Uroporphyrinogen I (BioDeep_00000005940)

 

Secondary id: BioDeep_00001869260

human metabolite PANOMIX_OTCML-2023 Endogenous PANOMIX_OTCML-2025


Metabolite Card


3-[9,14,19-tris(2-carboxyethyl)-5,10,15,20-tetrakis(carboxymethyl)-21,22,23,24-tetraazapentacyclo[16.2.1.1³,⁶.1⁸,¹¹.1¹³,¹⁶]tetracosa-1(20),3,5,8,10,13,15,18-octaen-4-yl]propanoic acid

  Formula: C40H44N4O16 (836.2752)
Chinese Names: 尿卟啉原I
  Spectrum Hits: Top Source Homo sapiens(otcml) 26.91%

Reviewed

Last reviewed on 2025-06-20.

Cite this Page

Uroporphyrinogen I. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/uroporphyrinogen_i (retrieved 2025-11-14) (BioDeep RN: BioDeep_00000005940). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

Molecular Structure

SMILES: C1C2=C(C(=C(N2)CC3=C(C(=C(N3)CC4=C(C(=C(N4)CC5=C(C(=C1N5)CC(=O)O)CCC(=O)O)CC(=O)O)CCC(=O)O)CC(=O)O)CCC(=O)O)CC(=O)O)CCC(=O)O
InChI: InChI=1S/C40H44N4O16/c45-33(46)5-1-17-21(9-37(53)54)29-14-26-19(3-7-35(49)50)23(11-39(57)58)31(43-26)16-28-20(4-8-36(51)52)24(12-40(59)60)32(44-28)15-27-18(2-6-34(47)48)22(10-38(55)56)30(42-27)13-25(17)41-29/h41-44H,1-16H2,(H,45,46)(H,47,48)(H,49,50)(H,51,52)(H,53,54)(H,55,56)(H,57,58)(H,59,60)


Description

Uroporphyrinogens are porphyrinogen variants in which each pyrrole ring has one acetate side chain and one propionate side chain; it is formed by condensation 4 four molecules of porphobilinogen. 4 isomers are possible but only 2 commoly are found, types I and III. Uroporphyrinogen III is a functional intermediate in heme biosynthesis while Uroporphyrinogen I is produced in an abortive side reaction. [HMDB]. Uroporphyrinogen I is found in many foods, some of which are great horned owl, nutmeg, lime, and cascade huckleberry.
Uroporphyrinogens are porphyrinogen variants in which each pyrrole ring has one acetate side chain and one propionate side chain; it is formed by condensation 4 four molecules of porphobilinogen. 4 isomers are possible but only 2 commoly are found, types I and III. Uroporphyrinogen III is a functional intermediate in heme biosynthesis while Uroporphyrinogen I is produced in an abortive side reaction.

Synonyms

13 synonym names

3-[9,14,19-tris(2-carboxyethyl)-5,10,15,20-tetrakis(carboxymethyl)-21,22,23,24-tetraazapentacyclo[16.2.1.1³,⁶.1⁸,¹¹.1¹³,¹⁶]tetracosa-1(20),3,5,8,10,13,15,18-octaen-4-yl]propanoic acid; 3,8,13,18-Tetrakis(carboxymethyl)-5,10,15,20,22,24-hexahydro-21H,23H-porphine-2,7,12,17-tetrapropanoic acid; 3,8,13,18-Tetrakis(carboxymethyl)-5,10,15,20,22,24-hexahydro-(8ci)-2,7,12,17-porphinetetrapropionic acid; 3,8,13,18-Tetrakis(carboxymethyl)-5,10,15,20,22,24-hexahydro-21H,23H-porphine-2,7,12,17-tetrapropanoate; 3,8,13,18-Tetrakis(carboxymethyl)-5,10,15,20,22,24-hexahydro-(8ci)-2,7,12,17-porphinetetrapropionate; 3,8,13,18-Tetrakis(carboxymethyl)-5,10,15,20,22,24-hexahydroporphyrin-2,7,12,17-tetrapropanoic acid; 3,8,13,18-Tetrakis(carboxymethyl)-5,10,15,20,22,24-hexahydroporphyrin-2,7,12,17-tetrapropionic acid; 3,8,13,18-Tetrakis(carboxymethyl)-5,10,15,20,22,24-hexahydroporphyrin-2,7,12,17-tetrapropionate; 3,8,13,18-Tetrakis(carboxymethyl)-5,10,15,20,22,24-hexahydroporphyrin-2,7,12,17-tetrapropanoate; Uroporphyrinogen-I; Uroporphyrinogen I; Urogen I; Uro'gen I



Cross Reference

15 cross reference id

Classification Terms

Related Pathways

Reactome()

BioCyc()

PlantCyc()

Biological Process

32 related biological process reactions.

Reactome(10)

BioCyc()

WikiPathways(1)

Plant Reactome()

INOH(1)

PlantCyc()

COVID-19 Disease Map()

PathBank(20)

PharmGKB()

2 organism taxonomy source information

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

Sub-cellular location Genes
Cytoplasm 5 AIP, CAT, CPOX, DTNB, HMBS
Peripheral membrane protein 2 CYP1B1, PPOX
Endoplasmic reticulum membrane 2 CYP1B1, HSP90B1
Nucleus 6 AIP, ALAD, DTNB, FEN1, GATA1, HSP90B1
cytosol 8 AIP, ALAD, CAT, CPOX, HMBS, HSP90B1, UROD, UROS
dendrite 1 DTNB
mitochondrial membrane 1 PPOX
nucleoplasm 5 AIP, CD2, FEN1, GATA1, UROD
Cell membrane 1 CD2
Synapse 2 DTNB, PPOX
cell surface 2 CD2, EPO
Golgi apparatus 1 CD2
Golgi membrane 1 C1GALT1
mitochondrial inner membrane 3 AIP, FECH, PPOX
postsynapse 2 DTNB, PPOX
smooth endoplasmic reticulum 1 HSP90B1
synaptic vesicle 1 PPOX
plasma membrane 3 CD2, DTNB, F9
Membrane 7 AIP, C1GALT1, CAT, CPOX, CYP1B1, FEN1, HSP90B1
extracellular exosome 5 ALAD, CAT, EPO, F9, HSP90B1
endoplasmic reticulum 1 HSP90B1
extracellular space 2 EPO, F9
perinuclear region of cytoplasm 2 HSP90B1, PPOX
mitochondrion 8 AIP, CAT, CPOX, CYP1B1, FECH, FEN1, PPOX, UROS
protein-containing complex 4 CAT, CD2, FEN1, HSP90B1
intracellular membrane-bounded organelle 3 AIP, CAT, CYP1B1
Microsome membrane 1 CYP1B1
postsynaptic density 1 DTNB
Single-pass type I membrane protein 1 CD2
Secreted 2 EPO, F9
extracellular region 7 ALAD, CAT, CD2, EPO, F9, HSP90B1, PPOX
cytoplasmic side of plasma membrane 1 CD2
Mitochondrion matrix 1 AIP
mitochondrial matrix 3 AIP, CAT, FECH
transcription regulator complex 1 GATA1
external side of plasma membrane 1 CD2
neuronal dense core vesicle lumen 1 PPOX
cytoplasmic vesicle 1 PPOX
nucleolus 1 FEN1
midbody 1 HSP90B1
cell-cell junction 1 CD2
Single-pass type II membrane protein 1 C1GALT1
Mitochondrion inner membrane 2 FECH, PPOX
focal adhesion 2 CAT, HSP90B1
Peroxisome 1 CAT
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
mitochondrial intermembrane space 2 CPOX, PPOX
collagen-containing extracellular matrix 2 F9, HSP90B1
chromatin 1 GATA1
Nucleus, nucleolus 1 FEN1
chromosome, telomeric region 1 FEN1
aryl hydrocarbon receptor complex 1 AIP
Nucleus, nucleoplasm 1 FEN1
Cell projection, dendrite 1 DTNB
Melanosome 1 HSP90B1
cell body 1 EPO
sperm plasma membrane 1 HSP90B1
basal plasma membrane 1 DTNB
ficolin-1-rich granule lumen 2 ALAD, CAT
secretory granule lumen 3 ALAD, CAT, EPO
Golgi lumen 1 F9
endoplasmic reticulum lumen 2 F9, HSP90B1
transcription repressor complex 1 GATA1
Sarcoplasmic reticulum lumen 1 HSP90B1
Basal cell membrane 1 DTNB
protein-DNA complex 1 GATA1
Rough endoplasmic reticulum 1 PPOX
Intermembrane side 1 PPOX
mitochondrial small ribosomal subunit 1 AIP
inhibitory synapse 1 DTNB
endocytic vesicle lumen 1 HSP90B1
catalase complex 1 CAT
endoplasmic reticulum chaperone complex 1 HSP90B1
[Isoform FENMIT]: Mitochondrion 1 FEN1


Literature Reference