Dimercaprol (BioDeep_00000005034)
Secondary id: BioDeep_00001867864
human metabolite blood metabolite Chemicals and Drugs Toxin
代谢物信息卡片
2,3-Dimercaptopropanol, cadmium
化学式: C3H8OS2 (124.0017)
中文名称: 二巯基丙醇
谱图信息:
最多检出来源 Homo sapiens(blood) 5.4%
分子结构信息
SMILES: C(C(CS)S)O
InChI: InChI=1S/C3H8OS2/c4-1-3(6)2-5/h3-6H,1-2H2
描述信息
Dimercaprol is a traditional chelating agent developed by British biochemists at Oxford University during World War II. It was developed as an experimental antidote against the arsenic-based poison gas Lewisite. It has been used clinically since 1949 in arsenic, cadmium and mercury poisoning. In addition, it has in the past been used for the treatment of Wilsons disease, a genetic disorder in which the body tends to retain copper. Dimercaprol is a potentially toxic drug, and its use may be accompanied by multiple side effects.
V - Various > V03 - All other therapeutic products > V03A - All other therapeutic products > V03AB - Antidotes
D064449 - Sequestering Agents > D002614 - Chelating Agents
同义名列表
44 个代谢物同义名
2,3-Dimercaptopropanol, cadmium; Cadmium 2,3-dimercaptopropanol; Cadmium 2,3 dimercaptopropanol; Anti-lewisite agent, british; 3-Hydroxy-1,2-propanedithiol; British anti-lewisite agent; British anti lewisite agent; Taylor brand OF dimercaprol; 2,3-Dimercaptol-1-propanol; Knoll brand OF dimercaprol; 2,3-disulfanylpropan-1-ol; 1,2-Dimercapto-3-propanol; 2,3-Dimercapto-1-propanol; alpha,beta-Dithioglycerol; 2,3-Mercaptopropan-1-ol; 2,3 Dimercaptopropanol; Anti-lewisite, british; 2,3-Dimercaptopropanol; British anti lewisite; 2,3 Dithiopropan 1 O1; British anti-lewisite; 2,3-Dithiopropan-1-O1; British antilewisite; 2,3-Mercaptopropanol; Α,β-dithioglycerol; a,b-Dithioglycerol; Dimercaptopropanol; 1,2-Dithioglycerol; 2,3-Dithiopropanol; Dithioglycerine; Dithioglycerol; 2,3-Dimercapro; Dimercaprolum; DIMERCAPROL; Oil, bal in; In oil, bal; BAL in oil; Sulphactin; Sulfactin; Dicaptol; B.A.L.; BAL; Dimercaprol; Dimercaprol
数据库引用编号
18 个数据库交叉引用编号
- ChEBI: CHEBI:64198
- KEGG: C02924
- KEGGdrug: D89691
- KEGGdrug: D00167
- PubChem: 3080
- HMDB: HMDB0015677
- Metlin: METLIN2278
- DrugBank: DB06782
- ChEMBL: CHEMBL1597
- Wikipedia: Dimercaprol
- MeSH: Dimercaprol
- chemspider: 2971
- CAS: 59-52-9
- PMhub: MS000017715
- PubChem: 5847
- NIKKAJI: J2.808H
- RefMet: Dimercaprol
- KNApSAcK: 64198
分类词条
相关代谢途径
Reactome(0)
BioCyc(4)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Salem Harry-Hernandez, Jeffrey Thiboutot, Momen M Wahidi, Coral X Giovacchini, Jose De Cardenas, Catherine Meldrum, Jenna G Los, Peter B Illei, Samira Shojaee, Thomas Eissenberg, David DiBardino, Heather Giannini, Fabien Maldonado, Lance Roller, Lonny B Yarmus, Christopher M Kapp. Bronchoalveolar Lavage (BAL) and Pathologic Assessment of Electronic Cigarette or Vaping Product Use-associated Lung Injury (EVALI): The EVALI-BAL Study, A Multicenter Cohort.
Journal of bronchology & interventional pulmonology.
2023 Apr; 30(2):144-154. doi:
10.1097/lbr.0000000000000890. [PMID: 35993570] - Alyssa Bonnier, Anum Nida, Woon Hean Chong, Santu Saha, Biplab K Saha. Vaping Associated Acute Eosinophilic Pneumonia: A Clinical and Radiologic Mimicker of COVID-19.
Prague medical report.
2023; 124(3):283-292. doi:
10.14712/23362936.2023.22. [PMID: 37736951] - Claudia María García-Cuellar, Claudio Cabral-Romero, Rene Hernández-Delgadillo, Juan Manuel Solis-Soto, Irene Meester, Yesennia Sánchez-Pérez, Sergio Eduardo Nakagoshi-Cepeda, Nayely Pineda-Aguilar, Rosa Isela Sánchez-Nájera, María Argelia Akemi Nakagoshi-Cepeda, Shankararaman Chellam. Bismuth Lipophilic Nanoparticles (BisBAL NP) Inhibit the Growth of Tumor Cells in a Mouse Melanoma Model.
Anti-cancer agents in medicinal chemistry.
2022; 22(14):2548-2557. doi:
10.2174/1871520622666220215124434. [PMID: 35168526] - Liangqin Shi, Yazhou Lin, Yucheng Jiao, Seth A Herr, Jonathan Tang, Edmond Rogers, Zhengli Chen, Riyi Shi. Acrolein scavenger dimercaprol offers neuroprotection in an animal model of Parkinson's disease: implication of acrolein and TRPA1.
Translational neurodegeneration.
2021 04; 10(1):13. doi:
10.1186/s40035-021-00239-0. [PMID: 33910636] - Renyan Tang, Jianmin Zhu, Ying Liu, Ning Wu, Jinbin Han. Formulation Comprising Arsenic Trioxide and Dimercaprol Enhances Radiosensitivity of Pancreatic Cancer Xenografts.
Technology in cancer research & treatment.
2021 Jan; 20(?):15330338211036324. doi:
10.1177/15330338211036324. [PMID: 34433326] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Chun-Yuan Hsiao, Chip Gresham, Mark R Marshall. Treatment of lead and arsenic poisoning in anuric patients - a case report and narrative review of the literature.
BMC nephrology.
2019 10; 20(1):374. doi:
10.1186/s12882-019-1561-1. [PMID: 31623560] - Jianhong Hu, Kevin Y Wang, Tao Wang. Diffuse palmoplantar keratotic papules and melanosis.
International journal of dermatology.
2019 Jan; 58(1):e9-e10. doi:
10.1111/ijd.14265. [PMID: 30345510] - Angela L Chiew, Christian Gluud, Jesper Brok, Nick A Buckley. Interventions for paracetamol (acetaminophen) overdose.
The Cochrane database of systematic reviews.
2018 02; 2(?):CD003328. doi:
10.1002/14651858.cd003328.pub3. [PMID: 29473717] - Rene Hernandez-Delgadillo, Claudia María García-Cuéllar, Yesennia Sánchez-Pérez, Nayely Pineda-Aguilar, Marco Antonio Martínez-Martínez, Eyra Elvyra Rangel-Padilla, Sergio Eduardo Nakagoshi-Cepeda, Juan Manuel Solís-Soto, Rosa Isela Sánchez-Nájera, María Argelia Akemi Nakagoshi-Cepeda, Shankararaman Chellam, Claudio Cabral-Romero. In vitro evaluation of the antitumor effect of bismuth lipophilic nanoparticles (BisBAL NPs) on breast cancer cells.
International journal of nanomedicine.
2018; 13(?):6089-6097. doi:
10.2147/ijn.s179095. [PMID: 30323596] - Ran Tian, Riyi Shi. Dimercaprol is an acrolein scavenger that mitigates acrolein-mediated PC-12 cells toxicity and reduces acrolein in rat following spinal cord injury.
Journal of neurochemistry.
2017 06; 141(5):708-720. doi:
10.1111/jnc.14025. [PMID: 28301040] - Hernandez-Delgadillo Rene, Appala Raju Badireddy, Martínez-Sanmiguel Juan José, Contreras-Cordero Juan Francisco, Martinez-Gonzalez Gustavo Israel, Sánchez-Nájera Rosa Isela, Shankararaman Chellam, Cabral-Romero Claudio. Cytotoxic Effect of Lipophilic Bismuth Dimercaptopropanol Nanoparticles on Epithelial Cells.
Journal of nanoscience and nanotechnology.
2016 Jan; 16(1):203-9. doi:
10.1166/jnn.2016.10735. [PMID: 27398446] - Chih-Yun Kuo, Hui-Chun Wang, Po-Hsiung Kung, Chi-Yu Lu, Chieh-Yu Liao, Ming-Tsang Wu, Chin-Chung Wu. Identification of CalDAG-GEFI as an intracellular target for the vicinal dithiol binding agent phenylarsine oxide in human platelets.
Thrombosis and haemostasis.
2014 May; 111(5):892-901. doi:
10.1160/th13-07-0629. [PMID: 24352565] - Bhupesh Sharma, P M Sharma. Arsenic toxicity induced endothelial dysfunction and dementia: pharmacological interdiction by histone deacetylase and inducible nitric oxide synthase inhibitors.
Toxicology and applied pharmacology.
2013 Nov; 273(1):180-8. doi:
10.1016/j.taap.2013.07.017. [PMID: 23921152] - Saritha Sannadi, Praveen Kumar Kadeyala, Rajarami Reddy Gottipolu. Reversal effect of monoisoamyl dimercaptosuccinic acid (MiADMSA) for arsenic and lead induced perturbations in apoptosis and antioxidant enzymes in developing rat brain.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience.
2013 Nov; 31(7):586-97. doi:
10.1016/j.ijdevneu.2013.07.003. [PMID: 23906897] - Babak Mostafazadeh, Amir Kiani, Ebrahim Mohamadi, Fatemeh Shaki, Farshad Hosein Shirazi. Mercury exposure of gold mining workers in the northwest of Iran.
Pakistan journal of pharmaceutical sciences.
2013 Nov; 26(6):1267-70. doi:
. [PMID: 24191337] - M S Sasan, N Hadavi, R Afshari, S R Mousavi, A Alizadeh, Mahdi Balali-Mood. Metal mercury poisoning in two boys initially treated for brucellosis in Mashhad, Iran.
Human & experimental toxicology.
2012 Feb; 31(2):193-6. doi:
10.1177/0960327111417265. [PMID: 21803782] - Kelly E Coller, Nicholas S Heaton, Kristi L Berger, Jacob D Cooper, Jessica L Saunders, Glenn Randall. Molecular determinants and dynamics of hepatitis C virus secretion.
PLoS pathogens.
2012 Jan; 8(1):e1002466. doi:
10.1371/journal.ppat.1002466. [PMID: 22241992] - A R Badireddy, S Chellam. Bismuth dimercaptopropanol (BisBAL) inhibits formation of multispecies wastewater flocs.
Journal of applied microbiology.
2011 Jun; 110(6):1426-37. doi:
10.1111/j.1365-2672.2011.05002.x. [PMID: 21410850] - Robert D Cox, Jeffrey Orledge. Inadvertent poisoning of seven teenagers with monosodium methanearsonate.
Clinical toxicology (Philadelphia, Pa.).
2011 Mar; 49(3):167-70. doi:
10.3109/15563650.2011.559473. [PMID: 21495885] - Sarah Hassan, Mohammad Usman Shaikh, Natasha Ali, Mehmood Riaz. Copper sulphate toxicity in a young male complicated by methemoglobinemia, rhabdomyolysis and renal failure.
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP.
2010 Jul; 20(7):490-1. doi:
07.2010/jcpsp.490491. [PMID: 20642956] - Alicia Pérez-Llamazares, Cristóbal J Galbán-Malagón, Jesús R Aboal, J Angel Fernández, Alejo Carballeira. Evaluation of cations and chelating agents as extracellular extractants for Cu, Pb, V and Zn in the sequential elution technique applied to the terrestrial moss Pseudoscleropodium purum.
Ecotoxicology and environmental safety.
2010 May; 73(4):507-14. doi:
10.1016/j.ecoenv.2009.12.019. [PMID: 20092897] - Stefan Trümpler, Sascha Nowak, Björn Meermann, Gerhard A Wiesmüller, Wolfgang Buscher, Michael Sperling, Uwe Karst. Detoxification of mercury species--an in vitro study with antidotes in human whole blood.
Analytical and bioanalytical chemistry.
2009 Nov; 395(6):1929-35. doi:
10.1007/s00216-009-3105-1. [PMID: 19768643] - Meng Huang, Yi-Ting Wang, Paul C Ho. Quantification of arsenic compounds using derivatization, solvent extraction and liquid chromatography electrospray ionization tandem mass spectrometry.
Journal of pharmaceutical and biomedical analysis.
2008 Dec; 48(5):1381-91. doi:
10.1016/j.jpba.2008.09.018. [PMID: 18977105] - Roy Cohen, Merav Marom, Daphne Atlas. Depolarization-evoked secretion requires two vicinal transmembrane cysteines of syntaxin 1A.
PloS one.
2007 Dec; 2(12):e1273. doi:
10.1371/journal.pone.0001273. [PMID: 18060067] - S J S Flora, Smrati Bhadauria, G M Kannan, Nutan Singh. Arsenic induced oxidative stress and the role of antioxidant supplementation during chelation: a review.
Journal of environmental biology.
2007 Apr; 28(2 Suppl):333-47. doi:
. [PMID: 17929749] - Jan Magdalan, Małgorzata Smolarek, Barbara Porebska, Marcin Zawadzki, Piotr Dyś. [Two different clinical cases of acute arsenic trioxide intoxication].
Przeglad lekarski.
2007; 64(4-5):336-8. doi:
NULL. [PMID: 17724905] - F W Santos, J B T Rocha, C W Nogueira. 2,3-Dimercaptopropanol, 2,3-dimercaptopropane-1-sulfonic acid and meso-2,3-dimercaptosuccinic acid increase lead-induced inhibition of delta-aminolevulinate dehydratase in vitro and ex vivo.
Toxicology in vitro : an international journal published in association with BIBRA.
2006 Apr; 20(3):317-23. doi:
10.1016/j.tiv.2005.08.006. [PMID: 16168622] - M-P Perriol, D Devos, J-F Hurtevent, V Tiffreau, F Saulnier, A Destee, L Defebvre. [A case of neuropathy mimicking Guillain-Barré syndrome after arsenic intoxication].
Revue neurologique.
2006 Mar; 162(3):374-7. doi:
10.1016/s0035-3787(06)75025-1. [PMID: 16585894] - H Vasken Aposhian, Mary M Aposhian. Arsenic toxicology: five questions.
Chemical research in toxicology.
2006 Jan; 19(1):1-15. doi:
10.1021/tx050106d. [PMID: 16411650] - F W Santos, C E Gonçales, J B T Rocha, Cristina Wayne Nogueira. 2,3-Dimercaptopropanol, 2,3-dimercaptopropane-1-sulfonic acid and meso-2,3-dimercaptosuccinic acid acute administration diferentially change biochemical parameters in mice.
Basic & clinical pharmacology & toxicology.
2005 Apr; 96(4):331-4. doi:
10.1111/j.1742-7843.2005.pto960409.x. [PMID: 15755317] - Taciane Roza, Nilce Coelho Peixoto, Aurea Welter, Erico Marlon Moraes Flores, Maria Ester Pereira. 2,3-Dimercapto-1-propanol does not alter the porphobilinogen synthase inhibition but decreases the mercury content in liver and kidney of suckling rats exposed to HgCl2.
Basic & clinical pharmacology & toxicology.
2005 Apr; 96(4):302-8. doi:
10.1111/j.1742-7843.2005.pto960405.x. [PMID: 15755313] - Akira Namera, Mikio Yashiki. [Practical analysis of toxic substances useful for clinical toxicology--14--arsenics].
Chudoku kenkyu : Chudoku Kenkyukai jun kikanshi = The Japanese journal of toxicology.
2005 Apr; 18(2):157-60. doi:
NULL. [PMID: 16045178] - Hideaki Shimada, Masaaki Nagano, Takayuki Funakoshi, Yorishige Imamura. Effects of chelating agents on distribution and excretion of terbium in mice.
Toxicology mechanisms and methods.
2005; 15(3):181-4. doi:
10.1080/15376520590945595. [PMID: 20021081] - F Wong, L K Hung, C H Wong, P C Ho. Suicidal mercury injection into the upper limb: a case study.
Hand surgery : an international journal devoted to hand and upper limb surgery and related research : journal of the Asia-Pacific Federation of Societies for Surgery of the Hand.
2004 Dec; 9(2):225-8. doi:
10.1142/s0218810404002352. [PMID: 15810110] - C E Byers, E R Holloway, W D Korte, J R Smith, E D Clarkson, G E Platoff, B R Capacio. Gas chromatographic-mass spectrometric determination of british anti-lewisite in plasma.
Journal of analytical toxicology.
2004 Jul; 28(5):384-9. doi:
10.1093/jat/28.5.384. [PMID: 15239860] - Magali Mas, Pierre Cavaillès, Céline Colacios, Jean-François Subra, Dominique Lagrange, Maryline Calise, Marie-Odile Christen, Philippe Druet, Lucette Pelletier, Dominique Gauguier, Gilbert J Fournié. Studies of congenic lines in the Brown Norway rat model of Th2-mediated immunopathological disorders show that the aurothiopropanol sulfonate-induced immunological disorder (Aiid3) locus on chromosome 9 plays a major role compared to Aiid2 on chromosome 10.
Journal of immunology (Baltimore, Md. : 1950).
2004 May; 172(10):6354-61. doi:
10.4049/jimmunol.172.10.6354. [PMID: 15128826] - Xiufen Lu, Lora L Arnold, Samuel M Cohen, William R Cullen, X Chris Le. Speciation of dimethylarsinous acid and trimethylarsine oxide in urine from rats fed with dimethylarsinic acid and dimercaptopropane sulfonate.
Analytical chemistry.
2003 Dec; 75(23):6463-8. doi:
10.1021/ac034868u. [PMID: 14640715] - Y O Y Soo, C H Wong, J F Griffith, T Y K Chan. Subcutaneous injection of metallic mercury.
Human & experimental toxicology.
2003 Jun; 22(6):345-8. doi:
10.1191/0960327103ht345cr. [PMID: 12856958] - Céline Basset, Jacqueline Vadrot, Jacques Denis, Joël Poupon, Elie Serge Zafrani. Prolonged cholestasis and ductopenia following gold salt therapy.
Liver international : official journal of the International Association for the Study of the Liver.
2003 Apr; 23(2):89-93. doi:
10.1034/j.1600-0676.2003.00806.x. [PMID: 12654130] - Takashi Kon, Katsuhiko Akiyama, Toyotaka Aiba. [Shotgun injury of head and neck: case report].
No shinkei geka. Neurological surgery.
2002 May; 30(5):517-21. doi:
. [PMID: 11993175] - Yoshito Kumagai, Sachie Koide, Keiko Taguchi, Akiko Endo, Yumi Nakai, Toshikazu Yoshikawa, Nobuhiro Shimojo. Oxidation of proximal protein sulfhydryls by phenanthraquinone, a component of diesel exhaust particles.
Chemical research in toxicology.
2002 Apr; 15(4):483-9. doi:
10.1021/tx0100993. [PMID: 11952333] - Binh T Ly, Saralyn R Williams, Richard F Clark. Mercuric oxide poisoning treated with whole-bowel irrigation and chelation therapy.
Annals of emergency medicine.
2002 Mar; 39(3):312-5. doi:
10.1067/mem.2002.119508. [PMID: 11867987] - Abdollah Karimi, Farahbakhsh Moniri, Aliasghar Nasihatkon, Mohammad Jafar Zarepoor, Abdolvahhab Alborzi. Mercury exposure among residents of a building block in Shiraz, Iran.
Environmental research.
2002 Jan; 88(1):41-3. doi:
10.1006/enrs.2001.4273. [PMID: 11896667] - C W Nogueira, J B Rocha, D O Souza. Effect of dithiol chelating agents on [3H]MK-801 and [3H]glutamate binding to synaptic plasma membranes.
Neurochemical research.
2001 Dec; 26(12):1305-10. doi:
10.1023/a:1014297401088. [PMID: 11885782] - Y Kamijo, K Soma, K Yosimura, T Ohwada. Acute mercuric chloride poisoning: effect of co-ingested milk on outcome and continued hyperamylasemia.
Veterinary and human toxicology.
2001 Oct; 43(5):277-9. doi:
NULL. [PMID: 11577931] - S Lombard, M E Helmy, G Piéroni. Lipolytic activity of ricin from Ricinus sanguineus and Ricinus communis on neutral lipids.
The Biochemical journal.
2001 Sep; 358(Pt 3):773-81. doi:
10.1042/0264-6021:3580773. [PMID: 11535138] - N Gupta, T D Porter. Garlic and garlic-derived compounds inhibit human squalene monooxygenase.
The Journal of nutrition.
2001 Jun; 131(6):1662-7. doi:
10.1093/jn/131.6.1662. [PMID: 11385050] - B P Laden, T D Porter. Inhibition of human squalene monooxygenase by tellurium compounds: evidence of interaction with vicinal sulfhydryls.
Journal of lipid research.
2001 Feb; 42(2):235-40. doi:
. [PMID: 11181753] - C W Nogueira, F A Soares, R C Bolzan, M C Jacques-Silva, D O Souza, J B Rocha. Investigations into the mechanism of 2,3-dimercaptopropanol neurotoxicity.
Neurochemical research.
2000 Dec; 25(12):1553-8. doi:
10.1023/a:1026658217907. [PMID: 11152384] - P Pai, S Thomas, N Hoenich, R Roberts, I House, A Brown. Treatment of a case of severe mercuric salt overdose with DMPS (dimercapo-1-propane sulphonate) and continuous haemofiltration.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2000 Nov; 15(11):1889-90. doi:
10.1093/ndt/15.11.1889. [PMID: 11071989] - A Fidder, D Noort, A G Hulst, L P de Jong, H P Benschop. Biomonitoring of exposure to lewisite based on adducts to haemoglobin.
Archives of toxicology.
2000 Jul; 74(4-5):207-14. doi:
10.1007/s002040000117. [PMID: 10959794] - M Mas, J F Subra, D Lagrange, S Pilipenko-Appolinaire, N Kermarrec, D Gauguier, P Druet, G J Fournié. Rat chromosome 9 bears a major susceptibility locus for IgE response.
European journal of immunology.
2000 Jun; 30(6):1698-705. doi:
10.1002/1521-4141(200006)30:6<1698::aid-immu1698>3.0.co;2-f. [PMID: 10898507] - P O Ozuah. Mercury poisoning.
Current problems in pediatrics.
2000 Mar; 30(3):91-9. doi:
10.1067/mps.2000.104054. [PMID: 10742922] - P Domenico, J M Tomas, S Merino, X Rubires, B A Cunha. Surface antigen exposure by bismuth dimercaprol suppression of Klebsiella pneumoniae capsular polysaccharide.
Infection and immunity.
1999 Feb; 67(2):664-9. doi:
10.1128/iai.67.2.664-669.1999. [PMID: 9916074] - A de la Torre, M Bellés, J M Llobet, E Mayayo, J L Domingo. Comparison of the effectiveness of 2,3-dimercaptopropanol (BAL) and meso-2,3-dimercaptosuccinic acid (DMSA) as protective agents against mercuric chloride-induced nephrotoxicity in rats.
Biological trace element research.
1998 Jul; 63(1):1-10. doi:
10.1007/bf02785272. [PMID: 9764565] - M Liu, J C Pelling, J Ju, E Chu, D E Brash. Antioxidant action via p53-mediated apoptosis.
Cancer research.
1998 Apr; 58(8):1723-9. doi:
". [PMID: 9563490] - E Eber, T Uhlig, C McMenamin, P D Sly. Leflunomide, a novel immunomodulating agent, prevents the development of allergic sensitization in an animal model of allergic asthma.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.
1998 Mar; 28(3):376-84. doi:
10.1046/j.1365-2222.1998.00240.x. [PMID: 9543089] - Y Kamijo, K Soma, Y Asari, T Ohwada. Survival after massive arsenic poisoning self-treated by high fluid intake.
Journal of toxicology. Clinical toxicology.
1998; 36(1-2):27-9. doi:
10.3109/15563659809162579. [PMID: 9541037] - P Hantson, F Lula, M Lievens, P Mahieu. Extremely high plasma zinc following zinc chloride ingestion.
Journal of toxicology. Clinical toxicology.
1998; 36(4):375-7. doi:
10.3109/15563659809028036. [PMID: 9711206] - N H Virstiuk. [The effect of aurotherapy on the level of unsaturated fatty acids during the treatment of rheumatoid arthritis patients].
Likars'ka sprava.
1997 Sep; ?(5):166-70. doi:
NULL. [PMID: 9491733] - H Mückter, B Liebl, F X Reichl, G Hunder, U Walther, B Fichtl. Are we ready to replace dimercaprol (BAL) as an arsenic antidote?.
Human & experimental toxicology.
1997 Aug; 16(8):460-5. doi:
10.1177/096032719701600807. [PMID: 9292286] - T Emanuelli, J B Rocha, M E Pereira, L O Porciuncula, V M Morsch, A F Martins, D O Souza. Effect of mercuric chloride intoxication and dimercaprol treatment on delta-aminolevulinate dehydratase from brain, liver and kidney of adult mice.
Pharmacology & toxicology.
1996 Sep; 79(3):136-43. doi:
10.1111/j.1600-0773.1996.tb00257.x. [PMID: 8884872] - J B Johansen, A Abildtrup, N E Ebbehøj, S R Kristensen, O Eshøj. [Acute arsenic poisoning].
Ugeskrift for laeger.
1996 Jul; 158(29):4201-2. doi:
NULL. [PMID: 8701539] - R H Adamson. Protein tyrosine phosphorylation modulates microvessel permeability in frog mesentery.
Microcirculation (New York, N.Y. : 1994).
1996 Jun; 3(2):245-7. doi:
10.3109/10739689609148297. [PMID: 8839449] - N Kermarrec, C Dubay, B De Gouyon, C Blanpied, D Gauguier, K Gillespie, P W Mathieson, P Druet, M Lathrop, F Hirsch. Serum IgE concentration and other immune manifestations of treatment with gold salts are linked to the MHC and IL4 regions in the rat.
Genomics.
1996 Jan; 31(1):111-4. doi:
10.1006/geno.1996.0016. [PMID: 8808287] - P Hantson, M Lievens, P Mahieu. Accidental ingestion of a zinc and copper sulfate preparation.
Journal of toxicology. Clinical toxicology.
1996; 34(6):725-30. doi:
10.3109/15563659609013836. [PMID: 8941204] - N Kermarrec, C Blanpied, L Pelletier, N Feingold, C Mandet, P Druet, F Hirsch. Genetic study of gold-salt-induced immune disorders in the rat.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
1995 Dec; 10(12):2187-91. doi:
10.1093/ndt/10.12.2187. [PMID: 8808209] - N M Cullen, L R Wolf, D St Clair. Pediatric arsenic ingestion.
The American journal of emergency medicine.
1995 Jul; 13(4):432-5. doi:
10.1016/0735-6757(95)90133-7. [PMID: 7605532] - C B Burns, B Currie. The efficacy of chelation therapy and factors influencing mortality in lead intoxicated petrol sniffers.
Australian and New Zealand journal of medicine.
1995 Jun; 25(3):197-203. doi:
10.1111/j.1445-5994.1995.tb01521.x. [PMID: 7487685] - H V Aposhian, R M Maiorino, D Gonzalez-Ramirez, M Zuniga-Charles, Z Xu, K M Hurlbut, P Junco-Munoz, R C Dart, M M Aposhian. Mobilization of heavy metals by newer, therapeutically useful chelating agents.
Toxicology.
1995 Mar; 97(1-3):23-38. doi:
10.1016/0300-483x(95)02965-b. [PMID: 7716789] - B Liebl, H Mückter, E Doklea, B Fichtl, W Forth. Influence of 2,3-dimercaptopropanol and other sulfur compounds on oxophenylarsine-mediated inhibition of glucose uptake in MDCK cells.
The Analyst.
1995 Mar; 120(3):771-4. doi:
10.1039/an9952000771. [PMID: 7741227] - V Le Cabec, I Maridonneau-Parini. Complete and reversible inhibition of NADPH oxidase in human neutrophils by phenylarsine oxide at a step distal to membrane translocation of the enzyme subunits.
The Journal of biological chemistry.
1995 Feb; 270(5):2067-73. doi:
10.1074/jbc.270.5.2067. [PMID: 7530716] - S Cloarec, G Deschênes, M Sagnier, J C Rolland, H Nivet. [Arterial hypertension due to mercury poisoning: diagnostic value of captopril].
Archives de pediatrie : organe officiel de la Societe francaise de pediatrie.
1995 Jan; 2(1):43-6. doi:
10.1016/0929-693x(96)89808-3. [PMID: 7735425] - P Houeto, P Sandouk, F J Baud, P Levillain. Elemental mercury vapour toxicity: treatment and levels in plasma and urine.
Human & experimental toxicology.
1994 Dec; 13(12):848-52. doi:
10.1177/096032719401301205. [PMID: 7718304] - P E McKinney, J Brent, K Kulig. Acute zinc chloride ingestion in a child: local and systemic effects.
Annals of emergency medicine.
1994 Jun; 23(6):1383-7. doi:
10.1016/s0196-0644(94)70367-1. [PMID: 7515217] - N Ashizawa, H Okumura, F Kobayashi, T Aotsuka, R Asakura, K Arai, N Ashikawa, A Matsuura. Inhibitory activities of metal chelators on endothelin-converting enzyme. II. In vivo studies.
Biological & pharmaceutical bulletin.
1994 Feb; 17(2):212-6. doi:
10.1248/bpb.17.212. [PMID: 8205118] - F X Reichl, H Kreppel, L Szinicz, H Mückter, B Fichtl, W Forth. Effect of various antidotes on the biliary and intestinal excretion of arsenic in situ and into the feces in vivo in guinea-pigs after injection of As2O3.
Archives of toxicology.
1994; 69(1):35-8. doi:
10.1007/s002040050134. [PMID: 7536408] - M C Fletcher, L E Samelson, C H June. Complex effects of phenylarsine oxide in T cells. Induction of tyrosine phosphorylation and calcium mobilization independent of CD45 expression.
The Journal of biological chemistry.
1993 Nov; 268(31):23697-703. doi:
10.1016/s0021-9258(19)49517-3. [PMID: 7693695] - H Mückter, S Islambouli, E Doklea, C Hopfer, L Szinicz, B Fichtl, W Forth. Isolated rat kidney tubules as a screening system for arsenic antidotes.
Toxicology and applied pharmacology.
1993 Jul; 121(1):118-28. doi:
10.1006/taap.1993.1136. [PMID: 8393218] - P G Mullen, A C Windsor, C J Walsh, C R Blocher, B J Fisher, S K Leeper-Woodford, G J Jesmok, A A Fowler, H J Sugerman. Combined ibuprofen and monoclonal antibody to tumor necrosis factor-alpha attenuate hemodynamic dysfunction and sepsis-induced acute lung injury.
The Journal of trauma.
1993 May; 34(5):612-20; discussion 620. doi:
10.1097/00005373-199305000-00002. [PMID: 8098775] - J Rencová, V Volf, M M Jones, P K Singh. Relative effectiveness of dithiol and dithiocarbamate chelating agents in reducing retention of polonium-210 in rats.
International journal of radiation biology.
1993 Feb; 63(2):223-32. doi:
10.1080/09553009314550291. [PMID: 8094419] - H Shimada, S Fukudome, M Kiyozumi, T Funakoshi, T Adachi, A Yasutake, S Kojima. Further study of effects of chelating agents on excretion of inorganic mercury in rats.
Toxicology.
1993 Jan; 77(1-2):157-69. doi:
10.1016/0300-483x(93)90146-j. [PMID: 8442011] - M E O'Connor. CaEDTA vs CaEDTA plus BAL to treat children with elevated blood lead levels.
Clinical pediatrics.
1992 Jul; 31(7):386-90. doi:
10.1177/000992289203100701. [PMID: 1617861] - S Ia Ornat, D P Aleksandruk. [A method for the permanent maintainance aurotherapy of rheumatoid arthritis patients under the control of gold excretion].
Likars'ka sprava.
1992 May; ?(5):43-6. doi:
NULL. [PMID: 1359710] - D Mathieu, M Mathieu-Nolf, M Germain-Alonso, R Neviere, D Furon, F Wattel. Massive arsenic poisoning--effect of hemodialysis and dimercaprol on arsenic kinetics.
Intensive care medicine.
1992; 18(1):47-50. doi:
10.1007/bf01706427. [PMID: 1578049] - H V Aposhian, R M Maiorino, M Rivera, D C Bruce, R C Dart, K M Hurlbut, D J Levine, W Zheng, Q Fernando, D Carter. Human studies with the chelating agents, DMPS and DMSA.
Journal of toxicology. Clinical toxicology.
1992; 30(4):505-28. doi:
10.3109/15563659209017938. [PMID: 1331491] - J H Graziano, N J Lolacono, T Moulton, M E Mitchell, V Slavkovich, C Zarate. Controlled study of meso-2,3-dimercaptosuccinic acid for the management of childhood lead intoxication.
The Journal of pediatrics.
1992 Jan; 120(1):133-9. doi:
10.1016/s0022-3476(05)80618-3. [PMID: 1309865] - M M Jones, M G Cherian, P K Singh, M A Basinger, S G Jones. A comparative study of the influence of vicinal dithiols and a dithiocarbamate on the biliary excretion of cadmium in rat.
Toxicology and applied pharmacology.
1991 Sep; 110(2):241-50. doi:
10.1016/s0041-008x(05)80006-7. [PMID: 1891771] - G M Schmidt, D A Horak, J C Niland, S R Duncan, S J Forman, J A Zaia. A randomized, controlled trial of prophylactic ganciclovir for cytomegalovirus pulmonary infection in recipients of allogeneic bone marrow transplants; The City of Hope-Stanford-Syntex CMV Study Group.
The New England journal of medicine.
1991 Apr; 324(15):1005-11. doi:
10.1056/nejm199104113241501. [PMID: 1848679] - M J Florentine, D J Sanfilippo. Elemental mercury poisoning.
Clinical pharmacy.
1991 Mar; 10(3):213-21. doi:
. [PMID: 1645633] - O E Roses, J C García Fernández, E C Villaamil, N Camussa, S A Minetti, M Martínez de Marco, P N Quiroga, P Rattay, A Sassone, G Valle. Mass poisoning by sodium arsenite.
Journal of toxicology. Clinical toxicology.
1991; 29(2):209-13. doi:
10.3109/15563659109038613. [PMID: 2051508] - S Ia Ornat. [A method of continuous aurotherapy for rheumatoid arthritis patients under the control of gold excretion].
Sovetskaia meditsina.
1991; ?(7):82-3. doi:
NULL. [PMID: 1683012] - B Rowens, D Guerrero-Betancourt, C A Gottlieb, R J Boyes, M S Eichenhorn. Respiratory failure and death following acute inhalation of mercury vapor. A clinical and histologic perspective.
Chest.
1991 Jan; 99(1):185-90. doi:
10.1378/chest.99.1.185. [PMID: 1984951] - Iu N Kovalev, I I Il'in. [The chrysotherapy of patients with Reiter's disease].
Terapevticheskii arkhiv.
1991; 63(12):123-5. doi:
NULL. [PMID: 1687091] - N V Chichasova, M Z Kanevskaia, G A Slobodina, V A Varshavskiĭ, O V Krel', A A Krel'. [A comparative evaluation of parenteral and oral preparations of gold and D-penicillamine in the treatment of rheumatoid nephropathy].
Terapevticheskii arkhiv.
1991; 63(5):97-101. doi:
NULL. [PMID: 1679571] - A M Hilmy, N A el-Domiaty, M A Kamal, M A Mohamed, W E Abou Samra. Effect of some arsenic antagonists on the toxicity, distribution and excretion of arsenite and arsenate in rats.
Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology.
1991; 99(3):357-62. doi:
10.1016/0742-8413(91)90256-s. [PMID: 1685407] - S Ia Ornat. [The effect of aurotherapy on the content of corticotropin, cortisol, aldosterone and insulin in the blood serum of rheumatoid arthritis patients].
Vrachebnoe delo.
1991 Jan; ?(1):61-5. doi:
NULL. [PMID: 1672783] - H Tournade, L Pelletier, R Pasquier, M C Vial, C Mandet, P Druet. Graft-versus-host reactions in the rat mimic toxin-induced autoimmunity.
Clinical and experimental immunology.
1990 Aug; 81(2):334-8. doi:
10.1111/j.1365-2249.1990.tb03341.x. [PMID: 2387096]
