Pancuronium (BioDeep_00000006531)

Main id: BioDeep_00000859287

Secondary id: BioDeep_00001868442

human metabolite blood metabolite


代谢物信息卡片


Pancuronium

化学式: C35H60N2O4+2 (572.4553)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(=O)OC1CC2CCC3C(C2(CC1[N+]4(CCCCC4)C)C)CCC5(C3CC(C5OC(=O)C)[N+]6(CCCCC6)C)C
InChI: InChI=1S/C35H60N2O4/c1-24(38)40-32-21-26-13-14-27-28(35(26,4)23-31(32)37(6)19-11-8-12-20-37)15-16-34(3)29(27)22-30(33(34)41-25(2)39)36(5)17-9-7-10-18-36/h26-33H,7-23H2,1-6H3/q+2/t26-,27+,28-,29-,30-,31-,32-,33-,34-,35-/m0/s1

描述信息

D018373 - Peripheral Nervous System Agents > D009465 - Neuromuscular Agents > D009466 - Neuromuscular Blocking Agents
M - Musculo-skeletal system > M03 - Muscle relaxants > M03A - Muscle relaxants, peripherally acting agents
D018377 - Neurotransmitter Agents > D018678 - Cholinergic Agents > D018680 - Cholinergic Antagonists
C78281 - Agent Affecting Musculoskeletal System > C29696 - Muscle Relaxant

同义名列表

2 个代谢物同义名

Pancuronium; BDBM86425



数据库引用编号

13 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 9 ADRA1A, ALB, ATN1, AXIN2, CDH5, CHAT, PIK3C2A, POMC, PVR
Peripheral membrane protein 1 ACHE
Nucleus 7 ACHE, ADRA1A, ALB, ATN1, AXIN2, CHAT, PIK3C2A
cytosol 6 ADRA1A, ALB, AVP, AXIN2, CHAT, PIK3C2A
dendrite 1 AVP
trans-Golgi network 1 PIK3C2A
centrosome 2 ALB, AXIN2
nucleoplasm 5 ADRA1A, ATN1, CDH5, PIK3C2A, SCNN1G
Cell membrane 4 ACHE, ADRA1A, CDH5, PIK3C2A
Early endosome membrane 1 NMB
Multi-pass membrane protein 3 ADRA1A, CACNA1I, SCNN1G
Synapse 2 ACHE, CHAT
cell junction 2 ATN1, CDH5
cell surface 3 ACHE, CDH5, PVR
Golgi apparatus 2 ACHE, ALB
Golgi membrane 1 INS
neuromuscular junction 1 ACHE
plasma membrane 14 ACHE, ADRA1A, AXIN2, BCHE, CACNA1I, CDH5, EDNRA, IGHE, KNG1, NMB, PIK3C2A, PVR, REN, SCNN1G
Membrane 7 ACHE, CACNA1I, CDH5, NMB, PIK3C2A, PVR, REN
apical plasma membrane 1 SCNN1G
caveola 1 ADRA1A
extracellular exosome 4 ALB, KNG1, PIK3C2A, SCNN1G
endoplasmic reticulum 1 ALB
extracellular space 11 ACHE, ALB, AVP, BCHE, IGHE, INS, KNG1, NMB, POMC, PVR, REN
perinuclear region of cytoplasm 2 ACHE, ATN1
adherens junction 2 CDH5, PVR
bicellular tight junction 1 CDH5
protein-containing complex 1 ALB
intracellular membrane-bounded organelle 2 ADRA1A, PIK3C2A
Single-pass type I membrane protein 3 CDH5, IGHE, NMB
Secreted 8 ACHE, ALB, AVP, BCHE, INS, NMB, POMC, REN
extracellular region 10 ACHE, ALB, AVP, BCHE, IGHE, INS, KNG1, NMB, POMC, REN
Single-pass membrane protein 1 PVR
Extracellular side 1 ACHE
anchoring junction 2 ALB, ATN1
Nucleus membrane 1 ADRA1A
nuclear membrane 2 ADRA1A, CDH5
external side of plasma membrane 2 CDH5, SCNN1G
beta-catenin destruction complex 1 AXIN2
Melanosome membrane 1 NMB
apical part of cell 1 REN
cell-cell junction 1 CDH5
vesicle 1 PIK3C2A
Apical cell membrane 1 SCNN1G
focal adhesion 1 PVR
Cell junction, adherens junction 1 CDH5
basement membrane 1 ACHE
collagen-containing extracellular matrix 1 KNG1
secretory granule 2 AVP, POMC
Cell projection, neuron projection 1 NMB
neuron projection 2 CHAT, NMB
ciliary basal body 1 ALB
IgE immunoglobulin complex 1 IGHE
centriole 1 ALB
Secreted, extracellular space 1 KNG1
Golgi apparatus, trans-Golgi network 1 PIK3C2A
spindle pole 1 ALB
blood microparticle 3 ALB, BCHE, KNG1
Lipid-anchor, GPI-anchor 1 ACHE
[Isoform 2]: Cell membrane 1 IGHE
endosome lumen 1 INS
Membrane, caveola 1 ADRA1A
sodium channel complex 1 SCNN1G
side of membrane 1 ACHE
clathrin-coated vesicle 1 PIK3C2A
secretory granule lumen 2 INS, POMC
Golgi lumen 1 INS
endoplasmic reticulum lumen 4 ALB, BCHE, INS, KNG1
nuclear matrix 1 ATN1
platelet alpha granule lumen 2 ALB, KNG1
voltage-gated calcium channel complex 1 CACNA1I
phosphatidylinositol 3-kinase complex 1 PIK3C2A
Cytoplasmic vesicle, clathrin-coated vesicle 1 PIK3C2A
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
neuronal dense core vesicle 1 AVP
nuclear envelope lumen 1 BCHE
clathrin-coated endocytic vesicle membrane 1 AVP
synaptic cleft 1 ACHE
catenin complex 1 CDH5
[Isoform 3]: Cell membrane 1 IGHE
[Isoform 1]: Secreted 1 IGHE
IgE B cell receptor complex 1 IGHE
immunoglobulin complex, circulating 1 IGHE
[Isoform H]: Cell membrane 1 ACHE
ciliary transition fiber 1 ALB


文献列表

  • Rafał Skowronek, Małgorzata Korczyńska, Joanna Kulikowska, Joanna Nowicka, Stanisława Kabiesz-Neniczka. Patient's death as a result of mistakenly injection of pancuronium. Archiwum medycyny sadowej i kryminologii. 2017 ; 67(4):254-263. doi: 10.5114/amsik.2017.75056. [PMID: 29663745]
  • Theodoros Karaiskos, Periklis Tomos, Irene Asouhidou, Nikolaos Nikiteas, Theodoros Kontakiotis, Apostolos Papalois. Oxidative and pre-inflammatory stress in wedge resection of pulmonary parenchyma using the radiofrequency ablation technique in a swine model. Journal of cardiothoracic surgery. 2012 Jan; 7(?):7. doi: 10.1186/1749-8090-7-7. [PMID: 22260184]
  • Petrus R de Jong, Alvin W L Schadenberg, Theo van den Broek, Jeffrey M Beekman, Femke van Wijk, Paul J Coffer, Berent J Prakken, Nicolaas J G Jansen. STAT3 regulates monocyte TNF-alpha production in systemic inflammation caused by cardiac surgery with cardiopulmonary bypass. PloS one. 2012; 7(4):e35070. doi: 10.1371/journal.pone.0035070. [PMID: 22506067]
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  • Kari Leino, Markku Hynynen, Jouko Jalonen, Markku Salmenperä, Harry Scheinin, Riku Aantaa. Renal effects of dexmedetomidine during coronary artery bypass surgery: a randomized placebo-controlled study. BMC anesthesiology. 2011 May; 11(?):9. doi: 10.1186/1471-2253-11-9. [PMID: 21605394]
  • Marlieke Visser, Mariska Davids, Hein J Verberne, Wouter E M Kok, Hans W M Niessen, Lenny M W van Venrooij, Riccardo Cocchieri, Willem Wisselink, Bas A J M de Mol, Paul A M van Leeuwen. Rationale and design of a proof-of-concept trial investigating the effect of uninterrupted perioperative (par)enteral nutrition on amino acid profile, cardiomyocytes structure, and cardiac perfusion and metabolism of patients undergoing coronary artery bypass grafting. Journal of cardiothoracic surgery. 2011 Mar; 6(?):36. doi: 10.1186/1749-8090-6-36. [PMID: 21439030]
  • Adak Nasiripourdori, Valérie Taly, Thomas Grutter, Antoine Taly. From toxins targeting ligand gated ion channels to therapeutic molecules. Toxins. 2011 03; 3(3):260-93. doi: 10.3390/toxins3030260. [PMID: 22069709]
  • Jan Benes, Jiri Chvojka, Roman Sykora, Jaroslav Radej, Ales Krouzecky, Ivan Novak, Martin Matejovic. Searching for mechanisms that matter in early septic acute kidney injury: an experimental study. Critical care (London, England). 2011; 15(5):R256. doi: 10.1186/cc10517. [PMID: 22030145]
  • Johan Fenhammar, Andreas Andersson, Jakob Forestier, Eddie Weitzberg, Alf Sollevi, Hans Hjelmqvist, Robert Frithiof. Endothelin receptor A antagonism attenuates renal medullary blood flow impairment in endotoxemic pigs. PloS one. 2011; 6(7):e21534. doi: 10.1371/journal.pone.0021534. [PMID: 21760895]
  • Sayed Imam Mohamed Zayed. Flow injection potentiometric determination of pancuronium bromide in pharmaceutical preparation and urine samples using modified carbon paste electrodes. Chemical & pharmaceutical bulletin. 2011; 59(2):254-9. doi: 10.1248/cpb.59.254. [PMID: 21297308]
  • Danilo Teixeira Noritomi, Adriano José Pereira, Diogo Diniz Gomes Bugano, Paulo Sergio Rehder, Eliézer Silva. Impact of Plasma-Lyte pH 7.4 on acid-base status and hemodynamics in a model of controlled hemorrhagic shock. Clinics (Sao Paulo, Brazil). 2011; 66(11):1969-74. doi: 10.1590/s1807-59322011001100019. [PMID: 22086530]
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  • Beyazit Zencirci. Sertraline-induced pseudocholinesterase enzyme deficiency. International journal of general medicine. 2010 Nov; 3(?):375-8. doi: 10.2147/ijgm.s14365. [PMID: 21189834]
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  • Gnanapragasam Arunachalam, Isaac K Sundar, Jae-Woong Hwang, Hongwei Yao, Irfan Rahman. Emphysema is associated with increased inflammation in lungs of atherosclerosis-prone mice by cigarette smoke: implications in comorbidities of COPD. Journal of inflammation (London, England). 2010 Jul; 7(?):34. doi: 10.1186/1476-9255-7-34. [PMID: 20663150]
  • Somsmorn Chittrakarn, Niwat Keawpradub, Kitja Sawangjaroen, Supaporn Kansenalak, Benjamas Janchawee. The neuromuscular blockade produced by pure alkaloid, mitragynine and methanol extract of kratom leaves (Mitragyna speciosa Korth.). Journal of ethnopharmacology. 2010 Jun; 129(3):344-9. doi: 10.1016/j.jep.2010.03.035. [PMID: 20371282]
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  • Rosanna Vaschetto, Jan W Kuiper, René J P Musters, Etto C Eringa, Francesco Della Corte, Kanneganti Murthy, A B Johan Groeneveld, Frans B Plötz. Renal hypoperfusion and impaired endothelium-dependent vasodilation in an animal model of VILI: the role of the peroxynitrite-PARP pathway. Critical care (London, England). 2010; 14(2):R45. doi: 10.1186/cc8932. [PMID: 20346119]
  • Elsayed M Elmistekawy, Lee Errett, Hosam F Fawzy. Predictors of packed red cell transfusion after isolated primary coronary artery bypass grafting--the experience of a single cardiac center: a prospective observational study. Journal of cardiothoracic surgery. 2009 May; 4(?):20. doi: 10.1186/1749-8090-4-20. [PMID: 19422707]
  • Sampa Dutta Gupta, Soumendu Pal, Anupam Goswami, Sandip Bhadra, Sripurna Mandal, Chandashi Naskar, Sudakshina Mukherjee, Debasish Boral. A Comparative Study to Determine the Effect of Intravenous Magnesium on Postoperative Bleeding after on Pump CABG in Patients Receiving Pre-Operative Aspirin. Indian journal of anaesthesia. 2009 Apr; 53(2):197-203. doi: NULL. [PMID: 20640123]
  • Young-Ah Koo, BoEun Lee, Hyun-Jung Park, JongYeob Choi, EunYoung Lee, DooSeok Choi. Altered vascular endothelial growth factor expression during GnRH antagonist protocol in women of reproductive age with normal baseline hormone profiles. Fertility and sterility. 2009 Mar; 91(3):744-8. doi: 10.1016/j.fertnstert.2007.12.068. [PMID: 18321491]
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  • Man Liu, James P Dilger. Site selectivity of competitive antagonists for the mouse adult muscle nicotinic acetylcholine receptor. Molecular pharmacology. 2009 Jan; 75(1):166-73. doi: 10.1124/mol.108.051060. [PMID: 18842832]
  • Elaine Campana Sanches Bornia, Erika Bando, Miguel Machinski, Monalisa Wolski Pereira, Wilson Alves-Do-Prado. Presynaptic M1, M2, and A1 receptors play roles in tetanic fade induced by pancuronium or cisatracurium. Journal of anesthesia. 2009; 23(4):513-9. doi: 10.1007/s00540-009-0790-z. [PMID: 19921360]
  • Imad Abboud, Nicolas Lerolle, Saik Urien, Jean-Marc Tadié, Françoise Leviel, Jean-Yves Fagon, Christophe Faisy. Pharmacokinetics of epinephrine in patients with septic shock: modelization and interaction with endogenous neurohormonal status. Critical care (London, England). 2009; 13(4):R120. doi: 10.1186/cc7972. [PMID: 19622169]
  • Sebastian Brandt, Tomas Regueira, Hendrik Bracht, Francesca Porta, Siamak Djafarzadeh, Jukka Takala, José Gorrasi, Erika Borotto, Vladimir Krejci, Luzius B Hiltebrand, Lukas E Bruegger, Guido Beldi, Ludwig Wilkens, Philipp M Lepper, Ulf Kessler, Stephan M Jakob. Effect of fluid resuscitation on mortality and organ function in experimental sepsis models. Critical care (London, England). 2009; 13(6):R186. doi: 10.1186/cc8179. [PMID: 19930656]
  • Matthias Derwall, Christian Stoppe, David Brücken, Rolf Rossaint, Michael Fries. Changes in S-100 protein serum levels in survivors of out-of-hospital cardiac arrest treated with mild therapeutic hypothermia: a prospective, observational study. Critical care (London, England). 2009; 13(2):R58. doi: 10.1186/cc7785. [PMID: 19368739]
  • Gisele P Oliveira, Mariana B G Oliveira, Raquel S Santos, Letícia D Lima, Cristina M Dias, Alexandre M Ab' Saber, Walcy R Teodoro, Vera L Capelozzi, Rachel N Gomes, Patricia T Bozza, Paolo Pelosi, Patricia R M Rocco. Intravenous glutamine decreases lung and distal organ injury in an experimental model of abdominal sepsis. Critical care (London, England). 2009; 13(3):R74. doi: 10.1186/cc7888. [PMID: 19454012]
  • Maria A Hegeman, Marije P Hennus, Cobi J Heijnen, Patricia Ac Specht, Burkhard Lachmann, Nicolaas Jg Jansen, Adrianus J van Vught, Pieter M Cobelens. Ventilator-induced endothelial activation and inflammation in the lung and distal organs. Critical care (London, England). 2009; 13(6):R182. doi: 10.1186/cc8168. [PMID: 19917112]
  • Ricardo Antonio G Barbosa, Silvia Regina C Jorge Santos, Paul F White, Valéria A Pereira, Carlos R Silva Filho, Luiz M S Malbouisson, Maria José C Carmona. Effects of cardiopulmonary bypass on propofol pharmacokinetics and bispectral index during coronary surgery. Clinics (Sao Paulo, Brazil). 2009; 64(3):215-21. doi: 10.1590/s1807-59322009000300012. [PMID: 19330248]
  • C Motamed, P Fanen, P Feiss, K Kirov, P Duvaldestin. Dose-response effect of serum butyrylcholinesterase activity after clinical doses of pancuronium. European journal of clinical pharmacology. 2008 Nov; 64(11):1043-5. doi: 10.1007/s00228-008-0548-9. [PMID: 18766333]
  • Isabelle Streuli, Timothée Fraisse, Christine Pillet, Victoria Ibecheole, Paul Bischof, Dominique de Ziegler. Serum antimüllerian hormone levels remain stable throughout the menstrual cycle and after oral or vaginal administration of synthetic sex steroids. Fertility and sterility. 2008 Aug; 90(2):395-400. doi: 10.1016/j.fertnstert.2007.06.023. [PMID: 17919608]
  • R Scott Obach, Franco Lombardo, Nigel J Waters. Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals. 2008 Jul; 36(7):1385-405. doi: 10.1124/dmd.108.020479. [PMID: 18426954]
  • Yves Denizot, Alexandre Leguyader, Elisabeth Cornu, Marc Laskar, Isabelle Orsel, Christelle Vincent, Nathalie Nathan. Alterations in plasma soluble vascular endothelial growth factor receptor-1 (sFlt-1) concentrations during coronary artery bypass graft surgery: relationships with post-operative complications. Journal of cardiothoracic surgery. 2008 Apr; 3(?):16. doi: 10.1186/1749-8090-3-16. [PMID: 18423019]
  • Rita Katznelson, George N Djaiani, Leonid Minkovich, Ludwik Fedorko, Jo Carroll, Michael A Borger, Robert J Cusimano, Jacek Karski. Prevalence of claustrophobia and magnetic resonance imaging after coronary artery bypass graft surgery. Neuropsychiatric disease and treatment. 2008 Apr; 4(2):487-93. doi: 10.2147/ndt.s2699. [PMID: 18728736]
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  • Yves Denizot, Alexandre Leguyader, Elisabeth Cornu, Marc Laskar, Isabelle Orsel, Christelle Vincent, Nathalie Nathan. Release of soluble vascular endothelial growth factor receptor-1 (sFlt-1) during coronary artery bypass surgery. Journal of cardiothoracic surgery. 2007 Sep; 2(?):38. doi: 10.1186/1749-8090-2-38. [PMID: 17888151]
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