C1C(=O)OC2C1CCC(=C)C1CC(O)C(=C)C12
InChI: InChI=1S/C15H18O3/c1-7-4-5-10-8(2)15(17)18-14(10)13-9(3)12(16)6-11(7)13/h10-14,16H,1-6H2/t10-,11-,12-,13-,14-/m0/s1

描述信息

A sesquiterpene lactone that is decahydroazuleno[4,5-b]furan-2(3H)-one substituted by methylidene groups at positions 3, 6 and 9 and a hydroxy group at position 8.

同义名列表

3 个代谢物同义名

Zaluzanin C; NSC177851; Zaluzanin C



数据库引用编号

15 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

59 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 6 ACADM, CCL3, DLX5, GLI3, PPARG, PTGS2
Peripheral membrane protein 1 PTGS2
Endoplasmic reticulum membrane 2 NRF1, PTGS2
Nucleus 9 ACADM, CEBPA, DLX5, GABPA, GLI3, NRF1, PPARA, PPARG, TFAM
cytosol 6 CCL3, GLI3, IL1B, NRF1, PPARG, TFAM
mitochondrial membrane 1 ACADM
nucleoplasm 6 CEBPA, GABPA, GLI3, NRF1, PPARA, PPARG
RNA polymerase II transcription regulator complex 2 CEBPA, PPARG
Golgi membrane 1 INS
mitochondrial inner membrane 1 HADHA
Cytoplasm, cytosol 1 IL1B
Lysosome 1 IL1B
plasma membrane 1 IFNLR1
Membrane 1 IFNLR1
axon 1 ACADM
caveola 1 PTGS2
extracellular exosome 2 BMP3, NRF1
endoplasmic reticulum 1 PTGS2
extracellular space 8 BMP3, CCL2, CCL3, CCL4, CXCL2, CXCL9, IL1B, INS
perinuclear region of cytoplasm 1 PPARG
mitochondrion 3 ACADM, HADHA, TFAM
protein-containing complex 2 PTGS2, TFAM
intracellular membrane-bounded organelle 3 CEBPA, GLI3, PPARG
Microsome membrane 1 PTGS2
Single-pass type I membrane protein 1 IFNLR1
Secreted 5 BMP3, CCL2, CCL3, IL1B, INS
extracellular region 8 BMP3, CCL2, CCL3, CCL4, CXCL2, CXCL9, IL1B, INS
Mitochondrion matrix 1 ACADM
mitochondrial matrix 2 ACADM, TFAM
transcription regulator complex 1 CEBPA
external side of plasma membrane 1 CXCL9
nucleolus 2 CEBPA, GLI3
Single-pass type II membrane protein 1 NRF1
Mitochondrion inner membrane 1 HADHA
mitochondrial nucleoid 2 HADHA, TFAM
secretory granule 1 IL1B
axoneme 1 GLI3
ciliary tip 1 GLI3
nuclear speck 1 GLI3
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
receptor complex 1 PPARG
neuron projection 1 PTGS2
ciliary base 1 GLI3
cilium 1 GLI3
chromatin 6 CEBPA, DLX5, GABPA, NRF1, PPARA, PPARG
endosome lumen 1 INS
secretory granule lumen 1 INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 2 INS, PTGS2
transcription repressor complex 1 GLI3
transport vesicle 1 INS
Single-pass type III membrane protein 1 NRF1
Secreted, extracellular exosome 1 IL1B
mitochondrial fatty acid beta-oxidation multienzyme complex 1 HADHA
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
GLI-SUFU complex 1 GLI3
C/EBP complex 1 CEBPA
CHOP-C/EBP complex 1 CEBPA
Mitochondrion matrix, mitochondrion nucleoid 1 TFAM
[Isoform 4]: Nucleus, nucleolus 1 CEBPA
interleukin-28 receptor complex 1 IFNLR1
[Endoplasmic reticulum membrane sensor NFE2L1]: Endoplasmic reticulum membrane 1 NRF1
[Transcription factor NRF1]: Nucleus 1 NRF1


文献列表

  • Ji-Won Jung, Feng Wang, Ayman Turk, Jeong-Su Park, Hwan Ma, Yuanqiang Ma, Hye-Rin Noh, Guoyan Sui, Dong-Su Shin, Mi-Kyeong Lee, Yoon Seok Roh. Zaluzanin C Alleviates Inflammation and Lipid Accumulation in Kupffer Cells and Hepatocytes by Regulating Mitochondrial ROS. Molecules (Basel, Switzerland). 2023 Nov; 28(22):. doi: 10.3390/molecules28227484. [PMID: 38005205]
  • Navneet Kishore, Pradeep Kumar, Karuna Shanker, Akhilesh Kumar Verma. Human disorders associated with inflammation and the evolving role of natural products to overcome. European journal of medicinal chemistry. 2019 Oct; 179(?):272-309. doi: 10.1016/j.ejmech.2019.06.034. [PMID: 31255927]
  • Sang Zin Choi, Min Cheol Yang, Sang Un Choi, Kang Ro Lee. Cytotoxic terpenes and lignans from the roots of Ainsliaea acerifolia. Archives of pharmacal research. 2006 Mar; 29(3):203-8. doi: 10.1007/bf02969394. [PMID: 16596992]
  • Chang-Ming Sun, Wan-Jr Syu, Ming-Jaw Don, Jang-Jih Lu, Gum-Hee Lee. Cytotoxic sesquiterpene lactones from the root of Saussurea lappa. Journal of natural products. 2003 Sep; 66(9):1175-80. doi: 10.1021/np030147e. [PMID: 14510592]
  • C L Cantrell, S G Franzblau, N H Fischer. Antimycobacterial plant terpenoids. Planta medica. 2001 Nov; 67(8):685-94. doi: 10.1055/s-2001-18365. [PMID: 11731906]
  • J M Megaw, L D Johnson. Glycoprotein synthesized by cultured cells: effects of serum concentrations and buffers on sugar content. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). 1979 May; 161(1):60-5. doi: 10.3181/00379727-161-40490. [PMID: 441071]