Prostaglandin G2 (BioDeep_00000629491)
Main id: BioDeep_00000006016
代谢物信息卡片
9S,11R-epidioxy-15S-hydroperoxy-5Z,13E-prostadienoic acid
化学式: C20H32O6 (368.2199)
中文名称: 前列腺素 G2
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCCCC(C=CC1C2CC(C1CC=CCCCC(=O)O)OO2)OO
InChI: InChI=1S/C20H32O6/c1-2-3-6-9-15(24-23)12-13-17-16(18-14-19(17)26-25-18)10-7-4-5-8-11-20(21)22/h4,7,12-13,15-19,23H,2-3,5-6,8-11,14H2,1H3,(H,21,22)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1
描述信息
D009676 - Noxae > D016877 - Oxidants > D010545 - Peroxides
同义名列表
数据库引用编号
13 个数据库交叉引用编号
- ChEBI: CHEBI:27647
- KEGG: C05956
- PubChem: 5280883
- DrugBank: DB03866
- LipidMAPS: LMFA03010009
- CAS: 51982-36-6
- MetaboLights: MTBLC27647
- PubChem: 8240
- PDB-CCD: PGX
- 3DMET: B01930
- NIKKAJI: J10.404C
- RefMet: PGG2
- KNApSAcK: 27647
分类词条
相关代谢途径
Reactome(11)
- Metabolism
- Biological oxidations
- Phase I - Functionalization of compounds
- Metabolism of vitamins and cofactors
- Metabolism of lipids
- Fatty acid metabolism
- Metabolism of water-soluble vitamins and cofactors
- Arachidonic acid metabolism
- Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
- Nicotinate metabolism
- Nicotinamide salvaging
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
2 个相关的物种来源信息
- 3039 - Euglena gracilis: 10.3389/FBIOE.2021.662655
- 9606 - Homo sapiens: 10.1007/S11306-016-1051-4
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- David M Aronoff, Olivier Boutaud, Lawrence J Marnett, John A Oates. Inhibition of prostaglandin H2 synthases by salicylate is dependent on the oxidative state of the enzymes.
The Journal of pharmacology and experimental therapeutics.
2003 Feb; 304(2):589-95. doi:
10.1124/jpet.102.042853. [PMID: 12538810] - Olivier Boutaud, David M Aronoff, Jacob H Richardson, Lawrence J Marnett, John A Oates. Determinants of the cellular specificity of acetaminophen as an inhibitor of prostaglandin H(2) synthases.
Proceedings of the National Academy of Sciences of the United States of America.
2002 May; 99(10):7130-5. doi:
10.1073/pnas.102588199. [PMID: 12011469] - T D Foley. The cyclooxygenase hydroperoxide product PGG(2) activates synaptic nitric oxide synthase: a possible antioxidant response to membrane lipid peroxidation.
Biochemical and biophysical research communications.
2001 Aug; 286(2):235-8. doi:
10.1006/bbrc.2001.5378. [PMID: 11500026] - M d'Ischia, A Palumbo, F Buzzo. Interactions of nitric oxide with lipid peroxidation products under aerobic conditions: inhibitory effects on the formation of malondialdehyde and related thiobarbituric acid-reactive substances.
Nitric oxide : biology and chemistry.
2000 Feb; 4(1):4-14. doi:
10.1006/niox.1999.0268. [PMID: 10733868] - G Wu, C Wei, R J Kulmacz, Y Osawa, A L Tsai. A mechanistic study of self-inactivation of the peroxidase activity in prostaglandin H synthase-1.
The Journal of biological chemistry.
1999 Apr; 274(14):9231-7. doi:
10.1074/jbc.274.14.9231. [PMID: 10092596] - J L Johnson, K R Maddipati. Paradoxical effects of resveratrol on the two prostaglandin H synthases.
Prostaglandins & other lipid mediators.
1998 Jun; 56(2-3):131-43. doi:
10.1016/s0090-6980(98)00052-5. [PMID: 9785383] - A l Tsai, C Wei, H K Baek, R J Kulmacz, H E Van Wart. Comparison of peroxidase reaction mechanisms of prostaglandin H synthase-1 containing heme and mangano protoporphyrin IX.
The Journal of biological chemistry.
1997 Apr; 272(14):8885-94. doi:
10.1074/jbc.272.14.8885. [PMID: 9083007] - J A Handler, R M Danilowicz, T E Eling. Mitogenic signaling by epidermal growth factor (EGF), but not platelet-derived growth factor, requires arachidonic acid metabolism in BALB/c 3T3 cells. Modulation of EGF-dependent c-myc expression by prostaglandins.
The Journal of biological chemistry.
1990 Mar; 265(7):3669-73. doi:
. [PMID: 2105952] - J Quilley, J C McGiff, A Nasjletti. Role of endoperoxides in arachidonic acid-induced vasoconstriction in the isolated perfused kidney of the rat.
British journal of pharmacology.
1989 Jan; 96(1):111-6. doi:
10.1111/j.1476-5381.1989.tb11790.x. [PMID: 2522332] - G C Agnoli, R Borgatti, M Cacciari, S Dorigoni, C Garutti, E Ikonomu, M Marinelli. [Urinary excretion of prostanoids in the course of changes in diuresis over short and long terms respectively].
Bollettino della Societa italiana di biologia sperimentale.
1987 Apr; 63(4):357-63. doi:
NULL. [PMID: 3447615] - B Mayer, H Gleispach, W R Kukovetz. Formation of 6,15-diketoprostaglandin F1 alpha from prostaglandin G2 by bovine aortic endothelial cells.
Biochimica et biophysica acta.
1987 Apr; 918(3):209-16. doi:
10.1016/0005-2760(87)90223-2. [PMID: 3032265] - M Hecker, A Hatzelmann, V Ullrich. Preparative HPLC purification of prostaglandin endoperoxides and isolation of novel cyclooxygenase-derived arachidonic acid metabolites.
Biochemical pharmacology.
1987 Mar; 36(6):851-5. doi:
10.1016/0006-2952(87)90175-4. [PMID: 3105538] - F Franchi, P Lo Sapio, G Strazzulla, G Fabbri, A Scardi, M Pinzani, G Laffi, M Mannelli. Acute effect of furosemide on renal kallikrein and prostaglandin systems in mild to moderate essential hypertension.
International journal of clinical pharmacology, therapy, and toxicology.
1987 Jan; 25(1):44-9. doi:
NULL. [PMID: 3549580] - A Danon, T V Zenser, D L Thomasson, M O Palmier, B B Davis. Eicosanoid synthesis by rabbit hydronephrotic cortical interstitial cells in culture.
The Journal of pharmacology and experimental therapeutics.
1986 Jul; 238(1):95-9. doi:
. [PMID: 3088262] - H A Kontos. George E. Brown memorial lecture. Oxygen radicals in cerebral vascular injury.
Circulation research.
1985 Oct; 57(4):508-16. doi:
10.1161/01.res.57.4.508. [PMID: 2994903] - J R Beetens, A E Van Hoydonck, A G Herman. Stimulation of prostacyclin production by vitamin C in ram seminal vesicle microsomes: possible mode of action.
Archives internationales de pharmacodynamie et de therapie.
1985 Sep; 277(1):56-65. doi:
. [PMID: 3904652] - H J Kramer, R Düsing, K Glänzer, J Kipnowski, D Klingmüller, H Meyer-Lehnert. Effects of aprotinin on renal function.
Contributions to nephrology.
1984; 42(?):233-41. doi:
10.1159/000409982. [PMID: 6085300]
