24,25-Dihydroxyvitamin D (BioDeep_00000006580)

 

Secondary id: BioDeep_00000028182, BioDeep_00000173723, BioDeep_00000873022, BioDeep_00001868115

human metabolite Endogenous blood metabolite


代谢物信息卡片


(6R)-6-[(1R,3aS,4E,7aR)-4-{2-[(1Z,5R)-5-hydroxy-2-methylidenecyclohexylidene]ethylidene}-7a-methyl-octahydro-1H-inden-1-yl]-2-methylheptane-2,3-diol

化学式: C27H44O3 (416.329)
中文名称: 24,25-二羟基维生素 D3, 司骨化醇
谱图信息: 最多检出来源 Homo sapiens(lipidsearch) 7.16%

分子结构信息

SMILES: C=C1CCC(O)CC1=CC=C1CCCC2(C)C1CCC2C(C)CCC(O)C(C)(C)O
InChI: InChI=1S/C27H44O3/c1-18-8-12-22(28)17-21(18)11-10-20-7-6-16-27(5)23(13-14-24(20)27)19(2)9-15-25(29)26(3,4)30/h10-11,19,22-25,28-30H,1,6-9,12-17H2,2-5H3/b20-10+,21-11-/t19-,22+,23-,24+,25-,27-/m1/s1

描述信息

24,25-Dihydroxyvitamin D (24R,25(OH)2D3) circulates in blood at concentrations about 1000 times higher than 1alpha,25(OH)2D3. 24-Hydroxylase is present in the proximal convoluted tubule cells of the kidney and in virtual all target cells of 1alpha,25(OH)2D3. Interestingly, 1alpha,25(OH)2D3 is a very strong inducer of 24-hydroxylase activity and 24R,25(OH)2D3 formation. Also parathyroid hormone (PTH) regulates 24-hydroxylase activity but in a tissue specific manner, i.e. inhibitory in the kidney while a synergistic effect together with 1alpha,25(OH)2D3 is observed in osteoblasts. Generally, 24-hydroxylation has been considered the first step in the degradation pathway of 1alpha,25(OH)2D3 and 25-(OH)D3. However, through the past decades data have accumulated that 24R,25(OH)2D3 is not merely a degradation product but has effects on its own. Classic studies have demonstrated the significance of 24R,25(OH)2D3 for normal chicken egg hatchability and calcium and phosphorus homeostasis. More recently it became apparent that 24R,25(OH)2D3 also has distinct effects on cartilage in particular the resting zone cells. 24R,25(OH)2D3 stimulates osteocalcin synthesis in human osteoblasts. 24R,25(OH)2D3 plays a role in bone metabolism but that it acts in concert with 1alpha,25(OH)2D3 to obtain an optimal effect. (PMID: 11179746).
D018977 - Micronutrients > D014815 - Vitamins > D004100 - Dihydroxycholecalciferols
D018977 - Micronutrients > D014815 - Vitamins > D006887 - Hydroxycholecalciferols
D000077264 - Calcium-Regulating Hormones and Agents
D050071 - Bone Density Conservation Agents

同义名列表

22 个代谢物同义名

(6R)-6-[(1R,3aS,4E,7aR)-4-{2-[(1Z,5R)-5-hydroxy-2-methylidenecyclohexylidene]ethylidene}-7a-methyl-octahydro-1H-inden-1-yl]-2-methylheptane-2,3-diol; (3b,5Z,7E)-9,10-Secocholesta-5,7,10(19)-triene-3,24,25-triol; 24,25-Dihydroxyvitamin D 3, (3beta,5Z,7E,24R)-isomer; (24S)-24,25-Dihydroxyvitamin D3; (24R)-24,25-Dihydroxyvitamin D3; 24R,25-Dihydroxycholecalciferol; 24,25 Dihydroxycholecalciferol; 24,25-Dihydroxycholecalciferol; 24,25 Dihydroxyvitamin D 3; Dihydroxyvitamin D3, 24,25; 24,25-Dihydroxyvitamin D 3; 24,25-Dihydroxy-vitamin D; 24,25-Dihydroxyvitamin D3; 24,25 Dihydroxyvitamin D3; 24,25-Dihydroxyvitamin D; 24,25-hydroxyvitamin D3; 24,25-Dihydroxyvitamin; 24-Hydroxycalcidiol; 24 25-Dihydroxy VD3; Secalciferol; Vitamin D; Secalciferol



数据库引用编号

22 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

4 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 15 ALB, BGLAP, CALCA, CAT, CYP27B1, EGFR, ESR1, FGF23, GC, LPAR1, MTDH, ODC1, PRL, SDF4, VDR
Peripheral membrane protein 3 CYP1B1, ESR1, GC
Endosome membrane 1 EGFR
Endoplasmic reticulum membrane 4 CYP1B1, EGFR, GC, MTDH
Mitochondrion membrane 1 CYP27B1
Nucleus 6 ALB, EGFR, ESR1, MTDH, PRL, VDR
cytosol 7 ALB, CAT, ESR1, GC, ODC1, PRKCQ, VDR
dendrite 1 BGLAP
nuclear body 1 MTDH
trans-Golgi network 1 GC
centrosome 1 ALB
nucleoplasm 3 ESR1, PRL, VDR
RNA polymerase II transcription regulator complex 2 PRL, VDR
Cell membrane 4 EGFR, ESR1, LPAR1, SDF4
Cytoplasmic side 1 ESR1
ruffle membrane 1 EGFR
Early endosome membrane 1 EGFR
Multi-pass membrane protein 2 GC, LPAR1
cell junction 1 EGFR
cell surface 2 EGFR, LPAR1
dendritic shaft 1 LPAR1
glutamatergic synapse 2 EGFR, LPAR1
Golgi apparatus 4 ALB, ESR1, GC, SDF4
Golgi membrane 2 EGFR, INS
lysosomal membrane 1 GC
mitochondrial inner membrane 1 CYP24A1
neuronal cell body 2 CALCA, LPAR1
presynaptic membrane 1 LPAR1
Lysosome 1 GC
endosome 2 EGFR, LPAR1
plasma membrane 5 EGFR, ESR1, LPAR1, PRKCQ, SDF4
terminal bouton 1 CALCA
Membrane 7 CAT, CYP1B1, EGFR, ESR1, GC, MTDH, SDF4
apical plasma membrane 2 EGFR, MTDH
basolateral plasma membrane 1 EGFR
extracellular exosome 4 ALB, CAT, GC, SDF4
Lysosome membrane 1 GC
Lumenal side 1 GC
endoplasmic reticulum 4 ALB, GC, MTDH, SDF4
extracellular space 9 ALB, BGLAP, CALCA, EGFR, FGF23, GC, INS, PRL, PTH
lysosomal lumen 1 GC
perinuclear region of cytoplasm 2 EGFR, MTDH
Cell junction, tight junction 1 MTDH
bicellular tight junction 1 MTDH
intercellular canaliculus 1 MTDH
mitochondrion 4 CAT, CYP1B1, CYP24A1, CYP27B1
protein-containing complex 4 ALB, CAT, EGFR, ESR1
intracellular membrane-bounded organelle 2 CAT, CYP1B1
Microsome membrane 1 CYP1B1
Single-pass type I membrane protein 1 EGFR
Secreted 7 ALB, BGLAP, CALCA, FGF23, GC, INS, PRL
extracellular region 9 ALB, BGLAP, CALCA, CAT, FGF23, GC, INS, PRL, PTH
Single-pass membrane protein 1 MTDH
mitochondrial outer membrane 1 CYP27B1
hippocampal mossy fiber to CA3 synapse 1 CALCA
mitochondrial matrix 1 CAT
anchoring junction 1 ALB
transcription regulator complex 1 ESR1
centriolar satellite 1 PRKCQ
Nucleus membrane 1 MTDH
nuclear membrane 2 EGFR, MTDH
dendritic spine 1 LPAR1
perikaryon 1 BGLAP
vesicle 1 BGLAP
postsynaptic membrane 1 LPAR1
Membrane raft 1 EGFR
focal adhesion 2 CAT, EGFR
GABA-ergic synapse 1 LPAR1
Peroxisome 1 CAT
intracellular vesicle 1 EGFR
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
Late endosome 1 SDF4
receptor complex 2 EGFR, VDR
ciliary basal body 1 ALB
chromatin 3 ESR1, PRL, VDR
centriole 1 ALB
[Isoform 5]: Cytoplasm 1 SDF4
Nucleus, nucleolus 1 MTDH
spindle pole 1 ALB
blood microparticle 2 ALB, GC
fibrillar center 1 MTDH
endosome lumen 2 INS, PRL
euchromatin 1 ESR1
basal plasma membrane 1 EGFR
synaptic membrane 1 EGFR
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 2 CAT, INS
Golgi apparatus lumen 1 SDF4
Golgi lumen 4 BGLAP, FGF23, INS, SDF4
endoplasmic reticulum lumen 4 ALB, BGLAP, FGF23, INS
platelet alpha granule lumen 1 ALB
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
immunological synapse 1 PRKCQ
neuronal dense core vesicle 1 CALCA
aggresome 1 PRKCQ
clathrin-coated endocytic vesicle membrane 1 EGFR
[Isoform 1]: Nucleus 1 ESR1
bleb 1 SDF4
multivesicular body, internal vesicle lumen 1 EGFR
Shc-EGFR complex 1 EGFR
catalase complex 1 CAT
ciliary transition fiber 1 ALB
[Isoform 1]: Golgi apparatus lumen 1 SDF4


文献列表

  • Anastasia Alexandridou, Dietrich A Volmer. 2-fluoro-1-methylpyridinium p-toluene sulfonate: a new LC-MS/MS derivatization reagent for vitamin D metabolites. Journal of lipid research. 2023 08; 64(8):100409. doi: 10.1016/j.jlr.2023.100409. [PMID: 37406930]
  • Simon Hsu, Leila R Zelnick, Yvonne S Lin, Cora M Best, Bryan R Kestenbaum, Kenneth E Thummel, Andrew N Hoofnagle, Ian H de Boer. Validation of the 24,25-dihydroxyvitamin D3 to 25-hydroxyvitamin D3 ratio as a biomarker of 25-hydroxyvitamin D3 clearance. The Journal of steroid biochemistry and molecular biology. 2022 03; 217(?):106047. doi: 10.1016/j.jsbmb.2021.106047. [PMID: 34954017]
  • Sieglinde Zelzer, Caroline Le Goff, Stéphanie Peeters, Chiara Calaprice, Andreas Meinitzer, Dietmar Enko, Walter Goessler, Markus Herrmann, Etienne Cavalier. Comparison of two LC-MS/MS methods for the quantification of 24,25-dihydroxyvitamin D3 in patients and external quality assurance samples. Clinical chemistry and laboratory medicine. 2022 01; 60(1):74-81. doi: 10.1515/cclm-2021-0792. [PMID: 34727586]
  • Dae-Hyun Ko, Sun-Hee Jun, Youngwon Nam, Sang H Song, Minje Han, Yeo-Min Yun, Kyunghoon Lee, Junghan Song. Multiplex LC-MS/MS for simultaneous determination of 25-hydroxyvitamin D, 24,25-dihydroxyvitamin D3, albumin, and vitamin D-binding protein with its isoforms: One-step estimation of bioavailable vitamin D and vitamin D metabolite ratio. The Journal of steroid biochemistry and molecular biology. 2021 02; 206(?):105796. doi: 10.1016/j.jsbmb.2020.105796. [PMID: 33259939]
  • Hyun-Ki Kim, Hye Jin Chung, Hương Giang Lê, Byoung-Kuk Na, Min-Chul Cho. Serum 24,25-dihydroxyvitamin D level in general Korean population and its relationship with other vitamin D biomarkers. PloS one. 2021; 16(2):e0246541. doi: 10.1371/journal.pone.0246541. [PMID: 33606762]
  • Alexandra Povaliaeva, Ekaterina Pigarova, Artem Zhukov, Viktor Bogdanov, Larisa Dzeranova, Olga Mel'nikova, Elena Pekareva, Natalya Malysheva, Vitaliy Ioutsi, Larisa Nikankina, Liudmila Rozhinskaya. Evaluation of Vitamin D Metabolism in Patients with Type 1 Diabetes Mellitus in the Setting of Cholecalciferol Treatment. Nutrients. 2020 Dec; 12(12):. doi: 10.3390/nu12123873. [PMID: 33352890]
  • Sieglinde Zelzer, Andreas Meinitzer, Dietmar Enko, Sebastian Simstich, Caroline Le Goff, Etienne Cavalier, Markus Herrmann, Walter Goessler. Simultaneous determination of 24,25- and 25,26-dihydroxyvitamin D3 in serum samples with liquid-chromatography mass spectrometry - A useful tool for the assessment of vitamin D metabolism. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2020 Nov; 1158(?):122394. doi: 10.1016/j.jchromb.2020.122394. [PMID: 33091679]
  • Anna E Goodroe, Casey Fitz, Michael L Power, Ricki J Colman, Saverio Capuano, Toni E Ziegler. Evaluation of vitamin D3 metabolites in Callithrix jacchus (common marmoset). American journal of primatology. 2020 06; 82(6):e23131. doi: 10.1002/ajp.23131. [PMID: 32270886]
  • Etienne Cavalier, Loreen Huyghebaert, Olivier Rousselle, Anne-Catherine Bekaert, Stéphanie Kovacs, Laura Vranken, Stéphanie Peeters, Caroline Le Goff, Aurélie Ladang. Simultaneous measurement of 25(OH)-vitamin D and 24,25(OH)2-vitamin D to define cut-offs for CYP24A1 mutation and vitamin D deficiency in a population of 1200 young subjects. Clinical chemistry and laboratory medicine. 2020 01; 58(2):197-201. doi: 10.1515/cclm-2019-0996. [PMID: 31804956]
  • Hanfei Zhu, Ruihan Wu, Zijun Gu, Minghui Ji, Qin Xu. Vitamin D3 Is Transformed into 1,25(OH)2D3 by Triggering CYP3A11(CYP3A4) Activity and Hydrolyzing Midazolam. Medical science monitor : international medical journal of experimental and clinical research. 2019 Dec; 25(?):9159-9166. doi: 10.12659/msm.917904. [PMID: 31787743]
  • Adrian R Martineau, Kenneth E Thummel, Zhican Wang, David A Jolliffe, Barbara J Boucher, Simon J Griffin, Nita G Forouhi, Graham A Hitman. Differential Effects of Oral Boluses of Vitamin D2 vs Vitamin D3 on Vitamin D Metabolism: A Randomized Controlled Trial. The Journal of clinical endocrinology and metabolism. 2019 12; 104(12):5831-5839. doi: 10.1210/jc.2019-00207. [PMID: 31199458]
  • Anja C Baur, Julia Kühn, Corinna Brandsch, Frank Hirche, Gabriele I Stangl. Intake of ergosterol increases the vitamin D concentrations in serum and liver of mice. The Journal of steroid biochemistry and molecular biology. 2019 11; 194(?):105435. doi: 10.1016/j.jsbmb.2019.105435. [PMID: 31352023]
  • Vito Francic, Stan R Ursem, Niek F Dirks, Martin H Keppel, Verena Theiler-Schwetz, Christian Trummer, Marlene Pandis, Valentin Borzan, Martin R Grübler, Nicolas D Verheyen, Winfried März, Andreas Tomaschitz, Stefan Pilz, Annemieke C Heijboer, Barbara Obermayer-Pietsch. The Effect of Vitamin D Supplementation on its Metabolism and the Vitamin D Metabolite Ratio. Nutrients. 2019 Oct; 11(10):. doi: 10.3390/nu11102539. [PMID: 31640241]
  • Naoya Toriu, Keiichi Sumida, Masahiko Oguro, Yoichi Oshima, Hiroki Mizuno, Eiko Hasegawa, Tatsuya Suwabe, Masahiro Kawada, Toshiharu Ueno, Noriko Hayami, Akinari Sekine, Rikako Hiramatsu, Masayuki Yamanouchi, Junichi Hoshino, Naoki Sawa, Kenmei Takaichi, Kenichi Ohashi, Keiichi Kinowaki, Takeshi Fujii, Ryosuke Date, Yoshifumi Ubara. Increase of 1,25 dihydroxyvitamin D in sarcoidosis patients with renal dysfunction. Clinical and experimental nephrology. 2019 Oct; 23(10):1202-1210. doi: 10.1007/s10157-019-01760-3. [PMID: 31240503]
  • Anjali Verma, D Joshua Cohen, Nofrat Schwartz, Chandana Muktipaty, Jennifer E Koblinski, Barbara D Boyan, Zvi Schwartz. 24R,25-Dihydroxyvitamin D3 regulates breast cancer cells in vitro and in vivo. Biochimica et biophysica acta. General subjects. 2019 10; 1863(10):1498-1512. doi: 10.1016/j.bbagen.2019.05.013. [PMID: 31125679]
  • Anjali Verma, Zvi Schwartz, Barbara D Boyan. 24R,25-dihydroxyvitamin D3 modulates tumorigenicity in breast cancer in an estrogen receptor-dependent manner. Steroids. 2019 10; 150(?):108447. doi: 10.1016/j.steroids.2019.108447. [PMID: 31302113]
  • Glenville Jones, Martin Kaufmann. Update on pharmacologically-relevant vitamin D analogues. British journal of clinical pharmacology. 2019 06; 85(6):1095-1102. doi: 10.1111/bcp.13781. [PMID: 30308088]
  • Martin Kaufmann, Corine Martineau, Alice Arabian, Mary Traynor, René St-Arnaud, Glenville Jones. Calcioic acid: In vivo detection and quantification of the terminal C24-oxidation product of 25-hydroxyvitamin D3 and related intermediates in serum of mice treated with 24,25-dihydroxyvitamin D3. The Journal of steroid biochemistry and molecular biology. 2019 04; 188(?):23-28. doi: 10.1016/j.jsbmb.2018.12.001. [PMID: 30553931]
  • G D Carter, F Ahmed, J Berry, E Cavalier, R Durazo-Arvizu, E Gunter, G Jones, J Jones, K Phinney, C T Sempos, P J Twomey, E L Williams, S A Wise. External Quality Assessment of 24,25-dihydroxyvitamin D3 (24,25(OH)2D3) assays. The Journal of steroid biochemistry and molecular biology. 2019 03; 187(?):130-133. doi: 10.1016/j.jsbmb.2018.11.010. [PMID: 30476591]
  • Danyang Li, Louisa E Jeffery, Carl Jenkinson, Stephanie R Harrison, Rene F Chun, John S Adams, Karim Raza, Martin Hewison. Serum and synovial fluid vitamin D metabolites and rheumatoid arthritis. The Journal of steroid biochemistry and molecular biology. 2019 03; 187(?):1-8. doi: 10.1016/j.jsbmb.2018.10.008. [PMID: 30611909]
  • Cora M Best, Eva K Pressman, Ruth Anne Queenan, Elizabeth Cooper, Kimberly O O'Brien. Longitudinal changes in serum vitamin D binding protein and free 25-hydroxyvitamin D in a multiracial cohort of pregnant adolescents. The Journal of steroid biochemistry and molecular biology. 2019 02; 186(?):79-88. doi: 10.1016/j.jsbmb.2018.09.019. [PMID: 30278215]
  • Qi Dai, Xiangzhu Zhu, JoAnn E Manson, Yiqing Song, Xingnan Li, Adrian A Franke, Rebecca B Costello, Andrea Rosanoff, Hui Nian, Lei Fan, Harvey Murff, Reid M Ness, Douglas L Seidner, Chang Yu, Martha J Shrubsole. Magnesium status and supplementation influence vitamin D status and metabolism: results from a randomized trial. The American journal of clinical nutrition. 2018 12; 108(6):1249-1258. doi: 10.1093/ajcn/nqy274. [PMID: 30541089]
  • Suvi T Itkonen, Elina T Pajula, Kirsten G Dowling, George Lj Hull, Kevin D Cashman, Christel Je Lamberg-Allardt. Poor bioavailability of vitamin D2 from ultraviolet-irradiated D2-rich yeast in rats. Nutrition research (New York, N.Y.). 2018 11; 59(?):36-43. doi: 10.1016/j.nutres.2018.07.008. [PMID: 30442231]
  • Albert Shieh, Christina Ma, Rene F Chun, Jonas Wittwer-Schegg, Leon Swinkels, Tonnie Huijs, Jeffrey Wang, Ines Donangelo, Martin Hewison, John S Adams. Associations Between Change in Total and Free 25-Hydroxyvitamin D With 24,25-Dihydroxyvitamin D and Parathyroid Hormone. The Journal of clinical endocrinology and metabolism. 2018 09; 103(9):3368-3375. doi: 10.1210/jc.2018-00515. [PMID: 29931358]
  • Michiyasu Ishizawa, Daisuke Akagi, Makoto Makishima. Lithocholic Acid Is a Vitamin D Receptor Ligand That Acts Preferentially in the Ileum. International journal of molecular sciences. 2018 07; 19(7):. doi: 10.3390/ijms19071975. [PMID: 29986424]
  • Cora M Best, Eva K Pressman, Ruth Anne Queenan, Elizabeth Cooper, Françoise Vermeylen, Kimberly O O'Brien. Gestational Age and Maternal Serum 25-hydroxyvitamin D Concentration Interact to Affect the 24,25-dihydroxyvitamin D Concentration in Pregnant Adolescents. The Journal of nutrition. 2018 06; 148(6):868-875. doi: 10.1093/jn/nxy043. [PMID: 29796622]
  • Anouk M M Vaes, Michael Tieland, Margot F de Regt, Jonas Wittwer, Luc J C van Loon, Lisette C P G M de Groot. Dose-response effects of supplementation with calcifediol on serum 25-hydroxyvitamin D status and its metabolites: A randomized controlled trial in older adults. Clinical nutrition (Edinburgh, Scotland). 2018 06; 37(3):808-814. doi: 10.1016/j.clnu.2017.03.029. [PMID: 28433267]
  • Stephanie A Bora, Mary J Kennett, Philip B Smith, Andrew D Patterson, Margherita T Cantorna. Regulation of vitamin D metabolism following disruption of the microbiota using broad spectrum antibiotics. The Journal of nutritional biochemistry. 2018 06; 56(?):65-73. doi: 10.1016/j.jnutbio.2018.01.011. [PMID: 29459310]
  • Laura A Graeff-Armas, Martin Kaufmann, Elizabeth Lyden, Glenville Jones. Serum 24,25-dihydroxyvitamin D3 response to native vitamin D2 and D3 Supplementation in patients with chronic kidney disease on hemodialysis. Clinical nutrition (Edinburgh, Scotland). 2018 06; 37(3):1041-1045. doi: 10.1016/j.clnu.2017.04.020. [PMID: 28506446]
  • Hemamalini Ketha, Tom D Thacher, Sara S Oberhelman, Philip R Fischer, Ravinder J Singh, Rajiv Kumar. Comparison of the effect of daily versus bolus dose maternal vitamin D3 supplementation on the 24,25-dihydroxyvitamin D3 to 25-hydroxyvitamin D3 ratio. Bone. 2018 05; 110(?):321-325. doi: 10.1016/j.bone.2018.02.024. [PMID: 29486367]
  • Robin Taylor Wilson, Loren D Masters, Jill S Barnholtz-Sloan, Anna C Salzberg, Terryl J Hartman. Ancestry-Adjusted Vitamin D Metabolite Concentrations in Association With Cytochrome P450 3A Polymorphisms. American journal of epidemiology. 2018 04; 187(4):754-766. doi: 10.1093/aje/kwx187. [PMID: 28673024]
  • Charles Ginsberg, Ronit Katz, Ian H de Boer, Bryan R Kestenbaum, Michel Chonchol, Michael G Shlipak, Mark J Sarnak, Andrew N Hoofnagle, Dena E Rifkin, Pranav S Garimella, Joachim H Ix. The 24,25 to 25-hydroxyvitamin D ratio and fracture risk in older adults: The cardiovascular health study. Bone. 2018 02; 107(?):124-130. doi: 10.1016/j.bone.2017.11.011. [PMID: 29155243]
  • Stephanie A Bora, Mary J Kennett, Philip B Smith, Andrew D Patterson, Margherita T Cantorna. The Gut Microbiota Regulates Endocrine Vitamin D Metabolism through Fibroblast Growth Factor 23. Frontiers in immunology. 2018; 9(?):408. doi: 10.3389/fimmu.2018.00408. [PMID: 29599772]
  • Neus Fabregat-Cabello, Jordi Farre-Segura, Loreen Huyghebaert, Stéphanie Peeters, Caroline Le Goff, Jean-Claude Souberbielle, Étienne Cavalier. A fast and simple method for simultaneous measurements of 25(OH)D, 24,25(OH)2D and the Vitamin D Metabolite Ratio (VMR) in serum samples by LC-MS/MS. Clinica chimica acta; international journal of clinical chemistry. 2017 Oct; 473(?):116-123. doi: 10.1016/j.cca.2017.08.024. [PMID: 28842174]
  • Zona Batacchi, Cassianne Robinson-Cohen, Andrew N Hoofnagle, Tamara Isakova, Bryan Kestenbaum, Kevin J Martin, Myles S Wolf, Ian H de Boer. Effects of Vitamin D2 Supplementation on Vitamin D3 Metabolism in Health and CKD. Clinical journal of the American Society of Nephrology : CJASN. 2017 Sep; 12(9):1498-1506. doi: 10.2215/cjn.00530117. [PMID: 28768705]
  • Stephen A Wise, Susan S-C Tai, Michael A Nelson, Carolyn Q Burdette, Johanna E Camara, Andrew N Hoofnagle, Thomas J Laha, Graham D Carter, Julia Jones, Emma L Williams, Zoe J Barclay, Glenville Jones, Martin Kaufmann, Neil Binkley, Amita Kapoor, Toni Ziegler, Kevin D Cashman, Kirsten G Dowling, Christopher T Sempos. Interlaboratory Comparison for the Determination of 24,25-Dihydroxyvitamin D₃ in Human Serum Using Liquid Chromatography with Tandem Mass Spectrometry. Journal of AOAC International. 2017 Sep; 100(5):1308-1317. doi: 10.5740/jaoacint.17-0183. [PMID: 28741469]
  • Jonathan C Y Tang, Holly Nicholls, Isabelle Piec, Christopher J Washbourne, John J Dutton, Sarah Jackson, Julie Greeves, William D Fraser. Reference intervals for serum 24,25-dihydroxyvitamin D and the ratio with 25-hydroxyvitamin D established using a newly developed LC-MS/MS method. The Journal of nutritional biochemistry. 2017 08; 46(?):21-29. doi: 10.1016/j.jnutbio.2017.04.005. [PMID: 28437713]
  • Martin Kaufmann, Nicole Morse, Billy Joe Molloy, Donald P Cooper, Karl Peter Schlingmann, Arnaud Molin, Marie Laure Kottler, J Christopher Gallagher, Laura Armas, Glenville Jones. Improved Screening Test for Idiopathic Infantile Hypercalcemia Confirms Residual Levels of Serum 24,25-(OH)2 D3 in Affected Patients. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2017 Jul; 32(7):1589-1596. doi: 10.1002/jbmr.3135. [PMID: 28304097]
  • Kirsten G Dowling, George Hull, Jouko Sundvall, Christel Lamberg-Allardt, Kevin D Cashman. Improved accuracy of an tandem liquid chromatography-mass spectrometry method measuring 24R,25-dihydroxyvitamin D3 and 25-hydroxyvitamin D metabolites in serum using unspiked controls and its application to determining cross-reactivity of a chemiluminescent microparticle immunoassay. Journal of chromatography. A. 2017 May; 1497(?):102-109. doi: 10.1016/j.chroma.2017.03.058. [PMID: 28372841]
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