Sarmentosin (BioDeep_00000006734)

 

Secondary id: BioDeep_00001870161

human metabolite PANOMIX_OTCML-2023 Endogenous natural product


代谢物信息卡片


(Z)-2-(hydroxymethyl)-4-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxybut-2-enenitrile

化学式: C11H17NO7 (275.1005)
中文名称: 垂盆草甙
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 19.76%

分子结构信息

SMILES: C(=C(\C#N)/CO)\CO[C@H]1[C@@H]([C@H]([C@@H]([C@@H](CO)O1)O)O)O
InChI: InChI=1S/C11H17NO7/c12-3-6(4-13)1-2-18-11-10(17)9(16)8(15)7(5-14)19-11/h1,7-11,13-17H,2,4-5H2/b6-1-

描述信息

Sarmentosin is found in fruits. Sarmentosin is isolated from Ribes nigrum (blackcurrant

同义名列表

9 个代谢物同义名

(Z)-2-(hydroxymethyl)-4-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxybut-2-enenitrile; (2Z)-2-(hydroxymethyl)-4-{[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}but-2-enenitrile; 4-(b-D-Glucopyranosyloxy)-2-(hydroxymethyl)-2-butenenitrile, 9ci; Sarmentosine; Sarmentosin?; Sarmentosin; Nigrumin; 2-Butenenitrile,4-(beta-D-glucopyranosyloxy)-2-(hydroxymethyl)-, (E)-; Sarmentosin



数据库引用编号

15 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

32 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 5 AIMP2, CASP3, KEAP1, PINK1, TLR4
Endosome membrane 1 TLR4
Nucleus 5 AIMP2, CASP3, JUN, KEAP1, PINK1
cytosol 5 AIMP2, CASP3, GPT, KEAP1, PINK1
nucleoplasm 3 CASP3, JUN, KEAP1
RNA polymerase II transcription regulator complex 1 JUN
Cell membrane 2 TLR4, TNF
Synapse 1 TAC1
cell surface 2 TLR4, TNF
glutamatergic synapse 1 CASP3
growth cone 1 PINK1
mitochondrial inner membrane 1 PINK1
neuronal cell body 3 CASP3, TAC1, TNF
Cytoplasm, cytosol 2 AIMP2, PINK1
plasma membrane 2 TLR4, TNF
Membrane 3 AIMP2, PINK1, TLR4
axon 2 PINK1, TAC1
extracellular exosome 1 GPT
endoplasmic reticulum 2 KEAP1, PINK1
extracellular space 2 TAC1, TNF
perinuclear region of cytoplasm 2 PINK1, TLR4
mitochondrion 1 PINK1
postsynaptic density 1 CASP3
Single-pass type I membrane protein 1 TLR4
Secreted 1 TRH
extracellular region 3 TAC1, TNF, TRH
Mitochondrion outer membrane 1 PINK1
Single-pass membrane protein 1 PINK1
mitochondrial outer membrane 1 PINK1
transcription regulator complex 1 JUN
centriolar satellite 1 KEAP1
external side of plasma membrane 2 TLR4, TNF
midbody 1 KEAP1
Early endosome 1 TLR4
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Mitochondrion inner membrane 1 PINK1
Membrane raft 1 TNF
mitochondrial intermembrane space 1 PINK1
secretory granule 1 TRH
Cell projection, ruffle 1 TLR4
ruffle 1 TLR4
receptor complex 1 TLR4
chromatin 2 JUN, PINK1
phagocytic cup 2 TLR4, TNF
cytoskeleton 1 PINK1
nuclear chromosome 1 JUN
actin filament 1 KEAP1
Cul3-RING ubiquitin ligase complex 1 KEAP1
euchromatin 1 JUN
cell body 1 PINK1
lipopolysaccharide receptor complex 1 TLR4
death-inducing signaling complex 1 CASP3
aminoacyl-tRNA synthetase multienzyme complex 1 AIMP2
Lewy body 1 PINK1
astrocyte projection 1 PINK1
transcription factor AP-1 complex 1 JUN
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
inclusion body 1 KEAP1
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Nanna Bjarnholt, Mirosław Nakonieczny, Andrzej Kędziorski, Diane M Debinski, Stephen F Matter, Carl Erik Olsen, Mika Zagrobelny. Occurrence of sarmentosin and other hydroxynitrile glucosides in Parnassius (papilionidae) butterflies and their food plants. Journal of chemical ecology. 2012 May; 38(5):525-37. doi: 10.1007/s10886-012-0114-x. [PMID: 22527055]
  • Khalid Hussain, Zhari Ismail, Amirin Sadikun, Pazilah Ibrahim. Standardization and in vivo antioxidant activity of ethanol extracts of fruit and leaf of Piper sarmentosum. Planta medica. 2010 Mar; 76(5):418-25. doi: 10.1055/s-0029-1186279. [PMID: 19862670]
  • Li-Hua Lian, Xuejun Jin, Yan-Ling Wu, Xing Fu Cai, Jung Joon Lee, Ji-Xing Nan. Hepatoprotective effects of Sedum sarmentosum on D-galactosamine/lipopolysaccharide-induced murine fulminant hepatic failure. Journal of pharmacological sciences. 2010; 114(2):147-57. doi: 10.1254/jphs.10045fp. [PMID: 20838028]
  • Hong Zhang, Rui Xu, Zhongliang Hu, Xuchang He, Donglu Bai, Xiaoyu Li, Xiaofeng Wang. Synthesis of aglycon analogues of sarmentosin and their bioactivity of lymphocyte proliferation. Bioorganic & medicinal chemistry letters. 2002 Dec; 12(24):3543-5. doi: 10.1016/s0960-894x(02)00801-6. [PMID: 12443772]