Jintan (BioDeep_00000000594)
Secondary id: BioDeep_00000871995
PANOMIX_OTCML-2023
代谢物信息卡片
(2S,3S,4S,5R,6R)-6-[(2S,3R,4S,5S,6S)-2-[[(3S,4aR,6aR,6bS,8aS,11S,12aR,14aR,14bS)-11-carboxy-4,4,6a,6b,8a,11,14b-heptamethyl-14-oxo-2,3,4a,5,6,7,8,9,10,12,12a,14a-dodecahydro-1H-picen-3-yl]oxy]-6-carboxy-4,5-dihydroxyoxan-3-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid;azane
化学式: C42H61O16.NH4 (839.4303)
中文名称: 甘草酸一铵, 甘草酸铵, 甘草酸铵盐, 甘草酸单铵
谱图信息:
最多检出来源 Chinese Herbal Medicine(otcml) 91.87%
分子结构信息
SMILES: CC1(C2CCC3(C(C2(CCC1OC4C(C(C(C(O4)C(=O)O)O)O)OC5C(C(C(C(O5)C(=O)O)O)O)O)C)C(=O)C=C6C3(CCC7(C6CC(CC7)(C)C(=O)O)C)C)C)C.N
InChI: /m0./s1
描述信息
Monoammonium glycyrrhizinate is an organic molecular entity.
An oleanolic acid from GLYCYRRHIZA that has some antiallergic, antibacterial, and antiviral properties. It is used topically for allergic or infectious skin inflammation and orally for its aldosterone effects in electrolyte regulation.
D000893 - Anti-Inflammatory Agents
Ammonium glycyrrhizinate (Monoammonium glycyrrhizinate) has various pharmacological actions such as anti-inflammatory, antiallergic, antigastriculcer, and antihepatitis activities.
Ammonium glycyrrhizinate (Monoammonium glycyrrhizinate) has various pharmacological actions such as anti-inflammatory, antiallergic, antigastriculcer, and antihepatitis activities.
同义名列表
75 个代谢物同义名
(2S,3S,4S,5R,6R)-6-[(2S,3R,4S,5S,6S)-2-[[(3S,4aR,6aR,6bS,8aS,11S,12aR,14aR,14bS)-11-carboxy-4,4,6a,6b,8a,11,14b-heptamethyl-14-oxo-2,3,4a,5,6,7,8,9,10,12,12a,14a-dodecahydro-1H-picen-3-yl]oxy]-6-carboxy-4,5-dihydroxyoxan-3-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid;azane; (2S,3S,4S,5R,6R)-6-[(2S,3R,4S,5S,6S)-2-[[(3S,4aR,6aR,6bS,8aS,11S,12aR,14aR,14bS)-11-carboxy-4,4,6a,6b,8a,11,14b-heptamethyl-14-oxo-2,3,4a,5,6,7,8,9,10,12,12a,14a-dodecahydro-1H-picen-3-yl]oxy]-6-carboxy-4,5-dihydroxyoxan-3-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylicacid;azane; .alpha.-D-Glucopyranosiduronic acid, (3.beta.,20.beta.)-20-carboxy-11-oxo-30-norolean-12-en-3-yl 2-O-.beta.-D-glucopyranuronosyl-, monoammonium salt; .ALPHA.-D-GLUCOPYRANOSIDURONIC ACID, (3-.BETA.,20-.BETA.)-20-CARBOXY-11-OXO-30-NOROLEAN-12-EN-3-YL 2-O-.BETA.-D-GLUCOPYRANURONOSYL-, AMMONIATE; alpha-D-Glucopyranosiduronic acid, (3beta,20beta)-20-carboxy-11-oxo-30-norolean-12-en-3-yl 2-O-beta-D-glucopyranuronosyl-, ammonium salt (1:1); .ALPHA.-D-GLUCOPYRANOSIDURONIC ACID, (3-.BETA.,20.BETA.)-20-CARBOXY-11-OXO-30-NOROLEAN-12-EN-3-YL 2-O-.BETA.-D-GLUCOPYRANURONOSYL-, AMMONIATE; alpha-D-Glucopyranosiduronic acid, (3beta,20beta)-20-carboxy-11-oxo-30-norolean-12-en-3-yl 2-O-beta-D-glucopyranuronosyl-, monoammonium salt; alpha-D-Glucopyranosiduronic acid, (3-beta,20-beta)-20-carboxy-11-oxo-30-norolean-12-en-3-yl 2-O-beta-D-glucopyranuronosyl-, ammoniate; alpha-D-Glucopyranosiduronic acid, (3beta,20beta)-20-carboxy-11-oxo-30-norlean-12-en-3-yl-2-O-beta-D- -glucopyranuronosyl-, ammoniate; Monoammonium (3beta,20beta)-20-carboxy-11-oxo-30-norolean-12-en-3-yl 2-O-beta-D-glucopyranuronosyl-alpha-D-glucopyranosidu; alpha-D-Glucopyranosiduronic acid, (3beta,20beta)-20-carboxy-11-oxo-30-norolean-12-en-3-yl 2-O-beta-D-glucopyranuronosyl-,; Ammonium Glycyrrhizate, Pharmaceutical Secondary Standard; Certified Reference Material; Ammonium glycyrrhizate, United States Pharmacopeia (USP) Reference Standard; Glycyrrhizic acid ammonium salt, primary pharmaceutical reference standard; Glycyrrhizate monoammonium, European Pharmacopoeia (EP) Reference Standard; Ammonium glycyrrhizate, European Pharmacopoeia (EP) Reference Standard; Glycyrrhizic acid ammonium salt, analytical standard, for HPLC; Glycyrrhizin, ammoniated (Glycyrrhiza spp.); GLYCYRRHIZIC ACID, AMMONIUM SALT [WHO-DD]; Glycyrrhizinic acid, ammonium salt (1:1); AMMONIUM GLYCYRRHIZATE [EP MONOGRAPH]; Monoammonium glycyrrhizinate hydrate; Glycyrrhizic acid, monoammonium salt; AMMONIUM DIHYDROGEN GLYCYRRHIZINATE; glycyrrhizic acid monoammonium salt; GLYCYRRHIZIN, AMMONIATED ANHYDROUS; Monoammonium glycyrrhizinate (JAN); MONOAMMONIUM GLYCYRRHIZINATE [JAN]; MONOAMMONIUM GLYCYRRHIZINATE [FCC]; Monoammonium 18|A-glycyrrhizinate; Glycyrrhizic acid, ammonium salt; Ammonium Glycyrrhizinate (AMGZ); GLYCYRRHIZIN, AMMONIATED [FHFI]; Glycyrrhizic acid ammonium salt; Glycyrrhizin Acid Ammonium Salt; AMMONIUM GLYCYRRHIZATE [USP-RS]; AMMONIUM GLYCYRRHIZATE [INCI]; AMMONIATED GLYCYRRHIZIN [FCC]; GLYCYRRHIZIN, AMMONIATED [II]; Monoammonium glycyrrhizinate; AMMONIUM GLYCYRRHIZATE [II]; Ammonium glycyrrhizate (NF); ILRKKHJEINIICQ-OOFFSTKBSA-N; Monoammonium glycyrrhizate; Glycyrrhizin, ammoniated; AMMONIUM GLYCYRRHIZINATE; Glycyrrhizin ammoniacal; GLYCYRRHIZIN AMMONIATED; Ammoniated glycyrrhizin; Ammonium glycyrrhizate; Acid, Glycyrrhetinic; Glycyrrhetinic Acid; Glycyron No.1 (TN); Acid, Glycyrrhetic; Glycyrrhetic acid; UNII-3VRD35U26C; Acid, Uralenic; Acid, Rhetinic; Uralenic acid; AMGZ;Glycyram; Rhetinic Acid; Magnasweet; 3VRD35U26C; Arthrodont; Glycyrram; Enoxolone; Glyciram; Glycyram; Glycamil; Jintan; 12, Po; Po 12; AMGZ; Glycyrrhizic acid (ammonium salt); Monoammonium glycyrrhizinate
数据库引用编号
11 个数据库交叉引用编号
- ChEBI: CHEBI:81864
- KEGG: C18610
- KEGGdrug: D04987
- PubChem: 62074
- MeSH: Glycyrrhetinic Acid
- ChemIDplus: 0053956040
- CAS: 53956-04-0
- CAS: 1407-03-0
- medchemexpress: HY-76225
- PubChem: 124489284
- KNApSAcK: 81864
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Yamei Jiang, Chengzhe Cai, Pingbao Zhang, Yongsheng Luo, Jingjing Guo, Jiawei Li, Ruiming Rong, Yi Zhang, Tongyu Zhu. Transcriptional profile changes after treatment of ischemia reperfusion injury-induced kidney fibrosis with 18β-glycyrrhetinic acid.
Renal failure.
2022 Dec; 44(1):660-671. doi:
10.1080/0886022x.2022.2061998. [PMID: 35699239] - Cuneyt Caglayan, Fatih Mehmet Kandemir, Adnan Ayna, Cihan Gür, Sefa Küçükler, Ekrem Darendelioğlu. Neuroprotective effects of 18β-glycyrrhetinic acid against bisphenol A-induced neurotoxicity in rats: involvement of neuronal apoptosis, endoplasmic reticulum stress and JAK1/STAT1 signaling pathway.
Metabolic brain disease.
2022 08; 37(6):1931-1940. doi:
10.1007/s11011-022-01027-z. [PMID: 35699857] - Huawei Li, Jia You, Xi Yang, Yuanfeng Wei, Lingnan Zheng, Yaqin Zhao, Ying Huang, Zhao Jin, Cheng Yi. Glycyrrhetinic acid: A potential drug for the treatment of COVID-19 cytokine storm.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2022 Jul; 102(?):154153. doi:
10.1016/j.phymed.2022.154153. [PMID: 35636166] - Zhangting Wang, Jiang Ma, Yisheng He, Kai-Kei Miu, Sheng Yao, Chunping Tang, Yang Ye, Ge Lin. Nrf2-mediated liver protection by 18β-glycyrrhetinic acid against pyrrolizidine alkaloid-induced toxicity through PI3K/Akt/GSK3β pathway.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2022 Jul; 102(?):154162. doi:
10.1016/j.phymed.2022.154162. [PMID: 35598524] - Liqin Wang, Haiming Deng, Tengyu Wang, Yun Qiao, Jianbing Zhu, Mingfeng Xiong. Investigation into the protective effects of hypaconitine and glycyrrhetinic acid against chronic heart failure of the rats.
BMC complementary medicine and therapies.
2022 Jun; 22(1):160. doi:
10.1186/s12906-022-03632-y. [PMID: 35710396] - Fang-Ning Chen, Xiu-Li Wang, Rui-Rui Xu, Xiao-Jie Wang, Jing-Hua Ruan. [Preparation of tanshinone Ⅱ_A-glycyrrhetinic acid solid lipid nanoparticles and its inhibitory effect on acne].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2022 May; 47(9):2449-2456. doi:
10.19540/j.cnki.cjcmm.20210323.303. [PMID: 35531692] - Ling-Chun Chen, Wei-Jie Cheng, Shyr-Yi Lin, Ming-Tse Hung, Ming-Thau Sheu, Hong-Liang Lin, Chien-Ming Hsieh. CPT11 with P-glycoprotein/CYP 3A4 dual-function inhibitor by self-nanoemulsifying nanoemulsion combined with gastroretentive technology to enhance the oral bioavailability and therapeutic efficacy against pancreatic adenocarcinomas.
Drug delivery.
2021 Dec; 28(1):2205-2217. doi:
10.1080/10717544.2021.1989087. [PMID: 34662257] - David J Morris, Andrew S Brem, Alex Odermatt. Modulation of 11β-hydroxysteroid dehydrogenase functions by the cloud of endogenous metabolites in a local microenvironment: The glycyrrhetinic acid-like factor (GALF) hypothesis.
The Journal of steroid biochemistry and molecular biology.
2021 11; 214(?):105988. doi:
10.1016/j.jsbmb.2021.105988. [PMID: 34464733] - Ibtesam S Alanazi, Mohamed Emam, Mabrouk Elsabagh, Saad Alkahtani, Mohamed M Abdel-Daim. The protective effects of 18β-glycyrrhetinic acid against acrylamide-induced cellular damage in diabetic rats.
Environmental science and pollution research international.
2021 Nov; 28(41):58322-58330. doi:
10.1007/s11356-021-14742-4. [PMID: 34117542] - Tao Yang, Jing Zhou, Lei Fang, Minmin Wang, Maimaitiyiming Dilinuer, Aikemu Ainiwaer. Protection function of 18β-glycyrrhetinic acid on rats with high-altitude pulmonary hypertension based on 1H NMR metabonomics technology.
Analytical biochemistry.
2021 10; 631(?):114342. doi:
10.1016/j.ab.2021.114342. [PMID: 34419454] - Yusen Xiang, Mengge Wang, Hongzhuan Chen, Lili Chen. Potential therapeutic approaches for the early entry of SARS-CoV-2 by interrupting the interaction between the spike protein on SARS-CoV-2 and angiotensin-converting enzyme 2 (ACE2).
Biochemical pharmacology.
2021 10; 192(?):114724. doi:
10.1016/j.bcp.2021.114724. [PMID: 34371003] - V E Vallejo-Garcia, A Barrio-Rodriguez, M Heras-Benito. [Acute myocardial infarction and severe hypokalaemia due to liquorice consumption during COVID-19 confinement].
Hipertension y riesgo vascular.
2021 Jul; 38(3):e10-e12. doi:
10.1016/j.hipert.2021.02.004. [PMID: 33715981] - Luisa Diomede, Marten Beeg, Alessio Gamba, Oscar Fumagalli, Marco Gobbi, Mario Salmona. Can Antiviral Activity of Licorice Help Fight COVID-19 Infection?.
Biomolecules.
2021 06; 11(6):. doi:
10.3390/biom11060855. [PMID: 34201172] - Hongbo Wang, Jiawei Zuo, Liang Zha, Xia Jiang, Caixia Wu, Yong-An Yang, Wenjian Tang, Tianlu Shi. Design and synthesis of novel glycyrrhetin ureas as anti-inflammatory agents for the treatment of acute kidney injury.
Bioorganic chemistry.
2021 05; 110(?):104755. doi:
10.1016/j.bioorg.2021.104755. [PMID: 33652342] - T M J van Bakel, J M van der Klooster, F Borst, L C Urlings-Strop. [Hypokalemia due to a liquorice-containing thirst-quencher].
Nederlands tijdschrift voor geneeskunde.
2020 11; 164(?):. doi:
. [PMID: 33331713] - Hong Ding, Wenjun Deng, Lingling Ding, Xiaoqun Ye, Shanye Yin, Weishan Huang. Glycyrrhetinic acid and its derivatives as potential alternative medicine to relieve symptoms in nonhospitalized COVID-19 patients.
Journal of medical virology.
2020 10; 92(10):2200-2204. doi:
10.1002/jmv.26064. [PMID: 32458502] - Min Huang, Ping Gong, Yuetong Wang, Xiaorui Xie, Zhuangshi Ma, Qihao Xu, Dan Liu, Yongkui Jing, Linxiang Zhao. Synthesis and antitumor effects of novel 18β-glycyrrhetinic acid derivatives featuring an exocyclic α,β-unsaturated carbonyl moiety in ring A.
Bioorganic chemistry.
2020 10; 103(?):104187. doi:
10.1016/j.bioorg.2020.104187. [PMID: 32890994] - Elazer R Edelman, Neel M Butala, Laura L Avery, Andrew L Lundquist, Anand S Dighe. Case 30-2020: A 54-Year-Old Man with Sudden Cardiac Arrest.
The New England journal of medicine.
2020 Sep; 383(13):1263-1275. doi:
10.1056/nejmcpc2002420. [PMID: 32966726] - Chenxiao Shan, Qi Yuan, Xiaobing Cui, Chuan Chai, Sheng Yu, Hongmei Wen, Xi Huang. Simultaneous quantitation of glycyrrhetic acid and puerarin in plasma using ultra flow liquid chromatography tandem mass spectrometry and application in a pharmacokinetics study in healthy and alcoholic liver injury rats.
Biomedical chromatography : BMC.
2020 Jun; 34(6):e4818. doi:
10.1002/bmc.4818. [PMID: 32110832] - Xiaoli Cheng, Linwei Qiu, Fen Wang. 18α-Glycyrrhetinic acid (GA) ameliorates fructose-induced nephropathy in mice by suppressing oxidative stress, dyslipidemia and inflammation.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2020 May; 125(?):109702. doi:
10.1016/j.biopha.2019.109702. [PMID: 32106383] - Jiaying Song, Huizhen Dai, Huan Zhang, Yanchao Liu, Wenjing Zhang. Influence of glycyrrhetinic acid on the pharmacokinetics of warfarin in rats.
Xenobiotica; the fate of foreign compounds in biological systems.
2020 May; 50(5):602-605. doi:
10.1080/00498254.2019.1671637. [PMID: 31542982] - Hesham Eed Desouky, Guang-Zhen Jiang, Ding-Dong Zhang, Kenneth Prudence Abasubong, Xiangyang Yuan, Xiang-Fei Li, Wen-Bin Liu. Influences of glycyrrhetinic acid (GA) dietary supplementation on growth, feed utilization, and expression of lipid metabolism genes in channel catfish (Ictalurus punctatus) fed a high-fat diet.
Fish physiology and biochemistry.
2020 Apr; 46(2):653-663. doi:
10.1007/s10695-019-00740-4. [PMID: 31897860] - Seon Yu Lee, Ji Hyun Jeong, Bo Na Kim, So Jung Park, Yang-Chun Park, Guk Yeo Lee. LC-MS/MS analysis of puerarin and 18β-glycyrrhetinic acid in human plasma after oral administration of Samso-eum and its application to pharmacokinetic study.
Biomedical chromatography : BMC.
2020 Apr; 34(4):e4774. doi:
10.1002/bmc.4774. [PMID: 31813157] - Atsushi Tsuge, Shinsuke Hisaka, Hiroaki Hayashi, Mitsuhiko Nose. Effect of hot water extract of a glycyrrhizin-deficient strain of Glycyrrhiza uralensis on contact hypersensitivity in mice.
Journal of natural medicines.
2020 Mar; 74(2):415-420. doi:
10.1007/s11418-019-01386-5. [PMID: 31916003] - Xiaofeng Shen, Ling Li, Qihan Ma, Hua Chen, Jiangping Wang, Lei Lv, Yuwei Li. Pharmacokinetic study of eight bioactive components following oral administration of Zhiqiao Gancao decoction and observation of its clinical efficacy.
Biomedical chromatography : BMC.
2020 Feb; 34(2):e4706. doi:
10.1002/bmc.4706. [PMID: 31629372] - Junko Ishizaki, Chihiro Nakano, Kana Kitagawa, Yukio Suga, Yoshimichi Sai. A Previously Unknown Drug-Drug Interaction Is Suspected in Delayed Elimination of Plasma Methotrexate in High-Dose Methotrexate Therapy.
The Annals of pharmacotherapy.
2020 01; 54(1):29-35. doi:
10.1177/1060028019870445. [PMID: 31416331] - Amr Hefnawy, Islam H Khalil, Kholoud Arafa, Marwan Emara, Ibrahim M El-Sherbiny. Dual-Ligand Functionalized Core-Shell Chitosan-Based Nanocarrier for Hepatocellular Carcinoma-Targeted Drug Delivery.
International journal of nanomedicine.
2020; 15(?):821-837. doi:
10.2147/ijn.s240359. [PMID: 32103939] - Ting Zhou, Xin Tang, Wei Zhang, Jianfang Feng, Wei Wu. Preparation and in vitro and in vivo evaluations of 10-hydroxycamptothecin liposomes modified with stearyl glycyrrhetinate.
Drug delivery.
2019 Dec; 26(1):673-679. doi:
10.1080/10717544.2019.1636422. [PMID: 31266376] - Xujie Jiang, Ge Kuang, Xia Gong, Rong Jiang, Tianjun Xie, Hongtao Tie, Shengwang Wu, Ting Wang, Jingyuan Wan, Bin Wang. Glycyrrhetinic acid pretreatment attenuates liver ischemia/reperfusion injury via inhibiting TLR4 signaling cascade in mice.
International immunopharmacology.
2019 Nov; 76(?):105870. doi:
10.1016/j.intimp.2019.105870. [PMID: 31493667] - Jennifer A Easton, Ahmad K Albuloushi, Miriam A F Kamps, Gladys H M R Brouns, Jos L V Broers, Barry J Coull, Vincent Oji, Michel van Geel, Maurice A M van Steensel, Patricia E Martin. A rare missense mutation in GJB3 (Cx31G45E) is associated with a unique cellular phenotype resulting in necrotic cell death.
Experimental dermatology.
2019 10; 28(10):1106-1113. doi:
10.1111/exd.13542. [PMID: 29570224] - Fei Zhou, Gao-Rong Wu, De-Sheng Cai, Bing Xu, Meng-Meng Yan, Tao Ma, Wen-Bo Guo, Wen-Xi Zhang, Xue-Mei Huang, Xiao-Hui Jia, Yu-Qin Yang, Feng Gao, Peng-Long Wang, Hai-Min Lei. Synthesis and biological activity of glycyrrhetinic acid derivatives as antitumor agents.
European journal of medicinal chemistry.
2019 Sep; 178(?):623-635. doi:
10.1016/j.ejmech.2019.06.029. [PMID: 31226654] - Neng Zhou, Caiyuan Zou, Menglin Qin, Yi Li, Jiayi Huang. A simple method for evaluation pharmacokinetics of glycyrrhetinic acid and potential drug-drug interaction between herbal ingredients.
Scientific reports.
2019 08; 9(1):11308. doi:
10.1038/s41598-019-47880-4. [PMID: 31383927] - Jun-Jin Liu, Yao Cheng, Yun-Yun Shao, Zhuang-Peng Chang, Yi-Ting Guo, Xiao-Juan Feng, Ding Xu, Jing-Ping Zhang, Yan Song, Rui-Gang Hou. Comparative pharmacokinetics and metabolites study of seven major bioactive components of Shaoyao-Gancao decoction in normal and polycystic ovary syndrome rats by ultra high pressure liquid chromatography with tandem mass spectrometry.
Journal of separation science.
2019 Aug; 42(15):2534-2549. doi:
10.1002/jssc.201900002. [PMID: 31144455] - J Ji, Y Gui, Y H Wang, Y Hou, K B Chen, K H Xi, X W Chen, X H Liu, X B Zhang. [The inhibition of 18β-sodium glycyrrhetinic acid on thymic stromal lymphopoietin expression in the nasal mucosa of allergic rhinitis rats].
Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery.
2019 Jun; 54(6):456-463. doi:
10.3760/cma.j.issn.1673-0860.2019.06.011. [PMID: 31262112] - Mitsuhiko Nose, Kazuma Yamanaka, Shinsuke Hisaka, Takayuki Inui, Noriaki Kawano, Shigeki Hayashi, Atsuyuki Hishida, Hiroyuki Fuchino, Nobuo Kawahara, Kayo Yoshimatsu. Evaluation of the safety and efficacy of Glycyrrhiza uralensis root extracts produced using artificial hydroponic-field hybrid cultivation systems II: comparison of serum concentration of glycyrrhetinic acid serum concentration in mice.
Journal of natural medicines.
2019 Jun; 73(3):661-666. doi:
10.1007/s11418-019-01312-9. [PMID: 31028662] - Shuobin Liang, Man Li, Xiaojuan Yu, Hongwei Jin, Yongmin Zhang, Lihe Zhang, Demin Zhou, Sulong Xiao. Synthesis and structure-activity relationship studies of water-soluble β-cyclodextrin-glycyrrhetinic acid conjugates as potential anti-influenza virus agents.
European journal of medicinal chemistry.
2019 Mar; 166(?):328-338. doi:
10.1016/j.ejmech.2019.01.074. [PMID: 30731401] - Yin Wu, Pengqian Wang, Haotian Yang, Feng Sui. UPLC-Q-TOF-MS and UPLC-MS/MS methods for metabolism profiles and pharmacokinetics of major compounds in Xuanmai Ganjie Granules.
Biomedical chromatography : BMC.
2019 Mar; 33(3):e4449. doi:
10.1002/bmc.4449. [PMID: 30513133] - Mohamed A Morsy, Snehal S Patel, Azza A K El-Sheikh, Jignasa K Savjani, Anroop B Nair, Jigar N Shah, Katharigatta N Venugopala. Computational and Biological Comparisons of Plant Steroids as Modulators of Inflammation through Interacting with Glucocorticoid Receptor.
Mediators of inflammation.
2019; 2019(?):3041438. doi:
10.1155/2019/3041438. [PMID: 31263381] - Shou-Yan Wu, Shi-Chao Cui, Le Wang, Yi-Ting Zhang, Xiao-Xia Yan, Heng-Lei Lu, Guo-Zhen Xing, Jin Ren, Li-Kun Gong. 18β-Glycyrrhetinic acid protects against alpha-naphthylisothiocyanate-induced cholestasis through activation of the Sirt1/FXR signaling pathway.
Acta pharmacologica Sinica.
2018 Dec; 39(12):1865-1873. doi:
10.1038/s41401-018-0110-y. [PMID: 30061734] - Feiyan Liu, Dan Yang, Yawen Liu, Qianqian Cao, Yulian Sun, Qiong Wang, Hao Tang. Improving dispersive property, biocompatibility and targeting gene transfection of graphene oxide by covalent attachment of polyamidoamine dendrimer and glycyrrhetinic acid.
Colloids and surfaces. B, Biointerfaces.
2018 Nov; 171(?):622-628. doi:
10.1016/j.colsurfb.2018.07.067. [PMID: 30103151] - Osamu Morinaga, Kan'ichiro Ishiuchi, Takeshi Ohkita, Chuanting Tian, Asuka Hirasawa, Miaki Mitamura, Yasuhito Maki, Tomoya Yasujima, Hiroaki Yuasa, Toshiaki Makino. Isolation of a novel glycyrrhizin metabolite as a causal candidate compound for pseudoaldosteronism.
Scientific reports.
2018 10; 8(1):15568. doi:
10.1038/s41598-018-33834-9. [PMID: 30348944] - Rauf Melekoglu, Osman Ciftci, Sevil Eraslan, Saadet Alan, Nese Basak. The Protective Effects of Glycyrrhetinic Acid and Chrysin against Ischemia-Reperfusion Injury in Rat Ovaries.
BioMed research international.
2018; 2018(?):5421308. doi:
10.1155/2018/5421308. [PMID: 29862276] - Bo Ge, Daping Yang, Xinmou Wu, Jing Zhu, Wu Wei, Bin Yang. Cytoprotective effects of glycyrrhetinic acid liposome against cyclophosphamide-induced cystitis through inhibiting inflammatory stress.
International immunopharmacology.
2018 Jan; 54(?):139-144. doi:
10.1016/j.intimp.2017.11.010. [PMID: 29136560] - Tsuneharu Suzuki, Michiko Tsukahara, Yuko Akasaka, Hideo Inoue. A highly sensitive LC-MS/MS method for simultaneous determination of glycyrrhizin and its active metabolite glycyrrhetinic acid: Application to a human pharmacokinetic study after oral administration.
Biomedical chromatography : BMC.
2017 Dec; 31(12):. doi:
10.1002/bmc.4032. [PMID: 28623864] - Su Jin, Xiu-Li Wang, Geng Li. [Preparation and in vivo study of liposomes mediated by glycyrrhetinic acid derivative ligand 18-GA-Gly].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2017 Nov; 42(21):4120-4126. doi:
10.19540/j.cnki.cjcmm.20170928.024. [PMID: 29271149] - Na Zhang, Yueting Li, Jing Sun, Chun Li, Yuelin Song, Jun Li, Pengfei Tu, Yunfang Zhao. Simultaneous Determination of Twenty-Five Compounds in Rat Plasma Using Ultra-High Performance Liquid Chromatography-Polarity Switching Tandem Mass Spectrometry and Its Application to a Pharmacokinetic Study.
Molecules (Basel, Switzerland).
2017 Oct; 22(11):. doi:
10.3390/molecules22111853. [PMID: 29084165] - Andrey V Markov, Alexandra V Sen'kova, Dawid Warszycki, Oksana V Salomatina, Nariman F Salakhutdinov, Marina A Zenkova, Evgeniya B Logashenko. Soloxolone methyl inhibits influenza virus replication and reduces virus-induced lung inflammation.
Scientific reports.
2017 10; 7(1):13968. doi:
10.1038/s41598-017-14029-0. [PMID: 29070858] - Zhaoyu Wang, Yao Lan, MingHao Chen, Cailing Wen, Yanxian Hu, Zhongqiu Liu, Ling Ye. Eriodictyol, Not Its Glucuronide Metabolites, Attenuates Acetaminophen-Induced Hepatotoxicity.
Molecular pharmaceutics.
2017 09; 14(9):2937-2951. doi:
10.1021/acs.molpharmaceut.7b00345. [PMID: 28654297] - Firouzeh Manouchehri, Yahya Izadmanesh, Jahan B Ghasemi. Characterization of the interaction of glycyrrhizin and glycyrrhetinic acid with bovine serum albumin by spectrophotometric-gradient flow injection titration technique and molecular modeling simulations.
International journal of biological macromolecules.
2017 Sep; 102(?):92-103. doi:
10.1016/j.ijbiomac.2017.02.106. [PMID: 28377238] - Qianying Chen, Hongzhu Chen, Wenjie Wang, Jiali Liu, Wenyue Liu, Ping Ni, Guowei Sang, Guangji Wang, Fang Zhou, Jingwei Zhang. Glycyrrhetic acid, but not glycyrrhizic acid, strengthened entecavir activity by promoting its subcellular distribution in the liver via efflux inhibition.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2017 Aug; 106(?):313-327. doi:
10.1016/j.ejps.2017.06.015. [PMID: 28627473] - Taoguang Huo, Ying Fang, Yinghua Zhang, Yanlei Wang, Cong Feng, Mingmei Yuan, Shouyun Wang, Mo Chen, Hong Jiang. Plasma metabolomics study of the hepatoprotective effect of glycyrrhetinic acid on realgar-induced sub-chronic hepatotoxicity in mice via 1H NMR analysis.
Journal of ethnopharmacology.
2017 Aug; 208(?):36-43. doi:
10.1016/j.jep.2017.06.043. [PMID: 28673699] - Jinglong Wang, Dandan Zheng, Yingzi Wang, Chao Zhang, Xiumei Sun. Pharmacokinetics study of Erhuang decoction extracts in rats by HPLC-MS/MS.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2017 Aug; 1059(?):35-42. doi:
10.1016/j.jchromb.2017.05.019. [PMID: 28570935] - Wenping Wang, Yaya Lei, Hong Sui, Wenping Zhang, Rongyue Zhu, Jun Feng, Hong Wang. Fabrication and evaluation of nanoparticle-assembled BSA microparticles for enhanced liver delivery of glycyrrhetinic acid.
Artificial cells, nanomedicine, and biotechnology.
2017 Jun; 45(4):740-747. doi:
10.1080/21691401.2016.1193024. [PMID: 27267996] - Yifei Yang, Lingyun Yang, Yaodan Han, Zhenwei Wu, Pan Chen, Huibin Zhang, Jinpei Zhou. Protective effects of hepatocyte-specific glycyrrhetic derivatives against carbon tetrachloride-induced liver damage in mice.
Bioorganic chemistry.
2017 06; 72(?):42-50. doi:
10.1016/j.bioorg.2017.03.009. [PMID: 28346874] - Ayman M Mahmoud, Omnia E Hussein, Walaa G Hozayen, Sanaa M Abd El-Twab. Methotrexate hepatotoxicity is associated with oxidative stress, and down-regulation of PPARγ and Nrf2: Protective effect of 18β-Glycyrrhetinic acid.
Chemico-biological interactions.
2017 May; 270(?):59-72. doi:
10.1016/j.cbi.2017.04.009. [PMID: 28414158] - Bin Ji, Limeng Zhuo, Bin Yang, Yang Wang, Lin Li, Miao Yu, Yunli Zhao, Zhiguo Yu. Development and validation of a sensitive and fast UPLC-MS/MS method for simultaneous determination of seven bioactive compounds in rat plasma after oral administration of Guizhi-gancao decoction.
Journal of pharmaceutical and biomedical analysis.
2017 Apr; 137(?):23-32. doi:
10.1016/j.jpba.2017.01.021. [PMID: 28088663] - Zenya Saito, Yugo Kaneko, Akira Kinoshita, Yusuke Kurita, Kyuto Odashima, Tsugumi Horikiri, Yutaka Yoshii, Aya Seki, Yoshitaka Seki, Hiroshi Takeda, Kazuyoshi Kuwano. Effectiveness of hepatoprotective drugs for anti-tuberculosis drug-induced hepatotoxicity: a retrospective analysis.
BMC infectious diseases.
2016 Nov; 16(1):668. doi:
10.1186/s12879-016-2000-6. [PMID: 27835982] - Md Ataur Rahman, Kausik Bishayee, Khadija Habib, Ali Sadra, Sung-Oh Huh. 18α-Glycyrrhetinic acid lethality for neuroblastoma cells via de-regulating the Beclin-1/Bcl-2 complex and inducing apoptosis.
Biochemical pharmacology.
2016 10; 117(?):97-112. doi:
10.1016/j.bcp.2016.08.006. [PMID: 27520483] - Sanaa M Abd El-Twab, Walaa G Hozayen, Omnia E Hussein, Ayman M Mahmoud. 18β-Glycyrrhetinic acid protects against methotrexate-induced kidney injury by up-regulating the Nrf2/ARE/HO-1 pathway and endogenous antioxidants.
Renal failure.
2016 Oct; 38(9):1516-1527. doi:
10.1080/0886022x.2016.1216722. [PMID: 27499091] - Yi Zhu, Yong Gao, Caroline Tao, Mengle Shao, Shangang Zhao, Wei Huang, Ting Yao, Joshua A Johnson, Tiemin Liu, Aaron M Cypess, Olga Gupta, William L Holland, Rana K Gupta, David C Spray, Herbert B Tanowitz, Lei Cao, Matthew D Lynes, Yu-Hua Tseng, Joel K Elmquist, Kevin W Williams, Hua V Lin, Philipp E Scherer. Connexin 43 Mediates White Adipose Tissue Beiging by Facilitating the Propagation of Sympathetic Neuronal Signals.
Cell metabolism.
2016 09; 24(3):420-433. doi:
10.1016/j.cmet.2016.08.005. [PMID: 27626200] - Raman Rohilla, Tarun Garg, Jitender Bariwal, Amit K Goyal, Goutam Rath. Development, optimization and characterization of glycyrrhetinic acid-chitosan nanoparticles of atorvastatin for liver targeting.
Drug delivery.
2016 Sep; 23(7):2290-2297. doi:
10.3109/10717544.2014.977460. [PMID: 25379806] - Chun Chih Chen, Dennis Kolosov, Scott P Kelly. The liquorice root derivative glycyrrhetinic acid can ameliorate ionoregulatory disturbance in rainbow trout (Oncorhynchus mykiss) abruptly exposed to ion-poor water.
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology.
2016 09; 199(?):120-129. doi:
10.1016/j.cbpa.2016.05.020. [PMID: 27220746] - Tianming Wang, Liqing Ding, Huajia Jin, Rong Shi, Yuanyuan Li, Jiasheng Wu, Yifei Li, Li Zhu, Yueming Ma. Simultaneous quantification of catechin, epicatechin, liquiritin, isoliquiritin, liquiritigenin, isoliquiritigenin, piperine and glycyrrhetinic acid in rat plasma by HPLC-MS/MS: application to a pharmacokinetic study of Longhu Rendan pills.
Biomedical chromatography : BMC.
2016 Aug; 30(8):1166-74. doi:
10.1002/bmc.3662. [PMID: 26613237] - Xue Ding, Yuming Sun, Qing Wang, Tingting Pu, Xiaohui Li, Yaqing Pan, Yang Yang. Pharmacokinetics and pharmacodynamics of glycyrrhetinic acid with Paeoniflorin after transdermal administration in dysmenorrhea model mice.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2016 Jul; 23(8):864-71. doi:
10.1016/j.phymed.2016.05.005. [PMID: 27288922] - Kasper Moller Boje Rasmussen, Thomas Hartig Braunstein, Max Salomonsson, Jens Christian Brasen, Charlotte Mehlin Sorensen. Contribution of K(+) channels to endothelium-derived hypolarization-induced renal vasodilation in rats in vivo and in vitro.
Pflugers Archiv : European journal of physiology.
2016 07; 468(7):1139-1149. doi:
10.1007/s00424-016-1805-x. [PMID: 26965146] - Taotao Ma, Cheng Huang, Xiaoming Meng, Xiaofeng Li, Yilong Zhang, Shuai Ji, Jun Li, Min Ye, Hong Liang. A potential adjuvant chemotherapeutics, 18β-glycyrrhetinic acid, inhibits renal tubular epithelial cells apoptosis via enhancing BMP-7 epigenetically through targeting HDAC2.
Scientific reports.
2016 05; 6(?):25396. doi:
10.1038/srep25396. [PMID: 27145860] - Hongjing Cui, Ran Wang, Ying Zhou, Chang Shu, Fengjuan Song, Wenying Zhong. Dual-function fluorescent probe for cancer imaging and therapy.
Luminescence : the journal of biological and chemical luminescence.
2016 May; 31(3):813-20. doi:
10.1002/bio.3028. [PMID: 26387677] - B Darvishi, S Manoochehri, M Esfandyari-Manesh, N Samadi, M Amini, F Atyabi, R Dinarvand. Enhanced Cellular Cytotoxicity and Antibacterial Activity of 18-β-Glycyrrhetinic Acid by Albumin-conjugated PLGA Nanoparticles.
Drug research.
2015 Dec; 65(12):617-23. doi:
10.1055/s-0034-1390487. [PMID: 25607747] - Jinque Luo, Mei Liu, Xin Wu, Yannong Dou, Yufeng Xia, Yue Dai, Zhifeng Wei. DGAEE, a newly synthesized derivative of glycyrrhetinic acid, potently attenuates mouse septic shock via its main metabolite DGA in an IL-10-dependent manner.
International immunopharmacology.
2015 Dec; 29(2):583-590. doi:
10.1016/j.intimp.2015.09.025. [PMID: 26456500] - Hua Yang, Tingshu Jiang, Ping Li, Qishan Mao. The protection of glycyrrhetinic acid (GA) towards acetaminophen (APAP)-induced toxicity partially through fatty acids metabolic pathway.
African health sciences.
2015 Sep; 15(3):1023-7. doi:
10.4314/ahs.v15i3.42. [PMID: 26957996] - Sang-Bum Kim, Hyun-Jong Cho, Yeong Shik Kim, Dae-Duk Kim, In-Soo Yoon. Modulation of Cytochrome P450 Activity by 18β-Glycyrrhetic Acid and its Consequence on Buspirone Pharmacokinetics in Rats.
Phytotherapy research : PTR.
2015 Aug; 29(8):1188-94. doi:
10.1002/ptr.5365. [PMID: 26010440] - Wei-Man Zhao, Shu-Wen Jiang, Yang Chen, Ze-Yu Zhong, Zhong-Jian Wang, Mian Zhang, Ying Li, Ping Xu, Li Liu, Xiao-Dong Liu. Laminaria japonica increases plasma exposure of glycyrrhetinic acid following oral administration of Liquorice extract in rats.
Chinese journal of natural medicines.
2015 Jul; 13(7):540-9. doi:
10.1016/s1875-5364(15)30049-2. [PMID: 26233845] - Bin Zhou, Jingze Zhang, Shanshan Wu, Qu Zhuo, Wenyuan Gao, Juan Hao, Shuli Man. The influence of compatibility of processed radix Aconiti Kusnezoffii on the pharmacokinetic of four components in Glycyrrhiza uralensis Fisch.
Journal of ethnopharmacology.
2015 Jul; 169(?):1-7. doi:
10.1016/j.jep.2015.03.059. [PMID: 25889555] - Xiu-Feng Wang, Qian-Mei Zhou, Yi-Yu Lu, Hui Zhang, Shuang Huang, Shi-Bing Su. Glycyrrhetinic acid potently suppresses breast cancer invasion and metastasis by impairing the p38 MAPK-AP1 signaling axis.
Expert opinion on therapeutic targets.
2015 May; 19(5):577-87. doi:
10.1517/14728222.2015.1012156. [PMID: 25828376] - Wen-Wen Qi, Hai-Yan Yu, Hui Guo, Jun Lou, Zhi-Ming Wang, Peng Liu, Anne Sapin-Minet, Philippe Maincent, Xue-Chuan Hong, Xian-Ming Hu, Yu-Ling Xiao. Doxorubicin-loaded glycyrrhetinic acid modified recombinant human serum albumin nanoparticles for targeting liver tumor chemotherapy.
Molecular pharmaceutics.
2015 Mar; 12(3):675-83. doi:
10.1021/mp500394v. [PMID: 25584860] - Chun Chih Chen, Dennis Kolosov, Scott P Kelly. Effect of the liquorice root derivatives on salt and water balance in a teleost fish, rainbow trout (Oncorhynchus mykiss).
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology.
2015 Feb; 180(?):86-97. doi:
10.1016/j.cbpa.2014.09.041. [PMID: 25460830] - Hiroyuki Kitagawa, Masaya Munekage, Kengo Ichikawa, Ian Fukudome, Eri Munekage, Yuka Takezaki, Takashi Matsumoto, Yasushi Igarashi, Haruo Hanyu, Kazuhiro Hanazaki. Pharmacokinetics of Active Components of Yokukansan, a Traditional Japanese Herbal Medicine after a Single Oral Administration to Healthy Japanese Volunteers: A Cross-Over, Randomized Study.
PloS one.
2015; 10(7):e0131165. doi:
10.1371/journal.pone.0131165. [PMID: 26151135] - Jingjing Li, Tong Chen, Feng Deng, Jingyuan Wan, Yalan Tang, Pei Yuan, Liangke Zhang. Synthesis, characterization, and in vitro evaluation of curcumin-loaded albumin nanoparticles surface-functionalized with glycyrrhetinic acid.
International journal of nanomedicine.
2015; 10(?):5475-87. doi:
10.2147/ijn.s88253. [PMID: 26346750] - Jingde Chen, Hong Jiang, Yin Wu, Yandong Li, Yong Gao. A novel glycyrrhetinic acid-modified oxaliplatin liposome for liver-targeting and in vitro/vivo evaluation.
Drug design, development and therapy.
2015; 9(?):2265-75. doi:
10.2147/dddt.s81722. [PMID: 25945038] - Zhiqing Tian, Chengling Yang, Wei Wang, Zhi Yuan. Shieldable tumor targeting based on pH responsive self-assembly/disassembly of gold nanoparticles.
ACS applied materials & interfaces.
2014 Oct; 6(20):17865-76. doi:
10.1021/am5045339. [PMID: 25233129] - Yi Ma, Yan Gui, Youhu Wang, Kehu Xi, Xiaowan Chen, Fuhong Zhang, Chunxia Ma, Hao Hong, Xiangyi Liu, Ying Jiang, Ming Dong, Guijun Yang, Xiaobing Zhang. [The effect of 18β-glycyrrhetinic acid on tight junctions of the nasal mucosa epithelial cells in rat models with allergic rhinitis].
Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery.
2014 Oct; 28(20):1590-4. doi:
NULL. [PMID: 25764760] - M Nishihara, J Takahashi, T Kondo, K Mouri, S Asahi. Main metabolic pathways of TAK-802, a novel drug candidate for voiding dysfunction, in humans: the involvement of carbonyl reduction by 11β-hydroxysteroid dehydrogenase 1.
Drug research.
2014 Sep; 64(9):476-84. doi:
10.1055/s-0033-1363221. [PMID: 24357138] - Qinhui Wang, Lei Shi, Xiuling Tang, Qingwei Wang, Xueliang Dang, Yan Zhang. Pharmacokinetic study of multiple active constituents from Kushen-Gancao Decoction after oral administration in rat by HPLC-MS/MS.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2014 Aug; 965(?):19-26. doi:
10.1016/j.jchromb.2014.05.038. [PMID: 24976484] - Pravat Kumar Parida, Abhijit Sau, Tamashree Ghosh, Kuladip Jana, Kaushik Biswas, Sanghamitra Raha, Anup Kumar Misra. Synthesis and evaluation of triazole linked glycosylated 18β-glycyrrhetinic acid derivatives as anticancer agents.
Bioorganic & medicinal chemistry letters.
2014 Aug; 24(16):3865-8. doi:
10.1016/j.bmcl.2014.06.054. [PMID: 25027936] - Bo Sun, Ming Zhang, Qi Zhang, Kunpeng Ma, Haijing Li, Famei Li, Fangting Dong, Xianzhong Yan. Metabonomics study of the effects of pretreatment with glycyrrhetinic acid on mesaconitine-induced toxicity in rats.
Journal of ethnopharmacology.
2014 Jul; 154(3):839-46. doi:
10.1016/j.jep.2014.05.010. [PMID: 24846827] - Miyoung Park, Ji-Hae Lee, Jin Kyu Choi, Yong Deog Hong, Il-Hong Bae, Kyung-Min Lim, Young-Ho Park, Hunjoo Ha. 18β-glycyrrhetinic acid attenuates anandamide-induced adiposity and high-fat diet induced obesity.
Molecular nutrition & food research.
2014 Jul; 58(7):1436-46. doi:
10.1002/mnfr.201300763. [PMID: 24687644] - Lilong Jiang, Qiong Wang, Shu Shen, Tongshu Xiao, Youbin Li. Discovery of glycyrrhetinic acid as an orally active, direct inhibitor of blood coagulation factor xa.
Thrombosis research.
2014 Mar; 133(3):501-6. doi:
10.1016/j.thromres.2013.12.025. [PMID: 24412029] - Ling-ling Jia, Ze-yu Zhong, Feng Li, Zhao-li Ling, Yang Chen, Wei-man Zhao, Ying Li, Shu-wen Jiang, Ping Xu, Yang Yang, Meng-yue Hu, Li Liu, Xiao-dong Liu. Aggravation of clozapine-induced hepatotoxicity by glycyrrhetinic acid in rats.
Journal of pharmacological sciences.
2014; 124(4):468-79. doi:
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Biochemistry. Biokhimiia.
2014 Jan; 79(1):25-30. doi:
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International journal of nanomedicine.
2014; 9(?):695-710. doi:
10.2147/ijn.s55255. [PMID: 24493926] - Toshiaki Makino. 3-Monoglucuronyl glycyrrhretinic acid is a possible marker compound related to licorice-induced pseudoaldosteronism.
Biological & pharmaceutical bulletin.
2014; 37(6):898-902. doi:
10.1248/bpb.b13-00997. [PMID: 24882402] - Jian-yuan Li, Hong-yan Cao, Ping Liu, Gen-hong Cheng, Ming-yu Sun. Glycyrrhizic acid in the treatment of liver diseases: literature review.
BioMed research international.
2014; 2014(?):872139. doi:
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Drug research.
2013 Dec; 63(12):620-4. doi:
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European journal of drug metabolism and pharmacokinetics.
2013 Dec; 38(4):283-93. doi:
10.1007/s13318-013-0121-5. [PMID: 23430690] - Hideaki Yamaguchi, Yumi Kidachi, Katsuyoshi Kamiie, Toshiro Noshita, Hironori Umetsu, Yoko Fuke, Kazuo Ryoyama. Utilization of 6-(methylsulfinyl)hexyl isothiocyanate for sensitization of tumor cells to antitumor agents in combination therapies.
Biochemical pharmacology.
2013 Aug; 86(4):458-68. doi:
10.1016/j.bcp.2013.06.008. [PMID: 23791871] - Tsukasa Ishida, Ikuya Miki, Toshihito Tanahashi, Saori Yagi, Yasuyuki Kondo, Jun Inoue, Shoji Kawauchi, Sin Nishiumi, Masaru Yoshida, Hideko Maeda, Chisato Tode, Atsuko Takeuchi, Hirokazu Nakayama, Takeshi Azuma, Shigeto Mizuno. Effect of 18β-glycyrrhetinic acid and hydroxypropyl γcyclodextrin complex on indomethacin-induced small intestinal injury in mice.
European journal of pharmacology.
2013 Aug; 714(1-3):125-31. doi:
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Experimental cell research.
2013 Jul; 319(12):1839-1851. doi:
10.1016/j.yexcr.2013.03.032. [PMID: 23578767] - Xiao-Ling Guo, Bo Liang, Xue-Wei Wang, Fu-Gang Fan, Jing Jin, Rui Lan, Jing-Hui Yang, Xiao-Chun Wang, Lei Jin, Qin Cao. Glycyrrhizic acid attenuates CCl₄-induced hepatocyte apoptosis in rats via a p53-mediated pathway.
World journal of gastroenterology.
2013 Jun; 19(24):3781-91. doi:
10.3748/wjg.v19.i24.3781. [PMID: 23840116] - Tao Li, Yi-Wei Wang, Yan-Li Wang, Ri-Xin Liang, Dong Zhang, Hui-Hui Zhang, Li Chen, Zhong-Ming Zhou, Wei-Peng Yang. [LC-MS quantification and pharmacokinetics of the multi-constituents of Huangqin Tang in rat plasma after different single oral doses].
Yao xue xue bao = Acta pharmaceutica Sinica.
2013 Jun; 48(6):917-24. doi:
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