Racanisodamine (BioDeep_00000005174)
代谢物信息卡片
(6S)-6-Hydroxyhyoscyamine
化学式: C17H23NO4 (305.1627)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(feces) 18.25%
分子结构信息
SMILES: CN1C2CC(CC1C(C2)O)OC(=O)C(CO)C3=CC=CC=C3
InChI: InChI=1S/C17H23NO4/c1-18-12-7-13(9-15(18)16(20)8-12)22-17(21)14(10-19)11-5-3-2-4-6-11/h2-6,12-16,19-20H,7-10H2,1H3/t12?,13-,14?,15?,16?/m0/s1
数据库引用编号
12 个数据库交叉引用编号
- KEGG: C03325
- PubChem: 439976
- PubChem: 2198
- Metlin: METLIN64424
- MetaCyc: CPD-2202
- KNApSAcK: C00002274
- PMhub: MS000017895
- ChEBI: CHEBI:15645
- PubChem: 6173
- PDB-CCD: OVR
- 3DMET: B04889
- NIKKAJI: J33.369G
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
- 4079 - Hyoscyamus niger: 10.1016/0031-9422(89)80374-7
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Fei Tang, Dong Liu, Feng Wan, Li Zhang, Li-Yue Xu, Jing-Nan Zhang, Xiao-Lan Zhao, Hui Ao, Cheng Peng. Ameliorative effect of anisodamine (654-1/654-2) against myocardial dysfunction induced by septic shock via the NF-κB/NLRP-3 or the PI3K-AKT/NF-κB pathway.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2024 Jan; 123(?):155277. doi:
10.1016/j.phymed.2023.155277. [PMID: 38128396] - Yuan Zhang, Jiayu Zou, Feng Wan, Fu Peng, Cheng Peng. Update on the sources, pharmacokinetics, pharmacological action, and clinical application of anisodamine.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2023 May; 161(?):114522. doi:
10.1016/j.biopha.2023.114522. [PMID: 37002581] - Juan M Minoia, María E Villanueva, Guillermo J Copello, Julián Rodríguez Talou, Alejandra B Cardillo. Recycling of hyoscyamine 6β-hydroxylase for the in vitro production of anisodamine and scopolamine.
Applied microbiology and biotechnology.
2023 Apr; ?(?):. doi:
10.1007/s00253-023-12537-w. [PMID: 37099059] - Yan Qiu, Zhi Ouyang, Jian Zhong, Junyi Shen, Wenli Jiang, Yan Liu, Feng Wan, Ye Zeng. Anisodamine hydrobromide attenuates oxidative stress and proinflammatory cytokines in septic rats induced by cecal ligation and puncture.
Cellular and molecular biology (Noisy-le-Grand, France).
2022 Dec; 68(12):54-60. doi:
10.14715/cmb/2022.68.12.11. [PMID: 37130180] - Wei Wei, Ni Kong, Meng-Zhen Liu, Ting Han, Jun-Feng Xu, Chong Liu. Anisodamine potently inhibits SARS-CoV-2 infection in vitro and targets its main protease.
Biochemical and biophysical research communications.
2022 08; 616(?):8-13. doi:
10.1016/j.bbrc.2022.05.024. [PMID: 35636257] - Yuetian Yu, Cheng Zhu, Yucai Hong, Lin Chen, Zhiping Huang, Jiancang Zhou, Xin Tian, Dadong Liu, Bo Ren, Cao Zhang, Caibao Hu, Xinan Wang, Rui Yin, Yuan Gao, Zhongheng Zhang. Effectiveness of anisodamine for the treatment of critically ill patients with septic shock: a multicentre randomized controlled trial.
Critical care (London, England).
2021 09; 25(1):349. doi:
10.1186/s13054-021-03774-4. [PMID: 34579741] - Shu Zhang, Xianzhi Xu, Yuanhong Huang, Siyuan Sun, Chengqi Jin, Hao Ji, Dong Sun, Anzhou Xia. Anisodamine ameliorates ischemia/reperfusion-induced renal injury in rats through activation of the extracellular signal-regulated kinase (ERK) pathway and anti-apoptotic effect.
Die Pharmazie.
2021 05; 76(5):220-224. doi:
10.1691/ph.2021.1302. [PMID: 33964996] - Lingjiang Zeng, Qiaozhuo Zhang, Chunxue Jiang, Yueyue Zheng, Youwei Zuo, Jianbo Qin, Zhihua Liao, Hongping Deng. Development of Atropa belladonna L. Plants with High-Yield Hyoscyamine and without Its Derivatives Using the CRISPR/Cas9 System.
International journal of molecular sciences.
2021 Feb; 22(4):. doi:
10.3390/ijms22041731. [PMID: 33572199] - Zile Wang, Pimiao Zheng, Jianyi Wang, Shuang He, Zhenhui Ren, Yanfang Zhang, Jincheng Xiong, Haiyang Jiang. Indirect competitive enzyme-linked immunosorbent assay based on a broad-spectrum monoclonal antibody for tropane alkaloids detection in pig urine, pork and cereal flours.
Food chemistry.
2021 Feb; 337(?):127617. doi:
10.1016/j.foodchem.2020.127617. [PMID: 32799156] - Feng Wan, Xiaoqiang Du, Huan Liu, Xueling He, Ye Zeng. Protective effect of anisodamine hydrobromide on lipopolysaccharide-induced acute kidney injury.
Bioscience reports.
2020 07; 40(7):. doi:
10.1042/bsr20201812. [PMID: 32573678] - Zhiwei Xu, Tong Wang, Liang Chen, Ying Lou, Xiaoyan Sun, Jinqi Jiang. Treatment of dilated cardiomyopathy caused by coronary microvascular dysfunction with anisodamine: a report of 5 cases.
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan.
2020 04; 40(2):340-342. doi:
. [PMID: 32242401] - Yiyi Yan, Xingchen Huo, Taoshan Ai, Jianguo Su. β-glucan and anisodamine can enhance the immersion immune efficacy of inactivated cyprinid herpesvirus 2 vaccine in Carassius auratus gibelio.
Fish & shellfish immunology.
2020 Mar; 98(?):285-295. doi:
10.1016/j.fsi.2020.01.025. [PMID: 31962149] - Tengfei Zhao, Siqi Li, Jing Wang, Qi Zhou, Chunxian Yang, Feng Bai, Xiaozhong Lan, Min Chen, Zhihua Liao. Engineering Tropane Alkaloid Production Based on Metabolic Characterization of Ornithine Decarboxylase in Atropa belladonna.
ACS synthetic biology.
2020 02; 9(2):437-448. doi:
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Frontiers in immunology.
2020; 11(?):595342. doi:
10.3389/fimmu.2020.595342. [PMID: 33633726] - Tianxiang Lei, Huan Wang, Songling Li, Xiaojian Cai, Shilong Chen, Tingfeng Cheng, Jianwei Shen, Shengbo Shi, Dangwei Zhou. Comparison of Profiling of Hairy Root of Two Tibetan Medicinal Plants Przewalskia tangutica Maxim. and Anisodus tanguticus Maxim.
Current pharmaceutical biotechnology.
2020; 21(6):516-527. doi:
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BMC nephrology.
2019 06; 20(1):223. doi:
10.1186/s12882-019-1394-y. [PMID: 31208365] - Daniel Schlesinger, Rachel Davidovich Rikanati, Sergei Volis, Adi Faigenboim, Vera Vendramin, Federica Cattonaro, Matthew Hooper, Elad Oren, Mark Taylor, Yaron Sitrit, Moshe Inbar, Efraim Lewinsohn. Alkaloid chemodiversity in Mandragora spp. is associated with loss-of-functionality of MoH6H, a hyoscyamine 6β-hydroxylase gene.
Plant science : an international journal of experimental plant biology.
2019 Jun; 283(?):301-310. doi:
10.1016/j.plantsci.2019.03.013. [PMID: 31128700] - Jiacheng Zhang, Xiaozhe Fu, Yanqi Zhang, Wentao Zhu, Yong Zhou, Gailing Yuan, Xiaoling Liu, Taoshan Ai, Lingbing Zeng, Jianguo Su. Chitosan and anisodamine improve the immune efficacy of inactivated infectious spleen and kidney necrosis virus vaccine in Siniperca chuatsi.
Fish & shellfish immunology.
2019 Jun; 89(?):52-60. doi:
10.1016/j.fsi.2019.03.040. [PMID: 30904683] - Kathrin Laura Kohnen, Selahaddin Sezgin, Michael Spiteller, Hansjörg Hagels, Oliver Kayser. Localization and Organization of Scopolamine Biosynthesis in Duboisia myoporoides R. Br.
Plant & cell physiology.
2018 Jan; 59(1):107-118. doi:
10.1093/pcp/pcx165. [PMID: 29095998] - Xiaopeng Yuan, Yitao Zheng, Chuanbao Chen, Changxi Wang. Anisodamine inhibits endoplasmic reticulum stress-associated TXNIP/NLRP3 inflammasome activation in rhabdomyolysis-induced acute kidney injury.
Apoptosis : an international journal on programmed cell death.
2017 Dec; 22(12):1524-1531. doi:
10.1007/s10495-017-1414-y. [PMID: 28918467] - Xiao Li, Wei Qiang, Fei Qiu, Min Chen, Xiao-zhong Lan, Zhi-hua Liao, Xiao-qiang Liu. [Cloning and characterization of an aromatic amino acid aminotransferase(ArAT) gene involved in tropane alkaloid biosynthesis from Hyoscyamus niger].
Yao xue xue bao = Acta pharmaceutica Sinica.
2017 Jan; 52(1):172-9. doi:
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Scientific reports.
2016 11; 6(?):37709. doi:
10.1038/srep37709. [PMID: 27874086] - Arik Eisenkraft, Avshalom Falk. Possible role for anisodamine in organophosphate poisoning.
British journal of pharmacology.
2016 06; 173(11):1719-27. doi:
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Journal of biotechnology.
2015 Oct; 211(?):123-9. doi:
10.1016/j.jbiotec.2015.07.019. [PMID: 26239231] - Szymon Dziomba, Teresa Łepek, Zbigniew Jaremicz, Maria Łuczkiewicz, Adam Prahl, Piotr Kowalski. Simultaneous determination of scopolamine, hyoscyamine and anisodamine in in vitro growth media of selected Solanaceae hairy roots by CE method.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2015 Sep; 1001(?):17-21. doi:
10.1016/j.jchromb.2015.06.029. [PMID: 26253806] - Fengjie Tian, Cuiyun Li, Xin Wang, Shuangxia Ren, Ning Li, Qi Liu, Sufeng Zhou, Yang Lu, Di Zhao, Xijing Chen. Comparative study on pharmacokinetics of a series of anticholinergics, atropine, anisodamine, anisodine, scopolamine and tiotropium in rats.
European journal of drug metabolism and pharmacokinetics.
2015 Sep; 40(3):245-53. doi:
10.1007/s13318-014-0192-y. [PMID: 24748278] - Yun-bin Jiang, Yan Gou, Mao-hua Yuan, Yu-ying Ma, Juan Zhou, Pi-e Wu. [HPLC Fingerprint of Anisodus tanguticus Root].
Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials.
2015 May; 38(5):957-61. doi:
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Journal of separation science.
2014 Oct; 37(19):2664-74. doi:
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Cytokine.
2014 Mar; 66(1):78-86. doi:
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Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology.
2014 Mar; 30(2):184-8. doi:
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Drug and chemical toxicology.
2014 Jan; 37(1):100-6. doi:
10.3109/01480545.2013.834347. [PMID: 24274456] - Chong-Hui Li, Xuan Zhang, Xin-Lan Ge, Xin Huang, Ai-Qun Zhang, Wan-Qing Gu. Effects of combined anisodamine and neostigmine treatment on the inflammatory response and liver regeneration of obstructive jaundice rats after hepatectomy.
BioMed research international.
2014; 2014(?):362024. doi:
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Phytochemical analysis : PCA.
2014 Jan; 25(1):29-35. doi:
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Electrophoresis.
2013 Nov; 34(20-21):2962-9. doi:
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Journal of separation science.
2013 Oct; 36(19):3184-90. doi:
10.1002/jssc.201300451. [PMID: 23897549] - Nengsheng Ye, Jian Li, Chong Gao, Yali Xie. Simultaneous determination of atropine, scopolamine, and anisodamine in Flos daturae by capillary electrophoresis using a capillary coated by graphene oxide.
Journal of separation science.
2013 Aug; 36(16):2698-702. doi:
10.1002/jssc.201300304. [PMID: 23868645] - Ya-hua Liu, Jie Zhang, Zheng Dai, Man-hong Zhou, Yu-hua Li, Xue-lian Yin, Wei Zhang, Hong Shen. [Protection of anisodamine on the mitochondrial injury induced by oxidative stress in swine with cardiac arrest].
Zhonghua wei zhong bing ji jiu yi xue.
2013 May; 25(5):290-3. doi:
10.3760/cma.j.issn.2095-4352.2013.05.013. [PMID: 23663580] - Ya-hua Liu, Man-hong Zhou, Zheng Dai, Jie Zhang, Hai-yan Zhu, Yu-hua Li, Xue-lian Yin, Wei Zhang, Hong Shen. [Protective effect of anisodamine against myocardial cell apoptosis through mitochondria impairment in cardiac arrest in pigs].
Zhonghua wei zhong bing ji jiu yi xue.
2013 Feb; 25(2):88-91. doi:
10.3760/cma.j.issn.2095-4352.2013.02.009. [PMID: 23648158] - Wei Geng, Xiang-Hua Fu, Xin-Shun Gu, Yan-Bo Wang, Xue-Chao Wang, Wei Li, Yun-Fa Jiang, Guo-Zhen Hao, Wei-Ze Fan, Ling Xue. Preventive effects of anisodamine against contrast-induced nephropathy in type 2 diabetics with renal insufficiency undergoing coronary angiography or angioplasty.
Chinese medical journal.
2012 Oct; 125(19):3368-72. doi:
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Acta pharmacologica Sinica.
2012 Jun; 33(6):761-6. doi:
10.1038/aps.2012.26. [PMID: 22580739] - Hui Wu, Zhefeng Fan. Mn-doped ZnS quantum dots for the room-temperature phosphorescence detection of raceanisodamine hydrochloride and atropine sulfate in biological fluids.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2012 May; 90(?):131-4. doi:
10.1016/j.saa.2012.01.041. [PMID: 22336044] - Yan-bo Wang, Xiang-hua Fu, Xin-shun Gu, Xue-chao Wang, Yu-jun Zhao, Guo-zhen Hao, Yun-fa Jiang, Wei-ze Fan, Wei-li Wu, Shi-qiang Li, Ling Xue. Safety and efficacy of anisodamine on prevention of contrast induced nephropathy in patients with acute coronary syndrome.
Chinese medical journal.
2012 Mar; 125(6):1063-7. doi:
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The Tohoku journal of experimental medicine.
2011 06; 224(2):91-7. doi:
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Planta medica.
2010 Mar; 76(4):402-5. doi:
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Journal of chromatography. A.
2010 Jan; 1217(1):171-4. doi:
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Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology.
2009 Nov; 25(4):557-60. doi:
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Journal of gastroenterology and hepatology.
2009 Jun; 24(6):1070-6. doi:
10.1111/j.1440-1746.2008.05756.x. [PMID: 19220677] - Yong-Yun Wei, Xiang-Hua Fu, Jun Liu. [Effect of intra-coronary injection of anisodamine on the slow-reflow phenomenon in patients with acute myocardial infarction after percutaneous coronary intervention].
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine.
2008 Apr; 28(4):295-9. doi:
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Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue.
2008 Mar; 20(3):183-6. doi:
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Journal of separation science.
2007 Jun; 30(9):1357-63. doi:
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Journal of applied toxicology : JAT.
2007 Mar; 27(2):116-21. doi:
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Yao xue xue bao = Acta pharmaceutica Sinica.
2006 Dec; 41(12):1166-9. doi:
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Journal of chromatography. A.
2005 Oct; 1091(1-2):32-9. doi:
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2005 Sep; 824(1-2):21-9. doi:
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Clinical and diagnostic laboratory immunology.
2005 Mar; 12(3):399-408. doi:
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2004 Oct; 809(2):265-71. doi:
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Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine.
2004 May; 24(5):422-6. doi:
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Cardiovascular toxicology.
2004; 4(4):375-84. doi:
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Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials.
2003 May; 26(5):385-7. doi:
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Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan.
2003 Mar; 23(1):59-61. doi:
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Acta pharmacologica Sinica.
2001 Dec; 22(12):1071-7. doi:
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World journal of gastroenterology.
2001 Aug; 7(4):572-4. doi:
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Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan.
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