2-Deoxy-2,3-dehydro-N-acetylneuraminic acid (BioDeep_00000005575)
Secondary id: BioDeep_00001869480
代谢物信息卡片
3-acetamido-4-hydroxy-2-(1,2,3-trihydroxypropyl)-3,4-dihydro-2H-pyran-6-carboxylic acid
化学式: C11H17NO8 (291.0954)
中文名称: N-乙酰-2,3-二脱氢-2-脱氧神经氨酸
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(=O)NC1C(C=C(OC1C(C(CO)O)O)C(=O)O)O
InChI: InChI=1S/C11H17NO8/c1-4(14)12-8-5(15)2-7(11(18)19)20-10(8)9(17)6(16)3-13/h2,5-6,8-10,13,15-17H,3H2,1H3,(H,12,14)(H,18,19)
描述信息
D004791 - Enzyme Inhibitors
同义名列表
数据库引用编号
14 个数据库交叉引用编号
- ChEBI: CHEBI:28062
- KEGG: C04580
- PubChem: 65309
- PubChem: 1553
- Metlin: METLIN66213
- DrugBank: DB03991
- ChEMBL: CHEMBL96712
- CAS: 24967-27-9
- PMhub: MS000018408
- PubChem: 7181
- PDB-CCD: DAN
- NIKKAJI: J534.549I
- RefMet: 2-Deoxy-2,3-dehydro-N-acetylneuraminic acid
- KNApSAcK: 28062
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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文献列表
- Ji-Young Park, Su Hwan Lim, Bo Ram Kim, Hyung Jae Jeong, Hyung-Jun Kwon, Gyu-Yong Song, Young Bae Ryu, Woo Song Lee. Sialidase inhibitory activity of diarylnonanoid and neolignan compounds extracted from the seeds of Myristica fragrans.
Bioorganic & medicinal chemistry letters.
2017 07; 27(14):3060-3064. doi:
10.1016/j.bmcl.2017.05.055. [PMID: 28551100] - Yongying Shi, Longlong Si, Xu Han, Zibo Fan, Shouxin Wang, Man Li, Jiaqi Sun, Yongmin Zhang, Demin Zhou, Sulong Xiao. Synthesis of novel pentacyclic triterpene-Neu5Ac2en derivatives and investigation of their in vitro anti-influenza entry activity.
MedChemComm.
2017 Jul; 8(7):1531-1541. doi:
10.1039/c7md00245a. [PMID: 30108865] - Nongluk Sriwilaijaroen, Sadagopan Magesh, Akihiro Imamura, Hiromune Ando, Hideharu Ishida, Miho Sakai, Erika Ishitsubo, Takanori Hori, Setsuko Moriya, Takeshi Ishikawa, Kazuo Kuwata, Takato Odagiri, Masato Tashiro, Hiroaki Hiramatsu, Kenji Tsukamoto, Taeko Miyagi, Hiroaki Tokiwa, Makoto Kiso, Yasuo Suzuki. A Novel Potent and Highly Specific Inhibitor against Influenza Viral N1-N9 Neuraminidases: Insight into Neuraminidase-Inhibitor Interactions.
Journal of medicinal chemistry.
2016 05; 59(10):4563-77. doi:
10.1021/acs.jmedchem.5b01863. [PMID: 27095056] - Saša Kastelic, Rebeka Lucijana Berčič, Ivanka Cizelj, Mateja Benčina, Laszlo Makrai, Olga Zorman-Rojs, Mojca Narat, Magne Bisgaard, Henrik Christensen, Dušan Benčina. Ornithobacterium rhinotracheale has neuraminidase activity causing desialylation of chicken and turkey serum and tracheal mucus glycoproteins.
Veterinary microbiology.
2013 Mar; 162(2-4):707-712. doi:
10.1016/j.vetmic.2012.09.018. [PMID: 23062950] - Enguang Feng, Woo-Jin Shin, Xuelian Zhu, Jian Li, Deju Ye, Jiang Wang, Mingyue Zheng, Jian-Ping Zuo, Kyoung Tai No, Xian Liu, Weiliang Zhu, Wei Tang, Baik-Lin Seong, Hualiang Jiang, Hong Liu. Structure-based design and synthesis of C-1- and C-4-modified analogs of zanamivir as neuraminidase inhibitors.
Journal of medicinal chemistry.
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The Journal of biological chemistry.
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10.1074/jbc.m112.346817. [PMID: 22403397] - Shigeko Kijimoto-Ochiai, Naoko Doi, Hiroko Matsukawa, Miwako Fujii, Koji Tomobe. Localization of sialidase-positive cells expressing Mac-1 and immunoglobulin in the mouse thymus.
Glycoconjugate journal.
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10.1023/b:glyc.0000033994.99464.ce. [PMID: 15238702] - T Suzuki, K Ikeda, N Koyama, C Hosokawa, T Kogure, T Takahashi, K I Jwa Hidari, D Miyamoto, K Tanaka, Y Suzuki. Inhibition of human parainfluenza virus type 1 sialidase by analogs of 2-deoxy-2,3-didehydro-N-acetylneuraminic acid.
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