Enflurane (BioDeep_00000006519)
Secondary id: BioDeep_00001867833
human metabolite blood metabolite Chemicals and Drugs
代谢物信息卡片
2-Chloro-1,1,2-trifluoroethyl difluoromethyl ether
化学式: C3H2ClF5O (183.9714)
中文名称: 易使宁
谱图信息:
最多检出来源 Homo sapiens(blood) 3.74%
分子结构信息
SMILES: C(C(F)(F)OC(F)F)(Cl)F
InChI: InChI=1S/C3H2ClF5O/c4-1(5)3(8,9)10-2(6)7/h1-2H
描述信息
Enflurane is only found in individuals that have used or taken this drug. It is an extremely stable inhalation anesthetic that allows rapid adjustments of anesthesia depth with little change in pulse or respiratory rate. [PubChem]Enflurane induces a reduction in junctional conductance by decreasing gap junction channel opening times and increasing gap junction channel closing times. Enflurane also activates calcium dependent ATPase in the sarcoplasmic reticulum by increasing the fluidity of the lipid membrane. It also appears to bind the D subunit of ATP synthase and NADH dehydogenase. Enflurane also binds to and angonizes the GABA receptor, the large conductance Ca2+ activated potassium channel, the glycine receptor, and antagonizes the glutamate receptor receptor. These yield a decreased depolarization and therefore, tissue excitability which results in anesthesia.
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D000777 - Anesthetics
N - Nervous system > N01 - Anesthetics > N01A - Anesthetics, general > N01AB - Halogenated hydrocarbons
C78272 - Agent Affecting Nervous System > C245 - Anesthetic Agent
同义名列表
20 个代谢物同义名
2-Chloro-1,1,2-trifluoroethyl difluoromethyl ether; 2-chloro-1-(difluoromethoxy)-1,1,2-trifluoroethane; Baxter anaesthesia brand OF enflurane; AstraZeneca brand OF enflurane; Anesthetic compound no. 347; Zeneca brand OF enflurane; Abbott brand OF enflurane; Pisa brand OF enflurane; Methylflurether; Anesthetic 347; Compound 347; enflurane; Enlirane; Ohio 347; Ethrane; Alyrane; Enfran; Efrane; Etran; Enflurane
数据库引用编号
19 个数据库交叉引用编号
- ChEBI: CHEBI:4792
- KEGG: C07516
- KEGGdrug: D83877
- KEGGdrug: D00543
- PubChem: 3226
- HMDB: HMDB0014373
- Metlin: METLIN2534
- DrugBank: DB00228
- ChEMBL: CHEMBL1257
- Wikipedia: Enflurane
- MeSH: Enflurane
- chemspider: 3113
- CAS: 132998-91-5
- CAS: 13838-16-9
- PMhub: MS000019568
- PubChem: 9719
- NIKKAJI: J3.127E
- RefMet: Enflurane
- KNApSAcK: 4792
分类词条
相关代谢途径
Reactome(0)
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PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
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Anesthesia and analgesia.
1998 Jun; 86(6):1322-7. doi:
10.1097/00000539-199806000-00036. [PMID: 9620528] - P Aitola, I Airo, S Kaukinen, P Ylitalo. Comparison of N2O and CO2 pneumoperitoneums during laparoscopic cholecystectomy with special reference to postoperative pain.
Surgical laparoscopy & endoscopy.
1998 Apr; 8(2):140-4. doi:
10.1097/00019509-199804000-00013. [PMID: 9566570] - K Asai, S Ishii, S Ohta, K Furusho. Fatal hyperammonaemia in argininosuccinic aciduria following enflurane anaesthesia.
European journal of pediatrics.
1998 Feb; 157(2):169-70. doi:
NULL. [PMID: 9504797] - M Imbriani, S Ghittori, G Pezzagno. The biological monitoring of inhalation anaesthetics.
Giornale italiano di medicina del lavoro ed ergonomia.
1998 Jan; 20(1):44-9. doi:
NULL. [PMID: 9546101] - P Bischoff, L Plümer, J Scholz, K Drögemeier, G von Knobelsdorff, J Schulte am Esch. [Effect of remifentanil on clinical and electroencephalographic parameters of depth of anesthesia in balanced anesthesia with propofol, enflurane or isoflurane].
Anaesthesiologie und Reanimation.
1998; 23(5):116-23. doi:
. [PMID: 9854329] - T Nishiyama, T Matsukawa, K Hanaoka, C M Conway. Interactions between nicardipine and enflurane, isoflurane, and sevoflurane.
Canadian journal of anaesthesia = Journal canadien d'anesthesie.
1997 Oct; 44(10):1071-6. doi:
10.1007/bf03019228. [PMID: 9350366] - A M Buzaleh, E S Vazquez, G Nuñez, A M del Carmen Batlle. Effect of chronic anesthesia on the drug-metabolizing enzyme system and heme pathway regulation.
General pharmacology.
1997 Apr; 28(4):577-82. doi:
10.1016/s0306-3623(96)00245-5. [PMID: 9147027] - G S Jan, W N Tong, A M Chan, T W Hui, J W Lo. Recovery from mivacurium block with or without anticholinesterase following continuous infusion in obstetric patients.
Anaesthesia and intensive care.
1996 Oct; 24(5):585-9. doi:
10.1177/0310057x9602400514. [PMID: 8909671] - M C de Almeida, F Latorre, H W Gervais, P P Kleeman. [The effects of age on onset and recovery from atracurium, rocuronium and vecuronium blockade].
Der Anaesthesist.
1996 Oct; 45(10):903-6. doi:
10.1007/s001010050324. [PMID: 8992904] - T Tashiro, T Takeda, A Oda, S Akamatsu, H Shimonaka, S Dohi. [Anesthetic management of a patient with renal cell carcinoma extending into the right atrium].
Masui. The Japanese journal of anesthesiology.
1996 Jul; 45(7):861-4. doi:
NULL. [PMID: 8741477] - G Neidhart, C Pabelick, I Kuhn, M Leuwer, J Vettermann. [Effect of halothane, enflurane and isoflurane on the pharmacodynamics of mivacurium in children].
Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS.
1996 Jun; 31(5):293-7. doi:
10.1055/s-2007-995923. [PMID: 8767242] - S Tanaka, H Tsuchida, K Nakabayashi, S Seki, A Namiki. The effects of sevoflurane, isoflurane, halothane, and enflurane on hemodynamic responses during an inhaled induction of anesthesia via a mask in humans.
Anesthesia and analgesia.
1996 Apr; 82(4):821-6. doi:
10.1097/00000539-199604000-00025. [PMID: 8615504] - F Xue, B Sun, Q Zou, L Luo. Effects of enflurane and isoflurane anesthesia on the pharmacokinetics of pancuronium in adult patients.
Chinese medical journal.
1996 Mar; 109(3):233-7. doi:
NULL. [PMID: 8758316] - Y Hashimoto, K Hirota, N Ohtomo, H Ishihara, A Matsuki. In vivo direct measurement of the bronchodilating effect of sevoflurane using a superfine fiberoptic bronchoscope: comparison with enflurane and halothane.
Journal of cardiothoracic and vascular anesthesia.
1996 Feb; 10(2):213-6. doi:
10.1016/s1053-0770(96)80240-0. [PMID: 8850400] - Y Saeki, Y Hasegawa, T Shibamoto, Y Yamaguchi, T Hayashi, S Tanaka, H G Wang, S Koyama. The effects of sevoflurane, enflurane, and isoflurane on baroreceptor-sympathetic reflex in rabbits.
Anesthesia and analgesia.
1996 Feb; 82(2):342-8. doi:
10.1097/00000539-199602000-00023. [PMID: 8561339] - G Wiesner, K Wild, S Schwürzer, M Merz, J Hobbhahn. [Serum fluoride concentrations and exocrine kidney function with sevoflurane and enflurane. An open, randomized, comparative phase III study of patients with healthy kidneys].
Der Anaesthesist.
1996 Jan; 45(1):31-6. doi:
10.1007/s001010050237. [PMID: 8678276] - R Hausmann, B Schmidt, B Schellmann, P Betz. Differential diagnosis of postoperative liver failure in a 12-year-old child.
International journal of legal medicine.
1996; 109(4):210-2. doi:
10.1007/bf01225520. [PMID: 9007637] - J G Kenna, R M Jones. The organ toxicity of inhaled anesthetics.
Anesthesia and analgesia.
1995 Dec; 81(6 Suppl):S51-66. doi:
10.1097/00000539-199512001-00008. [PMID: 7486149] - M M Lopez, D Kosk-Kosicka. How do volatile anesthetics inhibit Ca(2+)-ATPases?.
The Journal of biological chemistry.
1995 Nov; 270(47):28239-45. doi:
10.1074/jbc.270.47.28239. [PMID: 7499320] - E Blanco, M I Vidal, J Blanco, S Fagundo, O Campaña, J Alvarez. Comparison of maintenance and recovery characteristics of sevoflurane-nitrous oxide and enflurane-nitrous oxide anaesthesia.
European journal of anaesthesiology.
1995 Sep; 12(5):517-23. doi:
NULL. [PMID: 8542862] - P F Conzen, M Nuscheler, A Melotte, M Verhaegen, T Leupolt, H Van Aken, K Peter. Renal function and serum fluoride concentrations in patients with stable renal insufficiency after anesthesia with sevoflurane or enflurane.
Anesthesia and analgesia.
1995 Sep; 81(3):569-75. doi:
10.1097/00000539-199509000-00026. [PMID: 7653825] - I T Munday, P A Stoddart, R M Jones, J Lytle, M R Cross. Serum fluoride concentration and urine osmolality after enflurane and sevoflurane anesthesia in male volunteers.
Anesthesia and analgesia.
1995 Aug; 81(2):353-9. doi:
10.1097/00000539-199508000-00025. [PMID: 7618728] - R T Rooney, J Marijic, K A Stommel, Z J Bosnjak, A Aggarwal, J P Kampine, D F Stowe. Additive cardiac depression by volatile anesthetics in isolated hearts after chronic amiodarone treatment.
Anesthesia and analgesia.
1995 May; 80(5):917-24. doi:
10.1097/00000539-199505000-00011. [PMID: 7726434] - Z Qin, G Szabo, D S Cafiso. Anesthetics reduce the magnitude of the membrane dipole potential. Measurements in lipid vesicles using voltage-sensitive spin probes.
Biochemistry.
1995 Apr; 34(16):5536-43. doi:
10.1021/bi00016a027. [PMID: 7727414] - O Dural, M Kanbak, G Ciliv, U Aypar, K Erdem. Comparison of halothane, enflurane and isoflurane kidney effects through alanine aminopeptidase/urine creatinine values.
Anaesthesia and intensive care.
1995 Apr; 23(2):162-4. doi:
10.1177/0310057x9502300206. [PMID: 7793585] - T Sameshima, J Miyao, T Oda, Y Minoda, H Yoshida, N Yoshimura. [Effects of allopurinol on renal damage following renal ischemia].
Masui. The Japanese journal of anesthesiology.
1995 Mar; 44(3):349-56. doi:
NULL. [PMID: 7745787] - G Shirakami, T Magaribuchi, K Shingu, Y Saito, T O'higashi, K Nakao, K Mori. Effects of anesthesia and surgery on plasma endothelin levels.
Anesthesia and analgesia.
1995 Mar; 80(3):449-53. doi:
10.1097/00000539-199503000-00003. [PMID: 7864406] - K Saito, T Takayasu, J Nishigami, T Kondo, M Ohtsuji, Z Lin, T Ohshima. Determination of the volatile anesthetics halothane, enflurane, isoflurane, and sevoflurane in biological specimens by pulse-heating GC-MS.
Journal of analytical toxicology.
1995 Mar; 19(2):115-9. doi:
10.1093/jat/19.2.115. [PMID: 7769780]
