Guanosine 2',3'-cyclic phosphate (BioDeep_00000006085)

 

Secondary id: BioDeep_00001869079

human metabolite Endogenous


代谢物信息卡片


9-[(3aR,4R,6R,6aR)-2-hydroxy-6-(hydroxymethyl)-2-oxo-tetrahydro-2H-2λ⁵-furo[3,4-d][1,3,2]dioxaphosphol-4-yl]-2-amino-6,9-dihydro-3H-purin-6-one

化学式: C10H12N5O7P (345.0474332)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(feces) 0.12%

分子结构信息

SMILES: C1=NC2=C(N1C3C4C(C(O3)CO)OP(=O)(O4)O)N=C(NC2=O)N
InChI: InChI=1S/C10H12N5O7P/c11-10-13-7-4(8(17)14-10)12-2-15(7)9-6-5(3(1-16)20-9)21-23(18,19)22-6/h2-3,5-6,9,16H,1H2,(H,18,19)(H3,11,13,14,17)/t3-,5-,6-,9-/m1/s1

描述信息

2,3-Cyclic GMP is a cyclic guanosine derivative that is a precursor to 3-GMP. The enzyme 23-cyclic-nucleotide 2-phosphodiesterase (E.C. 3.1.4.16) catalyses the hydrolysis of both 2,3-cyclic AMP and 2,3-cyclic GMP into 3-AMP and 3-GMP, respectively, at the 3-terminal of RNA. 2,3-cyclic phosphate termini are produced, as either intermediates or final products, during RNA cleavage by many different endoribonucleases. The enzyme RNA 3-phosphate cyclase also converts the 3-terminal phosphate in RNA into the 2,3-cyclic phosphodiester in the ATP-dependent reaction which involves formation of the covalent cyclase-AMP and the RNA-N3 pp5 A intermediates (PMID: 10397337). This enzyme could be involved in the maintenance of cyclic ends in tRNA splicing intermediates or in the cyclization of the 3 end of U6 snRNA (PMID: 9184239). Guanosine-2,3-cyclic phosphate is capable of blocking DNA synthesis in vitro (PMID: 7528887). 2, 3-cGMP seems to preferentially stimulate mature T-cells while 3, 5-cGMP preferentially acts on B-cells (PMID: 163786).

同义名列表

19 个代谢物同义名

9-[(3aR,4R,6R,6aR)-2-hydroxy-6-(hydroxymethyl)-2-oxo-tetrahydro-2H-2λ⁵-furo[3,4-d][1,3,2]dioxaphosphol-4-yl]-2-amino-6,9-dihydro-3H-purin-6-one; 9-[(3aR,4R,6R,6aR)-2-hydroxy-6-(hydroxymethyl)-2-oxo-tetrahydro-2λ⁵-furo[3,4-d][1,3,2]dioxaphosphol-4-yl]-2-amino-3H-purin-6-one; Guanosine cyclic 2,3-(hydrogen phosphoric acid); Guanosine cyclic 2,3-(hydrogen phosphate); Cyclic guanosine 2,3-monophosphoric acid; Guanosine 2,3-cyclic monophosphoric acid; Guanosine cyclic-2,3-monophosphoric acid; O(2),O(3)-Hydroxyphosphoryl-guanosine; Guanosine 2,3-cyclic phosphoric acid; Guanosine cyclic 2,3 monophosphate; Guanosine cyclic 2,3-monophosphate; Guanosine cyclic-2,3-monophosphate; Guanosine 2,3-cyclic monophosphate; Cyclic guanosine 2,3-monophosphate; 2,3-Cyclic GMP, monosodium salt; Guanosine 2,3-cyclic phosphate; 2,3-Cyclic GMP, lithium salt; 2,3-Cyclic GMP, sodium salt; 2,3-Cyclic GMP



数据库引用编号

13 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

3 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Jingjing Guo, Jie Wang, Jingrong Fan, Yan Zhang, Wenpei Dong, Chang-Po Chen. Distinct Dynamic and Conformational Features of Human STING in Response to 2'3'-cGAMP and c-di-GMP. Chembiochem : a European journal of chemical biology. 2019 07; 20(14):1838-1847. doi: 10.1002/cbic.201900051. [PMID: 30895657]
  • Edwin K Jackson, Zaichuan Mi, Keri Janesko-Feldman, Travis C Jackson, Patrick M Kochanek. 2',3'-cGMP exists in vivo and comprises a 2',3'-cGMP-guanosine pathway. American journal of physiology. Regulatory, integrative and comparative physiology. 2019 06; 316(6):R783-R790. doi: 10.1152/ajpregu.00401.2018. [PMID: 30789788]