nisoldipine (BioDeep_00000398963)
Main id: BioDeep_00000006578
natural product Volatile Flavor Compounds
代谢物信息卡片
Nisoldipine (Sular)
化学式: C20H24N2O6 (388.1634284)
中文名称: 尼索地平
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1(=C(C(C(=C(N1)C)C(OC)=O)C2=CC=CC(=C2)[N+](=O)[O-])C(OCC(C)C)=O)C
InChI: InChI=1S/C20H24N2O6/c1-11(2)10-28-20(24)17-13(4)21-12(3)16(19(23)27-5)18(17)14-8-6-7-9-15(14)22(25)26/h6-9,11,18,21H,10H2,1-5H3
描述信息
C - Cardiovascular system > C08 - Calcium channel blockers > C08C - Selective calcium channel blockers with mainly vascular effects > C08CA - Dihydropyridine derivatives
C78274 - Agent Affecting Cardiovascular System > C270 - Antihypertensive Agent > C333 - Calcium Channel Blocker
D002317 - Cardiovascular Agents > D002121 - Calcium Channel Blockers
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents
D000077264 - Calcium-Regulating Hormones and Agents
D049990 - Membrane Transport Modulators
C93038 - Cation Channel Blocker
同义名列表
3 个代谢物同义名
数据库引用编号
16 个数据库交叉引用编号
- ChEBI: CHEBI:76917
- ChEBI: CHEBI:7577
- KEGG: C07699
- KEGGdrug: D00618
- PubChem: 4499
- DrugBank: DB00401
- ChEMBL: CHEMBL3192341
- ChEMBL: CHEMBL441428
- ChEMBL: CHEMBL1726
- MeSH: Nisoldipine
- CAS: 63675-72-9
- MoNA: CCMSLIB00000078275
- MoNA: CCMSLIB00000078274
- PubChem: 9901
- NIKKAJI: J19.554E
- KNApSAcK: 7577
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Veenu P Mundada, Mitali H Patel, Piyush K Mundada, Krutika K Sawant. Development of Self-Microemulsifying Drug Delivery System to Improve Nisoldipine Bioavailability: Cell Line and In Vivo Evaluations : Development of Self-Microemulsifying Drug Delivery System.
AAPS PharmSciTech.
2021 Oct; 22(8):256. doi:
10.1208/s12249-021-02109-4. [PMID: 34676456] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Nele Seemann, Andrea Welling, Ingo Rustenbeck. The inhibitor of connexin Cx36 channels, mefloquine, inhibits voltage-dependent Ca2+ channels and insulin secretion.
Molecular and cellular endocrinology.
2018 09; 472(?):97-106. doi:
10.1016/j.mce.2017.11.024. [PMID: 29208420] - Narendar Dudhipala, Karthik Yadav Janga, Thirupathi Gorre. Comparative study of nisoldipine-loaded nanostructured lipid carriers and solid lipid nanoparticles for oral delivery: preparation, characterization, permeation and pharmacokinetic evaluation.
Artificial cells, nanomedicine, and biotechnology.
2018; 46(sup2):616-625. doi:
10.1080/21691401.2018.1465068. [PMID: 29688077] - Narendar Dudhipala, Kishan Veerabrahma. Pharmacokinetic and pharmacodynamic studies of nisoldipine-loaded solid lipid nanoparticles developed by central composite design.
Drug development and industrial pharmacy.
2015; 41(12):1968-77. doi:
10.3109/03639045.2015.1024685. [PMID: 25830370] - Chia-Wen Hsu, Jinghua Zhao, Ruili Huang, Jui-Hua Hsieh, Jon Hamm, Xiaoqing Chang, Keith Houck, Menghang Xia. Quantitative high-throughput profiling of environmental chemicals and drugs that modulate farnesoid X receptor.
Scientific reports.
2014 Sep; 4(?):6437. doi:
10.1038/srep06437. [PMID: 25257666] - Min Li, Lin Yuan, Xiuqing Li, Xuran Zhi, Ning Sheng, Lantong Zhang. Studies on separation and pharmacokinetics of m-nisoldipine enantiomers in beagle dog plasma by LC/MS/MS.
Journal of pharmaceutical and biomedical analysis.
2013 Nov; 85(?):61-6. doi:
10.1016/j.jpba.2013.06.015. [PMID: 23892657] - Shruti Chopra, Natarajan Venkatesan, Guru V Betageri. Formulation of lipid bearing pellets as a delivery system for poorly soluble drugs.
International journal of pharmaceutics.
2013 Mar; 446(1-2):136-44. doi:
10.1016/j.ijpharm.2013.02.029. [PMID: 23422274] - Duo Wei, Wan-Yuan He, Qian-Zhou Lv. Effect of nisoldipine and olmesartan on endothelium-dependent vasodilation in essential hypertensive patients.
CNS neuroscience & therapeutics.
2012 May; 18(5):400-5. doi:
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2010 Nov; 878(29):2989-96. doi:
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Journal of chromatographic science.
2010 Jul; 48(6):517-22. doi:
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2009 Aug; 52(15):4844-52. doi:
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The American journal of medicine.
2009 Apr; 122(4):380-6. doi:
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2009 Apr; 43(4):338-41. doi:
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Yao xue xue bao = Acta pharmaceutica Sinica.
2008 Oct; 43(10):1011-8. doi:
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Drug metabolism and disposition: the biological fate of chemicals.
2008 Jul; 36(7):1385-405. doi:
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Heart and vessels.
2007 Nov; 22(6):404-9. doi:
10.1007/s00380-007-0984-y. [PMID: 18043999] - Ralf A Benndorf, Daniel Appel, Renke Maas, Edzard Schwedhelm, Ulrich O Wenzel, Rainer H Böger. Telmisartan improves endothelial function in patients with essential hypertension.
Journal of cardiovascular pharmacology.
2007 Oct; 50(4):367-71. doi:
10.1097/fjc.0b013e31811dfbe7. [PMID: 18049303] - Wonku Kang. Simple and sensitive determination of nisoldipine in plasma using liquid chromatography-tandem mass spectrometry.
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry.
2006 Dec; 22(12):1597-9. doi:
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Metabolism: clinical and experimental.
2006 Sep; 55(9):1159-64. doi:
10.1016/j.metabol.2006.04.013. [PMID: 16919533] - Hairong Wang, Lantong Zhang, Qiao Wang, Zhifang Yuan, Min Li. Validated LC-MS-MS method for determination of m-nisoldipine polymorphs in rat plasma and its application to pharmacokinetic studies.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2006 May; 835(1-2):71-6. doi:
10.1016/j.jchromb.2006.03.012. [PMID: 16567136] - Zunjian Zhang, Yuan Tian, Li Ni, Jinheng Li. High-performance liquid chromatography-electrospray ionization mass spectrometric determination of nisoldipine in human plasma.
Journal of chromatographic science.
2004 Oct; 42(9):501-5. doi:
10.1093/chromsci/42.9.501. [PMID: 15693192] - Maria Paula Marques, Eduardo Barbosa Coelho, Neife Aparecida Guinaim Dos Santos, Tufik José Magalhães Geleilete, Vera Lucia Lanchote. Dynamic and kinetic disposition of nisoldipine enantiomers in hypertensive patients presenting with type-2 diabetes mellitus.
European journal of clinical pharmacology.
2002 Dec; 58(9):607-14. doi:
10.1007/s00228-002-0528-4. [PMID: 12483453] - Satsuki Mochizuki, Bertrand Brassart, Aleksander Hinek. Signaling pathways transduced through the elastin receptor facilitate proliferation of arterial smooth muscle cells.
The Journal of biological chemistry.
2002 Nov; 277(47):44854-63. doi:
10.1074/jbc.m205630200. [PMID: 12244048] - Costas Fourtounas, Ioannis Kopelias, Despina Kiriaki, Basil Agroyannis. Increased cyclosporine blood levels after nisoldipine administration in a renal transplant recipient.
Transplant international : official journal of the European Society for Organ Transplantation.
2002 Nov; 15(11):586-8. doi:
10.1007/s00147-002-0438-5. [PMID: 12461666] - Michiteru Ohtani, Shizu Kawabata, Satoru Kariya, Katsuyoshi Uchino, Kei Itou, Hajime Kotaki, Kunio Kasuyama, Aki Morikawa, Isao Seo, Noriko Nishida. [Effect of grapefruit pulp on the pharmacokinetics of the dihydropyridine calcium antagonists nifedipine and nisoldipine].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.
2002 May; 122(5):323-9. doi:
10.1248/yakushi.122.323. [PMID: 12040751] - Robert W Schrier, Raymond O Estacio, Anne Esler, Philip Mehler. Effects of aggressive blood pressure control in normotensive type 2 diabetic patients on albuminuria, retinopathy and strokes.
Kidney international.
2002 Mar; 61(3):1086-97. doi:
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Life sciences.
2002 Feb; 70(13):1491-500. doi:
10.1016/s0024-3205(01)01494-1. [PMID: 11895100] - I Tong Mak, Jingyun Zhang, William B Weglicki. Protective effects of dihydropyridine Ca-blockers against endothelial cell oxidative injury due to combined nitric oxide and superoxide.
Pharmacological research.
2002 Jan; 45(1):27-33. doi:
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Journal of chromatography. B, Biomedical sciences and applications.
2001 Oct; 762(1):87-95. doi:
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The European journal of neuroscience.
2001 Jun; 13(12):2247-54. doi:
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Diabetes care.
2000 Dec; 23(12):1725-30. doi:
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Journal of neurophysiology.
2000 Sep; 84(3):1636-44. doi:
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American journal of kidney diseases : the official journal of the National Kidney Foundation.
2000 Aug; 36(2):368-77. doi:
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Clinical pharmacology and therapeutics.
2000 Mar; 67(3):201-14. doi:
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Annals of the New York Academy of Sciences.
2000; 899(?):403-6. doi:
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The Japanese journal of thoracic and cardiovascular surgery : official publication of the Japanese Association for Thoracic Surgery = Nihon Kyobu Geka Gakkai zasshi.
1999 Oct; 47(10):471-7. doi:
10.1007/bf03218046. [PMID: 10554416] - R Heinig, H G Adelmann, G Ahr. The effect of ketoconazole on the pharmacokinetics, pharmacodynamics and safety of nisoldipine.
European journal of clinical pharmacology.
1999 Mar; 55(1):57-60. doi:
10.1007/s002280050593. [PMID: 10206086] - R Heinig. Clinical pharmacokinetics of nisoldipine coat-core.
Clinical pharmacokinetics.
1998 Sep; 35(3):191-208. doi:
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General pharmacology.
1998 Sep; 31(3):385-91. doi:
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The New England journal of medicine.
1998 Mar; 338(10):645-52. doi:
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Journal of cardiovascular pharmacology.
1998; 32 Suppl 2(?):S18-23. doi:
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Journal of toxicology. Clinical toxicology.
1998; 36(1-2):125-7. doi:
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Experimental nephrology.
1997 Sep; 5(5):384-9. doi:
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International journal of clinical pharmacology and therapeutics.
1997 Aug; 35(8):341-51. doi:
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Angiology.
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Drugs.
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Journal of cardiovascular pharmacology.
1997 May; 29(5):586-92. doi:
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Diabetes.
1997 Mar; 46(3):481-7. doi:
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American journal of hypertension.
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Diabetes research and clinical practice.
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Cardiovascular drugs and therapy.
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Canadian journal of physiology and pharmacology.
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Cardiology.
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European journal of clinical pharmacology.
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Acta cardiologica.
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