Carboprost Tromethamine (BioDeep_00000006362)

 

Secondary id: BioDeep_00000597717

human metabolite blood metabolite Chemicals and Drugs Volatile Flavor Compounds


代谢物信息卡片


1,3-Dihydroxy-2-(hydroxymethyl)propan-2-aminium (5Z,9alpha,11beta,13E,15S)-9,11,15-trihydroxy-15-methylprosta-5,13-dien-1-Oic acid

化学式: C21H36O5 (368.2562606)
中文名称: 卡前列素
谱图信息: 最多检出来源 Homo sapiens(blood) 5.07%

分子结构信息

SMILES: CCCCCC(C)(C=CC1C(CC(C1CC=CCCCC(=O)O)O)O)O
InChI: InChI=1S/C21H36O5/c1-3-4-9-13-21(2,26)14-12-17-16(18(22)15-19(17)23)10-7-5-6-8-11-20(24)25/h5,7,12,14,16-19,22-23,26H,3-4,6,8-11,13,15H2,1-2H3,(H,24,25)/b7-5-,14-12+/t16-,17-,18+,19+,21+/m1/s1

描述信息

Carboprost Tromethamine is only found in individuals that have used or taken this drug. It is a nonsteroidal abortifacient agent that is effective in both the first and second trimesters of pregnancy. [PubChem]Carboprost is a synthetic prostaglandin. It binds the prostaglandin E2 receptor, causing myometrial contractions, casuing the induction of labour or the expulsion of the placenta. Prostaglandins occur naturally in the body and act at several sites in the body including the womb (uterus). They act on the muscles of the womb, causing them to contract.
G - Genito urinary system and sex hormones > G02 - Other gynecologicals > G02A - Uterotonics > G02AD - Prostaglandins
D012102 - Reproductive Control Agents > D000019 - Abortifacient Agents
D012102 - Reproductive Control Agents > D010120 - Oxytocics
C78568 - Prostaglandin Analogue

同义名列表

43 个代谢物同义名

1,3-Dihydroxy-2-(hydroxymethyl)propan-2-aminium (5Z,9alpha,11beta,13E,15S)-9,11,15-trihydroxy-15-methylprosta-5,13-dien-1-Oic acid; 1,3-Dihydroxy-2-(hydroxymethyl)propan-2-aminium (5Z,9alpha,11beta,13E,15S)-9,11,15-trihydroxy-15-methylprosta-5,13-dien-1-Oate; 1,3-Dihydroxy-2-(hydroxymethyl)propan-2-aminium (5Z,9α,11β,13E,15S)-9,11,15-trihydroxy-15-methylprosta-5,13-dien-1-Oic acid; 1,3-Dihydroxy-2-(hydroxymethyl)propan-2-aminium (5Z,9a,11b,13E,15S)-9,11,15-trihydroxy-15-methylprosta-5,13-dien-1-Oic acid; 1,3-Dihydroxy-2-(hydroxymethyl)propan-2-aminium (5Z,9a,11b,13E,15S)-9,11,15-trihydroxy-15-methylprosta-5,13-dien-1-Oate; 1,3-Dihydroxy-2-(hydroxymethyl)propan-2-aminium (5Z,9α,11β,13E,15S)-9,11,15-trihydroxy-15-methylprosta-5,13-dien-1-Oate; (5Z)-7-[(1R,2R,3S,5S)-3,5-dihydroxy-2-[(1E,3S)-3-hydroxy-3-methyloct-1-en-1-yl]cyclopentyl]hept-5-enoic acid; (5Z,9alpha,11alpha,13E,15S)-9,11,15-trihydroxy-15-methylprosta-5,13-dien-1-oic acid; 15(S)-15-Methylprostaglandin F2alpha tromethamine; (15S)-15-Methylprostaglandin F2alpha tromethamine; (15S)-15-Methylprostaglandin F2α tromethamine; 15(S)-15-Methylprostaglandin F2a tromethamine; 15(S)-15-Methylprostaglandin F2α tromethamine; (15S)-15-Methylprostaglandin F2a tromethamine; 15(S)-15-Methyl-PGF2alpha tromethamine salt; 15-Methylprostaglandin F2alpha-tromethamine; (15S)-15-Methyl-PGF2alpha tromethamine salt; (15S)-15-Methyl-PGF2a tromethamine salt; 15(S)-15-Methyl-PGF2α tromethamine salt; 15(S)-15-Methyl-PGF2a tromethamine salt; (15S)-15-Methyl-PGF2α tromethamine salt; (15S)-15-Methylprostaglandin F2alpha; 15(S)-15-Methylprostaglandin F2alpha; (15S)-15-Methylprostaglandin F2a; 15(S)-15-Methylprostaglandin F2α; (15S)-15-Methylprostaglandin F2α; 15(S)-15-Methylprostaglandin F2a; 15(S)-15-Methyl-PGF2alpha; (15S)-15-Methyl-PGF2alpha; Carboprost tromethamine; 15(S)-15-Methyl-PGF2a; (15S)-15-Methyl-PGF2α; (15S)-15-Methyl-PGF2a; Carboprost trometamol; 15(S)-15-Methyl-PGF2α; Carboprostum; Prostin m-15; 9α,11α,15S-trihydroxy-15-methyl-prosta-5Z,13E-dien-1-oic acid; 15(S)-15-methyl Prostaglandin F2α 15(S)-15-methyl PGF2α Carboprost; BCP17677; Carboprost



数据库引用编号

20 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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WikiPathways(0)

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INOH(0)

PlantCyc(0)

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1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Jinling Yan, Yongli Liu, Ruifen Jiao, Meixiang Li, Liqin Zhao. Effect of Low-Frequency Electric Pulse Technique Combined with Carboprost Methylate Suppositories on Recovery of Gastrointestinal Function and Postoperative Complications of Patients with Scarred Uterus Undergoing Secondary Cesarean Section. Journal of healthcare engineering. 2021; 2021(?):6143421. doi: 10.1155/2021/6143421. [PMID: 34868526]
  • J A Loughran, T L Kitchen, S Sindhakar, M Ashraf, M Awad, E J Kealaher. Rotational thromboelastometry (ROTEM®)-guided diagnosis and management of amniotic fluid embolism. International journal of obstetric anesthesia. 2019 05; 38(?):127-130. doi: 10.1016/j.ijoa.2018.09.001. [PMID: 30279053]
  • Lei Yin, Xiangjun Meng, Xiaotong Zhou, Tinglan Zhang, Heping Sun, Zhichao Yang, Bo Yang, Ning Xiao, J Paul Fawcett, Yan Yang, Jingkai Gu. Simultaneous determination of carboprost methylate and its active metabolite carboprost in dog plasma by liquid chromatography-tandem mass spectrometry with positive/negative ion-switching electrospray ionization and its application to a pharmacokinetic study. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2015 Aug; 998-999(?):8-14. doi: 10.1016/j.jchromb.2015.05.039. [PMID: 26149245]
  • Anuradha Srivastava, Praveen K Gupta, Greg A Knock, Philip I Aaronson, Santosh K Mishra, Vellanki Ravi Prakash. Effect of ceramide on the contractility of pregnant rat uterus. European journal of pharmacology. 2007 Jul; 567(1-2):159-65. doi: 10.1016/j.ejphar.2007.04.013. [PMID: 17490636]
  • R Gracious Ross, K Sathishkumar, Ajit Kumar Naik, Dnyaneshwar U Bawankule, Souvendra N Sarkar, Santosh K Mishra, Vellanki Ravi Prakash. Mechanisms of lipopolysaccharide-induced changes in effects of contractile agonists on pregnant rat myometrium. American journal of obstetrics and gynecology. 2004 Feb; 190(2):532-40. doi: 10.1016/s0002-9378(03)00949-9. [PMID: 14981402]
  • Marc Bygdeman. Pharmacokinetics of prostaglandins. Best practice & research. Clinical obstetrics & gynaecology. 2003 Oct; 17(5):707-16. doi: 10.1016/s1521-6934(03)00043-9. [PMID: 12972009]
  • R F Lamont, D J Morgan, M Logue, H Gordon. A prospective randomised trial to compare the efficacy and safety of hemabate and syntometrine for the prevention of primary postpartum haemorrhage. Prostaglandins & other lipid mediators. 2001 Oct; 66(3):203-10. doi: 10.1016/s0090-6980(01)00154-x. [PMID: 11577783]
  • H Su, E Li, L Weng. [Mifepristone for induction of labor]. Zhonghua fu chan ke za zhi. 1996 Nov; 31(11):676-80. doi: NULL. [PMID: 9387530]
  • Z Y Yang, E Li, S S Yu. [15-Methyl-PGF2 alpha vaginal suppository for induction of term labor]. Zhonghua fu chan ke za zhi. 1994 May; 29(5):273-5, 316. doi: . [PMID: 7956549]
  • M Bygdeman, M L Swahn. Antiprogestin drugs: research and clinical use in Sweden. Law, medicine & health care : a publication of the American Society of Law & Medicine. 1992; 20(3):157-60. doi: 10.1111/j.1748-720x.1992.tb01183.x. [PMID: 1434756]
  • ". Recently introduced products. Drug and therapeutics bulletin. 1991 Mar; 29(5):17-9. doi: ". [PMID: 1935601]
  • X L Yang, X R Wu. The dynamic changes of several reproductive hormones during termination of early pregnancy by RU486 in combination with PG-05 in Chinese women. Advances in contraception : the official journal of the Society for the Advancement of Contraception. 1988 Dec; 4(4):319-26. doi: 10.1007/bf01849274. [PMID: 3252730]
  • T G Kennedy, P E Doktorcik. Effects of analogues of prostaglandin E2 and F2 alpha on the decidual cell reaction in the rat. Prostaglandins. 1988 Feb; 35(2):207-19. doi: 10.1016/0090-6980(88)90088-3. [PMID: 3163155]
  • C G Liu, M Z Dai, W K Li, G M Liu, Z M Lin, R H Ma. [Interceptive action of azastene and its effects on plasma progesterone in pregnant rats and rabbits]. Zhongguo yao li xue bao = Acta pharmacologica Sinica. 1987 Nov; 8(6):540-3. doi: NULL. [PMID: 3451668]
  • C G Liu, W K Li, G M Liu, Z M Lin. [Effects of 15-methyl-prostaglandin F2 alpha on uterine contraction and plasma progesterone]. Sheng li xue bao : [Acta physiologica Sinica]. 1986 Oct; 38(5):539-44. doi: . [PMID: 3823934]
  • M Borten, E A Friedman. Postconceptional induction of menses with double prostaglandin F2 alpha impact. American journal of obstetrics and gynecology. 1984 Dec; 150(8):1006-7. doi: 10.1016/0002-9378(84)90404-6. [PMID: 6507528]
  • C H Spilman, D C Beuving, A D Forbes, T J Roseman, R M Bennett, J J Biermacher, M E Tuttle. Menses induction in rhesus monkeys using a controlled-release vaginal delivery system containing (15S) 15-methyl prostaglandin F2 alpha methyl ester. Fertility and sterility. 1984 Oct; 42(4):638-43. doi: 10.1016/s0015-0282(16)48151-3. [PMID: 6489542]
  • M Bygdeman, N Christenssen, K Gréen, O Vesterqvist, T J Roseman, M E Tuttle, C H Spilman. Menses induction and second-trimester pregnancy termination using a polymeric controlled release vaginal delivery system containing (15S)15-methyl PGF2 alpha methyl ester. Contraception. 1983 Feb; 27(2):141-51. doi: 10.1016/0010-7824(83)90085-9. [PMID: 6303690]
  • L S Wan, A J Stiber, J Turkel. Termination of very early pregnancy by vaginal suppositories-(15S)-15-methyl prostaglandin F2 alpha methyl ester. Contraception. 1981 Dec; 24(6):603-15. doi: 10.1016/0010-7824(81)90012-3. [PMID: 6173156]
  • S R Gould, A R Brash, M E Conolly, J E Lennard-Jones. Studies of prostaglandins and sulphasalazine in ulcerative colitis. Prostaglandins and medicine. 1981 Feb; 6(2):165-82. doi: 10.1016/0161-4630(81)90088-4. [PMID: 6113614]
  • M Toppozada, H El-Sokkary, M El-Abd, A El-Fazary, H A El-Rahman. Induction of human luteolysis by high dose infusions of 150methyl PGF2 alpha. Prostaglandins and medicine. 1981 Feb; 6(2):203-11. doi: 10.1016/0161-4630(81)90090-2. [PMID: 7244028]
  • C R Vader, M M Mathias, C L Schatte. Pulmonary prostaglandin metabolism during normobaric hyperoxia. Prostaglandins and medicine. 1981 Jan; 6(1):101-10. doi: 10.1016/s0161-4630(81)80013-4. [PMID: 6261283]
  • J W Wilks. Inhibition of the monkey corpus luteum with 15-methyl prostaglandins. Prostaglandins. 1980 Nov; 20(5):793-805. doi: 10.1016/0090-6980(80)90134-3. [PMID: 7465867]
  • J W Wilks. Effects of (15S)-15-methyl prostaglandin E2 alpha methyl ester and estrogens upon the corpus luteum and conceptus of the rhesus monkey. Prostaglandins. 1980 Nov; 20(5):807-23. doi: 10.1016/0090-6980(80)90135-5. [PMID: 7465868]
  • J Scher, D Y Jeng, T D Kerenyi. Post-conceptional induction of menses with a single vaginal suppository of (15S)-15-methyl prostaglandin F2 alpha methyl ester. Prostaglandins. 1980 Sep; 20(3):469-79. doi: 10.1016/0090-6980(80)90034-9. [PMID: 6252575]
  • C A Eddy. Ovum transport in the rhesus monkey following postovulatory intravaginal 15(S)-15-methyl prostaglandin F2 alpha-methyl ester administration. American journal of obstetrics and gynecology. 1980 Aug; 137(8):966-71. doi: 10.1016/s0002-9378(16)32840-x. [PMID: 6773419]
  • S Roy, P F Brenner, R P Marrs, D R Mishell. Termination of early gestation with a single vaginal suppository of (15S)-15-methyl-prostaglandin F2alpha methyl ester. Contraception. 1980 Aug; 22(2):137-52. doi: 10.1016/0010-7824(80)90058-x. [PMID: 7449379]
  • N H Lauersen, K H Wilson. Early pregnancy interruption with two 15-ME-PGF2a suppositories. Contraception. 1980 Mar; 21(3):273-82. doi: 10.1016/0010-7824(80)90006-2. [PMID: 7389352]
  • A Bhaskar, V Dimov, S Baliga, G Kinra, V Hingorani, K R Laumas. Plasma levels of 15 (S) 15-methyl-PGF 2 alpha-methyl ester following vaginal administration for induction of abortion in women. Contraception. 1979 Nov; 20(5):519-31. doi: 10.1016/0010-7824(79)90057-x. [PMID: 527343]