Mucofan (BioDeep_00000615653)
代谢物信息卡片
2-Amino-3-[(carboxymethyl)sulfanyl]propanoic acid
化学式: C5H9NO4S (179.0252)
中文名称: 羧甲司坦
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C(C(C(=O)O)N)SCC(=O)O
InChI: InChI=1S/C5H9NO4S/c6-3(5(9)10)1-11-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)
描述信息
D019141 - Respiratory System Agents > D005100 - Expectorants
D000890 - Anti-Infective Agents
同义名列表
33 个代谢物同义名
2-Amino-3-[(carboxymethyl)sulfanyl]propanoic acid; (L)-2-Amino-3-(carboxymethylthio)propionic acid; 2-Amino-3-(carboxymethylthio)propionic acid; 3-[(Carboxymethyl)thio]-L-alanine; L-3-((Carboxymethyl)thio)alanine; 3-(Carboxymethylthio)-L-alanine; 3-[(Carboxymethyl)thio]alanine; 3-((Carboxymethyl)thio)alanine; S-(Carboxymethyl)-(R)-cysteine; 5-Amino-3-thiadihexanoic acid; (R)-S-(Carboxymethyl)cysteine; S-(Carboxymethyl)-L-cysteine; 3-(Carboxymethylthio)alanine; S-Carboxylmethyl-L-cysteine; s-carboxymethyl-l-cysteine; Carboxymethylated cysteine; S-(Carboxymethyl)cysteine; Carboxymethylenecysteine; 1-Carboxymethylcysteine; S-Carboxymethylcysteine; L-Carboxymethylcysteine; Carboxymethylcysteine; Carbocisteine; Rhinathiol; carbofuran; Thiodril; Mucodyne; Reomucil; Mucodine; Loviscol; Muciclar; Mucofan; Mucocis
数据库引用编号
6 个数据库交叉引用编号
- PubChem: 1080
- Metlin: METLIN86253
- ChEMBL: CHEMBL1447969
- MeSH: Carbocysteine
- CAS: 25390-17-4
- CAS: 2387-59-9
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
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The Journal of dermatology.
2020 Feb; 47(2):174-177. doi:
10.1111/1346-8138.15175. [PMID: 31840853] - Stephen C Mitchell, Glyn B Steventon. Phenylalanine 4-monooxygenase: the "sulfoxidation polymorphism".
Xenobiotica; the fate of foreign compounds in biological systems.
2020 Jan; 50(1):51-63. doi:
10.1080/00498254.2019.1636419. [PMID: 31233370] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
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PloS one.
2016; 11(2):e0148519. doi:
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Xenobiotica; the fate of foreign compounds in biological systems.
2015; 45(12):1047-53. doi:
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Cell stress & chaperones.
2013 Nov; 18(6):733-43. doi:
10.1007/s12192-013-0424-0. [PMID: 23580157] - Olumuyiwa S Falade, Steve R A Adewusi, Chris E Harwood. S-Carboxyethylcysteine (a constituent of Acacia seed) negatively affects casein protein utilization by rats.
Nutrition (Burbank, Los Angeles County, Calif.).
2012 Jul; 28(7-8):785-92. doi:
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Amino acids.
2012 May; 42(5):1967-73. doi:
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Molecular and cellular biochemistry.
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2006; 20(7):1153-60. doi:
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The Annals of occupational hygiene.
2005 Nov; 49(8):683-90. doi:
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Chemical research in toxicology.
2005 Aug; 18(8):1232-41. doi:
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Analytical biochemistry.
2004 Dec; 335(1):91-7. doi:
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Chinese medical journal.
2004 May; 117(5):689-94. doi:
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Drug metabolism and drug interactions.
2004; 20(1-2):1-10. doi:
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Farmaco (Societa chimica italiana : 1989).
2003 Dec; 58(12):1325-32. doi:
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Veterinary and human toxicology.
2003 Feb; 45(1):45-6. doi:
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European cytokine network.
2003 Jan; 14(1):20-6. doi:
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Drug metabolism and drug interactions.
2003; 19(4):241-55. doi:
10.1515/dmdi.2003.19.4.241. [PMID: 14768973] - Glyn B Steventon, Rosemary H Waring, Adrian C Williams. An investigation into the inter-relationships of sulphur xeno-biotransformation pathways in Parkinson's and motor neurone diseases.
Drug metabolism and drug interactions.
2003; 19(4):223-40. doi:
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2003; 65 Suppl 2(?):11-6. doi:
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Panminerva medica.
2001 Sep; 43(3):215-20. doi:
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1999 Sep; 27(9):1092-7. doi:
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Journal of mass spectrometry : JMS.
1997 Apr; 32(4):388-94. doi:
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Journal of cellular physiology.
1996 Aug; 168(2):248-54. doi:
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Urologia internationalis.
1996; 57(2):99-103. doi:
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Journal of hepatology.
1995 May; 22(5):551-60. doi:
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Journal of chromatography. B, Biomedical applications.
1995 Jan; 663(1):15-24. doi:
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1994 Oct; 660(1):164-9. doi:
10.1016/0378-4347(94)00280-0. [PMID: 7858709] - W L Gregory, O F James, I Turner, C O Meese, J R Idle. Re-evaluation of the metabolism of carbocisteine in a British white population.
Pharmacogenetics.
1993 Oct; 3(5):270-4. doi:
10.1097/00008571-199310000-00007. [PMID: 8287066] - R H Waring, P Emery. Management of early inflammatory arthritis. Genetic factors predicting persistent disease: the role of defective enzyme systems.
Bailliere's clinical rheumatology.
1992 Jun; 6(2):337-50. doi:
10.1016/s0950-3579(05)80178-5. [PMID: 1525843] - W L Gregory, O F James, J R Idle. Carbocisteine polymorphism and disease.
Lancet (London, England).
1992 Mar; 339(8793):616-7. doi:
10.1016/0140-6736(92)90902-f. [PMID: 1347115] - C Gordon, H Bradley, R H Waring, P Emery. Abnormal sulphur oxidation in systemic lupus erythematosus.
Lancet (London, England).
1992 Jan; 339(8784):25-6. doi:
10.1016/0140-6736(92)90144-r. [PMID: 1345954] - B Staffeldt, J Brockmöller, I Roots. Determination of S-carboxymethyl-L-cysteine and some of its metabolites in urine and serum by high-performance liquid chromatography using fluorescent pre-column labelling.
Journal of chromatography.
1991 Nov; 571(1-2):133-47. doi:
10.1016/0378-4347(91)80440-n. [PMID: 1810942] - C O Meese, C Fischer, A Küpfer, H Wisser, M Eichelbaum. Identification of the 'major' polymorphic carbocysteine metabolite as S-(carboxymethylthio)-L-cysteine.
Biochemical pharmacology.
1991 Oct; 42(10):R13-6. doi:
10.1016/0006-2952(91)90579-t. [PMID: 1741762] - A D MBewu, P N Durrington, D Bhatnagar, J P Miller, M I Mackness. Oral carbocisteine does not lower serum lipoprotein(a) levels.
Atherosclerosis.
1991 Oct; 90(2-3):219-20. doi:
10.1016/0021-9150(91)90118-m. [PMID: 1836948] - J Brockmöller, B Staffeldt, I Roots. Evaluation of proposed sulphoxidation pathways of carbocysteine in man by HPLC quantification.
European journal of clinical pharmacology.
1991; 40(4):387-92. doi:
10.1007/bf00265849. [PMID: 2050173] - U Hofmann, M Eichelbaum, S Seefried, C O Meese. Identification of thiodiglycolic acid, thiodiglycolic acid sulfoxide, and (3-carboxymethylthio)lactic acid as major human biotransformation products of S-carboxymethyl-L-cysteine.
Drug metabolism and disposition: the biological fate of chemicals.
1991 Jan; 19(1):222-6. doi:
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Acta neurologica Scandinavica. Supplementum.
1991; 136(?):19-23. doi:
10.1111/j.1600-0404.1991.tb05015.x. [PMID: 1801532] - C O Meese, P Fischer. Tracing the human metabolism of stable isotope-labelled drugs by ex vivo NMR spectroscopy. A revision of S-carboxymethyl-L-cysteine biotransformation.
Zeitschrift fur Naturforschung. C, Journal of biosciences.
1990 Nov; 45(11-12):1171-5. doi:
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Electrophoresis.
1990 Sep; 11(9):760-4. doi:
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Lancet (London, England).
1990 Jun; 335(8704):1527. doi:
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Analytical biochemistry.
1990 May; 187(1):136-40. doi:
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Lancet (London, England).
1990 May; 335(8697):1107. doi:
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Acta oto-laryngologica. Supplementum.
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Journal of inorganic biochemistry.
1989 Dec; 37(4):309-23. doi:
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The European respiratory journal.
1989 Nov; 2(10):955-60. doi:
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British journal of urology.
1989 Apr; 63(4):372-4. doi:
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1988 Oct; 13(4):253-6. doi:
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1988 Aug; 263(24):11780-5. doi:
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Journal of hepatology.
1988 Aug; 7(1):72-8. doi:
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Journal of chromatography.
1988 Jul; 428(2):301-10. doi:
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BMJ (Clinical research ed.).
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Arzneimittel-Forschung.
1985; 35(1):163-6. doi:
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British journal of clinical pharmacology.
1984 Oct; 18(4):507-21. doi:
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Toxicology.
1983 Nov; 28(4):313-21. doi:
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Xenobiotica; the fate of foreign compounds in biological systems.
1983 May; 13(5):311-7. doi:
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Biochemical pharmacology.
1982 Oct; 31(19):3151-4. doi:
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Biopharmaceutics & drug disposition.
1982 Jul; 3(3):275-81. doi:
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1982 Jul; 37(7):235-8. doi:
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Bollettino dell'Istituto sieroterapico milanese.
1982 Mar; 61(1):64-70. doi:
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Cancer research.
1982 Feb; 42(2):525-9. doi:
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Drug metabolism and disposition: the biological fate of chemicals.
1982 Jan; 10(1):61-2. doi:
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Clinical therapeutics.
1982; 4(6):480-8. doi:
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European journal of drug metabolism and pharmacokinetics.
1980; 5(1):49-52. doi:
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1979 Sep; 7(5):299-305. doi:
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Archives of toxicology.
1979 Jul; 42(3):159-69. doi:
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1979 Mar; 34(3):114-20. doi:
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Australian journal of biological sciences.
1979 Feb; 32(1):15-26. doi:
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Analytical biochemistry.
1979 Jan; 92(2):489-96. doi:
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1978 Dec; 67(12):1753-5. doi:
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European journal of clinical pharmacology.
1978 Nov; 14(3):177-84. doi:
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Xenobiotica; the fate of foreign compounds in biological systems.
1978 Oct; 8(10):621-8. doi:
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Xenobiotica; the fate of foreign compounds in biological systems.
1978 May; 8(5):265-70. doi:
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1978 Mar; 37(3):411-7. doi:
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Physiological chemistry and physics.
1978; 10(1):47-57. doi:
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Xenobiotica; the fate of foreign compounds in biological systems.
1977 Jul; 7(7):409-14. doi:
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International archives of occupational and environmental health.
1976 Oct; 38(1):69-75. doi:
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Die Naturwissenschaften.
1975 Nov; 62(11):541. doi:
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