Dihydrocortisol (BioDeep_00000005836)

 

Secondary id: BioDeep_00001869242

human metabolite PANOMIX_OTCML-2023 Endogenous


代谢物信息卡片


(5R,8S,9S,10S,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-2,4,5,6,7,8,9,11,12,14,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-3-one

化学式: C21H32O5 (364.225)
中文名称: 11-Beta,17-alpha,21-三羟基-5-beta-孕烯-3,20-二酮
谱图信息: 最多检出来源 Homo sapiens(feces) 26.16%

分子结构信息

SMILES: CC12CCC(=O)CC1CCC1C2C(O)CC2(C)C1CCC2(O)C(=O)CO
InChI: InChI=1S/C21H32O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h12,14-16,18,22,24,26H,3-11H2,1-2H3/t12-,14+,15+,16+,18-,19+,20+,21+/m1/s1

描述信息

Dihydrocortisol is the product of the enzyme steroid 5-beta-reductase (EC 1.3.1.3), which catalyzes the reduction of progesterone, androstenedione, 17-alpha-hydroxyprogesterone, testosterone, aldosterone, corticosterone, and cortisol to 5-beta-reduced metabolites. A deficiency in this enzyme is associated with a congenital defect in bile acid synthesis (OMIM: 235555). Dihydrocortisol is the substrate of the enzyme 3-alpha-hydroxysteroid dehydrogenase (EC 1.1.1.225, 1.1.1.213, 1.3.1.20, 1.1.1.50), and is an intermediate in bile acid biosynthesis, C21-steroid hormone metabolism, androgen and estrogen metabolism, and the metabolism of xenobiotics by cytochrome P450 (KEGG).
Dihydrocortisol is the product of the enzyme Steroid 5-beta-reductase [EC 1.3.1.3], which catalyzes the reduction of progesterone, androstenedione, 17-alpha-hydroxyprogesterone, testosterone, aldosterone, corticosterone and cortisol to 5-beta-reduced metabolites. A deficiency in this enzyme is associated with congenital defect in bile acid synthesis. (OMIM 235555)
5β-Dihydrocortisol, a metabolite of Cortisol, is a potential mineralocorticoid. 5β-Dihydrocortisol can potentiate glucocorticoid activity in raising the intraocular pressure. 5β-Dihydrocortisol causes breast cancer cell apoptosis[1][2][3][4][5].

同义名列表

21 个代谢物同义名

(5R,8S,9S,10S,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-2,4,5,6,7,8,9,11,12,14,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-3-one; (1S,2S,7R,10S,11S,14R,15S,17S)-14,17-dihydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadecan-5-one; 11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-2,4,5,6,7,8,9,11,12,14,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-3-one; 11beta,17alpha,21-Trihydroxy-5beta-pregnane-3,20-dione; (5beta,11beta)-11,17,21-Trihydroxypregnane-3,20-dione; 11-beta,17,21-Trihydroxy-5-beta-pregnane-3,20-dione; 5beta-pregnane-11beta,17alpha,21-triol-3,20-dione; 11beta,17,21-Trihydroxy-5beta-pregnane-3,20-dione; (5b,11b)-11,17,21-Trihydroxypregnane-3,20-dione; (5Β,11β)-11,17,21-trihydroxypregnane-3,20-dione; 11-b,17,21-Trihydroxy-5-b-pregnane-3,20-dione; 11-Β,17,21-trihydroxy-5-β-pregnane-3,20-dione; 11β,17α,21-Trihydroxy-5β-pregnane-3,20-dione; 11β,17,21-Trihydroxy-5β-pregnane-3,20-dione; 5Β-pregnane-11β,17α,21-triol-3,20-dione; 5b-Pregnane-11b,17a,21-triol-3,20-dione; 5-beta-Dihydrocortisol; 5beta-Dihydrocortisol; 5β-Dihydrocortisol; Dihydrocortisol; Dihydrocortisol



数据库引用编号

18 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

35 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(1)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(34)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 3 AKR1C3, NR3C1, SP1
Peripheral membrane protein 1 HSD17B6
Endosome membrane 1 CLCN5
Endoplasmic reticulum membrane 3 DHRS9, SRD5A1, SRD5A2
Nucleus 3 AKR1C3, NR3C1, SP1
cytosol 4 AKR1C3, CLCN5, HCCS, NR3C1
centrosome 1 NR3C1
nucleoplasm 3 CD2, NR3C1, SP1
Cell membrane 3 CD2, CLCN5, GLRA2
Lipid-anchor 1 HCCS
Early endosome membrane 1 HSD17B6
Multi-pass membrane protein 4 CLCN5, GLRA2, SRD5A1, SRD5A2
Golgi apparatus membrane 1 CLCN5
Synapse 2 GLRA2, NR3C1
cell surface 1 CD2
Golgi apparatus 2 CD2, CLCN5
Golgi membrane 2 CLCN5, INS
lysosomal membrane 1 CLCN5
mitochondrial inner membrane 1 HCCS
neuronal cell body 2 SRD5A1, SRD5A2
synaptic vesicle 1 CLCN5
plasma membrane 4 CD2, CLCN5, GCG, GLRA2
Membrane 5 CLCN5, GLRA2, HCCS, NR3C1, SRD5A1
extracellular exosome 2 AKR1C3, COL1A2
Lumenal side 1 HSD17B6
endoplasmic reticulum 1 HSD17B6
extracellular space 5 COL1A2, GCG, IL6, INS, SP1
perinuclear region of cytoplasm 1 SRD5A1
mitochondrion 2 HCCS, NR3C1
protein-containing complex 2 CD2, NR3C1
intracellular membrane-bounded organelle 3 DHRS9, GLRA2, HSD17B6
Microsome membrane 2 DHRS9, HSD17B6
Single-pass type I membrane protein 1 CD2
Secreted 5 COL1A2, GCG, IL6, INS, SP1
extracellular region 6 CD2, COL1A2, GCG, IL6, INS, SP1
cytoplasmic side of plasma membrane 1 CD2
mitochondrial matrix 1 NR3C1
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 NR3C1
external side of plasma membrane 1 CD2
Secreted, extracellular space, extracellular matrix 1 COL1A2
Early endosome 1 CLCN5
apical part of cell 1 CLCN5
cell-cell junction 1 CD2
Mitochondrion inner membrane 1 HCCS
Cytoplasm, cytoskeleton, spindle 1 NR3C1
spindle 1 NR3C1
GABA-ergic synapse 1 GLRA2
collagen trimer 1 COL1A2
collagen-containing extracellular matrix 1 COL1A2
nuclear speck 1 NR3C1
Postsynaptic cell membrane 1 GLRA2
neuron projection 1 GLRA2
chromatin 2 NR3C1, SP1
cell projection 1 GLRA2
Chromosome 1 NR3C1
transmembrane transporter complex 1 GLRA2
endosome lumen 1 INS
chloride channel complex 1 GLRA2
cell body fiber 2 SRD5A1, SRD5A2
Nucleus, nucleoplasm 1 NR3C1
euchromatin 1 SP1
secretory granule lumen 2 GCG, INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 4 COL1A2, GCG, IL6, INS
transcription repressor complex 1 SP1
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
protein-DNA complex 1 SP1
postsynaptic specialization membrane 1 GLRA2
[Isoform Alpha]: Cytoplasm 1 NR3C1
[Glucagon-like peptide 1]: Secreted 1 GCG
collagen type I trimer 1 COL1A2
[Isoform Beta]: Nucleus 1 NR3C1
[Isoform Alpha-B]: Nucleus 1 NR3C1
glycinergic synapse 1 GLRA2
interleukin-6 receptor complex 1 IL6


文献列表