Dihydrocortisol (BioDeep_00000005836)

 

Secondary id: BioDeep_00001869242

human metabolite PANOMIX_OTCML-2023 Endogenous


代谢物信息卡片


(5R,8S,9S,10S,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-2,4,5,6,7,8,9,11,12,14,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-3-one

化学式: C21H32O5 (364.2249622)
中文名称: 11-Beta,17-alpha,21-三羟基-5-beta-孕烯-3,20-二酮
谱图信息: 最多检出来源 Homo sapiens(blood) 0.16%

分子结构信息

SMILES: CC12CCC(=O)CC1CCC1C2C(O)CC2(C)C1CCC2(O)C(=O)CO
InChI: InChI=1S/C21H32O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h12,14-16,18,22,24,26H,3-11H2,1-2H3/t12-,14+,15+,16+,18-,19+,20+,21+/m1/s1

描述信息

Dihydrocortisol is the product of the enzyme steroid 5-beta-reductase (EC 1.3.1.3), which catalyzes the reduction of progesterone, androstenedione, 17-alpha-hydroxyprogesterone, testosterone, aldosterone, corticosterone, and cortisol to 5-beta-reduced metabolites. A deficiency in this enzyme is associated with a congenital defect in bile acid synthesis (OMIM: 235555). Dihydrocortisol is the substrate of the enzyme 3-alpha-hydroxysteroid dehydrogenase (EC 1.1.1.225, 1.1.1.213, 1.3.1.20, 1.1.1.50), and is an intermediate in bile acid biosynthesis, C21-steroid hormone metabolism, androgen and estrogen metabolism, and the metabolism of xenobiotics by cytochrome P450 (KEGG).
Dihydrocortisol is the product of the enzyme Steroid 5-beta-reductase [EC 1.3.1.3], which catalyzes the reduction of progesterone, androstenedione, 17-alpha-hydroxyprogesterone, testosterone, aldosterone, corticosterone and cortisol to 5-beta-reduced metabolites. A deficiency in this enzyme is associated with congenital defect in bile acid synthesis. (OMIM 235555)
5β-Dihydrocortisol, a metabolite of Cortisol, is a potential mineralocorticoid. 5β-Dihydrocortisol can potentiate glucocorticoid activity in raising the intraocular pressure. 5β-Dihydrocortisol causes breast cancer cell apoptosis[1][2][3][4][5].

同义名列表

20 个代谢物同义名

(5R,8S,9S,10S,11S,13S,14S,17R)-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-2,4,5,6,7,8,9,11,12,14,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-3-one; (1S,2S,7R,10S,11S,14R,15S,17S)-14,17-dihydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadecan-5-one; 11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-2,4,5,6,7,8,9,11,12,14,15,16-dodecahydro-1H-cyclopenta[a]phenanthren-3-one; 11beta,17alpha,21-Trihydroxy-5beta-pregnane-3,20-dione; (5beta,11beta)-11,17,21-Trihydroxypregnane-3,20-dione; 11-beta,17,21-Trihydroxy-5-beta-pregnane-3,20-dione; 5beta-pregnane-11beta,17alpha,21-triol-3,20-dione; 11beta,17,21-Trihydroxy-5beta-pregnane-3,20-dione; (5b,11b)-11,17,21-Trihydroxypregnane-3,20-dione; (5Β,11β)-11,17,21-trihydroxypregnane-3,20-dione; 11-b,17,21-Trihydroxy-5-b-pregnane-3,20-dione; 11-Β,17,21-trihydroxy-5-β-pregnane-3,20-dione; 11β,17α,21-Trihydroxy-5β-pregnane-3,20-dione; 11β,17,21-Trihydroxy-5β-pregnane-3,20-dione; 5Β-pregnane-11β,17α,21-triol-3,20-dione; 5b-Pregnane-11b,17a,21-triol-3,20-dione; 5-beta-Dihydrocortisol; 5beta-Dihydrocortisol; 5β-Dihydrocortisol; Dihydrocortisol



数据库引用编号

17 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

35 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(1)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(34)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
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