Dihydrotachysterol (BioDeep_00000006385)

   

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


(1S,3E,4S)-3-{2-[(1R,3aS,4E,7aR)-1-[(2R,3E,5R)-5,6-dimethylhept-3-en-2-yl]-7a-methyl-octahydro-1H-inden-4-ylidene]ethylidene}-4-methylcyclohexan-1-ol

化学式: C28H46O (398.3548)
中文名称: 多沙唑嗪杂质F
谱图信息: 最多检出来源 Viridiplantae(plant) 39.7%

分子结构信息

SMILES: CC(C)[C@@H](C)\C=C\[C@@H](C)[C@@]1([H])CC[C@@]2([H])\C(CCC[C@]12C)=C\C=C1/C[C@@H](O)CC[C@@H]1C
InChI: InChI=1S/C28H46O/c1-19(2)20(3)9-10-22(5)26-15-16-27-23(8-7-17-28(26,27)6)12-13-24-18-25(29)14-11-21(24)4/h9-10,12-13,19-22,25-27,29H,7-8,11,14-18H2,1-6H3/b10-9+,23-12+,24-13+/t20-,21-,22+,25-,26+,27-,28+/m0/s1

描述信息

Dihydrotachysterol is only found in individuals that have used or taken this drug. It is a vitamin D that can be regarded as a reduction product of vitamin D2. [PubChem]Once hydroxylated to 25-hydroxydihydrotachysterol, the modified drug binds to the vitamin D receptor. The bound form of the vitamin D receptor serves as a transcriptional regulator of bone matrix proteins, inducing the expression of osteocalcin and suppressing synthesis of type I collagen. Vitamin D (when bound to the vitamin D receptor)stimulates the expression of a number of proteins involved in transporting calcium from the lumen of the intestine, across the epithelial cells and into blood. This stimulates intestinal calcium absorption and increases renal phosphate excretion. These are functions that are normally carried out by the parathyroid hormone.
A - Alimentary tract and metabolism > A11 - Vitamins > A11C - Vitamin a and d, incl. combinations of the two > A11CC - Vitamin d and analogues
D018977 - Micronutrients > D014815 - Vitamins > D004872 - Ergocalciferols
D050071 - Bone Density Conservation Agents

同义名列表

15 个代谢物同义名

(1S,3E,4S)-3-{2-[(1R,3aS,4E,7aR)-1-[(2R,3E,5R)-5,6-dimethylhept-3-en-2-yl]-7a-methyl-octahydro-1H-inden-4-ylidene]ethylidene}-4-methylcyclohexan-1-ol; Anti-tetany substance 10; Dihydrotachysterolum; dihydrotachysterol; Dihydrotachysterin; Dihidrotaquisterol; Vitamin D4; HSDB 3314; Tachystin; Hytakerol; Calcamine; Dihydral; AT-10; AT 10; Dihydrotachysterol



数据库引用编号

19 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 11 ALB, AR, BGLAP, CALCA, CAST, EDN1, EGFR, PIK3C2A, PTGS2, SDF4, VDR
Golgi apparatus, trans-Golgi network membrane 1 AQP2
Peripheral membrane protein 2 ACHE, PTGS2
Endosome membrane 1 EGFR
Endoplasmic reticulum membrane 3 ALG11, EGFR, PTGS2
Nucleus 7 ACHE, ALB, AR, EGFR, GATA3, PIK3C2A, VDR
cytosol 6 ALB, AR, AVP, CAST, PIK3C2A, VDR
dendrite 2 AVP, BGLAP
trans-Golgi network 1 PIK3C2A
centrosome 1 ALB
nucleoplasm 5 AR, CAST, GATA3, PIK3C2A, VDR
RNA polymerase II transcription regulator complex 1 VDR
Cell membrane 5 ACHE, AQP2, EGFR, PIK3C2A, SDF4
ruffle membrane 1 EGFR
Early endosome membrane 1 EGFR
Multi-pass membrane protein 1 AQP2
Synapse 1 ACHE
cell junction 1 EGFR
cell surface 2 ACHE, EGFR
glutamatergic synapse 1 EGFR
Golgi apparatus 4 ACHE, ALB, AQP2, SDF4
Golgi membrane 2 EGFR, INS
neuromuscular junction 1 ACHE
neuronal cell body 1 CALCA
endosome 1 EGFR
plasma membrane 6 ACHE, AQP2, AR, EGFR, PIK3C2A, SDF4
terminal bouton 1 CALCA
Membrane 8 ACHE, ALG11, AQP2, AR, CAST, EGFR, PIK3C2A, SDF4
apical plasma membrane 2 AQP2, EGFR
basolateral plasma membrane 2 AQP2, EGFR
caveola 1 PTGS2
extracellular exosome 5 ALB, AQP2, BMP3, PIK3C2A, SDF4
endoplasmic reticulum 4 ALB, CAST, PTGS2, SDF4
extracellular space 11 ACHE, ALB, AVP, BGLAP, BMP3, CALCA, EDN1, EGFR, GAST, INS, PTH
perinuclear region of cytoplasm 3 ACHE, AQP2, EGFR
mitochondrion 1 CAST
protein-containing complex 4 ALB, AR, EGFR, PTGS2
intracellular membrane-bounded organelle 1 PIK3C2A
Microsome membrane 1 PTGS2
Single-pass type I membrane protein 1 EGFR
Secreted 9 ACHE, ALB, AVP, BGLAP, BMP3, CALCA, EDN1, GAST, INS
extracellular region 10 ACHE, ALB, AVP, BGLAP, BMP3, CALCA, EDN1, GAST, INS, PTH
Single-pass membrane protein 1 ALG11
basal part of cell 1 EDN1
hippocampal mossy fiber to CA3 synapse 1 CALCA
Extracellular side 1 ACHE
anchoring junction 1 ALB
nuclear membrane 1 EGFR
perikaryon 1 BGLAP
nucleolus 1 CAST
recycling endosome 1 AQP2
vesicle 2 BGLAP, PIK3C2A
Apical cell membrane 1 AQP2
Membrane raft 1 EGFR
focal adhesion 1 EGFR
basement membrane 1 ACHE
intracellular vesicle 1 EGFR
secretory granule 1 AVP
lateral plasma membrane 1 AQP2
nuclear speck 1 AR
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
Late endosome 1 SDF4
receptor complex 2 EGFR, VDR
neuron projection 1 PTGS2
ciliary basal body 1 ALB
chromatin 3 AR, GATA3, VDR
Chromosome 1 CAST
centriole 1 ALB
[Isoform 5]: Cytoplasm 1 SDF4
Golgi apparatus, trans-Golgi network 1 PIK3C2A
Nucleus, nucleolus 1 CAST
spindle pole 1 ALB
blood microparticle 1 ALB
Basolateral cell membrane 1 AQP2
Lipid-anchor, GPI-anchor 1 ACHE
fibrillar center 1 CAST
endosome lumen 1 INS
Cytoplasmic vesicle membrane 1 AQP2
side of membrane 1 ACHE
basal plasma membrane 1 EGFR
clathrin-coated vesicle 1 PIK3C2A
synaptic membrane 1 EGFR
secretory granule lumen 1 INS
Golgi apparatus lumen 1 SDF4
Golgi lumen 3 BGLAP, INS, SDF4
endoplasmic reticulum lumen 4 ALB, BGLAP, INS, PTGS2
platelet alpha granule lumen 1 ALB
phosphatidylinositol 3-kinase complex 1 PIK3C2A
Cytoplasmic vesicle, clathrin-coated vesicle 1 PIK3C2A
transport vesicle 2 EDN1, INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
neuronal dense core vesicle 2 AVP, CALCA
clathrin-coated endocytic vesicle membrane 2 AVP, EGFR
RNA polymerase I complex 1 CAST
synaptic cleft 1 ACHE
RNA polymerase I transcription regulator complex 1 CAST
bleb 1 SDF4
multivesicular body, internal vesicle lumen 1 EGFR
Shc-EGFR complex 1 EGFR
transport vesicle membrane 1 AQP2
rough endoplasmic reticulum lumen 1 EDN1
Weibel-Palade body 1 EDN1
[Isoform H]: Cell membrane 1 ACHE
lumenal side of membrane 1 AQP2
ciliary transition fiber 1 ALB
[Isoform 1]: Golgi apparatus lumen 1 SDF4


文献列表

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