Dyclonine (BioDeep_00000006623)
Secondary id: BioDeep_00001868236
human metabolite blood metabolite Chemicals and Drugs
代谢物信息卡片
化学式: C18H27NO2 (289.2042)
中文名称: 达克罗宁
谱图信息:
最多检出来源 Homo sapiens(blood) 12.21%
分子结构信息
SMILES: CCCCOC1=CC=C(C=C1)C(=O)CCN1CCCCC1
InChI: InChI=1S/C18H27NO2/c1-2-3-15-21-17-9-7-16(8-10-17)18(20)11-14-19-12-5-4-6-13-19/h7-10H,2-6,11-15H2,1H3
描述信息
Dyclonine is only found in individuals that have used or taken this drug. It is an oral anaesthetic found in Sucrets, an over the counter throat lozenge. It is also found in some varieties of the Cepacol sore throat spray.Dyclonine blocks both the initiation and conduction of nerve impulses by decreasing the neuronal membranes permeability to sodium ions. This reversibly stabilizes the membrane and inhibits depolarization, resulting in the failure of a propagated action potential and subsequent conduction blockade.
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D000777 - Anesthetics
R - Respiratory system > R02 - Throat preparations > R02A - Throat preparations > R02AD - Anesthetics, local
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
N - Nervous system > N01 - Anesthetics > N01B - Anesthetics, local
C78272 - Agent Affecting Nervous System > C245 - Anesthetic Agent
同义名列表
21 个代谢物同义名
1-(4-butoxyphenyl)-3-(piperidin-1-yl)propan-1-one; 1-(4-Butoxyphenyl)-3-(1-piperidinyl)-1-propanone; 2-(1-Piperidyl)ethyl p-butoxyphenyl ketone; 4-N-Butoxy-beta-(1-piperidyl)propiophenone; 4-N-Butoxy-β-(1-piperidyl)propiophenone; 4-N-Butoxy-b-(1-piperidyl)propiophenone; 4-Butoxy-beta-piperidinopropiophenone; 4-Butoxy-3-piperidinopropiophenone; 4-Butoxy-b-piperidinopropiophenone; 4-Butoxy-β-piperidinopropiophenone; 3-Piperidino-4-butoxypropiophenone; Dyclonine hydrochloride; Dyclonine HCL; Dycloninum; dyclonine; Diclonina; Dyclone; Sucrets; Tanac; Dyclonine; Dyclonine
数据库引用编号
16 个数据库交叉引用编号
- ChEBI: CHEBI:4724
- KEGG: C07881
- KEGGdrug: D07881
- PubChem: 3180
- HMDB: HMDB0014783
- Metlin: METLIN4005
- DrugBank: DB00645
- ChEMBL: CHEMBL1201217
- Wikipedia: Dyclonine
- chemspider: 3068
- CAS: 586-60-7
- PMhub: MS000019692
- PubChem: 10083
- PDB-CCD: N8R
- NIKKAJI: J6.738E
- RefMet: Dyclonine
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Adnan Iqbal, Joanna Bocian, Mateusz Przyborowski, Wacław Orczyk, Anna Nadolska-Orczyk. Are TaNAC Transcription Factors Involved in Promoting Wheat Yield by cis-Regulation of TaCKX Gene Family?.
International journal of molecular sciences.
2024 Feb; 25(4):. doi:
10.3390/ijms25042027. [PMID: 38396706] - Monika Vranic, Alexandre Perochon, Harriet Benbow, Fiona M Doohan. Comprehensive analysis of pathogen-responsive wheat NAC transcription factors: new candidates for crop improvement.
G3 (Bethesda, Md.).
2022 11; 12(11):. doi:
10.1093/g3journal/jkac247. [PMID: 36130261] - Qiang Liu, Jin Wang, Xin Wei, Juan Hu, Conghui Ping, Yue Gao, Chang Xie, Peiyu Wang, Peng Cao, Zhengyu Cao, Ye Yu, Dongdong Li, Jing Yao. Therapeutic inhibition of keratinocyte TRPV3 sensory channel by local anesthetic dyclonine.
eLife.
2021 04; 10(?):. doi:
10.7554/elife.68128. [PMID: 33876725] - Jian-Ming Chen, Dong-Dong Li, Yi-Shan Chen, Bo Lian, Xiao-Peng Wang, Yu-Hong Guo, Xiao-Long Xu, Po Huang, Teng-Fei Chen, Yang Liu, Qing-Quan Liu. The effectiveness of electro-acupuncture combined with dyclonine hydrochloride in relieving the side effects of gastroscopy: a controlled trial.
Annals of palliative medicine.
2021 Mar; 10(3):2958-2970. doi:
10.21037/apm-20-831. [PMID: 33691439] - Tuğçe Oruç, Sami Emre Küçük, Deniz Sezer. Lipid bilayer permeation of aliphatic amine and carboxylic acid drugs: rates of insertion, translocation and dissociation from MD simulations.
Physical chemistry chemical physics : PCCP.
2016 Sep; 18(35):24511-25. doi:
10.1039/c6cp05278a. [PMID: 27539552] - Daniel J Warner, Hongming Chen, Louis-David Cantin, J Gerry Kenna, Simone Stahl, Clare L Walker, Tobias Noeske. Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Drug metabolism and disposition: the biological fate of chemicals.
2012 Dec; 40(12):2332-41. doi:
10.1124/dmd.112.047068. [PMID: 22961681] - Liying Wu, Jianfang Liu, Yunhao Zhang, Yanning Hou. Development of a HPLC/MS/MS method for simultaneous determination of tinidazole, dyclonine and chlorhexidine in rat plasma and its application in the pharmacokinetic research of a film-forming solution.
Journal of pharmaceutical and biomedical analysis.
2012 Mar; 62(?):224-7. doi:
10.1016/j.jpba.2012.01.009. [PMID: 22305084] - Yasuto Kido, Pär Matsson, Kathleen M Giacomini. Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2.
Journal of medicinal chemistry.
2011 Jul; 54(13):4548-58. doi:
10.1021/jm2001629. [PMID: 21599003] - H Groeben, J Peters. Lidocaine exerts its effect on induced bronchospasm by mitigating reflexes, rather than by attenuation of smooth muscle contraction.
Acta anaesthesiologica Scandinavica.
2007 Mar; 51(3):359-64. doi:
10.1111/j.1399-6576.2006.01205.x. [PMID: 17390422] - Harald Groeben, Markus Schlicht, Sven Stieglitz, Goran Pavlakovic, Jürgen Peters. Both local anesthetics and salbutamol pretreatment affect reflex bronchoconstriction in volunteers with asthma undergoing awake fiberoptic intubation.
Anesthesiology.
2002 Dec; 97(6):1445-50. doi:
10.1097/00000542-200212000-00016. [PMID: 12459670] - H Groeben, T Grosswendt, M T Silvanus, G Pavlakovic, J Peters. Airway anesthesia alone does not explain attenuation of histamine-induced bronchospasm by local anesthetics: a comparison of lidocaine, ropivacaine, and dyclonine.
Anesthesiology.
2001 Mar; 94(3):423-8; discussion 5A. doi:
10.1097/00000542-200103000-00010. [PMID: 11374600]
