Tetraethylammonium (BioDeep_00000006517)
代谢物信息卡片
Tetraethylammonium
化学式: C8H20N+ (130.159566)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC[N+](CC)(CC)CC
InChI: InChI=1S/C8H20N/c1-5-9(6-2,7-3)8-4/h5-8H2,1-4H3/q+1
描述信息
D002317 - Cardiovascular Agents > D026902 - Potassium Channel Blockers
D049990 - Membrane Transport Modulators
同义名列表
1 个代谢物同义名
数据库引用编号
11 个数据库交叉引用编号
- ChEBI: CHEBI:44296
- KEGG: C07512
- PubChem: 5413
- DrugBank: DB08837
- ChEMBL: CHEMBL9324
- MeSH: Tetraethylammonium
- CAS: 66-40-0
- PMhub: MS000019566
- PubChem: 9715
- PDB-CCD: NET
- NIKKAJI: J91.253K
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
2 个相关的物种来源信息
- 4682 Allium sativum: 10.1007/S00216-005-0272-6
- 4682 Allium sativum: 10.1007/S00216-005-0272-6
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Kenshiro Watanabe, Kenji Hashimoto, Kota Hasegawa, Hiroki Shindo, Yushin Tsuruda, Kamila Kupisz, Mateusz Koselski, Piotr Wasko, Kazimierz Trebacz, Kazuyuki Kuchitsu. Rapid Propagation of Ca2+ Waves and Electrical Signals in the Liverwort Marchantia polymorpha.
Plant & cell physiology.
2024 May; 65(4):660-670. doi:
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Archives of biochemistry and biophysics.
2021 11; 712(?):109031. doi:
10.1016/j.abb.2021.109031. [PMID: 34534540] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
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The Journal of nutritional biochemistry.
2012 Mar; 23(3):278-86. doi:
10.1016/j.jnutbio.2010.12.005. [PMID: 21543207] - Patrik Rorsman, Matthias Braun, Quan Zhang. Regulation of calcium in pancreatic α- and β-cells in health and disease.
Cell calcium.
2012 Mar; 51(3-4):300-8. doi:
10.1016/j.ceca.2011.11.006. [PMID: 22177710] - Chang-Yu Chen, Andrew M Wo, De-Shien Jong. A microfluidic concentration generator for dose-response assays on ion channel pharmacology.
Lab on a chip.
2012 Feb; 12(4):794-801. doi:
10.1039/c1lc20548j. [PMID: 22222413] - Hye Kyung Lee, Kyoung Hwa Lee, Eui-Sic Cho. Bile Acid Inhibition of N-type Calcium Channel Currents from Sympathetic Ganglion Neurons.
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology.
2012 Feb; 16(1):25-30. doi:
10.4196/kjpp.2012.16.1.25. [PMID: 22416216] - Sumito Ito, Hiroyuki Kusuhara, Miyu Yokochi, Junko Toyoshima, Katsuhisa Inoue, Hiroaki Yuasa, Yuichi Sugiyama. Competitive inhibition of the luminal efflux by multidrug and toxin extrusions, but not basolateral uptake by organic cation transporter 2, is the likely mechanism underlying the pharmacokinetic drug-drug interactions caused by cimetidine in the kidney.
The Journal of pharmacology and experimental therapeutics.
2012 Feb; 340(2):393-403. doi:
10.1124/jpet.111.184986. [PMID: 22072731] - Russell W Teichert, Nathan J Smith, Shrinivasan Raghuraman, Doju Yoshikami, Alan R Light, Baldomero M Olivera. Functional profiling of neurons through cellular neuropharmacology.
Proceedings of the National Academy of Sciences of the United States of America.
2012 Jan; 109(5):1388-95. doi:
10.1073/pnas.1118833109. [PMID: 22307590] - Y Deng, E S K Ng, J H K Yeung, Y W Kwan, C B S Lau, J C M Koon, L Zhou, Z Zuo, P C Leung, K P Fung, F F Y Lam. Mechanisms of the cerebral vasodilator actions of isoflavonoids of Gegen on rat isolated basilar artery.
Journal of ethnopharmacology.
2012 Jan; 139(1):294-304. doi:
10.1016/j.jep.2011.11.021. [PMID: 22120017] - Jun Kyoung Lee, Dae Gill Kang, Ho-Sub Lee. Vascular relaxation induced by aqueous extract of Lespedeza cuneata via the NO-cGMP pathway.
Journal of natural medicines.
2012 Jan; 66(1):17-24. doi:
10.1007/s11418-011-0546-6. [PMID: 21607822] - Abdul Jabbar Shah, Anwarul Hassan Gilani. Aqueous-methanolic extract of sweet flag (Acorus calamus) possesses cardiac depressant and endothelial-derived hyperpolarizing factor-mediated coronary vasodilator effects.
Journal of natural medicines.
2012 Jan; 66(1):119-26. doi:
10.1007/s11418-011-0561-7. [PMID: 21826570] - Jinseok Heo, Frederick Sachs, Jianbin Wang, Susan Z Hua. Shear-induced volume decrease in MDCK cells.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2012; 30(2):395-406. doi:
10.1159/000339033. [PMID: 22759987] - Yu-Guang Ma, Wen-Chao Liu, Shuo Dong, Cheng Du, Xiao-Jun Wang, Jin-Sheng Li, Xiao-Ping Xie, Li Wu, Da-Chang Ma, Zhi-Bin Yu, Man-Jiang Xie. Activation of BK(Ca) channels in zoledronic acid-induced apoptosis of MDA-MB-231 breast cancer cells.
PloS one.
2012; 7(5):e37451. doi:
10.1371/journal.pone.0037451. [PMID: 22655048] - Lais Moraes de Oliveira, Aline Gabriela Rodrigues, Elaine Fernanda da Silva, Letícia Bonancio Cerqueira, Carlos Henrique Castro, Gustavo Rodrigues Pedrino, Maria Helena Catelli de Carvalho, Roberto Pontarolo, Elson Alves Costa, Francinete Ramos Campos, Fernando Paranaiba Filgueira, Paulo César Ghedini. Endothelium-Dependent Vasorelaxant Effect of Butanolic Fraction from Caryocar brasiliense Camb. Leaves in Rat Thoracic Aorta.
Evidence-based complementary and alternative medicine : eCAM.
2012; 2012(?):934142. doi:
10.1155/2012/934142. [PMID: 22927883] - Sandeep Khurana, Hema Raina, Valeria Pappas, Jean-Pierre Raufman, Thomas L Pallone. Effects of deoxycholylglycine, a conjugated secondary bile acid, on myogenic tone and agonist-induced contraction in rat resistance arteries.
PloS one.
2012; 7(2):e32006. doi:
10.1371/journal.pone.0032006. [PMID: 22359652] - Dong-Mei Zhang, Yong Li, Wai San Cheang, Chi Wai Lau, Shun-Ming Lin, Qian-Lan Zhang, Nan Yao, Ying Wang, Xin Wu, Yu Huang, Wen-Cai Ye. Cajaninstilbene acid relaxes rat renal arteries: roles of Ca2+ antagonism and protein kinase C-dependent mechanism.
PloS one.
2012; 7(10):e47030. doi:
10.1371/journal.pone.0047030. [PMID: 23056567] - Leigh D Plant. A Role for K2P Channels in the Operation of Somatosensory Nociceptors.
Frontiers in molecular neuroscience.
2012; 5(?):21. doi:
10.3389/fnmol.2012.00021. [PMID: 22403526] - Maria G Beconi, David Howland, Larry Park, Kathryn Lyons, Joseph Giuliano, Celia Dominguez, Ignacio Munoz-Sanjuan, Robert Pacifici. Pharmacokinetics of memantine in rats and mice.
PLoS currents.
2011 Dec; 3(?):RRN1291. doi:
10.1371/currents.rrn1291. [PMID: 22307216] - Raquel Moreira Britto, André Luiz Santos, Jader Santos Cruz, Antonio Nei Santana Gondim, Sandra Lauton-Santos, Aline Lara, Silvia Guatimosim, Carla Maria Lins Vasconcelos, Charles Dos Santos Estevam, Antonio Santos Dias, Evaleide Diniz Oliveira, Adriana Karla Lima, Rejane Cardoso Souza, Eduardo Antonio Conde-Garcia. Aqueous fraction from Costus spiralis (Jacq.) Roscoe leaf reduces contractility by impairing the calcium inward current in the mammalian myocardium.
Journal of ethnopharmacology.
2011 Nov; 138(2):382-9. doi:
10.1016/j.jep.2011.09.013. [PMID: 21963557] - Geneviève Irié-N'guessan, Pierre Champy, Gisèle Kouakou-Siransy, Armand Koffi, Brou Jérôme Kablan, Véronique Leblais. Tracheal relaxation of five Ivorian anti-asthmatic plants: role of epithelium and K⁺ channels in the effect of the aqueous-alcoholic extract of Dichrostachys cinerea root bark.
Journal of ethnopharmacology.
2011 Nov; 138(2):432-8. doi:
10.1016/j.jep.2011.09.016. [PMID: 21963567] - Renata Kurtyka, Andrzej Kita, Waldemar Karcz. Fusicoccin counteracts the toxic effect of cadmium on the growth of maize coleoptile segments.
Archives of environmental contamination and toxicology.
2011 Nov; 61(4):568-77. doi:
10.1007/s00244-011-9662-2. [PMID: 21424219] - Ana Maria Sampaio Assreuy, Nilson Vieira Pinto, Mário Rogério Lima Lima Mota, Ana Vaneska Passos Passos Meireles, João Batista Cajazeiras, Camila Bezerra Nobre, Pedro Marcos Gomes Soares, Benildo Sousa Cavada. Vascular smooth muscle relaxation by a lectin from Pisum arvense: evidences of endothelial NOS pathway.
Protein and peptide letters.
2011 Nov; 18(11):1107-11. doi:
10.2174/092986611797201011. [PMID: 21675947] - Thorsten Keller, Brigitte Egenberger, Valentin Gorboulev, Frank Bernhard, Zeljko Uzelac, Dmitry Gorbunov, Christophe Wirth, Stefan Koppatz, Volker Dötsch, Carola Hunte, Harald H Sitte, Hermann Koepsell. The large extracellular loop of organic cation transporter 1 influences substrate affinity and is pivotal for oligomerization.
The Journal of biological chemistry.
2011 Oct; 286(43):37874-86. doi:
10.1074/jbc.m111.289330. [PMID: 21896487] - C F Ng, C M Koon, D W S Cheung, M Y Lam, P C Leung, C B S Lau, K P Fung. The anti-hypertensive effect of Danshen (Salvia miltiorrhiza) and Gegen (Pueraria lobata) formula in rats and its underlying mechanisms of vasorelaxation.
Journal of ethnopharmacology.
2011 Oct; 137(3):1366-72. doi:
10.1016/j.jep.2011.08.006. [PMID: 21855622] - Xiang Li, Yun Jung Lee, Youn Chul Kim, Gil Saeng Jeong, Hao Zhen Cui, Hye Yoom Kim, Dae Gill Kang, Ho Sub Lee. Bakuchicin induces vascular relaxation via endothelium-dependent NO-cGMP signaling.
Phytotherapy research : PTR.
2011 Oct; 25(10):1574-8. doi:
10.1002/ptr.3478. [PMID: 21442677] - Yizhou Wang, Michael R Blatt. Anion channel sensitivity to cytosolic organic acids implicates a central role for oxaloacetate in integrating ion flux with metabolism in stomatal guard cells.
The Biochemical journal.
2011 Oct; 439(1):161-70. doi:
10.1042/bj20110845. [PMID: 21745184] - Jung Jun Kim, Deok Hyun Han, Soo Hyun Lim, Tae Hun Kim, Mee Ree Chae, Kyung Jin Chung, Sung Chul Kam, Ju-Hong Jeon, Jong Kwan Park, Sung Won Lee. Effects of Ginkgo biloba extracts with mirodenafil on the relaxation of corpus cavernosal smooth muscle and the potassium channel activity of corporal smooth muscle cells.
Asian journal of andrology.
2011 Sep; 13(5):742-6. doi:
10.1038/aja.2010.184. [PMID: 21478894] - Song Nan Jin, Jin Fu Wen, Xiang Li, Dae Gill Kang, Ho Sub Lee, Kyung Woo Cho. The mechanism of vasorelaxation induced by ethanol extract of Sophora flavescens in rat aorta.
Journal of ethnopharmacology.
2011 Sep; 137(1):547-52. doi:
10.1016/j.jep.2011.06.013. [PMID: 21704693] - Tomoya Yasujima, Kinya Ohta, Katsuhisa Inoue, Hiroaki Yuasa. Characterization of human OCT1-mediated transport of DAPI as a fluorescent probe substrate.
Journal of pharmaceutical sciences.
2011 Sep; 100(9):4006-12. doi:
10.1002/jps.22548. [PMID: 21437911] - Xiao-Zhang Yu, Fan Li, Kun Li. A possible new mechanism involved in ferro-cyanide metabolism by plants.
Environmental science and pollution research international.
2011 Sep; 18(8):1343-50. doi:
10.1007/s11356-011-0489-1. [PMID: 21465162] - Jin-Xia Zhu, Hong Xue, Tuo Ji, Ying Xing. Cellular localization of NKCC2 and its possible role in the Cl- absorption in the rat and human distal colonic epithelia.
Translational research : the journal of laboratory and clinical medicine.
2011 Sep; 158(3):146-54. doi:
10.1016/j.trsl.2011.04.003. [PMID: 21867980] - Yohei Miyamoto, Hiroshi Watanabe, Tsuyoshi Noguchi, Shunsuke Kotani, Makoto Nakajima, Daisuke Kadowaki, Masaki Otagiri, Toru Maruyama. Organic anion transporters play an important role in the uptake of p-cresyl sulfate, a uremic toxin, in the kidney.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2011 Aug; 26(8):2498-502. doi:
10.1093/ndt/gfq785. [PMID: 21303967] - Sunhapas Soodvilai, Jiriporn Nantavishit, Chatchai Muanprasat, Varanuj Chatsudthipong. Renal organic cation transporters mediated cadmium-induced nephrotoxicity.
Toxicology letters.
2011 Jul; 204(1):38-42. doi:
10.1016/j.toxlet.2011.04.005. [PMID: 21513783] - R Sordi, D Fernandes, B T Heckert, J Assreuy. Early potassium channel blockade improves sepsis-induced organ damage and cardiovascular dysfunction.
British journal of pharmacology.
2011 Jul; 163(6):1289-301. doi:
10.1111/j.1476-5381.2011.01324.x. [PMID: 21410460] - Kazuya Takeuchi, Tomoko Sugiura, Saki Umeda, Kazuki Matsubara, Masato Horikawa, Noritaka Nakamichi, David L Silver, Norihisa Ishiwata, Yukio Kato. Pharmacokinetics and hepatic uptake of eltrombopag, a novel platelet-increasing agent.
Drug metabolism and disposition: the biological fate of chemicals.
2011 Jun; 39(6):1088-96. doi:
10.1124/dmd.110.037960. [PMID: 21422191] - Toshinori Komatsu, Miki Hiasa, Takaaki Miyaji, Takuji Kanamoto, Takuya Matsumoto, Masato Otsuka, Yoshinori Moriyama, Hiroshi Omote. Characterization of the human MATE2 proton-coupled polyspecific organic cation exporter.
The international journal of biochemistry & cell biology.
2011 Jun; 43(6):913-8. doi:
10.1016/j.biocel.2011.03.005. [PMID: 21419862] - Fernanda da Rocha Lapa, Kelly Cristina Soares, Yanna Dantas Rattmann, Sandra Crestani, Fabiana Cristina Missau, Moacir Geraldo Pizzolatti, Maria Consuelo Andrade Marques, Lia Rieck, Adair Roberto Soares Santos. Vasorelaxant and hypotensive effects of the extract and the isolated flavonoid rutin obtained from Polygala paniculata L.
The Journal of pharmacy and pharmacology.
2011 Jun; 63(6):875-81. doi:
10.1111/j.2042-7158.2010.01240.x. [PMID: 21585387] - Ali Houeijeh, Estelle Aubry, Hélène Coridon, Karine Montaigne, Rony Sfeir, Philippe Deruelle, Laurent Storme. Effects of n-3 polyunsaturated fatty acids in the fetal pulmonary circulation.
Critical care medicine.
2011 Jun; 39(6):1431-8. doi:
10.1097/ccm.0b013e31821204fb. [PMID: 21378553] - Hui Chang, Yu-Guang Ma, Yun-Ying Wang, Zhen Song, Quan Li, Ning Yang, Hua-Zhou Zhao, Han-Zhong Feng, Yao-Ming Chang, Jin Ma, Zhi-Bin Yu, Man-Jiang Xie. High glucose alters apoptosis and proliferation in HEK293 cells by inhibition of cloned BK Ca channel.
Journal of cellular physiology.
2011 Jun; 226(6):1660-75. doi:
10.1002/jcp.22497. [PMID: 21413024] - Lars H Wegner, Bianca Flickinger, Christian Eing, Thomas Berghöfer, Petra Hohenberger, Wolfgang Frey, Peter Nick. A patch clamp study on the electro-permeabilization of higher plant cells: Supra-physiological voltages induce a high-conductance, K+ selective state of the plasma membrane.
Biochimica et biophysica acta.
2011 Jun; 1808(6):1728-36. doi:
10.1016/j.bbamem.2011.01.016. [PMID: 21296050]