5-L-Glutamyl-taurine (BioDeep_00000005980)

 

Secondary id: BioDeep_00001868904

human metabolite Endogenous


代谢物信息卡片


(2S)-2-amino-5-oxo-5-(2-sulfoethylamino)pentanoic acid

化学式: C7H14N2O6S (254.0573)
中文名称:
谱图信息: 最多检出来源 Mus musculus(blood) 5.13%

分子结构信息

SMILES: C(CC(=O)NCCS(=O)(=O)O)C(C(=O)O)N
InChI: InChI=1S/C7H14N2O6S/c8-5(7(11)12)1-2-6(10)9-3-4-16(13,14)15/h5H,1-4,8H2,(H,9,10)(H,11,12)(H,13,14,15)/t5-/m0/s1

描述信息

5-L-Glutamyl-taurine is an intermediate in Taurine and hypotaurine metabolism. 5-L-Glutamyl-taurine is produced from Taurine via the enzyme gamma-glutamyltranspeptidase (EC 2.3.2.2). [HMDB]
5-L-Glutamyl-taurine is an intermediate in Taurine and hypotaurine metabolism. 5-L-Glutamyl-taurine is produced from Taurine via the enzyme gamma-glutamyltranspeptidase (EC 2.3.2.2).

同义名列表

24 个代谢物同义名

(2S)-2-amino-5-oxo-5-(2-sulfoethylamino)pentanoic acid; (2S)-2-amino-4-[(2-sulfoethyl)carbamoyl]butanoic acid; gamma-L-Glutamyl-taurine; gamma-L-Glutamyltaurine; alpha-Glutamyl taurine; alpha-Glutamyltaurine; Glutaurin, (D)-isomer; gamma-Glutamyltaurine; 5-L-Glutamyl-taurine; Γ-L-glutamyltaurine; g-L-Glutamyltaurine; 5-Glutamyl-taurine; g-Glutamyltaurine; Γ-glutamyltaurine; Glautaurine; Glutaurinum; Glutaurina; Glutaurine; Glutaurin; Litoralon; gamma-GT; γ-GT; g-GT; 5-L-Glutamyl-taurine



数据库引用编号

17 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

4 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(4)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 6 ALB, CAT, HPGDS, NQO1, PIK3C2A, VEGFA
Peripheral membrane protein 1 GORASP1
Endosome membrane 1 TF
Endoplasmic reticulum membrane 1 CD4
Nucleus 4 ALB, NQO1, PIK3C2A, VEGFA
cytosol 7 ALB, CAT, GPT, HPGDS, LIPE, NQO1, PIK3C2A
dendrite 1 NQO1
trans-Golgi network 1 PIK3C2A
centrosome 1 ALB
nucleoplasm 2 HPGDS, PIK3C2A
Cell membrane 4 CD4, LIPE, PIK3C2A, TNF
Cytoplasmic side 1 GORASP1
Golgi apparatus membrane 1 GORASP1
Synapse 1 NQO1
cell surface 3 TF, TNF, VEGFA
Golgi apparatus 3 ALB, GORASP1, VEGFA
Golgi membrane 2 GORASP1, INS
neuronal cell body 2 NQO1, TNF
Cytoplasm, cytosol 2 LIPE, NQO1
plasma membrane 7 BCHE, CD4, GGT2P, IFNLR1, PIK3C2A, TF, TNF
Membrane 6 CAT, IFNLR1, LIPE, NQO1, PIK3C2A, VEGFA
apical plasma membrane 1 TF
caveola 1 LIPE
extracellular exosome 6 ALB, CAT, GGT2P, GPT, PIK3C2A, TF
endoplasmic reticulum 3 ALB, GGT2P, VEGFA
extracellular space 10 ALB, BCHE, CRP, IL10, IL6, INS, PTH, TF, TNF, VEGFA
perinuclear region of cytoplasm 2 GGT2P, TF
adherens junction 1 VEGFA
mitochondrion 1 CAT
protein-containing complex 2 ALB, CAT
intracellular membrane-bounded organelle 3 CAT, HPGDS, PIK3C2A
Single-pass type I membrane protein 2 CD4, IFNLR1
Secreted 8 ALB, BCHE, CRP, IL10, IL6, INS, TF, VEGFA
extracellular region 11 ALB, BCHE, CAT, CRP, IL10, IL6, INS, PTH, TF, TNF, VEGFA
basal part of cell 1 TF
mitochondrial matrix 1 CAT
anchoring junction 1 ALB
external side of plasma membrane 2 CD4, TNF
Secreted, extracellular space, extracellular matrix 1 VEGFA
cytoplasmic vesicle 1 TF
Early endosome 2 CD4, TF
clathrin-coated pit 1 TF
recycling endosome 2 TF, TNF
Single-pass type II membrane protein 1 TNF
vesicle 2 PIK3C2A, TF
Cytoplasm, perinuclear region 1 GGT2P
Membrane raft 2 CD4, TNF
focal adhesion 1 CAT
cis-Golgi network 1 GORASP1
extracellular matrix 1 VEGFA
Peroxisome 1 CAT
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
secretory granule 1 VEGFA
Late endosome 1 TF
ciliary basal body 1 ALB
phagocytic cup 1 TNF
centriole 1 ALB
Golgi apparatus, trans-Golgi network 1 PIK3C2A
spindle pole 1 ALB
blood microparticle 3 ALB, BCHE, TF
endosome lumen 1 INS
Lipid droplet 1 LIPE
Membrane, caveola 1 LIPE
basal plasma membrane 1 TF
clathrin-coated vesicle 1 PIK3C2A
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 3 CAT, INS, TF
HFE-transferrin receptor complex 1 TF
Golgi lumen 1 INS
endoplasmic reticulum lumen 6 ALB, BCHE, CD4, IL6, INS, TF
platelet alpha granule lumen 2 ALB, VEGFA
phosphatidylinositol 3-kinase complex 1 PIK3C2A
Cytoplasmic vesicle, clathrin-coated vesicle 1 PIK3C2A
endocytic vesicle 1 TF
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 2 GORASP1, INS
Golgi apparatus, cis-Golgi network membrane 1 GORASP1
nuclear envelope lumen 1 BCHE
clathrin-coated endocytic vesicle membrane 2 CD4, TF
vesicle coat 1 TF
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
T cell receptor complex 1 CD4
catalase complex 1 CAT
interleukin-6 receptor complex 1 IL6
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
ciliary transition fiber 1 ALB
dense body 1 TF
interleukin-28 receptor complex 1 IFNLR1
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Kristy R Kutanzi, Laura E Ewing, Charles M Skinner, Charles M Quick, Stefanie Kennon-McGill, Mitchell R McGill, Larry A Walker, Mahmoud A ElSohly, Bill J Gurley, Igor Koturbash. Safety and Molecular-Toxicological Implications of Cannabidiol-Rich Cannabis Extract and Methylsulfonylmethane Co-Administration. International journal of molecular sciences. 2020 Oct; 21(20):. doi: 10.3390/ijms21207808. [PMID: 33096940]
  • S Bittner, T Win, R Gupta. gamma-L-glutamyltaurine. Amino acids. 2005 Jun; 28(4):343-56. doi: 10.1007/s00726-005-0196-7. [PMID: 15838590]
  • S Baskin, D Bartuska, N Thampi, M McBride, J Finnigan. The effect of glutaurine on thyroid hormones in the rat. Neuropeptides. 1987 Jan; 9(1):45-50. doi: 10.1016/0143-4179(87)90031-x. [PMID: 3561723]
  • L Feuer, S U Nagy, G Csaba. Effect of glutaurine (gamma-l-glutamyl-taurine) on the serum glucocorticoid and estriol level in rats. Endokrinologie. 1982 Jul; 79(3):437-8. doi: NULL. [PMID: 7128556]
  • L Feuer, B L Tóth, L Bárdos. Effect of glutaurine (gamma-L-glutamyl-taurine) on serum, hepatic, and renal uric acid levels. Biochemical medicine. 1981 Dec; 26(3):326-9. doi: 10.1016/0006-2944(81)90008-9. [PMID: 7332543]
  • L Feuer, S Ormai. Effect of protein-free parathyroid extract (PF-PTE) and gamma-L-glutamyl-taurine (glutaurine) on X-ray induced hyperglycaemia in the rat. Acta medica Academiae Scientiarum Hungaricae. 1981; 38(2):159-62. doi: NULL. [PMID: 7034441]
  • NULL. How are tissue taurine concentrations regulated?. Advances in experimental medicine and biology. 1981; 139(?):403-26. doi: 10.1007/978-1-4757-0402-0_26. [PMID: 7331965]
  • L Feuer, K Gaál. Effect of glutaurine on plasma renin activity in the rat and the dog. General and comparative endocrinology. 1979 Nov; 39(3):330-5. doi: 10.1016/0016-6480(79)90129-1. [PMID: 499759]