Enflurane (BioDeep_00000006519)

 

Secondary id: BioDeep_00001867833

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


2-Chloro-1,1,2-trifluoroethyl difluoromethyl ether

化学式: C3H2ClF5O (183.97143319999998)
中文名称: 易使宁
谱图信息: 最多检出来源 Homo sapiens(blood) 25%

分子结构信息

SMILES: C(C(F)(F)OC(F)F)(Cl)F
InChI: InChI=1S/C3H2ClF5O/c4-1(5)3(8,9)10-2(6)7/h1-2H

描述信息

Enflurane is only found in individuals that have used or taken this drug. It is an extremely stable inhalation anesthetic that allows rapid adjustments of anesthesia depth with little change in pulse or respiratory rate. [PubChem]Enflurane induces a reduction in junctional conductance by decreasing gap junction channel opening times and increasing gap junction channel closing times. Enflurane also activates calcium dependent ATPase in the sarcoplasmic reticulum by increasing the fluidity of the lipid membrane. It also appears to bind the D subunit of ATP synthase and NADH dehydogenase. Enflurane also binds to and angonizes the GABA receptor, the large conductance Ca2+ activated potassium channel, the glycine receptor, and antagonizes the glutamate receptor receptor. These yield a decreased depolarization and therefore, tissue excitability which results in anesthesia.
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D000777 - Anesthetics
N - Nervous system > N01 - Anesthetics > N01A - Anesthetics, general > N01AB - Halogenated hydrocarbons
C78272 - Agent Affecting Nervous System > C245 - Anesthetic Agent

同义名列表

19 个代谢物同义名

2-Chloro-1,1,2-trifluoroethyl difluoromethyl ether; 2-chloro-1-(difluoromethoxy)-1,1,2-trifluoroethane; Baxter anaesthesia brand OF enflurane; AstraZeneca brand OF enflurane; Anesthetic compound no. 347; Zeneca brand OF enflurane; Abbott brand OF enflurane; Pisa brand OF enflurane; Methylflurether; Anesthetic 347; Compound 347; enflurane; Enlirane; Ohio 347; Ethrane; Alyrane; Enfran; Efrane; Etran



数据库引用编号

18 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Małgorzata Kupczewska-Dobecka. [Health hazards resulting from occupational exposure to enfluran - overview of tests and analysis of admissible concentration values]. Medycyna pracy. 2022 Feb; 73(1):51-69. doi: 10.13075/mp.5893.01204. [PMID: 35129537]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Balázs Fábián, Marcello Sega, Vladimir P Voloshin, Nikolai N Medvedev, Pál Jedlovszky. Lateral Pressure Profile and Free Volume Properties in Phospholipid Membranes Containing Anesthetics. The journal of physical chemistry. B. 2017 04; 121(13):2814-2824. doi: 10.1021/acs.jpcb.7b00990. [PMID: 28282987]
  • Derek R Laver, John Attia, Christopher Oldmeadow, Anthony W Quail. Cardiac Calcium Release Channel (Ryanodine Receptor 2) Regulation by Halogenated Anesthetics. Anesthesiology. 2017 Mar; 126(3):495-506. doi: 10.1097/aln.0000000000001519. [PMID: 28079567]
  • Tie-Cheng Liu. Influence of propofol, isoflurane and enflurance on levels of serum interleukin-8 and interleukin-10 in cancer patients. Asian Pacific journal of cancer prevention : APJCP. 2014; 15(16):6703-7. doi: 10.7314/apjcp.2014.15.16.6703. [PMID: 25169512]
  • Mária Darvas, Paul N M Hoang, Sylvain Picaud, Marcello Sega, Pál Jedlovszky. Anesthetic molecules embedded in a lipid membrane: a computer simulation study. Physical chemistry chemical physics : PCCP. 2012 Oct; 14(37):12956-69. doi: 10.1039/c2cp41581j. [PMID: 22903224]
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  • Tomoyoshi Seto, Hideto Isogai, Masayuki Ozaki, Shuichi Nosaka. Noble gas binding to human serum albumin using docking simulation: nonimmobilizers and anesthetics bind to different sites. Anesthesia and analgesia. 2008 Oct; 107(4):1223-8. doi: 10.1213/ane.0b013e31817f1317. [PMID: 18806031]
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  • So-Young Yoo, In-One Kim, Young-Il Kim, Kyoung Ho Lee, Min Woo Lee, Byung Jae Youn, Woo Sun Kim, Kyung Mo Yeon. Power Doppler imaging in acute renal vein occlusion and recanalization: a canine model. Korean journal of radiology. 2008 Mar; 9(2):128-33. doi: 10.3348/kjr.2008.9.2.128. [PMID: 18385559]
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  • Jeong-Yeon Hong, Jong In Oh. Effects of preoperative anxiety on gastric fluid acidity and volume. Journal of Korean medical science. 2005 Apr; 20(2):232-5. doi: 10.3346/jkms.2005.20.2.232. [PMID: 15831993]
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  • Reino Pöyhiä, Markku Hynynen, Timo Seppälä, Risto O Roine, Kalervo Verkkala, Klaus T Olkkola. Pharmacodynamics and pharmacokinetics of high-dose oxycodone infusion during and after coronary artery bypass grafting. Journal of cardiothoracic and vascular anesthesia. 2004 Dec; 18(6):748-54. doi: 10.1053/j.jvca.2004.08.013. [PMID: 15650985]
  • Pascal C Chiari, Paul S Pagel, Katsuya Tanaka, John G Krolikowski, Lynda M Ludwig, Raul A Trillo, Navneet Puri, Judy R Kersten, David C Warltier. Intravenous emulsified halogenated anesthetics produce acute and delayed preconditioning against myocardial infarction in rabbits. Anesthesiology. 2004 Nov; 101(5):1160-6. doi: 10.1097/00000542-200411000-00016. [PMID: 15505452]
  • Abdul H Sawas, Srinivas N Pentyala, Mario J Rebecchi. Binding of volatile anesthetics to serum albumin: measurements of enthalpy and solvent contributions. Biochemistry. 2004 Oct; 43(39):12675-85. doi: 10.1021/bi035941d. [PMID: 15449957]
  • Shi-hai Zhang, Shou-yong Wang, Shang-long Yao. Antioxidative effect of propofol during cardiopulmonary bypass in adults. Acta pharmacologica Sinica. 2004 Mar; 25(3):334-40. doi: NULL. [PMID: 15000887]
  • Ai-lun Luo, Jie Yi, Xiang-yang Guo, Hong-zhi Ren, Yu-guang Huang, Tie-hu Ye. Concentrations of propofol in cerebral spinal fluid: target-controlled infusion. Chinese medical journal. 2004 Feb; 117(2):231-4. doi: NULL. [PMID: 14975208]
  • Jeong-Jin Lee, Young-Soo Do, Jie-Ae Kim. Serum ethanol levels after alcohol sclerotherapy of arteriovenous malformations. Journal of Korean medical science. 2004 Feb; 19(1):51-4. doi: 10.3346/jkms.2004.19.1.51. [PMID: 14966341]
  • Hülya Türkan, Neslihan Bukan, Ahmet Sayal, Ahmet Aydin, M Hakan Bukan. Effects of halothane, enflurane, and isoflurane on plasma and erythrocyte antioxidant enzymes and trace elements. Biological trace element research. 2004; 102(1-3):105-12. doi: 10.1385/bter:102:1-3:105. [PMID: 15621932]
  • M Laisalmi, A Soikkeli, H Kokki, H Markkanen, A Yli-Hankala, P Rosenberg, L Lindgren. Fluoride metabolism in smokers and non-smokers following enflurane anaesthesia. British journal of anaesthesia. 2003 Dec; 91(6):800-4. doi: 10.1093/bja/aeg272. [PMID: 14633748]
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  • Koichi Nishikawa, Neil L Harrison. The actions of sevoflurane and desflurane on the gamma-aminobutyric acid receptor type A: effects of TM2 mutations in the alpha and beta subunits. Anesthesiology. 2003 Sep; 99(3):678-84. doi: 10.1097/00000542-200309000-00024. [PMID: 12960553]
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