Taxodione (BioDeep_00000007229)

   

PANOMIX_OTCML-2023 natural product


代谢物信息卡片


Taxodione

化学式: C20H26O3 (314.1882)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1CC([C@H]2[C@](C1)(C1=C(C(=O)C(=CC1=CC2=O)C(C)C)O)C)(C)C
InChI: InChI=1S/C20H26O3/c1-11(2)13-9-12-10-14(21)18-19(3,4)7-6-8-20(18,5)15(12)17(23)16(13)22/h9-11,18,23H,6-8H2,1-5H3/t18-,20+/m0/s1

描述信息

同义名列表

3 个代谢物同义名

Taxodione; NSC122419; Taxodione



数据库引用编号

15 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

54 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 7 BCL2, CASP8, EP300, FDPS, HDAC9, MAPK14, STAT5A
Peripheral membrane protein 1 ACHE
Endoplasmic reticulum membrane 1 BCL2
Nucleus 8 ACHE, BCL2, CASP8, EP300, HDAC9, MAPK14, PARP1, STAT5A
cytosol 8 BCL2, CASP8, DIABLO, EP300, FDPS, MAPK14, PARP1, STAT5A
nuclear body 1 PARP1
nucleoplasm 7 CASP8, EP300, FDPS, HDAC9, MAPK14, PARP1, STAT5A
RNA polymerase II transcription regulator complex 1 STAT5A
Cell membrane 1 ACHE
lamellipodium 1 CASP8
Synapse 1 ACHE
cell surface 1 ACHE
glutamatergic synapse 1 MAPK14
Golgi apparatus 1 ACHE
neuromuscular junction 1 ACHE
Cytoplasm, cytosol 2 DIABLO, PARP1
plasma membrane 2 ACHE, BCHE
Membrane 5 ACHE, BCL2, DIABLO, FDPS, PARP1
endoplasmic reticulum 1 BCL2
extracellular space 2 ACHE, BCHE
perinuclear region of cytoplasm 1 ACHE
mitochondrion 5 BCL2, CASP8, DIABLO, MAPK14, PARP1
protein-containing complex 3 BCL2, CASP8, PARP1
Secreted 2 ACHE, BCHE
extracellular region 3 ACHE, BCHE, MAPK14
cytoplasmic side of plasma membrane 1 DIABLO
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 2 BCL2, CASP8
mitochondrial matrix 1 FDPS
Extracellular side 1 ACHE
transcription regulator complex 3 EP300, HDAC9, PARP1
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
CD40 receptor complex 1 DIABLO
nucleolus 1 PARP1
Cell projection, lamellipodium 1 CASP8
pore complex 1 BCL2
Peroxisome 1 FDPS
basement membrane 1 ACHE
mitochondrial intermembrane space 1 DIABLO
nuclear speck 1 MAPK14
chromatin 3 EP300, PARP1, STAT5A
Chromosome 2 EP300, PARP1
cytoskeleton 1 CASP8
Nucleus, nucleolus 1 PARP1
spindle pole 1 MAPK14
nuclear replication fork 1 PARP1
chromosome, telomeric region 1 PARP1
blood microparticle 1 BCHE
Lipid-anchor, GPI-anchor 1 ACHE
site of double-strand break 1 PARP1
nuclear envelope 1 PARP1
cell body 1 CASP8
side of membrane 1 ACHE
myelin sheath 1 BCL2
ficolin-1-rich granule lumen 1 MAPK14
secretory granule lumen 1 MAPK14
endoplasmic reticulum lumen 1 BCHE
histone methyltransferase complex 1 HDAC9
histone deacetylase complex 1 HDAC9
nuclear envelope lumen 1 BCHE
synaptic cleft 1 ACHE
histone acetyltransferase complex 1 EP300
protein-DNA complex 2 EP300, PARP1
CD95 death-inducing signaling complex 1 CASP8
death-inducing signaling complex 1 CASP8
ripoptosome 1 CASP8
site of DNA damage 1 PARP1
[Poly [ADP-ribose] polymerase 1, processed N-terminus]: Chromosome 1 PARP1
[Poly [ADP-ribose] polymerase 1, processed C-terminus]: Cytoplasm 1 PARP1
BAD-BCL-2 complex 1 BCL2
[Isoform H]: Cell membrane 1 ACHE


文献列表

  • Yuki Uchihara, Kenji Tago, Hidetoshi Taguchi, Yuji Narukawa, Fumiyuki Kiuchi, Hiroomi Tamura, Megumi Funakoshi-Tago. Taxodione induces apoptosis in BCR-ABL-positive cells through ROS generation. Biochemical pharmacology. 2018 08; 154(?):357-372. doi: 10.1016/j.bcp.2018.05.018. [PMID: 29859988]
  • Łukasz Kuźma, Halina Wysokińska, Joanna Sikora, Paulina Olszewska, Elżbieta Mikiciuk-Olasik, Paweł Szymański. Taxodione and Extracts from Salvia austriaca Roots as Human Cholinesterase Inhibitors. Phytotherapy research : PTR. 2016 Feb; 30(2):234-42. doi: 10.1002/ptr.5521. [PMID: 26621777]
  • Negar Shafaei-Bajestani, Seyed Ahmad Emami, Javad Asili, Zahra Tayarani-Najaran. Anti-apoptotic effect of taxodione on serum/glucose deprivation-induced PC12 cells death. Cellular and molecular neurobiology. 2014 Nov; 34(8):1103-9. doi: 10.1007/s10571-014-0085-2. [PMID: 25187359]
  • L Kuźma, H Wysokińska, M Różalski, A Budzyńska, M Więckowska-Szakiel, B Sadowska, M Paszkiewicz, W Kisiel, B Różalska. Antimicrobial and anti-biofilm properties of new taxodione derivative from hairy roots of Salvia austriaca. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2012 Nov; 19(14):1285-7. doi: 10.1016/j.phymed.2012.07.016. [PMID: 22951394]
  • Z Habibi, Z Cheraghi, S Ghasemi, M Yousefi. A new highly hydroxylated triterpene from Salvia atropatana Bunge. Natural product research. 2012; 26(20):1910-3. doi: 10.1080/14786419.2011.628668. [PMID: 22017660]
  • Ł Kuźma, W Kisiel, A Królicka, H Wysokińska. Genetic transformation of Salvia austriaca by Agrobacterium rhizogenes and diterpenoid isolation. Die Pharmazie. 2011 Nov; 66(11):904-7. doi: . [PMID: 22204139]
  • Ahmed M Zaghloul, Ahmed A Gohar, Zein Al-abdin M Naiem, Fatma M Abdel Bar. Taxodione, a DNA-binding compound from Taxodium distichum L. (Rich.). Zeitschrift fur Naturforschung. C, Journal of biosciences. 2008 May; 63(5-6):355-60. doi: 10.1515/znc-2008-5-608. [PMID: 18669020]
  • D Rutherford, M Nielsen, N Tokutomi, N Akaike. Effects of plant diterpenes on the neuronal GABAA receptor-operated chloride current. Neuroreport. 1994 Dec; 5(18):2569-72. doi: 10.1097/00001756-199412000-00041. [PMID: 7696606]