Capillarisin (BioDeep_00000000656)

 

Secondary id: BioDeep_00000398479, BioDeep_00001867536

human metabolite PANOMIX_OTCML-2023 blood metabolite natural product


代谢物信息卡片


5,7-dihydroxy-2-(4-hydroxyphenoxy)-6-methoxy-4H-chromen-4-one

化学式: C16H12O7 (316.05830019999996)
中文名称: 茵陈色原酮
谱图信息: 最多检出来源 Homo sapiens(blood) 43.44%

分子结构信息

SMILES: COC1=C(C2=C(C=C1O)OC(=CC2=O)OC3=CC=C(C=C3)O)O
InChI: InChI=1S/C16H12O7/c1-21-16-11(19)6-12-14(15(16)20)10(18)7-13(23-12)22-9-4-2-8(17)3-5-9/h2-7,17,19-20H,1H3

描述信息

Capillarisin is a member of coumarins.
Capillarisin is a natural product found in Artemisia capillaris with data available.

同义名列表

9 个代谢物同义名

5,7-dihydroxy-2-(4-hydroxyphenoxy)-6-methoxy-4H-chromen-4-one; 5,7-dihydroxy-2-(4-hydroxyphenoxy)-6-methoxy-chromen-4-one; 5,7-dihydroxy-2-(4-hydroxyphenoxy)-6-methoxychromen-4-one; 5,7-dihydroxy-2-(4-hydroxy-phenoxy)-6-methoxychromone; 2-(p-Hydroxyphenoxy)-6-methoxy-5,7-dihydroxychromone; capillarisine; Capillarisin; AC1NQYDG; Capillarisin



数据库引用编号

18 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

20 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Guangyao Peng, Xiaoping Long. Capillarisin exerts antiasthmatic activity in neonatal rats via modulating the matrix remodeling. Pakistan journal of pharmaceutical sciences. 2020 Jul; 33(4(Supplementary)):1907-1915. doi: . [PMID: 33612476]
  • Akram Taleghani, Seyed Ahmad Emami, Zahra Tayarani-Najaran. Artemisia: a promising plant for the treatment of cancer. Bioorganic & medicinal chemistry. 2020 01; 28(1):115180. doi: 10.1016/j.bmc.2019.115180. [PMID: 31784199]
  • Ke-Hung Tsui, Ying-Ling Chang, Pei-Shan Yang, Chen-Pang Hou, Yu-Hsiang Lin, Bing-Wei Lin, Tsui-Hsia Feng, Horng-Heng Juang. The inhibitory effects of capillarisin on cell proliferation and invasion of prostate carcinoma cells. Cell proliferation. 2018 Apr; 51(2):e12429. doi: 10.1111/cpr.12429. [PMID: 29271007]
  • Ke-Hung Tsui, Ying-Ling Chang, Tsui-Hsia Feng, Chen-Pang Hou, Yu-Hsiang Lin, Pei-Shan Yang, Bing-Wei Lee, Horng-Heng Juang. Capillarisin blocks prostate-specific antigen expression on activation of androgen receptor in prostate carcinoma cells. The Prostate. 2018 03; 78(4):242-249. doi: 10.1002/pros.23463. [PMID: 29164633]
  • Minjee Kim, Jaemoo Chun, Hyun Ah Jung, Jae Sue Choi, Yeong Shik Kim. Capillarisin attenuates exercise-induced muscle damage through MAPK and NF-κB signaling. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2017 Aug; 32(?):30-36. doi: 10.1016/j.phymed.2017.04.007. [PMID: 28732805]
  • Salman Khan, Omer Shehzad, Jaemoo Chun, Ran Joo Choi, Saitbyul Park, Md Nurul Islam, Jae Sue Choi, Yeong Shik Kim. Anti-hyperalgesic and anti-allodynic activities of capillarisin via suppression of inflammatory signaling in animal model. Journal of ethnopharmacology. 2014 Mar; 152(3):478-86. doi: 10.1016/j.jep.2014.01.028. [PMID: 24495472]
  • Suckbae Han, Jong Hyun Lee, Chulwon Kim, Dongwoo Nam, Won-Seok Chung, Seok-Geun Lee, Kyoo Seok Ahn, Somi K Cho, Moonjae Cho, Kwang Seok Ahn. Capillarisin inhibits iNOS, COX-2 expression, and proinflammatory cytokines in LPS-induced RAW 264.7 macrophages via the suppression of ERK, JNK, and NF-κB activation. Immunopharmacology and immunotoxicology. 2013 Feb; 35(1):34-42. doi: 10.3109/08923973.2012.736522. [PMID: 23131135]
  • Salman Khan, Ran Joo Choi, Omer Shehzad, Hyun Pyo Kim, Md Nurul Islam, Jae Sue Choi, Yeong Shik Kim. Molecular mechanism of capillarisin-mediated inhibition of MyD88/TIRAP inflammatory signaling in in vitro and in vivo experimental models. Journal of ethnopharmacology. 2013 Jan; 145(2):626-37. doi: 10.1016/j.jep.2012.12.001. [PMID: 23237934]
  • Hye Kyung Kim, Bo Ram Choi, Yun Ok Bak, Chen Zhao, Sung Won Lee, Ju-Hong Jeon, Insuk So, Jong Kwan Park. The role of capillarisin from Artemisia capillaris on penile erection. Phytotherapy research : PTR. 2012 Jun; 26(6):800-5. doi: 10.1002/ptr.3635. [PMID: 22072532]
  • Akihito Mase, Bunsho Makino, Naoko Tsuchiya, Masahiro Yamamoto, Yoshio Kase, Shuuichi Takeda, Takaaki Hasegawa. Active ingredients of traditional Japanese (kampo) medicine, inchinkoto, in murine concanavalin A-induced hepatitis. Journal of ethnopharmacology. 2010 Feb; 127(3):742-9. doi: 10.1016/j.jep.2009.11.029. [PMID: 19962433]
  • Tzung-Yan Lee, Fang-Yu Chen, Hen-Hong Chang, Han-Chieh Lin. The effect of capillarisin on glycochenodeoxycholic acid-induced apoptosis and heme oxygenase-1 in rat primary hepatocytes. Molecular and cellular biochemistry. 2009 May; 325(1-2):53-9. doi: 10.1007/s11010-008-0019-8. [PMID: 19132499]
  • Haitao Lv, Hui Sun, Xijun Wang, Wenjun Sun, Guozheng Jiao, Dixin Zhou, Li Zhao, Hongxin Cao, Guangmei Zhang. Simultaneous determination by UPLC-ESI-MS of scoparone, capillarisin, rhein, and emodin in rat urine after oral administration of Yin Chen Hao Tang preparation. Journal of separation science. 2008 Mar; 31(4):659-66. doi: 10.1002/jssc.200700596. [PMID: 18264991]
  • C Y Chu, T H Tseng, J M Hwang, F P Chou, C J Wang. Protective effects of capillarisin on tert-butylhydroperoxide-induced oxidative damage in rat primary hepatocytes. Archives of toxicology. 1999 Jun; 73(4-5):263-8. doi: 10.1007/s002040050615. [PMID: 10463392]
  • X J Wang, H Sun, Z S Liu. [Quantitative analysis of 6,7-dimethylesculetin and capillarisine in Artemisia capillaris Thunb. and prescriptions containing the crude drug]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 1994 Nov; 19(11):667-70, 702. doi: . [PMID: 7893384]
  • T Ikenaga, M Hizako, M Tajima, K Nakashima. Production of choleretic substances in the capitulum, leaf and stem of Artemisia capillaris during the plant growth cycle. Biological & pharmaceutical bulletin. 1994 Jan; 17(1):150-1. doi: 10.1248/bpb.17.150. [PMID: 8148806]
  • T Komiya, M Tsukui, H Oshio. Letter: Capillarisin, a constituent from Artemisiae capillaris herba. Chemical & pharmaceutical bulletin. 1975 Jun; 23(6):1387-9. doi: 10.1248/cpb.23.1387. [PMID: 1182880]