pirenzepine (BioDeep_00001868386)
Main id: BioDeep_00000006514
代谢物信息卡片
pirenzepine
化学式: C19H21N5O2 (351.1695)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CN1CCN(CC1)CC(=O)n1c2ccccc2c(=O)[nH]c2cccnc12
InChI: InChI=1S/C19H21N5O2/c1-22-9-11-23(12-10-22)13-17(25)24-16-7-3-2-5-14(16)19(26)21-15-6-4-8-20-18(15)24/h2-8H,9-13H2,1H3,(H,21,26)
描述信息
A - Alimentary tract and metabolism > A02 - Drugs for acid related disorders > A02B - Drugs for peptic ulcer and gastro-oesophageal reflux disease (gord)
C78272 - Agent Affecting Nervous System > C66880 - Anticholinergic Agent > C29704 - Antimuscarinic Agent
D018377 - Neurotransmitter Agents > D018678 - Cholinergic Agents > D018680 - Cholinergic Antagonists
D005765 - Gastrointestinal Agents > D000897 - Anti-Ulcer Agents
同义名列表
2 个代谢物同义名
数据库引用编号
12 个数据库交叉引用编号
- ChEBI: CHEBI:8247
- KEGG: C07508
- KEGGdrug: D08389
- PubChem: 4848
- DrugBank: DB00670
- ChEMBL: CHEMBL9967
- MeSH: Pirenzepine
- PubChem: 9711
- CAS: 28797-61-7
- NIKKAJI: J20.030A
- RefMet: Pirenzepine
- KNApSAcK: 8247
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Takahiro Suzuki, Tomohiro Higuchi, Takuma Kagami, Takahiro Uotani, Mihoko Yamade, Shinya Tani, Yasushi Hamaya, Moriya Iwaizumi, Satoshi Osawa, Ken Sugimoto, Hiroaki Miyajima, Takahisa Furuta. Effects of pirenzepine on vonoprazan-induced gastric acid inhibition and hypergastrinemia.
European journal of clinical pharmacology.
2021 Jul; 77(7):971-978. doi:
10.1007/s00228-021-03162-5. [PMID: 34059932] - Huimei An, Hongzhen Fan, Song Chen, Siyuan Qi, Botao Ma, Jing Shi, Zhiren Wang, Fude Yang. Effects of Dose, Age, Sex, Body Weight, and Smoking on Plasma Concentrations of Olanzapine and N-desmethyl Olanzapine in Inpatients With Schizophrenia.
Journal of clinical psychopharmacology.
2021 May; 41(3):255-259. doi:
10.1097/jcp.0000000000001390. [PMID: 33814547] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
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2019 11; 96(5):629-640. doi:
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Archives of biochemistry and biophysics.
2018 08; 652(?):27-37. doi:
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2011 Apr; 134(3):637-43. doi:
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Therapeutic drug monitoring.
2006 Dec; 28(6):750-9. doi:
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Autonomic & autacoid pharmacology.
2006 Jul; 26(3):285-92. doi:
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Neuropharmacology.
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Biological & pharmaceutical bulletin.
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Life sciences.
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Gastroenterology.
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Journal of clinical psychopharmacology.
2003 Aug; 23(4):323-7. doi:
10.1097/01.jcp.0000085403.08426.f4. [PMID: 12920406] - Sharon J Gardiner, Judith H Kristensen, Evan J Begg, L Peter Hackett, Debbie A Wilson, Kenneth F Ilett, Rolland Kohan, Jonathan Rampono. Transfer of olanzapine into breast milk, calculation of infant drug dose, and effect on breast-fed infants.
The American journal of psychiatry.
2003 Aug; 160(8):1428-31. doi:
10.1176/appi.ajp.160.8.1428. [PMID: 12900304] - Tilmann Wetterling. [Type 2 diabetes and dyslipidemia. Side effects of 'Atypical' neuroleptics?].
Medizinische Klinik (Munich, Germany : 1983).
2003 Jul; 98(7):364-7. doi:
10.1007/s00063-003-1274-9. [PMID: 12937901] - Cheryl A Frye, Angela M Seliga. Olanzapine's effects to reduce fear and anxiety and enhance social interactions coincide with increased progestin concentrations of ovariectomized rats.
Psychoneuroendocrinology.
2003 Jul; 28(5):657-73. doi:
10.1016/s0306-4530(02)00049-5. [PMID: 12727133] - Bruce J Kinon, Virginia L Stauffer, Hillary C McGuire, Christopher J Kaiser, Ruth A Dickson, John S Kennedy. The effects of antipsychotic drug treatment on prolactin concentrations in elderly patients.
Journal of the American Medical Directors Association.
2003 Jul; 4(4):189-94. doi:
10.1097/01.jam.0000073959.30368.6b. [PMID: 12837139] - Daniel Becker, Olga Liver, Roberto Mester, Micha Rapoport, Abraham Weizman, Mordechai Weiss. Risperidone, but not olanzapine, decreases bone mineral density in female premenopausal schizophrenia patients.
The Journal of clinical psychiatry.
2003 Jul; 64(7):761-6. doi:
10.4088/jcp.v64n0704. [PMID: 12934975] - Younes Anini, Patricia L Brubaker. Muscarinic receptors control glucagon-like peptide 1 secretion by human endocrine L cells.
Endocrinology.
2003 Jul; 144(7):3244-50. doi:
10.1210/en.2003-0143. [PMID: 12810581] - Kyle M Kampman, Helen Pettinati, Kevin G Lynch, Thorne Sparkman, Charles P O'Brien. A pilot trial of olanzapine for the treatment of cocaine dependence.
Drug and alcohol dependence.
2003 Jun; 70(3):265-73. doi:
10.1016/s0376-8716(03)00009-7. [PMID: 12757964] - Isao Fukunishi, Yoshikazu Sato, Kyoko Kino, Tetsuo Shirai, Tateki Kitaoka. Hypothermia in a hemodialysis patient treated with olanzapine monotherapy.
Journal of clinical psychopharmacology.
2003 Jun; 23(3):314. doi:
10.1097/00004714-200306000-00013. [PMID: 12826994] - Giuseppina D'Amico, Clemente Cedro, Maria Rosaria Muscatello, Gianluca Pandolfo, Antonio Enrico Di Rosa, Rocco Zoccali, Diletta La Torre, Concetta D'Arrigo, Edoardo Spina. Olanzapine augmentation of paroxetine-refractory obsessive-compulsive disorder.
Progress in neuro-psychopharmacology & biological psychiatry.
2003 Jun; 27(4):619-23. doi:
10.1016/s0278-5846(03)00050-2. [PMID: 12787848] - M Pezza, L Busiello, S Palmese, M Cascella, M G Di Domenico, E De Robertis. [Rhabdomyolysis associated with respiratory infection in chronic psychiatric patients during neuroleptic treatment].
Minerva anestesiologica.
2003 Jun; 69(6):591-6. doi:
NULL. [PMID: 14564256] - Kara Lee Shirley, Yuen Y Hon, Scott R Penzak, Y W Francis Lam, Vicky Spratlin, Michael W Jann. Correlation of cytochrome P450 (CYP) 1A2 activity using caffeine phenotyping and olanzapine disposition in healthy volunteers.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.
2003 May; 28(5):961-6. doi:
10.1038/sj.npp.1300123. [PMID: 12644842] - Mirijam Fric, Gerd Laux. [Plasma prolactin level and incidence of adverse endocrinologic effects during therapy with atypical neuroleptics].
Psychiatrische Praxis.
2003 May; 30 Suppl 2(?):S97-101. doi:
NULL. [PMID: 14509051] - A Nel, B H Harvey. Haloperidol-induced dyskinesia is associated with striatal NO synthase suppression: reversal with olanzapine.
Behavioural pharmacology.
2003 May; 14(3):251-5. doi:
10.1097/00008877-200305000-00010. [PMID: 12799528] - Brigitte Ilien, Christelle Franchet, Philippe Bernard, Séverine Morisset, Claire Odile Weill, Jean-Jacques Bourguignon, Marcel Hibert, Jean-Luc Galzi. Fluorescence resonance energy transfer to probe human M1 muscarinic receptor structure and drug binding properties.
Journal of neurochemistry.
2003 May; 85(3):768-78. doi:
10.1046/j.1471-4159.2003.01717.x. [PMID: 12694403] - Murad Atmaca, Murat Kuloglu, Ertan Tezcan, Bilal Ustundag. Serum leptin and triglyceride levels in patients on treatment with atypical antipsychotics.
The Journal of clinical psychiatry.
2003 May; 64(5):598-604. doi:
10.4088/jcp.v64n0516. [PMID: 12755665] - Juan Antonio Carrillo, Angustias G Herráiz, Sara Isabel Ramos, Guillermo Gervasini, Sonia Vizcaíno, Julio Benítez. Role of the smoking-induced cytochrome P450 (CYP)1A2 and polymorphic CYP2D6 in steady-state concentration of olanzapine.
Journal of clinical psychopharmacology.
2003 Apr; 23(2):119-27. doi:
10.1097/00004714-200304000-00003. [PMID: 12640212] - Ezequiel Martí-Bonmatí, Eva San Valero-Carcelén, María Pilar Ortega-García, Ricardo Rubini-Puig. Olanzapine elevation of serum creatine kinase.
The Journal of clinical psychiatry.
2003 Apr; 64(4):483-4. doi:
10.4088/jcp.v64n0420f. [PMID: 12716258] - Bruce J Kinon, Julie A Gilmore, Hong Liu, Uriel M Halbreich. Hyperprolactinemia in response to antipsychotic drugs: characterization across comparative clinical trials.
Psychoneuroendocrinology.
2003 Apr; 28 Suppl 2(?):69-82. doi:
10.1016/s0306-4530(02)00128-2. [PMID: 12650682] - Yesim Ozarda Ilcol, M Sibel Gurun, Yavuz Taga, Ismail H Ulus. Choline increases serum insulin in rat when injected intraperitoneally and augments basal and stimulated aceylcholine release from the rat minced pancreas in vitro.
European journal of biochemistry.
2003 Mar; 270(5):991-9. doi:
10.1046/j.1432-1033.2003.03472.x. [PMID: 12603332] - Murad Atmaca, Murat Kuloglu, Ertan Tezcan, Omer Gecici, Bilal Ustundag. Weight gain, serum leptin and triglyceride levels in patients with schizophrenia on antipsychotic treatment with quetiapine, olanzapine and haloperidol.
Schizophrenia research.
2003 Mar; 60(1):99-100. doi:
10.1016/s0920-9964(02)00305-5. [PMID: 12505146] - Jean-Pierre Lindenmayer, Pal Czobor, Jan Volavka, Leslie Citrome, Brian Sheitman, Joseph P McEvoy, Thomas B Cooper, Miranda Chakos, Jeffrey A Lieberman. Changes in glucose and cholesterol levels in patients with schizophrenia treated with typical or atypical antipsychotics.
The American journal of psychiatry.
2003 Feb; 160(2):290-6. doi:
10.1176/appi.ajp.160.2.290. [PMID: 12562575] - Neeraj Berry, Sapna Pradhan, Rajesh Sagar, Suresh Kumar Gupta. Neuroleptic malignant syndrome in an adolescent receiving olanzapine-lithium combination therapy.
Pharmacotherapy.
2003 Feb; 23(2):255-9. doi:
10.1592/phco.23.2.255.32091. [PMID: 12587815] - Yasuhiro Hasui, Manabu Ikeda, Hirotaka Tanabe. [Porphyria].
Ryoikibetsu shokogun shirizu.
2003; ?(40):355-9. doi:
NULL. [PMID: 14626138] - Ibrahim Bilgen, Gülsen Oner, Mustafa Edremitlioğlu, Zeliha Alkan, Selma Cirrik. Involvement of cholinoceptors in cadmium-induced endothelial dysfunction.
Journal of basic and clinical physiology and pharmacology.
2003; 14(1):55-76. doi:
10.1515/jbcpp.2003.14.1.55. [PMID: 12901446] - Fabio Broglio, Cristina Gottero, Andrea Benso, Flavia Prodam, Felipe F Casanueva, Carlos Dieguez, Aart Jan van der Lely, Romano Deghenghi, Emanuela Arvat, Ezio Ghigo. Acetylcholine does not play a major role in mediating the endocrine responses to ghrelin, a natural ligand of the GH secretagogue receptor, in humans.
Clinical endocrinology.
2003 Jan; 58(1):92-8. doi:
10.1046/j.1365-2265.2003.01680.x. [PMID: 12519418] - Christine E Marx, Margaret J VanDoren, Gary E Duncan, Jeffrey A Lieberman, A Leslie Morrow. Olanzapine and clozapine increase the GABAergic neuroactive steroid allopregnanolone in rodents.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.
2003 Jan; 28(1):1-13. doi:
10.1038/sj.npp.1300015. [PMID: 12496935] - Hugh Jones, Vivienne A Curtis, Padraig Wright, Lyn S Pilowsky, James V Lucey. D-fenfluramine-evoked serotonergic responses in olanzapine-treated schizophrenic patients.
Psychiatry research.
2002 Dec; 113(1-2):41-7. doi:
10.1016/s0165-1781(02)00224-x. [PMID: 12467944] - M U Halldin, K Brismar, T Tuvemo, J Gustafsson. Insulin sensitivity and lipolysis in adolescent girls with poorly controlled type 1 diabetes: effect of anticholinergic treatment.
Clinical endocrinology.
2002 Dec; 57(6):735-43. doi:
10.1046/j.1365-2265.2002.01656.x. [PMID: 12460323] - Sybille Grieshaber, Alexander Jatzko, Georg Adler. [Mnestic impairment under olanzapine overdosage in an elderly patient].
Psychiatrische Praxis.
2002 Nov; 29(8):441-4. doi:
10.1055/s-2002-35510. [PMID: 12436366] - S M Saw, G Gazzard, K-G Au Eong, D T H Tan. Myopia: attempts to arrest progression.
The British journal of ophthalmology.
2002 Nov; 86(11):1306-11. doi:
10.1136/bjo.86.11.1306. [PMID: 12386095] - Carol E Koro, Donald O Fedder, Gilbert J L'Italien, Sheila Weiss, Laurence S Magder, Julie Kreyenbuhl, Dennis Revicki, Robert W Buchanan. An assessment of the independent effects of olanzapine and risperidone exposure on the risk of hyperlipidemia in schizophrenic patients.
Archives of general psychiatry.
2002 Nov; 59(11):1021-6. doi:
10.1001/archpsyc.59.11.1021. [PMID: 12418935] - Donna A Wirshing, Jennifer A Boyd, Laura R Meng, Jacob S Ballon, Stephen R Marder, William C Wirshing. The effects of novel antipsychotics on glucose and lipid levels.
The Journal of clinical psychiatry.
2002 Oct; 63(10):856-65. doi:
10.4088/jcp.v63n1002. [PMID: 12416594] - Hsien-Yuan Lane, Shi-Chin Guo, Tzung-Jeng Hwang, Ying-Sheue Chen, Joseph J Cheng, Ying-Chiao Lee, Chen-Jee Hong, Hai-Gwo Hwu, Wen-Ho Chang. Effects of olanzapine plasma concentrations on depressive symptoms in schizophrenia: a pilot study.
Journal of clinical psychopharmacology.
2002 Oct; 22(5):530-2. doi:
10.1097/00004714-200210000-00019. [PMID: 12352282] - Simon Croke, Anne Buist, L Peter Hackett, Kenneth F Ilett, Trevor R Norman, Graham D Burrows. Olanzapine excretion in human breast milk: estimation of infant exposure.
The international journal of neuropsychopharmacology.
2002 Sep; 5(3):243-7. doi:
10.1017/s1461145702003012. [PMID: 12366877] - Susumu Okabe, Kazuharu Furutani, Kazuhiko Maeda, Takeshi Aihara, Teruaki Fujishita, Shunsuke Tonai. [Regulatory mechanism of gastric acid secretion and mucosal integrity--an analysis with various gene deficient mice].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica.
2002 Sep; 120(3):159-71. doi:
10.1254/fpj.120.159. [PMID: 12271511]
