aromaticin (BioDeep_00000007280)

   

PANOMIX_OTCML-2023 natural product


代谢物信息卡片


DTXSID90874676

化学式: C15H18O3 (246.1256)
中文名称: 芳香堆心菊素
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C=C1C(=O)OC2CC(C)C3C=CC(=O)C3(C)CC12
InChI: InChI=1S/C15H18O3/c1-8-6-12-10(9(2)14(17)18-12)7-15(3)11(8)4-5-13(15)16/h4-5,8,10-12H,2,6-7H2,1,3H3/t8-,10-,11+,12+,15+/m1/s1

描述信息

A sesquiterpene lactone that is 3,3a,4,4a,7a,8,9,9a-octahydroazuleno[6,5-b]furan-2,5-dione substituted by methyl groups at positions 4a and 8 and a methylidene group at position 3. Isolated from the aerial parts of Inula hupehensis, it exhibits anti-inflammatory activity.

同义名列表

3 个代谢物同义名

aromaticin; DTXSID90874676; Aromaticin



数据库引用编号

16 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

28 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 11 AKT1, ALB, BCL2, CASP3, CAT, CYP2D6, MAPK14, PIK3CA, PTGS2, SIRT1, VEGFA
Peripheral membrane protein 2 ACHE, PTGS2
Endoplasmic reticulum membrane 4 BCL2, CYP2D6, CYP51A1, PTGS2
Nucleus 9 ACHE, AKT1, ALB, BCL2, CASP3, GABPA, MAPK14, SIRT1, VEGFA
cytosol 8 AKT1, ALB, BCL2, CASP3, CAT, MAPK14, PIK3CA, SIRT1
dendrite 1 CHRNA4
centrosome 1 ALB
nucleoplasm 5 AKT1, CASP3, GABPA, MAPK14, SIRT1
Cell membrane 4 ACHE, AKT1, CHRNA4, TNF
Lipid-anchor 1 CHRNA4
lamellipodium 2 AKT1, PIK3CA
Multi-pass membrane protein 1 CHRNA4
Synapse 2 ACHE, CHRNA4
cell cortex 1 AKT1
cell surface 3 ACHE, TNF, VEGFA
glutamatergic synapse 3 AKT1, CASP3, MAPK14
Golgi apparatus 3 ACHE, ALB, VEGFA
Golgi membrane 1 INS
lysosomal membrane 1 GAA
neuromuscular junction 1 ACHE
neuronal cell body 3 CASP3, CHRNA4, TNF
postsynapse 2 AKT1, CHRNA4
Lysosome 1 GAA
plasma membrane 7 ACHE, AKT1, BCHE, CHRNA4, GAA, PIK3CA, TNF
Membrane 9 ACHE, AKT1, BCL2, CAT, CHRNA4, CYP2D6, CYP51A1, GAA, VEGFA
caveola 1 PTGS2
extracellular exosome 3 ALB, CAT, GAA
Lysosome membrane 1 GAA
endoplasmic reticulum 5 ALB, BCL2, CYP2D6, PTGS2, VEGFA
extracellular space 7 ACHE, ALB, BCHE, IL10, INS, TNF, VEGFA
lysosomal lumen 1 GAA
perinuclear region of cytoplasm 2 ACHE, PIK3CA
adherens junction 1 VEGFA
intercalated disc 1 PIK3CA
mitochondrion 5 BCL2, CAT, CYP2D6, MAPK14, SIRT1
protein-containing complex 5 AKT1, ALB, BCL2, CAT, PTGS2
intracellular membrane-bounded organelle 4 CAT, CYP2D6, CYP51A1, GAA
Microsome membrane 3 CYP2D6, CYP51A1, PTGS2
postsynaptic density 1 CASP3
chromatin silencing complex 1 SIRT1
Secreted 7 ACHE, ALB, BCHE, GAA, IL10, INS, VEGFA
extracellular region 10 ACHE, ALB, BCHE, CAT, GAA, IL10, INS, MAPK14, TNF, VEGFA
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 3 BCL2, CYP2D6, CYP51A1
mitochondrial outer membrane 1 BCL2
mitochondrial matrix 1 CAT
Extracellular side 1 ACHE
anchoring junction 1 ALB
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
external side of plasma membrane 2 CHRNA4, TNF
Secreted, extracellular space, extracellular matrix 1 VEGFA
microtubule cytoskeleton 1 AKT1
nucleolus 1 SIRT1
cell-cell junction 1 AKT1
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
vesicle 1 AKT1
postsynaptic membrane 1 CHRNA4
heterochromatin 1 SIRT1
Membrane raft 1 TNF
pore complex 1 BCL2
focal adhesion 1 CAT
spindle 1 AKT1
extracellular matrix 1 VEGFA
Peroxisome 1 CAT
basement membrane 1 ACHE
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
Nucleus, PML body 1 SIRT1
PML body 1 SIRT1
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
secretory granule 1 VEGFA
nuclear speck 1 MAPK14
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 2 PTGS2, SIRT1
nuclear outer membrane 1 PTGS2
Postsynaptic cell membrane 1 CHRNA4
neuron projection 2 CHRNA4, PTGS2
ciliary basal body 2 AKT1, ALB
chromatin 2 GABPA, SIRT1
phagocytic cup 1 TNF
centriole 1 ALB
spindle pole 2 ALB, MAPK14
blood microparticle 2 ALB, BCHE
Lipid-anchor, GPI-anchor 1 ACHE
fibrillar center 1 SIRT1
nuclear envelope 1 SIRT1
endosome lumen 1 INS
tertiary granule membrane 1 GAA
euchromatin 1 SIRT1
side of membrane 1 ACHE
myelin sheath 1 BCL2
ficolin-1-rich granule lumen 2 CAT, MAPK14
secretory granule lumen 3 CAT, INS, MAPK14
Golgi lumen 1 INS
endoplasmic reticulum lumen 4 ALB, BCHE, INS, PTGS2
platelet alpha granule lumen 2 ALB, VEGFA
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
transport vesicle 1 INS
azurophil granule membrane 1 GAA
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
nuclear envelope lumen 1 BCHE
synaptic cleft 1 ACHE
ficolin-1-rich granule membrane 1 GAA
death-inducing signaling complex 1 CASP3
eNoSc complex 1 SIRT1
rDNA heterochromatin 1 SIRT1
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
acetylcholine-gated channel complex 1 CHRNA4
catalase complex 1 CAT
autolysosome lumen 1 GAA
BAD-BCL-2 complex 1 BCL2
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
[Isoform H]: Cell membrane 1 ACHE
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
ciliary transition fiber 1 ALB
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF
[SirtT1 75 kDa fragment]: Cytoplasm 1 SIRT1


文献列表

  • C L Cantrell, S G Franzblau, N H Fischer. Antimycobacterial plant terpenoids. Planta medica. 2001 Nov; 67(8):685-94. doi: 10.1055/s-2001-18365. [PMID: 11731906]