hopene (BioDeep_00000006106)

   


代谢物信息卡片


N-(3alpha,7beta,12alpha-trihydroxy-5beta-cholan-24-oyl)-taurine

化学式: C30H50 (410.3912)
中文名称: 何帕烯
谱图信息: 最多检出来源 Bos taurus(blood) 13.42%

分子结构信息

SMILES: C=C(C)C1CCC2(C)C1CCC1(C)C2CCC2C3(C)CCCC(C)(C)C3CCC21C
InChI: InChI=1S/C30H50/c1-20(2)21-12-17-27(5)22(21)13-18-29(7)24(27)10-11-25-28(6)16-9-15-26(3,4)23(28)14-19-30(25,29)8/h21-25H,1,9-19H2,2-8H3/t21-,22+,23+,24-,25-,27+,28+,29-,30-/m1/s1



数据库引用编号

16 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(2)

PlantCyc(1)

代谢反应

3 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(2)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(1)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

32 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 7 CAT, DNAH11, FDPS, NR5A2, PMP2, UTP20, XDH
Peripheral membrane protein 3 ACHE, CYP1B1, LSS
Endoplasmic reticulum membrane 5 CYP19A1, CYP1B1, FDFT1, LSS, PTGDS
Nucleus 3 ACHE, NR5A2, PMP2
cytosol 5 CAT, FDPS, LIPE, PMP2, XDH
nucleoplasm 3 FDPS, NR5A2, UTP20
RNA polymerase II transcription regulator complex 1 NR5A2
Cell membrane 2 ACHE, LIPE
Multi-pass membrane protein 3 ATP4A, CYP19A1, FDFT1
Synapse 1 ACHE
cell surface 1 ACHE
Golgi apparatus 2 ACHE, PTGDS
neuromuscular junction 1 ACHE
Cytoplasm, cytosol 1 LIPE
plasma membrane 3 ACHE, ATP4A, UTP20
Membrane 9 ACHE, ATP4A, CAT, CYP19A1, CYP1B1, FDFT1, FDPS, LIPE, LSS
apical plasma membrane 1 ATP4A
caveola 1 LIPE
extracellular exosome 3 CAT, PMP2, PTGDS
endoplasmic reticulum 2 CYP19A1, FDFT1
extracellular space 4 ACHE, ATP4A, PTGDS, XDH
perinuclear region of cytoplasm 2 ACHE, PTGDS
mitochondrion 2 CAT, CYP1B1
protein-containing complex 1 CAT
intracellular membrane-bounded organelle 2 CAT, CYP1B1
Microsome membrane 2 CYP19A1, CYP1B1
Secreted 2 ACHE, PTGDS
extracellular region 4 ACHE, CAT, DNAH11, PTGDS
mitochondrial matrix 2 CAT, FDPS
Extracellular side 1 ACHE
motile cilium 1 DNAH11
Nucleus membrane 1 PTGDS
nuclear membrane 1 PTGDS
nucleolus 1 UTP20
Apical cell membrane 1 ATP4A
Cytoplasm, perinuclear region 1 PTGDS
Cytoplasm, cytoskeleton 1 DNAH11
focal adhesion 1 CAT
microtubule 1 DNAH11
Peroxisome 3 CAT, FDPS, XDH
basement membrane 1 ACHE
sarcoplasmic reticulum 1 XDH
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
axoneme 1 DNAH11
chromatin 1 NR5A2
Nucleus, nucleolus 1 UTP20
Cytoplasm, cytoskeleton, cilium axoneme 1 DNAH11
Lipid-anchor, GPI-anchor 1 ACHE
Lipid droplet 2 LIPE, LSS
Membrane, caveola 1 LIPE
side of membrane 1 ACHE
myelin sheath 1 PMP2
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 1 CAT
small-subunit processome 1 UTP20
9+2 motile cilium 1 DNAH11
dynein complex 1 DNAH11
preribosome, small subunit precursor 1 UTP20
synaptic cleft 1 ACHE
Rough endoplasmic reticulum 1 PTGDS
90S preribosome 1 UTP20
catalase complex 1 CAT
potassium:proton exchanging ATPase complex 1 ATP4A
[Isoform H]: Cell membrane 1 ACHE
9+0 motile cilium 1 DNAH11
proximal portion of axoneme 1 DNAH11


文献列表

  • Dayane S Alvares, Matias Crosio, Natalia Wilke. Hopanoid Hopene Locates in the Interior of Membranes and Affects Their Properties. Langmuir : the ACS journal of surfaces and colloids. 2021 10; 37(40):11900-11908. doi: 10.1021/acs.langmuir.1c02030. [PMID: 34585578]
  • Jonna Bouwknegt, Sanne J Wiersma, Raúl A Ortiz-Merino, Eline S R Doornenbal, Petrik Buitenhuis, Martin Giera, Christoph Müller, Jack T Pronk. A squalene-hopene cyclase in Schizosaccharomyces japonicus represents a eukaryotic adaptation to sterol-limited anaerobic environments. Proceedings of the National Academy of Sciences of the United States of America. 2021 08; 118(32):. doi: 10.1073/pnas.2105225118. [PMID: 34353908]
  • Kang He, Lin-Lin Fan, Tian-Tai Wu, Jiang Du. A new xanthone glycoside from Pyrrosia sheareri. Natural product research. 2019 Oct; 33(20):2982-2987. doi: 10.1080/14786419.2018.1514398. [PMID: 30488728]
  • M N Melo, H I Ingólfsson, S J Marrink. Parameters for Martini sterols and hopanoids based on a virtual-site description. The Journal of chemical physics. 2015 Dec; 143(24):243152. doi: 10.1063/1.4937783. [PMID: 26723637]
  • Amy B Banta, Jeremy H Wei, Paula V Welander. A distinct pathway for tetrahymanol synthesis in bacteria. Proceedings of the National Academy of Sciences of the United States of America. 2015 Nov; 112(44):13478-83. doi: 10.1073/pnas.1511482112. [PMID: 26483502]
  • David Poger, Alan E Mark. The relative effect of sterols and hopanoids on lipid bilayers: when comparable is not identical. The journal of physical chemistry. B. 2013 Dec; 117(50):16129-40. doi: 10.1021/jp409748d. [PMID: 24299489]
  • Y Subhash, L Tushar, Ch Sasikala, Ch V Ramana. Falsirhodobacter halotolerans gen. nov., sp. nov., isolated from dry soils of a solar saltern. International journal of systematic and evolutionary microbiology. 2013 Jun; 63(Pt 6):2132-2137. doi: 10.1099/ijs.0.044107-0. [PMID: 23104358]
  • M Vyssotski, K C-Y Lee, K Lagutin, J Ryan, X C Morgan, M B Stott. Fatty Acids of Chthonomonas calidirosea, of a novel class Chthonomonadetes from a recently described phylum Armatimonadetes. Lipids. 2011 Dec; 46(12):1155-61. doi: 10.1007/s11745-011-3597-2. [PMID: 21805326]
  • Ryan F Seipke, Rosemary Loria. Hopanoids are not essential for growth of Streptomyces scabies 87-22. Journal of bacteriology. 2009 Aug; 191(16):5216-23. doi: 10.1128/jb.00390-09. [PMID: 19502399]
  • Martin Blumenberg, Birte I Oppermann, Rémy Guyoneaud, Walter Michaelis. Hopanoid production by Desulfovibrio bastinii isolated from oilfield formation water. FEMS microbiology letters. 2009 Apr; 293(1):73-8. doi: 10.1111/j.1574-6968.2009.01520.x. [PMID: 19222571]
  • Thomas Härtner, Kristina L Straub, Elmar Kannenberg. Occurrence of hopanoid lipids in anaerobic Geobacter species. FEMS microbiology letters. 2005 Feb; 243(1):59-64. doi: 10.1016/j.femsle.2004.11.039. [PMID: 15668001]
  • Cécile Joyeux, Samuel Fouchard, Pierre Llopiz, Serge Neunlist. Influence of the temperature and the growth phase on the hopanoids and fatty acids content of Frateuria aurantia (DSMZ 6220). FEMS microbiology ecology. 2004 Mar; 47(3):371-9. doi: 10.1016/s0168-6496(03)00302-7. [PMID: 19712325]
  • K Poralla, G Muth, T Härtner. Hopanoids are formed during transition from substrate to aerial hyphae in Streptomyces coelicolor A3(2). FEMS microbiology letters. 2000 Aug; 189(1):93-5. doi: 10.1111/j.1574-6968.2000.tb09212.x. [PMID: 10913872]