farnesyl diphosphate (BioDeep_00000638402)

Main id: BioDeep_00000001707

 

PANOMIX_OTCML-2023


代谢物信息卡片


2-trans,6-trans-Farnesyl diphosphate

化学式: C15H28O7P2 (382.1310198)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(=CCC/C(=C/CC/C(=C/COP(=O)(O)OP(=O)(O)O)/C)/C)C
InChI: InChI=1S/C15H28O7P2/c1-13(2)7-5-8-14(3)9-6-10-15(4)11-12-21-24(19,20)22-23(16,17)18/h7,9,11H,5-6,8,10,12H2,1-4H3,(H,19,20)(H2,16,17,18)/b14-9+,15-11+

描述信息

The trans,trans-stereoisomer of farnesyl diphosphate.

同义名列表

3 个代谢物同义名

2-trans,6-trans-Farnesyl diphosphate; farnesyl diphosphate; Farnesyl pyrophosphate



数据库引用编号

14 个数据库交叉引用编号

分类词条

28 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Sung Chul Park, Breanne N Steffan, Fang Yun Lim, Raveena Gupta, Fatma Ayaloglu Butun, Hongyu Chen, Rosa Ye, Timothy Decker, Chengcang C Wu, Neil L Kelleher, Jin Woo Bok, Nancy P Keller. Terpenoid balance in Aspergillus nidulans unveiled by heterologous squalene synthase expression. Science advances. 2024 Feb; 10(8):eadk7416. doi: 10.1126/sciadv.adk7416. [PMID: 38381828]
  • Xuan Song, Chang Liu, Khalid H Dhiloo, Chao-Qun Yi, Tian-Tao Zhang, Yong-Jun Zhang. Functional characterization of a geranylgeranyl diphosphate synthase in the leaf beetle Monolepta hieroglyphica. Archives of insect biochemistry and physiology. 2024 Feb; 115(2):e22088. doi: 10.1002/arch.22088. [PMID: 38349673]
  • Hayat Hage, Julie Couillaud, Asaf Salamov, Margot Loussouarn-Yvon, Fabien Durbesson, Elena Ormeño, Sacha Grisel, Katia Duquesne, Renaud Vincentelli, Igor Grigoriev, Gilles Iacazio, Marie-Noëlle Rosso. An HMM approach expands the landscape of sesquiterpene cyclases across the kingdom Fungi. Microbial genomics. 2023 Apr; 9(4):. doi: 10.1099/mgen.0.000990. [PMID: 37073784]
  • Jing Chen, Jing Tan, Xinyu Duan, Ying Wang, Jing Wen, Wei Li, Zhengguo Li, Guodong Wang, Haiyang Xu. Plastidial engineering with coupled farnesyl diphosphate pool reconstitution and enhancement for sesquiterpene biosynthesis in tomato fruit. Metabolic engineering. 2023 Mar; 77(?):41-52. doi: 10.1016/j.ymben.2023.03.002. [PMID: 36893914]
  • Liliane Sena Pinheiro, Valter Viana Andrade-Neto, Marcio Mantuano-Barradas, Elisa Cavalcante Pereira, Rodrigo Cesar Fernandes Barbosa, Marcia Cristina Campos de Oliveira, Rubem Figueiredo Sadok Menna-Barreto, Edézio Ferreira Cunha-Júnior, Eduardo Caio Torres-Santos. Biological effects of trans, trans-farnesol in Leishmania amazonensis. Frontiers in cellular and infection microbiology. 2023; 13(?):1221246. doi: 10.3389/fcimb.2023.1221246. [PMID: 38035328]
  • Cuicui Yu, Shixi Gao, Mei Rong, Mengjun Xiao, Yanhong Xu, Jianhe Wei. Identification and characterization of novel sesquiterpene synthases TPS9 and TPS12 from Aquilaria sinensis. PeerJ. 2023; 11(?):e15818. doi: 10.7717/peerj.15818. [PMID: 37663295]
  • Hoang V Tang, David L Berryman, Jorrel Mendoza, Jessica P Yactayo-Chang, Qin-Bao Li, Shawn A Christensen, Charles T Hunter, Norman Best, Eric Soubeyrand, Tariq A Akhtar, Gilles J Basset, Anna K Block. Dedicated farnesyl diphosphate synthases circumvent isoprenoid-derived growth-defense tradeoffs in Zea mays. The Plant journal : for cell and molecular biology. 2022 10; 112(1):207-220. doi: 10.1111/tpj.15941. [PMID: 35960639]
  • Nur Suhanawati Ashaari, Mohd Hairul Ab Rahim, Suriana Sabri, Kok Song Lai, Adelene Ai-Lian Song, Raha Abdul Rahim, Janna Ong Abdullah. Kinetic studies and homology modeling of a dual-substrate linalool/nerolidol synthase from Plectranthus amboinicus. Scientific reports. 2021 08; 11(1):17094. doi: 10.1038/s41598-021-96524-z. [PMID: 34429465]
  • Jianxun Zhu, Lihong Liu, Maobo Wu, Guiyang Xia, Pengcheng Lin, Jiachen Zi. Characterization of a Sesquiterpene Synthase Catalyzing Formation of Cedrol and Two Diastereoisomers of Tricho-Acorenol from Euphorbia fischeriana. Journal of natural products. 2021 06; 84(6):1780-1786. doi: 10.1021/acs.jnatprod.1c00126. [PMID: 34014675]
  • Lai Wang, Zu-Guo Zheng, Lingchang Meng, Lijun Zhu, Ping Li, Jun Chen, Hua Yang. Statins induce skeletal muscle atrophy via GGPP depletion-dependent myostatin overexpression in skeletal muscle and brown adipose tissue. Cell biology and toxicology. 2021 06; 37(3):441-460. doi: 10.1007/s10565-020-09558-w. [PMID: 33034787]
  • Sarah Ötzkan, Walter E Muller, W Gibson Wood, Gunter P Eckert. Effects of 7,8-Dihydroxyflavone on Lipid Isoprenoid and Rho Protein Levels in Brains of Aged C57BL/6 Mice. Neuromolecular medicine. 2021 03; 23(1):130-139. doi: 10.1007/s12017-020-08640-0. [PMID: 33377988]
  • Marie Chantal Lemfack, Wolfgang Brandt, Katja Krüger, Alexandra Gurowietz, Jacky Djifack, Jan-Philip Jung, Marius Hopf, Heiko Noack, Björn Junker, Stephan von Reuß, Birgit Piechulla. Reaction mechanism of the farnesyl pyrophosphate C-methyltransferase towards the biosynthesis of pre-sodorifen pyrophosphate by Serratia plymuthica 4Rx13. Scientific reports. 2021 02; 11(1):3182. doi: 10.1038/s41598-021-82521-9. [PMID: 33542330]
  • Chi Zhang, Dan-Dan Jin, Xi-Ying Wang, Lian Lou, Jian Yang. Key Enzymes for the Mevalonate Pathway in the Cardiovascular System. Journal of cardiovascular pharmacology. 2021 02; 77(2):142-152. doi: 10.1097/fjc.0000000000000952. [PMID: 33538531]
  • Yapei Zhao, Tian Hu, Ruiqi Liu, Zhiqiang Hao, Guoyan Liang, Guanglin Li. Biochemical Characterization and Function of Eight Microbial Type Terpene Synthases from Lycophyte Selaginella moellendorffii. International journal of molecular sciences. 2021 Jan; 22(2):. doi: 10.3390/ijms22020605. [PMID: 33435353]
  • Liping Wang, Jin Liang, Xin Xie, Jiang Liu, Qinqin Shen, Lixia Li, Qiang Wang. Direct formation of the sesquiterpeonid ether liguloxide by a terpene synthase in Senecio scandens. Plant molecular biology. 2021 Jan; 105(1-2):55-64. doi: 10.1007/s11103-020-01068-x. [PMID: 32915351]
  • Cheng-Yi Chiang, Chia-Cheng Chou, Hsin-Yang Chang, Min-Feng Hsu, Po-Jung Pao, Ming-Hui Chiang, Andrew H-J Wang. Biochemical and molecular dynamics studies of archaeal polyisoprenyl pyrophosphate phosphatase from Saccharolobus solfataricus. Enzyme and microbial technology. 2020 Sep; 139(?):109585. doi: 10.1016/j.enzmictec.2020.109585. [PMID: 32732034]
  • Seong Woo Choi, Si Won Choi, Jeesoo Chae, Hae Young Yoo, Jong-Il Kim, Sung Joon Kim. The novel high-frequency variant of TRPV3 p.A628T in East Asians showing faster sensitization in response to chemical agonists. Pflugers Archiv : European journal of physiology. 2019 10; 471(10):1273-1289. doi: 10.1007/s00424-019-02309-9. [PMID: 31612282]
  • Chuanbo Zhang, Man Li, Guang-Rong Zhao, Wenyu Lu. Alpha-Terpineol production from an engineered Saccharomyces cerevisiae cell factory. Microbial cell factories. 2019 Sep; 18(1):160. doi: 10.1186/s12934-019-1211-0. [PMID: 31547812]
  • Tsuyoshi Goto. A review of the studies on food-derived factors which regulate energy metabolism via the modulation of lipid-sensing nuclear receptors. Bioscience, biotechnology, and biochemistry. 2019 Apr; 83(4):579-588. doi: 10.1080/09168451.2018.1559025. [PMID: 30572788]
  • Satish R Malwal, Lu Chen, Hunter Hicks, Fiona Qu, Weidong Liu, Alli Shillo, Wen Xuan Law, Jianan Zhang, Neal Chandnani, Xu Han, Yingying Zheng, Chun-Chi Chen, Rey-Ting Guo, Ahmed AbdelKhalek, Mohamed N Seleem, Eric Oldfield. Discovery of Lipophilic Bisphosphonates That Target Bacterial Cell Wall and Quinone Biosynthesis. Journal of medicinal chemistry. 2019 03; 62(5):2564-2581. doi: 10.1021/acs.jmedchem.8b01878. [PMID: 30730737]
  • Qibin Yu, Ming Huang, Hongge Jia, Yuan Yu, Anne Plotto, Elizabeth A Baldwin, Jinhe Bai, Nian Wang, Frederick G Gmitter. Deficiency of valencene in mandarin hybrids is associated with a deletion in the promoter region of the valencene synthase gene. BMC plant biology. 2019 Mar; 19(1):101. doi: 10.1186/s12870-019-1701-6. [PMID: 30866831]
  • Şükrü Tüzmen, Galen Hostetter, Aprill Watanabe, Cumhur Ekmekçi, Patricia E Carrigan, Ishaiahu Shechter, Olli Kallioniemi, Laurence J Miller, Spyro Mousses. Characterization of farnesyl diphosphate farnesyl transferase 1 (FDFT1) expression in cancer. Personalized medicine. 2019 01; 16(1):51-65. doi: 10.2217/pme-2016-0058. [PMID: 30468409]
  • Yashpal S Chhonker, Staci L Haney, Veenu Bala, Sarah A Holstein, Daryl J Murry. Simultaneous Quantitation of Isoprenoid Pyrophosphates in Plasma and Cancer Cells Using LC-MS/MS. Molecules (Basel, Switzerland). 2018 Dec; 23(12):. doi: 10.3390/molecules23123275. [PMID: 30544938]
  • Sholeem Griffin, Gareth D Healey, I Martin Sheldon. Isoprenoids increase bovine endometrial stromal cell tolerance to the cholesterol-dependent cytolysin from Trueperella pyogenes. Biology of reproduction. 2018 10; 99(4):749-760. doi: 10.1093/biolre/ioy099. [PMID: 29688258]
  • Jason Lancaster, Ashot Khrimian, Sharon Young, Bryan Lehner, Katrin Luck, Anna Wallingford, Saikat Kumar B Ghosh, Philipp Zerbe, Andrew Muchlinski, Paul E Marek, Michael E Sparks, James G Tokuhisa, Claus Tittiger, Tobias G Köllner, Donald C Weber, Dawn E Gundersen-Rindal, Thomas P Kuhar, Dorothea Tholl. De novo formation of an aggregation pheromone precursor by an isoprenyl diphosphate synthase-related terpene synthase in the harlequin bug. Proceedings of the National Academy of Sciences of the United States of America. 2018 09; 115(37):E8634-E8641. doi: 10.1073/pnas.1800008115. [PMID: 30139915]
  • Xi Zhang, Tianyang Guo, Tong Xiang, Yiyang Dong, Jichuan Zhang, Liqun Zhang. Quantitation of isoprenoids for natural rubber biosynthesis in natural rubber latex by liquid chromatography with tandem mass spectrometry. Journal of chromatography. A. 2018 Jul; 1558(?):115-119. doi: 10.1016/j.chroma.2018.05.006. [PMID: 29773339]
  • Amanda L Zaleski, Beth A Taylor, Paul D Thompson. Coenzyme Q10 as Treatment for Statin-Associated Muscle Symptoms-A Good Idea, but…. Advances in nutrition (Bethesda, Md.). 2018 07; 9(4):519S-523S. doi: 10.1093/advances/nmy010. [PMID: 30032220]
  • Zhaojun Shen, Saisai Li, Bo Sheng, Qi Shen, Lu-Zhe Sun, Haiyan Zhu, Xueqiong Zhu. The role of atorvastatin in suppressing tumor growth of uterine fibroids. Journal of translational medicine. 2018 03; 16(1):53. doi: 10.1186/s12967-018-1430-x. [PMID: 29523174]
  • Sheila McCormick. Unilateral incompatibility is linked to reduced pollen expression of a farnesyl pyrophosphate synthase. The Plant journal : for cell and molecular biology. 2018 02; 93(3):415-416. doi: 10.1111/tpj.13814. [PMID: 29352523]
  • Wenhua Tan, Stefan Bartram, Wilhelm Boland. Mechanistic studies of sesquiterpene cyclases based on their carbon isotope ratios at natural abundance. Plant, cell & environment. 2018 Jan; 41(1):39-49. doi: 10.1111/pce.12901. [PMID: 28045196]
  • Jun-Ichiro Hattan, Kazutoshi Shindo, Tetsuya Sasaki, Norihiko Misawa. Isolation and Functional Characterization of New Terpene Synthase Genes from Traditional Edible Plants. Journal of oleo science. 2018; 67(10):1235-1246. doi: 10.5650/jos.ess18163. [PMID: 30305556]
  • Pavel Mikulecky, Elena Andreeva, Patricia Amara, Winfried Weissenhorn, Yvain Nicolet, Pauline Macheboeuf. Human viperin catalyzes the modification of GPP and FPP potentially affecting cholesterol synthesis. FEBS letters. 2018 01; 592(2):199-208. doi: 10.1002/1873-3468.12941. [PMID: 29251770]
  • Lixia Yang, Liangzhen Jiang, Wei Li, Yun Yang, Guolin Zhang, Yinggang Luo. A homomeric geranyl diphosphate synthase-encoding gene from Camptotheca acuminata and its combinatorial optimization for production of geraniol in Escherichia coli. Journal of industrial microbiology & biotechnology. 2017 Oct; 44(10):1431-1441. doi: 10.1007/s10295-017-1967-3. [PMID: 28695386]
  • Miho Takemura, Rie Tanaka, Norihiko Misawa. Pathway engineering for the production of β-amyrin and cycloartenol in Escherichia coli-a method to biosynthesize plant-derived triterpene skeletons in E. coli. Applied microbiology and biotechnology. 2017 Sep; 101(17):6615-6625. doi: 10.1007/s00253-017-8409-z. [PMID: 28710558]
  • Hiroyuki Kajiura, Nobuaki Suzuki, Yuji Tokumoto, Takuya Yoshizawa, Shinya Takeno, Kazuhito Fujiyama, Yoshinobu Kaneko, Hiroyoshi Matsumura, Yoshihisa Nakazawa. Two Eucommia farnesyl diphosphate synthases exhibit distinct enzymatic properties leading to end product preferences. Biochimie. 2017 Aug; 139(?):95-106. doi: 10.1016/j.biochi.2017.05.001. [PMID: 28478108]
  • Yating Hu, Yongjin J Zhou, Jichen Bao, Luqi Huang, Jens Nielsen, Anastasia Krivoruchko. Metabolic engineering of Saccharomyces cerevisiae for production of germacrene A, a precursor of beta-elemene. Journal of industrial microbiology & biotechnology. 2017 07; 44(7):1065-1072. doi: 10.1007/s10295-017-1934-z. [PMID: 28547322]
  • Hiroshi Sugimoto, Mie Iguchi, Fumihiro Jinno. Bioanalysis of farnesyl pyrophosphate in human plasma by high-performance liquid chromatography coupled to triple quadrupole tandem mass spectrometry and hybrid quadrupole Orbitrap high-resolution mass spectrometry. Analytical and bioanalytical chemistry. 2017 May; 409(14):3551-3560. doi: 10.1007/s00216-017-0293-y. [PMID: 28343347]
  • Vít Kosek, Milena Stránská, Marie Fenclová, Tomáš Ruml, Libor Vítek, Jana Hajšlová. High resolution mass spectrometry based method applicable for a wide range of 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase inhibitors in blood serum including intermediates and products of the cholesterol biosynthetic pathway. Journal of chromatography. A. 2017 Mar; 1489(?):86-94. doi: 10.1016/j.chroma.2017.01.084. [PMID: 28209347]
  • Jieying Qian, Yong Liu, Naixia Chao, Chengtong Ma, Qicong Chen, Jian Sun, Yaosheng Wu. Positive selection and functional divergence of farnesyl pyrophosphate synthase genes in plants. BMC molecular biology. 2017 02; 18(1):3. doi: 10.1186/s12867-017-0081-4. [PMID: 28160774]
  • Bingyin Peng, Manuel R Plan, Panagiotis Chrysanthopoulos, Mark P Hodson, Lars K Nielsen, Claudia E Vickers. A squalene synthase protein degradation method for improved sesquiterpene production in Saccharomyces cerevisiae. Metabolic engineering. 2017 01; 39(?):209-219. doi: 10.1016/j.ymben.2016.12.003. [PMID: 27939849]
  • Zhenqiu Li, Ruiping Gao, Qinggang Hao, Huifang Zhao, Longbin Cheng, Fang He, Li Liu, Xiuhua Liu, Wayne K W Chou, Huajie Zhu, David E Cane. The T296V Mutant of Amorpha-4,11-diene Synthase Is Defective in Allylic Diphosphate Isomerization but Retains the Ability To Cyclize the Intermediate (3R)-Nerolidyl Diphosphate to Amorpha-4,11-diene. Biochemistry. 2016 Dec; 55(48):6599-6604. doi: 10.1021/acs.biochem.6b01004. [PMID: 27933789]
  • Irena Pastar, Olivera Stojadinovic, Andrew P Sawaya, Rivka C Stone, Linsey E Lindley, Nkemcho Ojeh, Sasa Vukelic, Herbert H Samuels, Marjana Tomic-Canic. Skin Metabolite, Farnesyl Pyrophosphate, Regulates Epidermal Response to Inflammation, Oxidative Stress, and Migration. Journal of cellular physiology. 2016 11; 231(11):2452-63. doi: 10.1002/jcp.25357. [PMID: 26916741]
  • Umberto Salvagnin, Silvia Carlin, Sergio Angeli, Urska Vrhovsek, Gianfranco Anfora, Mickael Malnoy, Stefan Martens. Homologous and heterologous expression of grapevine E-(β)-caryophyllene synthase (VvGwECar2). Phytochemistry. 2016 Nov; 131(?):76-83. doi: 10.1016/j.phytochem.2016.08.002. [PMID: 27561253]
  • Jun-Bo Gou, Zhen-Qiu Li, Chang-Fu Li, Fang-Fang Chen, Shi-You Lv, Yan-Sheng Zhang. Molecular cloning and functional analysis of a 10-epi-junenol synthase from Inula hupehensis. Plant physiology and biochemistry : PPB. 2016 Sep; 106(?):288-94. doi: 10.1016/j.plaphy.2016.05.023. [PMID: 27231873]
  • Kenya Terabe, Nobunori Takahashi, Toki Takemoto, Warren Knudson, Naoki Ishiguro, Toshihisa Kojima. Simvastatin inhibits CD44 fragmentation in chondrocytes. Archives of biochemistry and biophysics. 2016 08; 604(?):1-10. doi: 10.1016/j.abb.2016.05.019. [PMID: 27242325]
  • Kayla J Temple, Elia N Wright, Carol A Fierke, Richard A Gibbs. Exploration of GGTase-I substrate requirements. Part 2: Synthesis and biochemical analysis of novel saturated geranylgeranyl diphosphate analogs. Bioorganic & medicinal chemistry letters. 2016 08; 26(15):3503-7. doi: 10.1016/j.bmcl.2016.06.035. [PMID: 27342751]
  • Paskorn Muangphrom, Hikaru Seki, Munenori Suzuki, Aya Komori, Mika Nishiwaki, Ryota Mikawa, Ery Odette Fukushima, Toshiya Muranaka. Functional Analysis of Amorpha-4,11-Diene Synthase (ADS) Homologs from Non-Artemisinin-Producing Artemisia Species: The Discovery of Novel Koidzumiol and (+)-α-Bisabolol Synthases. Plant & cell physiology. 2016 Aug; 57(8):1678-88. doi: 10.1093/pcp/pcw094. [PMID: 27273626]
  • Immo Burkhardt, Thomas Siemon, Matthias Henrot, Lena Studt, Sarah Rösler, Bettina Tudzynski, Mathias Christmann, Jeroen S Dickschat. Mechanistic Characterisation of Two Sesquiterpene Cyclases from the Plant Pathogenic Fungus Fusarium fujikuroi. Angewandte Chemie (International ed. in English). 2016 07; 55(30):8748-51. doi: 10.1002/anie.201603782. [PMID: 27294564]
  • Vincent Ricigliano, Santosh Kumar, Scott Kinison, Christopher Brooks, S Eric Nybo, Joe Chappell, Dianella G Howarth. Regulation of sesquiterpenoid metabolism in recombinant and elicited Valeriana officinalis hairy roots. Phytochemistry. 2016 May; 125(?):43-53. doi: 10.1016/j.phytochem.2016.02.011. [PMID: 26920719]
  • Ramesha H Jayaramaiah, Atul Anand, Supriya D Beedkar, Bhushan B Dholakia, Sachin A Punekar, Raviraj M Kalunke, Wasudeo N Gade, Hirekodathakallu V Thulasiram, Ashok P Giri. Functional characterization and transient expression manipulation of a new sesquiterpene synthase involved in β-caryophyllene accumulation in Ocimum. Biochemical and biophysical research communications. 2016 Apr; 473(1):265-271. doi: 10.1016/j.bbrc.2016.03.090. [PMID: 27005818]
  • Xiang Chen, Yuwei Wang, Jia Sun, Jin Wang, Hang Xun, Feng Tang. Cloning, expression and functional characterization of two sesquiterpene synthase genes from moso bamboo (Phyllostachys edulis). Protein expression and purification. 2016 Apr; 120(?):1-6. doi: 10.1016/j.pep.2015.11.019. [PMID: 26626450]
  • Asmita Pant, Thomas A Kocarek. Role of Phosphatidic Acid Phosphatase Domain Containing 2 in Squalestatin 1-Mediated Activation of the Constitutive Androstane Receptor in Primary Cultured Rat Hepatocytes. Drug metabolism and disposition: the biological fate of chemicals. 2016 Mar; 44(3):352-5. doi: 10.1124/dmd.115.068437. [PMID: 26700959]
  • Benjamin C Jennings, Amy M Danowitz, Yen-Chih Wang, Richard A Gibbs, Mark D Distefano, Carol A Fierke. Analogs of farnesyl diphosphate alter CaaX substrate specificity and reactions rates of protein farnesyltransferase. Bioorganic & medicinal chemistry letters. 2016 Feb; 26(4):1333-6. doi: 10.1016/j.bmcl.2015.12.079. [PMID: 26803203]
  • Mathias Woschek, Niels Kneip, Katrin Jurida, Ingo Marzi, Borna Relja. Simvastatin Reduces Cancerogenic Potential of Renal Cancer Cells via Geranylgeranyl Pyrophosphate and Mevalonate Pathway. Nutrition and cancer. 2016; 68(3):420-7. doi: 10.1080/01635581.2016.1152383. [PMID: 27042994]
  • Laura K Henry, Michael Gutensohn, Suzanne T Thomas, Joseph P Noel, Natalia Dudareva. Orthologs of the archaeal isopentenyl phosphate kinase regulate terpenoid production in plants. Proceedings of the National Academy of Sciences of the United States of America. 2015 Aug; 112(32):10050-5. doi: 10.1073/pnas.1504798112. [PMID: 26216978]
  • Annett Richter, Irmgard Seidl-Adams, Tobias G Köllner, Claudia Schaff, James H Tumlinson, Jörg Degenhardt. A small, differentially regulated family of farnesyl diphosphate synthases in maize (Zea mays) provides farnesyl diphosphate for the biosynthesis of herbivore-induced sesquiterpenes. Planta. 2015 Jun; 241(6):1351-61. doi: 10.1007/s00425-015-2254-z. [PMID: 25680349]
  • Prabhakar Lal Srivastava, Pankaj P Daramwar, Ramakrishnan Krithika, Avinash Pandreka, S Shiva Shankar, Hirekodathakallu V Thulasiram. Functional Characterization of Novel Sesquiterpene Synthases from Indian Sandalwood, Santalum album. Scientific reports. 2015 May; 5(?):10095. doi: 10.1038/srep10095. [PMID: 25976282]
  • Avinash Bhadani, Jayant Rane, Cristina Veresmortean, Sanjoy Banerjee, George John. Bio-inspired surfactants capable of generating plant volatiles. Soft matter. 2015 Apr; 11(15):3076-82. doi: 10.1039/c5sm00157a. [PMID: 25739905]
  • S Hartwig, T Frister, S Alemdar, Z Li, T Scheper, S Beutel. SUMO-fusion, purification, and characterization of a (+)-zizaene synthase from Chrysopogon zizanioides. Biochemical and biophysical research communications. 2015 Mar; 458(4):883-9. doi: 10.1016/j.bbrc.2015.02.053. [PMID: 25701786]
  • Nathalie Gatto, Abith Vattekkatte, Tobias Köllner, Jörg Degenhardt, Jonathan Gershenzon, Wilhelm Boland. Isotope sensitive branching and kinetic isotope effects to analyse multiproduct terpenoid synthases from Zea mays. Chemical communications (Cambridge, England). 2015 Mar; 51(18):3797-800. doi: 10.1039/c4cc10395e. [PMID: 25658388]
  • Katarina Cankar, Esmer Jongedijk, Martin Klompmaker, Timotej Majdic, Roland Mumm, Harro Bouwmeester, Dirk Bosch, Jules Beekwilder. (+)-Valencene production in Nicotiana benthamiana is increased by down-regulation of competing pathways. Biotechnology journal. 2015 Jan; 10(1):180-9. doi: 10.1002/biot.201400288. [PMID: 25159317]
  • Jonas Frohwitter, Sabine A E Heider, Petra Peters-Wendisch, Jules Beekwilder, Volker F Wendisch. Production of the sesquiterpene (+)-valencene by metabolically engineered Corynebacterium glutamicum. Journal of biotechnology. 2014 Dec; 191(?):205-13. doi: 10.1016/j.jbiotec.2014.05.032. [PMID: 24910970]
  • Veronica Gonzalez, Sabrina Touchet, Daniel J Grundy, Juan A Faraldos, Rudolf K Allemann. Evolutionary and mechanistic insights from the reconstruction of α-humulene synthases from a modern (+)-germacrene A synthase. Journal of the American Chemical Society. 2014 Oct; 136(41):14505-12. doi: 10.1021/ja5066366. [PMID: 25230152]
  • Y Yamamura, Y Mizuguchi, F Taura, F Kurosaki. Transcriptional activation of a geranylgeranyl diphosphate synthase gene, GGPPS2, isolated from Scoparia dulcis by treatment with methyl jasmonate and yeast extract. Journal of natural medicines. 2014 Oct; 68(4):748-53. doi: 10.1007/s11418-014-0855-7. [PMID: 25027024]
  • Yuechong Yue, Rangcai Yu, Yanping Fan. Characterization of two monoterpene synthases involved in floral scent formation in Hedychium coronarium. Planta. 2014 Oct; 240(4):745-62. doi: 10.1007/s00425-014-2127-x. [PMID: 25056927]
  • S Zafar, D E Coates, M P Cullinan, B K Drummond, T Milne, G J Seymour. Zoledronic acid and geranylgeraniol regulate cellular behaviour and angiogenic gene expression in human gingival fibroblasts. Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology. 2014 Oct; 43(9):711-21. doi: 10.1111/jop.12181. [PMID: 24762323]
  • Yun Ye, Runfa Wang, Liang Jin, Junhao Shen, Xiaotong Li, Ting Yang, Mengzhuo Zhou, Zhifan Yang, Yongqin Chen. Molecular cloning and differential expression analysis of a squalene synthase gene from Dioscorea zingiberensis, an important pharmaceutical plant. Molecular biology reports. 2014 Sep; 41(9):6097-104. doi: 10.1007/s11033-014-3487-9. [PMID: 24996285]
  • W Gibson Wood, Ling Li, Walter E Müller, Gunter P Eckert. Cholesterol as a causative factor in Alzheimer's disease: a debatable hypothesis. Journal of neurochemistry. 2014 May; 129(4):559-72. doi: 10.1111/jnc.12637. [PMID: 24329875]
  • Xinzheng Huang, Yutao Xiao, Tobias G Köllner, Wanna Zhang, Junxiang Wu, Juan Wu, Yuyuan Guo, Yongjun Zhang. Identification and characterization of (E)-β-caryophyllene synthase and α/β-pinene synthase potentially involved in constitutive and herbivore-induced terpene formation in cotton. Plant physiology and biochemistry : PPB. 2013 Dec; 73(?):302-8. doi: 10.1016/j.plaphy.2013.10.017. [PMID: 24184450]
  • Hanh T M Nguyen, Anjanasree K Neelakadan, Truyen N Quach, Babu Valliyodan, Rajesh Kumar, Zhanyuan Zhang, Henry T Nguyen. Molecular characterization of Glycine max squalene synthase genes in seed phytosterol biosynthesis. Plant physiology and biochemistry : PPB. 2013 Dec; 73(?):23-32. doi: 10.1016/j.plaphy.2013.07.018. [PMID: 24036394]
  • Chang-Qing Yang, Xiu-Ming Wu, Ju-Xin Ruan, Wen-Li Hu, Yin-Bo Mao, Xiao-Ya Chen, Ling-Jian Wang. Isolation and characterization of terpene synthases in cotton (Gossypium hirsutum). Phytochemistry. 2013 Dec; 96(?):46-56. doi: 10.1016/j.phytochem.2013.09.009. [PMID: 24074555]
  • K M Burgazli, K L Bui, M Mericliler, A T Albayrak, M Parahuleva, A Erdogan. The effects of different types of statins on proliferation and migration of HGF-induced Human Umbilical Vein Endothelial Cells (HUVECs). European review for medical and pharmacological sciences. 2013 Nov; 17(21):2874-83. doi: . [PMID: 24254555]
  • Bianca May, B Markus Lange, Matthias Wüst. Biosynthesis of sesquiterpenes in grape berry exocarp of Vitis vinifera L.: evidence for a transport of farnesyl diphosphate precursors from plastids to the cytosol. Phytochemistry. 2013 Nov; 95(?):135-44. doi: 10.1016/j.phytochem.2013.07.021. [PMID: 23954075]
  • Jian-bin Lan, Rang-cai Yu, Yun-yi Yu, Yan-ping Fan. Molecular cloning and expression of Hedychium coronarium farnesyl pyrophosphate synthase gene and its possible involvement in the biosynthesis of floral and wounding/herbivory induced leaf volatile sesquiterpenoids. Gene. 2013 Apr; 518(2):360-7. doi: 10.1016/j.gene.2013.01.007. [PMID: 23333605]
  • Joshua D Ochocki, Mark D Distefano. Prenyltransferase Inhibitors: Treating Human Ailments from Cancer to Parasitic Infections. MedChemComm. 2013 Mar; 4(3):476-492. doi: 10.1039/c2md20299a. [PMID: 25530833]
  • Hongzhen Wang, Junli Han, Selvaraju Kanagarajan, Anneli Lundgren, Peter E Brodelius. Studies on the expression of sesquiterpene synthases using promoter-β-glucuronidase fusions in transgenic Artemisia annua L. PloS one. 2013; 8(11):e80643. doi: 10.1371/journal.pone.0080643. [PMID: 24278301]
  • Juan A Faraldos, Veronica Gonzalez, Amang Li, Fanglei Yu, Mustafa Köksal, David W Christianson, Rudolf K Allemann. Probing the mechanism of 1,4-conjugate elimination reactions catalyzed by terpene synthases. Journal of the American Chemical Society. 2012 Dec; 134(51):20844-8. doi: 10.1021/ja311022s. [PMID: 23214943]
  • Petra M Bleeker, Rossana Mirabella, Paul J Diergaarde, Arjen VanDoorn, Alain Tissier, Merijn R Kant, Marcel Prins, Martin de Vos, Michel A Haring, Robert C Schuurink. Improved herbivore resistance in cultivated tomato with the sesquiterpene biosynthetic pathway from a wild relative. Proceedings of the National Academy of Sciences of the United States of America. 2012 Dec; 109(49):20124-9. doi: 10.1073/pnas.1208756109. [PMID: 23169639]
  • Kuo-Hsun Teng, Po-Huang Liang. Undecaprenyl diphosphate synthase, a cis-prenyltransferase synthesizing lipid carrier for bacterial cell wall biosynthesis. Molecular membrane biology. 2012 Nov; 29(7):267-73. doi: 10.3109/09687688.2012.674162. [PMID: 22471620]
  • Kota Kera, Seiji Takahashi, Tsuyoshi Sutoh, Tanetoshi Koyama, Toru Nakayama. Identification and characterization of a cis,trans-mixed heptaprenyl diphosphate synthase from Arabidopsis thaliana. The FEBS journal. 2012 Oct; 279(20):3813-27. doi: 10.1111/j.1742-4658.2012.08742.x. [PMID: 22883514]
  • Gero P Hooff, W Gibson Wood, Ji-Hyun Kim, Urule Igbavboa, Wei-Yi Ong, Walter E Muller, Gunter P Eckert. Brain isoprenoids farnesyl pyrophosphate and geranylgeranyl pyrophosphate are increased in aged mice. Molecular neurobiology. 2012 Aug; 46(1):179-85. doi: 10.1007/s12035-012-8285-6. [PMID: 22692983]
  • Rama Raju Baadhe, Naveen Kumar Mekala, Satwik Reddy Palagiri, Sreenivasa Rao Parcha. Development of petri net-based dynamic model for improved production of farnesyl pyrophosphate by integrating mevalonate and methylerythritol phosphate pathways in yeast. Applied biochemistry and biotechnology. 2012 Jul; 167(5):1172-82. doi: 10.1007/s12010-012-9583-1. [PMID: 22350871]
  • Raimund Nagel, Jonathan Gershenzon, Axel Schmidt. Nonradioactive assay for detecting isoprenyl diphosphate synthase activity in crude plant extracts using liquid chromatography coupled with tandem mass spectrometry. Analytical biochemistry. 2012 Mar; 422(1):33-8. doi: 10.1016/j.ab.2011.12.037. [PMID: 22266300]
  • Sol A Green, Xiuyin Chen, Niels J Nieuwenhuizen, Adam J Matich, Mindy Y Wang, Barry J Bunn, Yar-Khing Yauk, Ross G Atkinson. Identification, functional characterization, and regulation of the enzyme responsible for floral (E)-nerolidol biosynthesis in kiwifruit (Actinidia chinensis). Journal of experimental botany. 2012 Mar; 63(5):1951-67. doi: 10.1093/jxb/err393. [PMID: 22162874]
  • Franziska Exnowitz, Bernd Meyer, Thomas Hackl. NMR for direct determination of K(m) and V(max) of enzyme reactions based on the Lambert W function-analysis of progress curves. Biochimica et biophysica acta. 2012 Mar; 1824(3):443-9. doi: 10.1016/j.bbapap.2011.10.011. [PMID: 22079737]
  • Katrina Cornish, Wenshuang Xie. Natural rubber biosynthesis in plants: rubber transferase. Methods in enzymology. 2012; 515(?):63-82. doi: 10.1016/b978-0-12-394290-6.00004-5. [PMID: 22999170]
  • Verónica Keim, David Manzano, Francisco J Fernández, Marta Closa, Paola Andrade, Daniel Caudepón, Cristina Bortolotti, M Cristina Vega, Montserrat Arró, Albert Ferrer. Characterization of Arabidopsis FPS isozymes and FPS gene expression analysis provide insight into the biosynthesis of isoprenoid precursors in seeds. PloS one. 2012; 7(11):e49109. doi: 10.1371/journal.pone.0049109. [PMID: 23145086]
  • Axel Schmidt, Raimund Nagel, Trygve Krekling, Erik Christiansen, Jonathan Gershenzon, Paal Krokene. Induction of isoprenyl diphosphate synthases, plant hormones and defense signalling genes correlates with traumatic resin duct formation in Norway spruce (Picea abies). Plant molecular biology. 2011 Dec; 77(6):577-90. doi: 10.1007/s11103-011-9832-7. [PMID: 22002747]
  • Marc Clastre, Nicolas Papon, Vincent Courdavault, Nathalie Giglioli-Guivarc'h, Benoit St-Pierre, Andrew J Simkin. Subcellular evidence for the involvement of peroxisomes in plant isoprenoid biosynthesis. Plant signaling & behavior. 2011 Dec; 6(12):2044-6. doi: 10.4161/psb.6.12.18173. [PMID: 22080790]
  • Brian M Wasko, Jacqueline P Smits, Larry W Shull, David F Wiemer, Raymond J Hohl. A novel bisphosphonate inhibitor of squalene synthase combined with a statin or a nitrogenous bisphosphonate in vitro. Journal of lipid research. 2011 Nov; 52(11):1957-64. doi: 10.1194/jlr.m016089. [PMID: 21903868]
  • Sarah A Holstein, Craig H Kuder, Huaxiang Tong, Raymond J Hohl. Pleiotropic effects of a schweinfurthin on isoprenoid homeostasis. Lipids. 2011 Oct; 46(10):907-21. doi: 10.1007/s11745-011-3572-y. [PMID: 21633866]
  • Tsuyoshi Goto, Hiroyuki Nagai, Kahori Egawa, Young-Il Kim, Sota Kato, Aki Taimatsu, Tomoya Sakamoto, Shogo Ebisu, Takahiro Hohsaka, Hiroh Miyagawa, Shigeru Murakami, Nobuyuki Takahashi, Teruo Kawada. Farnesyl pyrophosphate regulates adipocyte functions as an endogenous PPARγ agonist. The Biochemical journal. 2011 Aug; 438(1):111-9. doi: 10.1042/bj20101939. [PMID: 21605082]
  • Sangsu Bang, Sungjae Yoo, Tae-Jin Yang, Hawon Cho, Sun Wook Hwang. Isopentenyl pyrophosphate is a novel antinociceptive substance that inhibits TRPV3 and TRPA1 ion channels. Pain. 2011 May; 152(5):1156-1164. doi: 10.1016/j.pain.2011.01.044. [PMID: 21353389]
  • Sung Ha Lee, Siham Raboune, J Michael Walker, Heather B Bradshaw. Distribution of endogenous farnesyl pyrophosphate and four species of lysophosphatidic acid in rodent brain. International journal of molecular sciences. 2010 Oct; 11(10):3965-76. doi: 10.3390/ijms11103965. [PMID: 21152313]
  • Gero P Hooff, Nina Patel, W Gibson Wood, Walter E Müller, Gunter P Eckert, Dietrich A Volmer. A rapid and sensitive assay for determining human brain levels of farnesyl-(FPP) and geranylgeranylpyrophosphate (GGPP) and transferase activities using UHPLC-MS/MS. Analytical and bioanalytical chemistry. 2010 Oct; 398(4):1801-8. doi: 10.1007/s00216-010-4088-7. [PMID: 20730526]
  • Mohammad A Asadollahi, Jérôme Maury, Michel Schalk, Anthony Clark, Jens Nielsen. Enhancement of farnesyl diphosphate pool as direct precursor of sesquiterpenes through metabolic engineering of the mevalonate pathway in Saccharomyces cerevisiae. Biotechnology and bioengineering. 2010 May; 106(1):86-96. doi: 10.1002/bit.22668. [PMID: 20091767]
  • Sumitra Miriyala, Thangaiah Subramanian, Manikandan Panchatcharam, Hongmei Ren, Mark I McDermott, Manjula Sunkara, Tracy Drennan, Susan S Smyth, H Peter Spielmann, Andrew J Morris. Functional characterization of the atypical integral membrane lipid phosphatase PDP1/PPAPDC2 identifies a pathway for interconversion of isoprenols and isoprenoid phosphates in mammalian cells. The Journal of biological chemistry. 2010 Apr; 285(18):13918-29. doi: 10.1074/jbc.m109.083931. [PMID: 20110354]
  • Nicholas Schramek, Huahong Wang, Werner Römisch-Margl, Birgit Keil, Tanja Radykewicz, Bernhard Winzenhörlein, Ludger Beerhues, Adelbert Bacher, Felix Rohdich, Jonathan Gershenzon, Benye Liu, Wolfgang Eisenreich. Artemisinin biosynthesis in growing plants of Artemisia annua. A 13CO2 study. Phytochemistry. 2010 Feb; 71(2-3):179-87. doi: 10.1016/j.phytochem.2009.10.015. [PMID: 19932496]
  • Axel Schmidt, Betty Wächtler, Ulrike Temp, Trygve Krekling, Armand Séguin, Jonathan Gershenzon. A bifunctional geranyl and geranylgeranyl diphosphate synthase is involved in terpene oleoresin formation in Picea abies. Plant physiology. 2010 Feb; 152(2):639-55. doi: 10.1104/pp.109.144691. [PMID: 19939949]