Cyclopentolate (BioDeep_00000006381)
Secondary id: BioDeep_00001868032
human metabolite blood metabolite Chemicals and Drugs
代谢物信息卡片
化学式: C17H25NO3 (291.1834)
中文名称: 环戊醇, 环戊酸酯
谱图信息:
最多检出来源 Homo sapiens(blood) 16.36%
分子结构信息
SMILES: CN(C)CCOC(=O)C(C1=CC=CC=C1)C1(O)CCCC1
InChI: InChI=1S/C17H25NO3/c1-18(2)12-13-21-16(19)15(14-8-4-3-5-9-14)17(20)10-6-7-11-17/h3-5,8-9,15,20H,6-7,10-13H2,1-2H3
描述信息
Cyclopentolate is only found in individuals that have used or taken this drug. It is a parasympatholytic anticholinergic used solely to obtain mydriasis or cycloplegia. [PubChem]By blocking muscarinic receptors, cyclopentolate produces dilatation of the pupil (mydriasis) and prevents the eye from accommodating for near vision (cycloplegia).
S - Sensory organs > S01 - Ophthalmologicals > S01F - Mydriatics and cycloplegics > S01FA - Anticholinergics
C78272 - Agent Affecting Nervous System > C66880 - Anticholinergic Agent > C29704 - Antimuscarinic Agent
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D010276 - Parasympatholytics
D018377 - Neurotransmitter Agents > D018678 - Cholinergic Agents > D018680 - Cholinergic Antagonists
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D009184 - Mydriatics
C78283 - Agent Affecting Organs of Special Senses > C29706 - Mydriatic Agent
同义名列表
52 个代谢物同义名
2-Phenyl-2-(1-hydroxycyclopentyl)ethanoic acid beta-(dimethylamino)ethyl ester; alpha-(1-Hydroxycyclopentyl)benzeneacetic acid 2-(dimethylamino)ethyl ester; 2-Phenyl-2-(1-hydroxycyclopentyl)ethanoic acid β-(dimethylamino)ethyl ester; 2-Phenyl-2-(1-hydroxycyclopentyl)ethanoic acid b-(dimethylamino)ethyl ester; 2-Phenyl-2-(1-hydroxycyclopentyl)ethanoate beta-(dimethylamino)ethyl ester; 1-Hydroxy-alpha-phenylcyclopentaneacetic acid 2-(dimethylamino)ethyl ester; alpha-(1-Hydroxycyclopentyl)benzeneacetate 2-(dimethylamino)ethyl ester; 2-Phenyl-2-(1-hydroxycyclopentyl)ethanoate β-(dimethylamino)ethyl ester; 2-Phenyl-2-(1-hydroxycyclopentyl)ethanoate b-(dimethylamino)ethyl ester; Α-(1-hydroxycyclopentyl)benzeneacetic acid 2-(dimethylamino)ethyl ester; a-(1-Hydroxycyclopentyl)benzeneacetic acid 2-(dimethylamino)ethyl ester; 1-Hydroxy-α-phenylcyclopentaneacetic acid 2-(dimethylamino)ethyl ester; 1-Hydroxy-a-phenylcyclopentaneacetic acid 2-(dimethylamino)ethyl ester; 1-Hydroxy-alpha-phenylcyclopentaneacetate 2-(dimethylamino)ethyl ester; 2-(Dimethylamino)ethyl 1-hydroxy-alpha-phenylcyclopentaneacetic acid; Α-(1-hydroxycyclopentyl)benzeneacetate 2-(dimethylamino)ethyl ester; 2-(Dimethylamino)ethyl 2-(1-hydroxycyclopentyl)-2-phenylacetic acid; a-(1-Hydroxycyclopentyl)benzeneacetate 2-(dimethylamino)ethyl ester; 1-Hydroxy-a-phenylcyclopentaneacetate 2-(dimethylamino)ethyl ester; 1-Hydroxy-α-phenylcyclopentaneacetate 2-(dimethylamino)ethyl ester; beta-(Dimethylamino)ethyl (1-hydroxycyclopentyl)phenylacetic acid; 2-(Dimethylamino)ethyl 1-hydroxy-α-phenylcyclopentaneacetic acid; 2-(Dimethylamino)ethyl 1-hydroxy-alpha-phenylcyclopentaneacetate; 2-(Dimethylamino)ethyl 1-hydroxy-a-phenylcyclopentaneacetic acid; 2-(Dimethylamino)ethyl 2-(1-hydroxycyclopentyl)-2-phenylacetate; beta-Dimethylaminoethyl (1-hydroxycyclopentyl)phenylacetic acid; b-(Dimethylamino)ethyl (1-hydroxycyclopentyl)phenylacetic acid; Β-(dimethylamino)ethyl (1-hydroxycyclopentyl)phenylacetic acid; beta-(Dimethylamino)ethyl (1-hydroxycyclopentyl)phenylacetate; 2-(Dimethylamino)ethyl 1-hydroxy-α-phenylcyclopentaneacetate; 2-(Dimethylamino)ethyl 1-hydroxy-a-phenylcyclopentaneacetate; b-Dimethylaminoethyl (1-hydroxycyclopentyl)phenylacetic acid; Β-dimethylaminoethyl (1-hydroxycyclopentyl)phenylacetic acid; beta-Dimethylaminoethyl (1-hydroxycyclopentyl)phenylacetate; Β-(dimethylamino)ethyl (1-hydroxycyclopentyl)phenylacetate; b-(Dimethylamino)ethyl (1-hydroxycyclopentyl)phenylacetate; b-Dimethylaminoethyl (1-hydroxycyclopentyl)phenylacetate; Β-dimethylaminoethyl (1-hydroxycyclopentyl)phenylacetate; (+-)-Cyclopentolic acid; (+-)-Cyclopentolate; Cyclopentolic acid; Bell pentolic acid; Cyclopentolatum; Cyclopentylate; Ciclopentolato; Bell pentolate; Cyclopentoiate; cyclopentolate; Diopentolate; Cyclogyl; Cyclopentolate; Cyclopentolate
数据库引用编号
16 个数据库交叉引用编号
- ChEBI: CHEBI:4024
- KEGG: C06932
- KEGGdrug: D07759
- PubChem: 2905
- HMDB: HMDB0015114
- Metlin: METLIN3972
- DrugBank: DB00979
- ChEMBL: CHEMBL1201338
- Wikipedia: Cyclopentolate
- MeSH: Cyclopentolate
- chemspider: 2802
- CAS: 512-15-2
- PMhub: MS000019411
- PubChem: 9149
- NIKKAJI: J6.274J
- KNApSAcK: 4024
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Prashant D Tailor, Marybeth K Farazdaghi, Sanjay V Patel, Keith H Baratz. Oleander-Associated Keratitis and Uveitis.
Cornea.
2022 Oct; 41(10):1305-1307. doi:
10.1097/ico.0000000000003032. [PMID: 36107850] - Amandine Bessonnat, Maria Vanore. Effect of topical cyclopentolate alone or combined with phenylephrine in healthy horses.
Veterinary ophthalmology.
2021 Nov; 24(6):582-590. doi:
10.1111/vop.12896. [PMID: 33982406] - Yuan Yuan Hu, Jian Feng Wu, Tai Liang Lu, Hui Wu, Wei Sun, Xing Rong Wang, Hong Sheng Bi, Jost B Jonas. Effect of cycloplegia on the refractive status of children: the Shandong children eye study.
PloS one.
2015; 10(2):e0117482. doi:
10.1371/journal.pone.0117482. [PMID: 25658329] - L Hu, K Dow. Focal seizures after instillation of cyclomydril to a neonate with congenital CMV infection.
Journal of neonatal-perinatal medicine.
2014 Jan; 7(2):147-9. doi:
10.3233/npm-1476413. [PMID: 25104124] - Nicole A Rozette, Suraporn Matragoon, Shivani Sethi, Stephanie Goei, Kalen B Manasco, Azza B El-Remessy. Systemic effects of ophthalmic cyclopentolate on body weight in neonatal mice.
Neonatology.
2014; 106(1):37-41. doi:
10.1159/000358228. [PMID: 24776747] - Swakshyar Saumya Pal, Rajiv Raman, Suganeswari Ganesan, Chinmaya Sahu, Tarun Sharma. Sankara Nethralaya Diabetic Retinopathy Epidemiology and Molecular Genetic Study (SN--DREAMS III): study design and research methodology.
BMC ophthalmology.
2011 Mar; 11(?):7. doi:
10.1186/1471-2415-11-7. [PMID: 21435202] - Jasenka Guduric-Fuchs, Wing Chen, Henrietta Price, Desmond B Archer, Tiziana Cogliati. RPE and neuronal differentiation of allotransplantated porcine ciliary epithelium-derived cells.
Molecular vision.
2011; 17(?):2580-95. doi:
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Journal of medical case reports.
2009 Nov; 3(?):115. doi:
10.1186/1752-1947-3-115. [PMID: 19946593] - Patricia Herold Gallego, Maria E Craig, Stephen Hing, Kim C Donaghue. Role of blood pressure in development of early retinopathy in adolescents with type 1 diabetes: prospective cohort study.
BMJ (Clinical research ed.).
2008 Aug; 337(?):a918. doi:
10.1136/bmj.a918. [PMID: 18728082] - Kyaw Lin Tu, Stephen B Kaye, Gediminas Sidaras, William Taylor, Alan Shenkin. Effect of intraocular surgery and ketamine on aqueous and serum cytokines.
Molecular vision.
2007 Jul; 13(?):1130-7. doi:
NULL. [PMID: 17653058] - Lining Qi, Neil D Danielson. Quantitative determination of pharmaceuticals using nano-electrospray ionization mass spectrometry after reversed phase mini-solid phase extraction.
Journal of pharmaceutical and biomedical analysis.
2005 Feb; 37(2):225-30. doi:
10.1016/j.jpba.2004.09.023. [PMID: 15708661] - Alan P Demayo, Marcus M Reidenberg. Grand mal seizure in a child 30 minutes after Cyclogyl (cyclopentolate hydrochloride) and 10\% Neo-Synephrine (phenylephrine hydrochloride) eye drops were instilled.
Pediatrics.
2004 May; 113(5):e499-500. doi:
10.1542/peds.113.5.e499. [PMID: 15121994] - F C Schlichtenbrede, K U Burkhardt, M C Bartram, R Wiedemann. [Biochemical stress monitoring during cataract surgery; phenylephrine 10\% shows no changes in serum-catecholamines in comparison with phenylephrine 5\%].
Klinische Monatsblatter fur Augenheilkunde.
2001 Jul; 218(7):479-83. doi:
10.1055/s-2001-16290. [PMID: 11512247] - T Eke, S Al-Husainy, M K Raynor. The spectrum of ocular inflammation caused by euphorbia plant sap.
Archives of ophthalmology (Chicago, Ill. : 1960).
2000 Jan; 118(1):13-6. doi:
10.1001/archopht.118.1.13. [PMID: 10636407] - M Haaga, T Kaila, L Salminen, P Ylitalo. Systemic and ocular absorption and antagonist activity of topically applied cyclopentolate in man.
Pharmacology & toxicology.
1998 Jan; 82(1):19-22. doi:
10.1111/j.1600-0773.1998.tb01392.x. [PMID: 9527641] - ". A 23-year-old maintenance employee in a fertilizer manufacturing plant was exposed to a high concentration of ammonia vapor after a pipe ruptured.
Journal of occupational and environmental medicine.
1995 Oct; 37(10):1187-8. doi:
". [PMID: 8542336] - K K Lahdes, R K Huupponen, T J Kaila. Ocular effects and systemic absorption of cyclopentolate eyedrops after canthal and conventional application.
Acta ophthalmologica.
1994 Dec; 72(6):698-702. doi:
10.1111/j.1755-3768.1994.tb04683.x. [PMID: 7747578] - K Lahdes, R Huupponen, T Kaila, D Monti, M F Saettone, L Salminen. Plasma concentrations and ocular effects of cyclopentolate after ocular application of three formulations.
British journal of clinical pharmacology.
1993 May; 35(5):479-83. doi:
10.1111/j.1365-2125.1993.tb04173.x. [PMID: 8512760] - K Lahdes, R Huupponen, T Kaila, T Ali-Melkkilä, L Salminen, M Saari. Systemic absorption of ocular cyclopentolate in children.
German journal of ophthalmology.
1992; 1(1):16-8. doi:
NULL. [PMID: 1477610] - S P Kothary, W Selezinka, E K Zsigmond. [Effect of cyclopentolate on human plasma cholinesterase].
Anesthesie, analgesie, reanimation.
1977 Jan; 34(1):55-9. doi:
. [PMID: 879507]
