cyclopentolate (BioDeep_00001868032)

Main id: BioDeep_00000006381

 


代谢物信息卡片


cyclopentolate

化学式: C17H25NO3 (291.1834)
中文名称: 环戊酸酯, 环戊醇
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CN(C)CCOC(=O)C(C1=CC=CC=C1)C2(CCCC2)O
InChI: InChI=1S/C17H25NO3/c1-18(2)12-13-21-16(19)15(14-8-4-3-5-9-14)17(20)10-6-7-11-17/h3-5,8-9,15,20H,6-7,10-13H2,1-2H3

描述信息

S - Sensory organs > S01 - Ophthalmologicals > S01F - Mydriatics and cycloplegics > S01FA - Anticholinergics
C78272 - Agent Affecting Nervous System > C66880 - Anticholinergic Agent > C29704 - Antimuscarinic Agent
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D010276 - Parasympatholytics
D018377 - Neurotransmitter Agents > D018678 - Cholinergic Agents > D018680 - Cholinergic Antagonists
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D009184 - Mydriatics
C78283 - Agent Affecting Organs of Special Senses > C29706 - Mydriatic Agent

同义名列表

3 个代谢物同义名

cyclopentolate; Cyclopentolate; Cyclopentolate



数据库引用编号

11 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 7 ACE, ATN1, BDNF, CNTF, FLNA, VEGFA, ZAP70
Peripheral membrane protein 2 ACHE, ZAP70
Nucleus 6 ACHE, ATN1, FLNA, MKI67, RERE, VEGFA
cytosol 4 FLNA, NGF, SCLY, ZAP70
dendrite 2 BDNF, NGF
nuclear body 2 MKI67, RERE
trans-Golgi network 1 FLNA
nucleoplasm 3 ATN1, MKI67, RERE
Cell membrane 5 ACE, ACHE, ADRB3, KCND2, ZAP70
Cell projection, growth cone 1 FLNA
Multi-pass membrane protein 2 ADRB3, KCND2
Synapse 2 ACHE, KCND2
cell junction 2 ATN1, KCND2
cell surface 3 ACHE, ICAM1, VEGFA
dendritic shaft 1 FLNA
glutamatergic synapse 2 FLNA, KCND2
Golgi apparatus 3 ACHE, SCLY, VEGFA
Golgi membrane 1 INS
neuromuscular junction 1 ACHE
neuronal cell body 1 KCND2
postsynapse 1 FLNA
synaptic vesicle 2 BDNF, NGF
Cytoplasm, cytosol 1 SCLY
Lysosome 1 ACE
endosome 1 ACE
plasma membrane 10 ACE, ACHE, ADRB3, BCHE, EDNRA, FLNA, ICAM1, IFNLR1, KCND2, ZAP70
Membrane 8 ACE, ACHE, BDNF, FLNA, ICAM1, IFNLR1, MKI67, VEGFA
axon 3 BDNF, CNTF, NGF
brush border 1 FLNA
extracellular exosome 3 ACE, FLNA, ICAM1
endoplasmic reticulum 1 VEGFA
extracellular space 9 ACE, ACHE, BCHE, BDNF, CNTF, ICAM1, INS, NGF, VEGFA
perinuclear region of cytoplasm 4 ACHE, ATN1, BDNF, FLNA
adherens junction 1 VEGFA
Single-pass type I membrane protein 3 ACE, ICAM1, IFNLR1
Secreted 8 ACE, ACHE, BCHE, BDNF, INS, MATN3, NGF, VEGFA
extracellular region 10 ACE, ACHE, BCHE, BDNF, CNTF, FLNA, INS, MATN3, NGF, VEGFA
neuronal cell body membrane 1 KCND2
Extracellular side 1 ACHE
anchoring junction 2 ATN1, KCND2
external side of plasma membrane 2 ACE, ICAM1
Secreted, extracellular space, extracellular matrix 1 VEGFA
actin cytoskeleton 1 FLNA
dendritic spine 1 KCND2
perikaryon 2 FLNA, KCND2
Z disc 1 FLNA
nucleolus 2 FLNA, MKI67
cell-cell junction 2 FLNA, ZAP70
postsynaptic membrane 1 KCND2
Membrane raft 1 ICAM1
Cytoplasm, cytoskeleton 1 FLNA
focal adhesion 2 FLNA, ICAM1
GABA-ergic synapse 1 KCND2
extracellular matrix 2 MATN3, VEGFA
basement membrane 1 ACHE
Cell projection, dendritic spine 1 KCND2
collagen-containing extracellular matrix 2 ICAM1, MATN3
secretory granule 1 VEGFA
Postsynaptic cell membrane 1 KCND2
receptor complex 1 ADRB3
axonal growth cone 1 FLNA
Chromosome 1 MKI67
Cell projection, podosome 1 FLNA
podosome 1 FLNA
brush border membrane 1 ACE
Nucleus, nucleolus 1 MKI67
Cytoplasm, cell cortex 1 FLNA
actin filament 1 FLNA
blood microparticle 1 BCHE
sperm midpiece 1 ACE
Lipid-anchor, GPI-anchor 1 ACHE
endosome lumen 2 INS, NGF
Cell projection, dendrite 1 KCND2
side of membrane 1 ACHE
basal plasma membrane 1 ACE
voltage-gated potassium channel complex 1 KCND2
plasma membrane raft 1 KCND2
secretory granule lumen 1 INS
Golgi lumen 2 INS, NGF
endoplasmic reticulum lumen 4 BCHE, BDNF, INS, MATN3
nuclear matrix 1 ATN1
platelet alpha granule lumen 1 VEGFA
matrilin complex 1 MATN3
histone deacetylase complex 1 RERE
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
immunological synapse 2 ICAM1, ZAP70
nuclear envelope lumen 1 BCHE
extrinsic component of cytoplasmic side of plasma membrane 1 ZAP70
synaptic cleft 1 ACHE
apical dendrite 1 FLNA
postsynaptic specialization membrane 1 KCND2
intracellular non-membrane-bounded organelle 1 FLNA
T cell receptor complex 1 ZAP70
actin filament bundle 1 FLNA
cortical cytoskeleton 1 FLNA
catalytic complex 1 SCLY
glycoprotein Ib-IX-V complex 1 FLNA
Myb complex 1 FLNA
[Angiotensin-converting enzyme, soluble form]: Secreted 1 ACE
[Isoform Testis-specific]: Cell membrane 1 ACE
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
[Isoform H]: Cell membrane 1 ACHE
[Neurotrophic factor BDNF precursor form]: Secreted 1 BDNF
interleukin-28 receptor complex 1 IFNLR1
Kv4.2-KChIP2 channel complex 1 KCND2


文献列表

  • Prashant D Tailor, Marybeth K Farazdaghi, Sanjay V Patel, Keith H Baratz. Oleander-Associated Keratitis and Uveitis. Cornea. 2022 Oct; 41(10):1305-1307. doi: 10.1097/ico.0000000000003032. [PMID: 36107850]
  • Amandine Bessonnat, Maria Vanore. Effect of topical cyclopentolate alone or combined with phenylephrine in healthy horses. Veterinary ophthalmology. 2021 Nov; 24(6):582-590. doi: 10.1111/vop.12896. [PMID: 33982406]
  • Yuan Yuan Hu, Jian Feng Wu, Tai Liang Lu, Hui Wu, Wei Sun, Xing Rong Wang, Hong Sheng Bi, Jost B Jonas. Effect of cycloplegia on the refractive status of children: the Shandong children eye study. PloS one. 2015; 10(2):e0117482. doi: 10.1371/journal.pone.0117482. [PMID: 25658329]
  • L Hu, K Dow. Focal seizures after instillation of cyclomydril to a neonate with congenital CMV infection. Journal of neonatal-perinatal medicine. 2014 Jan; 7(2):147-9. doi: 10.3233/npm-1476413. [PMID: 25104124]
  • Nicole A Rozette, Suraporn Matragoon, Shivani Sethi, Stephanie Goei, Kalen B Manasco, Azza B El-Remessy. Systemic effects of ophthalmic cyclopentolate on body weight in neonatal mice. Neonatology. 2014; 106(1):37-41. doi: 10.1159/000358228. [PMID: 24776747]
  • Swakshyar Saumya Pal, Rajiv Raman, Suganeswari Ganesan, Chinmaya Sahu, Tarun Sharma. Sankara Nethralaya Diabetic Retinopathy Epidemiology and Molecular Genetic Study (SN--DREAMS III): study design and research methodology. BMC ophthalmology. 2011 Mar; 11(?):7. doi: 10.1186/1471-2415-11-7. [PMID: 21435202]
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  • Alan P Demayo, Marcus M Reidenberg. Grand mal seizure in a child 30 minutes after Cyclogyl (cyclopentolate hydrochloride) and 10\% Neo-Synephrine (phenylephrine hydrochloride) eye drops were instilled. Pediatrics. 2004 May; 113(5):e499-500. doi: 10.1542/peds.113.5.e499. [PMID: 15121994]
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  • T Eke, S Al-Husainy, M K Raynor. The spectrum of ocular inflammation caused by euphorbia plant sap. Archives of ophthalmology (Chicago, Ill. : 1960). 2000 Jan; 118(1):13-6. doi: 10.1001/archopht.118.1.13. [PMID: 10636407]
  • M Haaga, T Kaila, L Salminen, P Ylitalo. Systemic and ocular absorption and antagonist activity of topically applied cyclopentolate in man. Pharmacology & toxicology. 1998 Jan; 82(1):19-22. doi: 10.1111/j.1600-0773.1998.tb01392.x. [PMID: 9527641]
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