Theasinensin A (BioDeep_00000640963)

Main id: BioDeep_00000007718

 

PANOMIX_OTCML-2023 natural product


代谢物信息卡片


Theasinensin A

化学式: C44H34O22 (914.1541663999999)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C12C=C(O)C=C(O)C=1C[C@@H](OC(=O)C1C=C(O)C(O)=C(O)C=1)[C@@H](C1C(C3C(O)=C(O)C(O)=CC=3[C@@H]3[C@H](OC(=O)C4C=C(O)C(O)=C(O)C=4)CC4C(O)=CC(O)=CC=4O3)=C(O)C(O)=C(O)C=1)O2
InChI: InChI=1S/C44H34O22/c45-15-5-21(47)17-11-31(65-43(61)13-1-23(49)35(55)24(50)2-13)41(63-29(17)7-15)19-9-27(53)37(57)39(59)33(19)34-20(10-28(54)38(58)40(34)60)42-32(12-18-22(48)6-16(46)8-30(18)64-42)66-44(62)14-3-25(51)36(56)26(52)4-14/h1-10,31-32,41-42,45-60H,11-12H2/t31-,32-,41-,42-/m1/s1

描述信息

A biflavonoid that is obtained by coupling of two molecules of (-)-epigallocatechin 3-gallate resulting in a bond between positions C-2 of the hydroxyphenyl ring. It is a natural product found in oolong tea.

同义名列表

2 个代谢物同义名

Theasinensin A; Theasinensin A



数据库引用编号

14 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

21 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Weiqi Xu, Yujie Huang, Sainan Tao, Wangting Zhou, Yujia Peng, Wei Dong, Xuhui Kan, Guijie Chen, Xiaoxiong Zeng, Zhonghua Liu. Effects of long-term administration of theasinensin A on healthy C57BL/6J mice: Enhancing the function of epididymal white adipose tissue and regulating the colonic microenvironment. Food chemistry. 2023 Mar; 403(?):134477. doi: 10.1016/j.foodchem.2022.134477. [PMID: 36358090]
  • Sainan Tao, Guijie Chen, Weiqi Xu, Yujia Peng, Peng Wan, Yi Sun, Xiaoxiong Zeng, Zhonghua Liu. Preparation of theasinensin A and theasinensin B and exploration of their inhibitory mechanism on α-glucosidase. Food & function. 2020 Apr; 11(4):3527-3538. doi: 10.1039/c9fo03054a. [PMID: 32255112]
  • Xuemei Guo, Piaopiao Long, Qilu Meng, Chi-Tang Ho, Liang Zhang. An emerging strategy for evaluating the grades of Keemun black tea by combinatory liquid chromatography-Orbitrap mass spectrometry-based untargeted metabolomics and inhibition effects on α-glucosidase and α-amylase. Food chemistry. 2018 Apr; 246(?):74-81. doi: 10.1016/j.foodchem.2017.10.148. [PMID: 29291881]
  • Wei-Lun Hung, Guliang Yang, Yu-Chuan Wang, Yi-Shiou Chiou, Yen-Chen Tung, Meei-Ju Yang, Bi-Ni Wang, Chi-Tang Ho, Yu Wang, Min-Hsiung Pan. Protective effects of theasinensin A against carbon tetrachloride-induced liver injury in mice. Food & function. 2017 Sep; 8(9):3276-3287. doi: 10.1039/c7fo00700k. [PMID: 28831484]
  • Jian Guo, Naoto Hirasaki, Yuji Miyata, Kazunari Tanaka, Takashi Tanaka, Xiao Wu, Yusuke Tahara, Kiyoshi Toko, Toshiro Matsui. Evaluating the Reduced Hydrophobic Taste Sensor Response of Dipeptides by Theasinensin A by Using NMR and Quantum Mechanical Analyses. PloS one. 2016; 11(6):e0157315. doi: 10.1371/journal.pone.0157315. [PMID: 27309380]
  • Ayami Hisanaga, Hisako Ishida, Kozue Sakao, Takayuki Sogo, Takuma Kumamoto, Fumio Hashimoto, De-Xing Hou. Anti-inflammatory activity and molecular mechanism of Oolong tea theasinensin. Food & function. 2014 Aug; 5(8):1891-7. doi: 10.1039/c4fo00152d. [PMID: 24947273]
  • Ju Qiu, Kanako Maekawa, Yuko Kitamura, Yuji Miyata, Kazunari Tanaka, Takashi Tanaka, Minoru Soga, Takanori Tsuda, Toshiro Matsui. Stimulation of glucose uptake by theasinensins through the AMP-activated protein kinase pathway in rat skeletal muscle cells. Biochemical pharmacology. 2014 Jan; 87(2):344-51. doi: 10.1016/j.bcp.2013.10.029. [PMID: 24225153]
  • Yuji Miyata, Shizuka Tamaru, Takashi Tanaka, Kei Tamaya, Toshiro Matsui, Yasuo Nagata, Kazunari Tanaka. Theflavins and theasinensin A derived from fermented tea have antihyperglycemic and hypotriacylglycerolemic effects in KK-A(y) mice and Sprague-Dawley rats. Journal of agricultural and food chemistry. 2013 Oct; 61(39):9366-72. doi: 10.1021/jf400123y. [PMID: 24011231]
  • Shizuka Tamaru, Kazuhiro Ohmachi, Yuji Miyata, Takashi Tanaka, Takashi Kubayasi, Yasuo Nagata, Kazunari Tanaka. Hypotriglyceridemic potential of fermented mixed tea made with third-crop green tea leaves and camellia (Camellia japonica) leaves in Sprague-Dawley rats. Journal of agricultural and food chemistry. 2013 Jun; 61(24):5817-23. doi: 10.1021/jf400938h. [PMID: 23705670]
  • De-Xing Hou, Satoko Masuzaki, Shunsuke Tanigawa, Fumio Hashimoto, Jihua Chen, Takayuki Sogo, Makoto Fujii. Oolong tea theasinensins attenuate cyclooxygenase-2 expression in lipopolysaccharide (LPS)-activated mouse macrophages: structure-activity relationship and molecular mechanisms. Journal of agricultural and food chemistry. 2010 Dec; 58(24):12735-43. doi: 10.1021/jf103605j. [PMID: 21082860]
  • Tsutomu Hatano, Miwako Kusuda, Mami Hori, Sumiko Shiota, Tomofusa Tsuchiya, Takashi Yoshida. Theasinensin A, a tea polyphenol formed from (-)-epigallocatechin gallate, suppresses antibiotic resistance of methicillin-resistant Staphylococcus aureus. Planta medica. 2003 Nov; 69(11):984-9. doi: 10.1055/s-2003-45142. [PMID: 14735433]
  • I Abe, Y Kashiwagi, H Noguchi, T Tanaka, Y Ikeshiro, Y Kashiwada. Ellagitannins and hexahydroxydiphenoyl esters as inhibitors of vertebrate squalene epoxidase. Journal of natural products. 2001 Aug; 64(8):1010-4. doi: 10.1021/np010100y. [PMID: 11520216]