Nisoldipine (BioDeep_00000006578)

 

Secondary id: BioDeep_00000398963

human metabolite blood metabolite Volatile Flavor Compounds


代谢物信息卡片


3-methyl 5-(2-methylpropyl) 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

化学式: C20H24N2O6 (388.1634284)
中文名称: 尼索地平
谱图信息: 最多检出来源 Homo sapiens(blood) 7.3%

分子结构信息

SMILES: CC1=C(C(C(=C(N1)C)C(=O)OCC(C)C)C2=CC=CC=C2[N+](=O)[O-])C(=O)OC
InChI: InChI=1S/C20H24N2O6/c1-11(2)10-28-20(24)17-13(4)21-12(3)16(19(23)27-5)18(17)14-8-6-7-9-15(14)22(25)26/h6-9,11,18,21H,10H2,1-5H3

描述信息

Nisoldipine is a 1,4-dihydropyridine calcium channel blocker. It acts primarily on vascular smooth muscle cells by stabilizing voltage-gated L-type calcium channels in their inactive conformation. By inhibiting the influx of calcium in smooth muscle cells, nisoldipine prevents calcium-dependent smooth muscle contraction and subsequent vasoconstriction. Nisoldipine may be used in alone or in combination with other agents in the management of hypertension.
C - Cardiovascular system > C08 - Calcium channel blockers > C08C - Selective calcium channel blockers with mainly vascular effects > C08CA - Dihydropyridine derivatives
C78274 - Agent Affecting Cardiovascular System > C270 - Antihypertensive Agent > C333 - Calcium Channel Blocker
D002317 - Cardiovascular Agents > D002121 - Calcium Channel Blockers
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents
D000077264 - Calcium-Regulating Hormones and Agents
D049990 - Membrane Transport Modulators
C93038 - Cation Channel Blocker

同义名列表

6 个代谢物同义名

3-methyl 5-(2-methylpropyl) 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate; nisoldipine; Bay K 5552; Nisoldipin; Sular; Nisoldipine



数据库引用编号

19 个数据库交叉引用编号

分类词条

相关代谢途径

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PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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文献列表

  • Veenu P Mundada, Mitali H Patel, Piyush K Mundada, Krutika K Sawant. Development of Self-Microemulsifying Drug Delivery System to Improve Nisoldipine Bioavailability: Cell Line and In Vivo Evaluations : Development of Self-Microemulsifying Drug Delivery System. AAPS PharmSciTech. 2021 Oct; 22(8):256. doi: 10.1208/s12249-021-02109-4. [PMID: 34676456]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Nele Seemann, Andrea Welling, Ingo Rustenbeck. The inhibitor of connexin Cx36 channels, mefloquine, inhibits voltage-dependent Ca2+ channels and insulin secretion. Molecular and cellular endocrinology. 2018 09; 472(?):97-106. doi: 10.1016/j.mce.2017.11.024. [PMID: 29208420]
  • Narendar Dudhipala, Karthik Yadav Janga, Thirupathi Gorre. Comparative study of nisoldipine-loaded nanostructured lipid carriers and solid lipid nanoparticles for oral delivery: preparation, characterization, permeation and pharmacokinetic evaluation. Artificial cells, nanomedicine, and biotechnology. 2018; 46(sup2):616-625. doi: 10.1080/21691401.2018.1465068. [PMID: 29688077]
  • Narendar Dudhipala, Kishan Veerabrahma. Pharmacokinetic and pharmacodynamic studies of nisoldipine-loaded solid lipid nanoparticles developed by central composite design. Drug development and industrial pharmacy. 2015; 41(12):1968-77. doi: 10.3109/03639045.2015.1024685. [PMID: 25830370]
  • Chia-Wen Hsu, Jinghua Zhao, Ruili Huang, Jui-Hua Hsieh, Jon Hamm, Xiaoqing Chang, Keith Houck, Menghang Xia. Quantitative high-throughput profiling of environmental chemicals and drugs that modulate farnesoid X receptor. Scientific reports. 2014 Sep; 4(?):6437. doi: 10.1038/srep06437. [PMID: 25257666]
  • Min Li, Lin Yuan, Xiuqing Li, Xuran Zhi, Ning Sheng, Lantong Zhang. Studies on separation and pharmacokinetics of m-nisoldipine enantiomers in beagle dog plasma by LC/MS/MS. Journal of pharmaceutical and biomedical analysis. 2013 Nov; 85(?):61-6. doi: 10.1016/j.jpba.2013.06.015. [PMID: 23892657]
  • Shruti Chopra, Natarajan Venkatesan, Guru V Betageri. Formulation of lipid bearing pellets as a delivery system for poorly soluble drugs. International journal of pharmaceutics. 2013 Mar; 446(1-2):136-44. doi: 10.1016/j.ijpharm.2013.02.029. [PMID: 23422274]
  • Duo Wei, Wan-Yuan He, Qian-Zhou Lv. Effect of nisoldipine and olmesartan on endothelium-dependent vasodilation in essential hypertensive patients. CNS neuroscience & therapeutics. 2012 May; 18(5):400-5. doi: 10.1111/j.1755-5949.2012.00304.x. [PMID: 22533725]
  • Dezhi Kong, Sanni Li, Xiaowei Zhang, Jianmin Gu, Man Liu, Yan Meng, Yan Fu, Xiaojin La, Gangqiang Xue, Lantong Zhang, Qiao Wang. Simultaneous determination of m-nisoldipine and its three metabolites in rat plasma by liquid chromatography-mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2010 Nov; 878(29):2989-96. doi: 10.1016/j.jchromb.2010.09.005. [PMID: 20870469]
  • Qiaoxia Zhang, Gengliang Yang, Haiyan Liu, Jing Yang, Yongna Yan, Ligai Bai. Preparation of a novel glycidyl methacrylate-based monolith and its application for the determination of m-nisoldipine in human plasma. Journal of chromatographic science. 2010 Jul; 48(6):517-22. doi: 10.1093/chromsci/48.6.517. [PMID: 20822671]
  • Piero Ruggenenti, Paolo Cravedi, Giuseppe Remuzzi. The RAAS in the pathogenesis and treatment of diabetic nephropathy. Nature reviews. Nephrology. 2010 Jun; 6(6):319-30. doi: 10.1038/nrneph.2010.58. [PMID: 20440277]
  • Manthena V S Varma, Bo Feng, R Scott Obach, Matthew D Troutman, Jonathan Chupka, Howard R Miller, Ayman El-Kattan. Physicochemical determinants of human renal clearance. Journal of medicinal chemistry. 2009 Aug; 52(15):4844-52. doi: 10.1021/jm900403j. [PMID: 19445515]
  • Michel Chonchol, Rita Dale, Robert W Schrier, Raymond Estacio. Serum phosphorus and cardiovascular mortality in type 2 diabetes. The American journal of medicine. 2009 Apr; 122(4):380-6. doi: 10.1016/j.amjmed.2008.09.039. [PMID: 19332233]
  • Adina F Turcu, Jonathan A White, Mark E Kulaga, Myra Skluth, Claudia B Gruss. Calcium channel blocker-associated small bowel angioedema. Journal of clinical gastroenterology. 2009 Apr; 43(4):338-41. doi: 10.1097/mcg.0b013e31815cf6b9. [PMID: 19077729]
  • Xue-yan Chen, Wei Zhang, Qing-feng Miao, Yong-jian Zhang. m-Nisoldipine attenuates monocrotaline-induced pulmonary hypertension by suppressing 5-HT/ERK MAPK pathway. Yao xue xue bao = Acta pharmaceutica Sinica. 2008 Oct; 43(10):1011-8. doi: NULL. [PMID: 19127864]
  • R Scott Obach, Franco Lombardo, Nigel J Waters. Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals. 2008 Jul; 36(7):1385-405. doi: 10.1124/dmd.108.020479. [PMID: 18426954]
  • Tsuyoshi Shiga, Yuichiro Yamada, Naoki Matsuda, Takanori Tanaka, Akinori Urae, Masayuki Hashiguchi, Nobuhisa Hagiwara, Hiroshi Kasanuki. Influence of cilnidipine or nisoldipine on sympathetic activity in healthy male subjects. Heart and vessels. 2007 Nov; 22(6):404-9. doi: 10.1007/s00380-007-0984-y. [PMID: 18043999]
  • Ralf A Benndorf, Daniel Appel, Renke Maas, Edzard Schwedhelm, Ulrich O Wenzel, Rainer H Böger. Telmisartan improves endothelial function in patients with essential hypertension. Journal of cardiovascular pharmacology. 2007 Oct; 50(4):367-71. doi: 10.1097/fjc.0b013e31811dfbe7. [PMID: 18049303]
  • Wonku Kang. Simple and sensitive determination of nisoldipine in plasma using liquid chromatography-tandem mass spectrometry. Analytical sciences : the international journal of the Japan Society for Analytical Chemistry. 2006 Dec; 22(12):1597-9. doi: 10.2116/analsci.22.1597. [PMID: 17159323]
  • Ralf A Benndorf, Tanja Rudolph, Daniel Appel, Edzard Schwedhelm, Renke Maas, Friedrich Schulze, Elisabeth Silberhorn, Rainer H Böger. Telmisartan improves insulin sensitivity in nondiabetic patients with essential hypertension. Metabolism: clinical and experimental. 2006 Sep; 55(9):1159-64. doi: 10.1016/j.metabol.2006.04.013. [PMID: 16919533]
  • Hairong Wang, Lantong Zhang, Qiao Wang, Zhifang Yuan, Min Li. Validated LC-MS-MS method for determination of m-nisoldipine polymorphs in rat plasma and its application to pharmacokinetic studies. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2006 May; 835(1-2):71-6. doi: 10.1016/j.jchromb.2006.03.012. [PMID: 16567136]
  • Zunjian Zhang, Yuan Tian, Li Ni, Jinheng Li. High-performance liquid chromatography-electrospray ionization mass spectrometric determination of nisoldipine in human plasma. Journal of chromatographic science. 2004 Oct; 42(9):501-5. doi: 10.1093/chromsci/42.9.501. [PMID: 15693192]
  • Maria Paula Marques, Eduardo Barbosa Coelho, Neife Aparecida Guinaim Dos Santos, Tufik José Magalhães Geleilete, Vera Lucia Lanchote. Dynamic and kinetic disposition of nisoldipine enantiomers in hypertensive patients presenting with type-2 diabetes mellitus. European journal of clinical pharmacology. 2002 Dec; 58(9):607-14. doi: 10.1007/s00228-002-0528-4. [PMID: 12483453]
  • Satsuki Mochizuki, Bertrand Brassart, Aleksander Hinek. Signaling pathways transduced through the elastin receptor facilitate proliferation of arterial smooth muscle cells. The Journal of biological chemistry. 2002 Nov; 277(47):44854-63. doi: 10.1074/jbc.m205630200. [PMID: 12244048]
  • Costas Fourtounas, Ioannis Kopelias, Despina Kiriaki, Basil Agroyannis. Increased cyclosporine blood levels after nisoldipine administration in a renal transplant recipient. Transplant international : official journal of the European Society for Organ Transplantation. 2002 Nov; 15(11):586-8. doi: 10.1007/s00147-002-0438-5. [PMID: 12461666]
  • Michiteru Ohtani, Shizu Kawabata, Satoru Kariya, Katsuyoshi Uchino, Kei Itou, Hajime Kotaki, Kunio Kasuyama, Aki Morikawa, Isao Seo, Noriko Nishida. [Effect of grapefruit pulp on the pharmacokinetics of the dihydropyridine calcium antagonists nifedipine and nisoldipine]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 2002 May; 122(5):323-9. doi: 10.1248/yakushi.122.323. [PMID: 12040751]
  • Robert W Schrier, Raymond O Estacio, Anne Esler, Philip Mehler. Effects of aggressive blood pressure control in normotensive type 2 diabetic patients on albuminuria, retinopathy and strokes. Kidney international. 2002 Mar; 61(3):1086-97. doi: 10.1046/j.1523-1755.2002.00213.x. [PMID: 11849464]
  • Kohji Takara, Mikio Kakumoto, Yusuke Tanigawara, Junko Funakoshi, Toshiyuki Sakaeda, Katsuhiko Okumura. Interaction of digoxin with antihypertensive drugs via MDR1. Life sciences. 2002 Feb; 70(13):1491-500. doi: 10.1016/s0024-3205(01)01494-1. [PMID: 11895100]
  • I Tong Mak, Jingyun Zhang, William B Weglicki. Protective effects of dihydropyridine Ca-blockers against endothelial cell oxidative injury due to combined nitric oxide and superoxide. Pharmacological research. 2002 Jan; 45(1):27-33. doi: 10.1006/phrs.2001.0903. [PMID: 11820858]
  • M P Marques, N A Santos, E B Coelho, P S Bonato, V L Lanchote. Enantioselective assay of nisoldipine in human plasma by chiral high-performance liquid chromatography combined with gas chromatographic-mass spectrometry: applications to pharmacokinetics. Journal of chromatography. B, Biomedical sciences and applications. 2001 Oct; 762(1):87-95. doi: 10.1016/s0378-4347(01)00352-8. [PMID: 11589462]
  • M Montero, M T Alonso, A Albillos, I Cuchillo-Ibáñez, R Olivares, A G García, J García-Sancho, J Alvarez. Control of secretion by mitochondria depends on the size of the local [Ca2+] after chromaffin cell stimulation. The European journal of neuroscience. 2001 Jun; 13(12):2247-54. doi: 10.1046/j.0953-816x.2001.01602.x. [PMID: 11454028]
  • L Tarnow, P Rossing, C Jensen, B V Hansen, H H Parving. Long-term renoprotective effect of nisoldipine and lisinopril in type 1 diabetic patients with diabetic nephropathy. Diabetes care. 2000 Dec; 23(12):1725-30. doi: 10.2337/diacare.23.12.1725. [PMID: 11128341]
  • B A Summers, J L Overholt, N R Prabhakar. Augmentation of L-type calcium current by hypoxia in rabbit carotid body glomus cells: evidence for a PKC-sensitive pathway. Journal of neurophysiology. 2000 Sep; 84(3):1636-44. doi: 10.1152/jn.2000.84.3.1636. [PMID: 10980033]
  • B Nielsen, H Grønbaek, R Osterby, A Flyvbjerg. Effect of nitrendipine and nisoldipine on renal structure and function in long-term experimental diabetes in rats. American journal of kidney diseases : the official journal of the National Kidney Foundation. 2000 Aug; 36(2):368-77. doi: 10.1053/ajkd.2000.8988. [PMID: 10922316]
  • H Takanaga, A Ohnishi, H Murakami, H Matsuo, S Higuchi, A Urae, S Irie, H Furuie, K Matsukuma, M Kimura, K Kawano, Y Orii, T Tanaka, Y Sawada. Relationship between time after intake of grapefruit juice and the effect on pharmacokinetics and pharmacodynamics of nisoldipine in healthy subjects. Clinical pharmacology and therapeutics. 2000 Mar; 67(3):201-14. doi: 10.1067/mcp.2000.104215. [PMID: 10741622]
  • I T Mak, J Zhang, W B Weglicki. Cytoprotective properties of nisoldipine and amlodipine against oxidative endothelial cell injury. Annals of the New York Academy of Sciences. 2000; 899(?):403-6. doi: 10.1111/j.1749-6632.2000.tb06204.x. [PMID: 10863557]
  • A Usui, M Kawamura, F Murakami, H Oshima, K Yoshida, M Hibi, R Nakayama. Protective effect of nisoldipine on myocardial ischemia during coronary bypass surgery. The Japanese journal of thoracic and cardiovascular surgery : official publication of the Japanese Association for Thoracic Surgery = Nihon Kyobu Geka Gakkai zasshi. 1999 Oct; 47(10):471-7. doi: 10.1007/bf03218046. [PMID: 10554416]
  • R Heinig, H G Adelmann, G Ahr. The effect of ketoconazole on the pharmacokinetics, pharmacodynamics and safety of nisoldipine. European journal of clinical pharmacology. 1999 Mar; 55(1):57-60. doi: 10.1007/s002280050593. [PMID: 10206086]
  • R Heinig. Clinical pharmacokinetics of nisoldipine coat-core. Clinical pharmacokinetics. 1998 Sep; 35(3):191-208. doi: 10.2165/00003088-199835030-00003. [PMID: 9784933]
  • G Díaz-Araya, L Godoy, L Naranjo, J A Squella, M E Letelier, L J Núñez-Vergara. Antioxidant effects of 1,4-dihydropyridine and nitroso aryl derivatives on the Fe+3/ascorbate-stimulated lipid peroxidation in rat brain slices. General pharmacology. 1998 Sep; 31(3):385-91. doi: 10.1016/s0306-3623(98)00034-2. [PMID: 9703206]
  • R O Estacio, B W Jeffers, W R Hiatt, S L Biggerstaff, N Gifford, R W Schrier. The effect of nisoldipine as compared with enalapril on cardiovascular outcomes in patients with non-insulin-dependent diabetes and hypertension. The New England journal of medicine. 1998 Mar; 338(10):645-52. doi: 10.1056/nejm199803053381003. [PMID: 9486993]
  • M Pahor, B M Psaty, C D Furberg. New evidence on the prevention of cardiovascular events in hypertensive patients with type 2 diabetes. Journal of cardiovascular pharmacology. 1998; 32 Suppl 2(?):S18-23. doi: 10.1097/00005344-199800004-00004. [PMID: 9736437]
  • H K Louagie, K M Vandewoude, D P Vogelaers, A G Verstraete. The measurement of nisoldipine serum concentration in a case of severe nisoldipine overdose. Journal of toxicology. Clinical toxicology. 1998; 36(1-2):125-7. doi: 10.3109/15563659809162600. [PMID: 9541058]
  • M L Kauker, E T Zawada, L M Kauker, R J Roman, L Rosivall. Evidence for distal tubular inhibition of calcium efflux by nisoldipine in the SHR rat. Experimental nephrology. 1997 Sep; 5(5):384-9. doi: . [PMID: 9386974]
  • R Heinig, G Ahr, Y Hayauchi, J Kuhlmann. Pharmacokinetics of the controlled-release nisoldipine coat-core tablet formulation. International journal of clinical pharmacology and therapeutics. 1997 Aug; 35(8):341-51. doi: NULL. [PMID: 9266290]
  • A Fujinishi, K Takahara, C Ohba, Y Nakashima, A Kuroiwa. Effects of nisoldipine on cytosolic calcium, platelet aggregation, and coagulation/fibrinolysis in patients with coronary artery disease. Angiology. 1997 Jun; 48(6):515-21. doi: 10.1177/000331979704800606. [PMID: 9194537]
  • H D Langtry, C M Spencer. Nisoldipine coat-core. A review of its pharmacodynamic and pharmacokinetic properties and clinical efficacy in the management of ischaemic heart disease. Drugs. 1997 May; 53(5):867-84. doi: 10.2165/00003495-199753050-00013. [PMID: 9129871]
  • J C Russell, P J Dolphin, S E Graham, R M Amy. Cardioprotective and hypolipidemic effects of nisoldipine in the JCR:LA-cp rat. Journal of cardiovascular pharmacology. 1997 May; 29(5):586-92. doi: 10.1097/00005344-199705000-00004. [PMID: 9213199]
  • P Rossing, L Tarnow, S Boelskifte, B R Jensen, F S Nielsen, H H Parving. Differences between nisoldipine and lisinopril on glomerular filtration rates and albuminuria in hypertensive IDDM patients with diabetic nephropathy during the first year of treatment. Diabetes. 1997 Mar; 46(3):481-7. doi: 10.2337/diab.46.3.481. [PMID: 9032106]
  • L H Opie, F O Müller, D P Myburgh, C Rosendorff, P Sareli, Y K Seedat, D J Weich, H G Luus. Efficacy and tolerability of nisoldipine coat-core formulation in the treatment of essential hypertension: The South African Multicenter ANCHOR Study. Ambulatory Nisoldipine Coat-Core Hypertension Outpatient Response (ANCHOR) Investigators. American journal of hypertension. 1997 Mar; 10(3):250-60. doi: 10.1016/s0895-7061(96)00384-6. [PMID: 9056681]
  • K P Patel, P L Zhang, D W Zeigler, M L Kauker. Renal response to volume expansion in streptozotocin-induced diabetic rats: influence of calcium channel blockade. Diabetes research and clinical practice. 1997 Mar; 35(2-3):69-74. doi: 10.1016/s0168-8227(97)01376-4. [PMID: 9179460]
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  • J Langan, L Rodríguez-Mañas, P Sareli, R Heinig. Nisoldipine CC: clinical experience in hypertension. Cardiology. 1997; 88 Suppl 1(?):56-62; discussion 63. doi: 10.1159/000177466. [PMID: 9118169]
  • H G Schaefer, R Heinig, G Ahr, H Adelmann, W Tetzloff, J Kuhlmann. Pharmacokinetic-pharmacodynamic modelling as a tool to evaluate the clinical relevance of a drug-food interaction for a nisoldipine controlled-release dosage form. European journal of clinical pharmacology. 1997; 51(6):473-80. doi: 10.1007/s002280050233. [PMID: 9112062]
  • H Sugawara, K Tobise, K Kikuchi. Antioxidant effects of calcium antagonists on rat myocardial membrane lipid peroxidation. Hypertension research : official journal of the Japanese Society of Hypertension. 1996 Dec; 19(4):223-8. doi: 10.1291/hypres.19.223. [PMID: 8986452]
  • R Michelucci, G Cipolla, D Passarelli, G Gatti, M Ochan, R Heinig, C A Tassinari, E Perucca. Reduced plasma nisoldipine concentrations in phenytoin-treated patients with epilepsy. Epilepsia. 1996 Nov; 37(11):1107-10. doi: 10.1111/j.1528-1157.1996.tb01032.x. [PMID: 8917062]
  • G L Plosker, D Faulds. Nisoldipine coat-core. A review of its pharmacology and therapeutic efficacy in hypertension. Drugs. 1996 Aug; 52(2):232-53. doi: 10.2165/00003495-199652020-00009. [PMID: 8841741]
  • V Gross, F C Luft. Nisoldipine and pressure-natriuresis curves in transgenic (mRen2)27 rats. Journal of hypertension. 1996 Apr; 14(4):529-35. doi: NULL. [PMID: 8761905]
  • W F Kauder, J A Watts. Antioxidant properties of dihydropyridines in isolated rat hearts. Biochemical pharmacology. 1996 Mar; 51(6):811-9. doi: 10.1016/0006-2952(95)02404-2. [PMID: 8602877]
  • C Letizia, F Barillà, S Cerci, A De Ciocchis, S Coassin, M A Mastroianni, C D'Ambrosio, P P Campa, D Scavo. Plasma endothelin-1 concentrations in patients with coronary artery disease during stress test before and after nisoldipine administration. Acta cardiologica. 1996; 51(2):165-72. doi: . [PMID: 8742913]
  • J Singh, A H Kaur, S Bansal, H Lal. Effect of nitrendipine, nimodipine and nisoldipine on water and electrolytes excretion in rats. Indian journal of physiology and pharmacology. 1996 Jan; 40(1):87-90. doi: NULL. [PMID: 8864778]
  • T Tavli, O Kozan, V G Cin, A Dogan, A Gokçin. The effects of nisoldipine on carotid artery stiffness and left ventricular functions. Japanese heart journal. 1995 Sep; 36(5):629-37. doi: 10.1536/ihj.36.629. [PMID: 8558767]
  • J M Capasso. Nisoldipine improves ventricular function in rats with ischemic heart failure. Journal of molecular and cellular cardiology. 1995 Sep; 27(9):1841-9. doi: 10.1016/0022-2828(95)90007-1. [PMID: 8523445]
  • S P Glasser, S Ripa, W T Garland, R Weiss, K Nademanee, S Singh, N Bittar. Antianginal and antiischemic efficacy of monotherapy extended-release nisoldipine (Coat Core) in chronic stable angina. Journal of clinical pharmacology. 1995 Aug; 35(8):780-4. doi: 10.1002/j.1552-4604.1995.tb04120.x. [PMID: 8522634]
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