Pirenzepine (BioDeep_00000006514)

 

Secondary id: BioDeep_00001868386

human metabolite blood metabolite


代谢物信息卡片


2-[2-(4-methylpiperazin-1-yl)acetyl]-2,4,9-triazatricyclo[9.4.0.0³,⁸]pentadeca-1(15),3(8),4,6,11,13-hexaen-10-one

化学式: C19H21N5O2 (351.1695)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(urine) 25.68%

分子结构信息

SMILES: CN1CCN(CC(=O)N2C3=CC=CC=C3C(=O)NC3=C2N=CC=C3)CC1
InChI: InChI=1S/C19H21N5O2/c1-22-9-11-23(12-10-22)13-17(25)24-16-7-3-2-5-14(16)19(26)21-15-6-4-8-20-18(15)24/h2-8H,9-13H2,1H3,(H,21,26)

描述信息

An antimuscarinic agent that inhibits gastric secretion at lower doses than are required to affect gastrointestinal motility, salivary, central nervous system, cardiovascular, ocular, and urinary function. It promotes the healing of duodenal ulcers and due to its cytoprotective action is beneficial in the prevention of duodenal ulcer recurrence. It also potentiates the effect of other antiulcer agents such as cimetidine and ranitidine. It is generally well tolerated by patients. [PubChem]
A - Alimentary tract and metabolism > A02 - Drugs for acid related disorders > A02B - Drugs for peptic ulcer and gastro-oesophageal reflux disease (gord)
C78272 - Agent Affecting Nervous System > C66880 - Anticholinergic Agent > C29704 - Antimuscarinic Agent
D018377 - Neurotransmitter Agents > D018678 - Cholinergic Agents > D018680 - Cholinergic Antagonists
D005765 - Gastrointestinal Agents > D000897 - Anti-Ulcer Agents

同义名列表

27 个代谢物同义名

2-[2-(4-methylpiperazin-1-yl)acetyl]-2,4,9-triazatricyclo[9.4.0.0³,⁸]pentadeca-1(15),3(8),4,6,11,13-hexaen-10-one; 11-((4-Methyl-1-piperazinyl)acetyl)-5,11-dihydro-6H-pyrido(2,3-b)(1,4)benzodiazepin-6-one; Boehringer ingelheim brand OF pirenzepine dihydrochloride; CT-Arzneimittel brand OF pirenzepine dihydrochloride; Ratiopharm brand OF pirenzepine dihydrochloride; Azupharma brand OF pirenzepine dihydrochloride; Dolorgiet brand OF pirenzepine dihydrochloride; Sagitta brand OF pirenzepine dihydrochloride; Dihydrochloride, pirenzepine; Pirenzepine dihydrochloride; Pirenzepin ratiopharm; Pirenzepin-ratiopharm; Von CT, pirenzepin; Pirenzepin von CT; Pirenzepinum; Gastrotsepin; Gastrozepin; Piren basan; pirenzepine; Pirenzepina; Pyrenzepine; Ulcoprotect; Piren-basan; Pirenzepin; Ulgescum; L-S 519; Pirenzepine



数据库引用编号

17 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 5 CA1, CA3, CHAT, PPY, PRL
Peripheral membrane protein 1 ACHE
Nucleus 3 ACHE, CHAT, PRL
cytosol 7 ATP12A, CA1, CA3, CHAT, LIPE, PRKCQ, SST
dendrite 2 CHRM1, DRD2
nucleoplasm 1 PRL
RNA polymerase II transcription regulator complex 1 PRL
Cell membrane 4 ACHE, CHRM1, DRD2, LIPE
Multi-pass membrane protein 3 ATP12A, CHRM1, DRD2
Golgi apparatus membrane 1 DRD2
Synapse 5 ACHE, CHAT, CHRM1, DRD2, TAC1
cell surface 1 ACHE
glutamatergic synapse 2 CHRM1, DRD2
Golgi apparatus 1 ACHE
Golgi membrane 2 DRD2, INS
neuromuscular junction 1 ACHE
neuronal cell body 2 SST, TAC1
presynaptic membrane 2 CHRM1, DRD2
Cytoplasm, cytosol 1 LIPE
acrosomal vesicle 1 DRD2
plasma membrane 7 ACHE, ATP12A, BCHE, CHRM1, DRD2, GCG, PRKCQ
synaptic vesicle membrane 1 DRD2
terminal bouton 1 GHRH
Membrane 3 ACHE, CHRM1, LIPE
apical plasma membrane 1 ATP12A
axon 3 CCK, DRD2, TAC1
basolateral plasma membrane 1 ATP12A
caveola 1 LIPE
extracellular exosome 1 CA1
extracellular space 12 ACHE, BCHE, CCK, GAST, GCG, GHRH, INS, PPY, PRL, SCT, SST, TAC1
perinuclear region of cytoplasm 1 ACHE
Schaffer collateral - CA1 synapse 1 CHRM1
Secreted 9 ACHE, BCHE, CCK, GAST, GCG, INS, PPY, PRL, SST
extracellular region 12 ACHE, BCHE, CCK, GAST, GCG, GHRH, INS, PPY, PRL, SCT, SST, TAC1
Extracellular side 1 ACHE
centriolar satellite 1 PRKCQ
ciliary membrane 1 DRD2
actin cytoskeleton 1 ATP12A
dendritic spine 1 DRD2
perikaryon 2 DRD2, GHRH
postsynaptic membrane 2 CHRM1, DRD2
Apical cell membrane 1 ATP12A
GABA-ergic synapse 2 DRD2, SST
basement membrane 1 ACHE
lateral plasma membrane 1 DRD2
Postsynaptic cell membrane 1 CHRM1
neuron projection 1 CHAT
cilium 1 DRD2
chromatin 1 PRL
blood microparticle 1 BCHE
non-motile cilium 1 DRD2
Lipid-anchor, GPI-anchor 1 ACHE
sperm flagellum 1 DRD2
endosome lumen 2 INS, PRL
Lipid droplet 1 LIPE
Membrane, caveola 1 LIPE
side of membrane 1 ACHE
secretory granule lumen 2 GCG, INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 3 BCHE, GCG, INS
axon terminus 2 CHRM1, DRD2
endocytic vesicle 1 DRD2
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
postsynaptic density membrane 1 CHRM1
immunological synapse 1 PRKCQ
neuronal dense core vesicle 1 SST
aggresome 1 PRKCQ
nuclear envelope lumen 1 BCHE
synaptic cleft 1 ACHE
dopaminergic synapse 1 DRD2
cholinergic synapse 1 CHRM1
[Glucagon-like peptide 1]: Secreted 1 GCG
G protein-coupled receptor complex 1 DRD2
potassium:proton exchanging ATPase complex 1 ATP12A
[Isoform H]: Cell membrane 1 ACHE


文献列表

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