Dimercaprol (BioDeep_00000005034)

 

Secondary id: BioDeep_00001867864

human metabolite blood metabolite Chemicals and Drugs Toxin


代谢物信息卡片


2,3-Dimercaptopropanol, cadmium

化学式: C3H8OS2 (124.00165580000001)
中文名称: 二巯基丙醇
谱图信息: 最多检出来源 Homo sapiens(blood) 6.08%

分子结构信息

SMILES: C(C(CS)S)O
InChI: InChI=1S/C3H8OS2/c4-1-3(6)2-5/h3-6H,1-2H2

描述信息

Dimercaprol is a traditional chelating agent developed by British biochemists at Oxford University during World War II. It was developed as an experimental antidote against the arsenic-based poison gas Lewisite. It has been used clinically since 1949 in arsenic, cadmium and mercury poisoning. In addition, it has in the past been used for the treatment of Wilsons disease, a genetic disorder in which the body tends to retain copper. Dimercaprol is a potentially toxic drug, and its use may be accompanied by multiple side effects.
V - Various > V03 - All other therapeutic products > V03A - All other therapeutic products > V03AB - Antidotes
D064449 - Sequestering Agents > D002614 - Chelating Agents

同义名列表

42 个代谢物同义名

2,3-Dimercaptopropanol, cadmium; Cadmium 2,3-dimercaptopropanol; Cadmium 2,3 dimercaptopropanol; Anti-lewisite agent, british; 3-Hydroxy-1,2-propanedithiol; British anti-lewisite agent; British anti lewisite agent; Taylor brand OF dimercaprol; 2,3-Dimercaptol-1-propanol; Knoll brand OF dimercaprol; 2,3-disulfanylpropan-1-ol; 1,2-Dimercapto-3-propanol; 2,3-Dimercapto-1-propanol; alpha,beta-Dithioglycerol; 2,3-Mercaptopropan-1-ol; 2,3 Dimercaptopropanol; Anti-lewisite, british; 2,3-Dimercaptopropanol; British anti lewisite; 2,3 Dithiopropan 1 O1; British anti-lewisite; 2,3-Dithiopropan-1-O1; British antilewisite; 2,3-Mercaptopropanol; Α,β-dithioglycerol; a,b-Dithioglycerol; Dimercaptopropanol; 1,2-Dithioglycerol; 2,3-Dithiopropanol; Dithioglycerine; Dithioglycerol; 2,3-Dimercapro; Dimercaprolum; DIMERCAPROL; Oil, bal in; In oil, bal; BAL in oil; Sulphactin; Sulfactin; Dicaptol; B.A.L.; BAL



数据库引用编号

17 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(4)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Salem Harry-Hernandez, Jeffrey Thiboutot, Momen M Wahidi, Coral X Giovacchini, Jose De Cardenas, Catherine Meldrum, Jenna G Los, Peter B Illei, Samira Shojaee, Thomas Eissenberg, David DiBardino, Heather Giannini, Fabien Maldonado, Lance Roller, Lonny B Yarmus, Christopher M Kapp. Bronchoalveolar Lavage (BAL) and Pathologic Assessment of Electronic Cigarette or Vaping Product Use-associated Lung Injury (EVALI): The EVALI-BAL Study, A Multicenter Cohort. Journal of bronchology & interventional pulmonology. 2023 Apr; 30(2):144-154. doi: 10.1097/lbr.0000000000000890. [PMID: 35993570]
  • Alyssa Bonnier, Anum Nida, Woon Hean Chong, Santu Saha, Biplab K Saha. Vaping Associated Acute Eosinophilic Pneumonia: A Clinical and Radiologic Mimicker of COVID-19. Prague medical report. 2023; 124(3):283-292. doi: 10.14712/23362936.2023.22. [PMID: 37736951]
  • Claudia María García-Cuellar, Claudio Cabral-Romero, Rene Hernández-Delgadillo, Juan Manuel Solis-Soto, Irene Meester, Yesennia Sánchez-Pérez, Sergio Eduardo Nakagoshi-Cepeda, Nayely Pineda-Aguilar, Rosa Isela Sánchez-Nájera, María Argelia Akemi Nakagoshi-Cepeda, Shankararaman Chellam. Bismuth Lipophilic Nanoparticles (BisBAL NP) Inhibit the Growth of Tumor Cells in a Mouse Melanoma Model. Anti-cancer agents in medicinal chemistry. 2022; 22(14):2548-2557. doi: 10.2174/1871520622666220215124434. [PMID: 35168526]
  • Liangqin Shi, Yazhou Lin, Yucheng Jiao, Seth A Herr, Jonathan Tang, Edmond Rogers, Zhengli Chen, Riyi Shi. Acrolein scavenger dimercaprol offers neuroprotection in an animal model of Parkinson's disease: implication of acrolein and TRPA1. Translational neurodegeneration. 2021 04; 10(1):13. doi: 10.1186/s40035-021-00239-0. [PMID: 33910636]
  • Renyan Tang, Jianmin Zhu, Ying Liu, Ning Wu, Jinbin Han. Formulation Comprising Arsenic Trioxide and Dimercaprol Enhances Radiosensitivity of Pancreatic Cancer Xenografts. Technology in cancer research & treatment. 2021 Jan; 20(?):15330338211036324. doi: 10.1177/15330338211036324. [PMID: 34433326]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
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  • Jianhong Hu, Kevin Y Wang, Tao Wang. Diffuse palmoplantar keratotic papules and melanosis. International journal of dermatology. 2019 Jan; 58(1):e9-e10. doi: 10.1111/ijd.14265. [PMID: 30345510]
  • Angela L Chiew, Christian Gluud, Jesper Brok, Nick A Buckley. Interventions for paracetamol (acetaminophen) overdose. The Cochrane database of systematic reviews. 2018 02; 2(?):CD003328. doi: 10.1002/14651858.cd003328.pub3. [PMID: 29473717]
  • Rene Hernandez-Delgadillo, Claudia María García-Cuéllar, Yesennia Sánchez-Pérez, Nayely Pineda-Aguilar, Marco Antonio Martínez-Martínez, Eyra Elvyra Rangel-Padilla, Sergio Eduardo Nakagoshi-Cepeda, Juan Manuel Solís-Soto, Rosa Isela Sánchez-Nájera, María Argelia Akemi Nakagoshi-Cepeda, Shankararaman Chellam, Claudio Cabral-Romero. In vitro evaluation of the antitumor effect of bismuth lipophilic nanoparticles (BisBAL NPs) on breast cancer cells. International journal of nanomedicine. 2018; 13(?):6089-6097. doi: 10.2147/ijn.s179095. [PMID: 30323596]
  • Ran Tian, Riyi Shi. Dimercaprol is an acrolein scavenger that mitigates acrolein-mediated PC-12 cells toxicity and reduces acrolein in rat following spinal cord injury. Journal of neurochemistry. 2017 06; 141(5):708-720. doi: 10.1111/jnc.14025. [PMID: 28301040]
  • Hernandez-Delgadillo Rene, Appala Raju Badireddy, Martínez-Sanmiguel Juan José, Contreras-Cordero Juan Francisco, Martinez-Gonzalez Gustavo Israel, Sánchez-Nájera Rosa Isela, Shankararaman Chellam, Cabral-Romero Claudio. Cytotoxic Effect of Lipophilic Bismuth Dimercaptopropanol Nanoparticles on Epithelial Cells. Journal of nanoscience and nanotechnology. 2016 Jan; 16(1):203-9. doi: 10.1166/jnn.2016.10735. [PMID: 27398446]
  • Chih-Yun Kuo, Hui-Chun Wang, Po-Hsiung Kung, Chi-Yu Lu, Chieh-Yu Liao, Ming-Tsang Wu, Chin-Chung Wu. Identification of CalDAG-GEFI as an intracellular target for the vicinal dithiol binding agent phenylarsine oxide in human platelets. Thrombosis and haemostasis. 2014 May; 111(5):892-901. doi: 10.1160/th13-07-0629. [PMID: 24352565]
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  • Saritha Sannadi, Praveen Kumar Kadeyala, Rajarami Reddy Gottipolu. Reversal effect of monoisoamyl dimercaptosuccinic acid (MiADMSA) for arsenic and lead induced perturbations in apoptosis and antioxidant enzymes in developing rat brain. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. 2013 Nov; 31(7):586-97. doi: 10.1016/j.ijdevneu.2013.07.003. [PMID: 23906897]
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  • A R Badireddy, S Chellam. Bismuth dimercaptopropanol (BisBAL) inhibits formation of multispecies wastewater flocs. Journal of applied microbiology. 2011 Jun; 110(6):1426-37. doi: 10.1111/j.1365-2672.2011.05002.x. [PMID: 21410850]
  • Robert D Cox, Jeffrey Orledge. Inadvertent poisoning of seven teenagers with monosodium methanearsonate. Clinical toxicology (Philadelphia, Pa.). 2011 Mar; 49(3):167-70. doi: 10.3109/15563650.2011.559473. [PMID: 21495885]
  • Sarah Hassan, Mohammad Usman Shaikh, Natasha Ali, Mehmood Riaz. Copper sulphate toxicity in a young male complicated by methemoglobinemia, rhabdomyolysis and renal failure. Journal of the College of Physicians and Surgeons--Pakistan : JCPSP. 2010 Jul; 20(7):490-1. doi: 07.2010/jcpsp.490491. [PMID: 20642956]
  • Alicia Pérez-Llamazares, Cristóbal J Galbán-Malagón, Jesús R Aboal, J Angel Fernández, Alejo Carballeira. Evaluation of cations and chelating agents as extracellular extractants for Cu, Pb, V and Zn in the sequential elution technique applied to the terrestrial moss Pseudoscleropodium purum. Ecotoxicology and environmental safety. 2010 May; 73(4):507-14. doi: 10.1016/j.ecoenv.2009.12.019. [PMID: 20092897]
  • Stefan Trümpler, Sascha Nowak, Björn Meermann, Gerhard A Wiesmüller, Wolfgang Buscher, Michael Sperling, Uwe Karst. Detoxification of mercury species--an in vitro study with antidotes in human whole blood. Analytical and bioanalytical chemistry. 2009 Nov; 395(6):1929-35. doi: 10.1007/s00216-009-3105-1. [PMID: 19768643]
  • Meng Huang, Yi-Ting Wang, Paul C Ho. Quantification of arsenic compounds using derivatization, solvent extraction and liquid chromatography electrospray ionization tandem mass spectrometry. Journal of pharmaceutical and biomedical analysis. 2008 Dec; 48(5):1381-91. doi: 10.1016/j.jpba.2008.09.018. [PMID: 18977105]
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  • S J S Flora, Smrati Bhadauria, G M Kannan, Nutan Singh. Arsenic induced oxidative stress and the role of antioxidant supplementation during chelation: a review. Journal of environmental biology. 2007 Apr; 28(2 Suppl):333-47. doi: . [PMID: 17929749]
  • Jan Magdalan, Małgorzata Smolarek, Barbara Porebska, Marcin Zawadzki, Piotr Dyś. [Two different clinical cases of acute arsenic trioxide intoxication]. Przeglad lekarski. 2007; 64(4-5):336-8. doi: NULL. [PMID: 17724905]
  • F W Santos, J B T Rocha, C W Nogueira. 2,3-Dimercaptopropanol, 2,3-dimercaptopropane-1-sulfonic acid and meso-2,3-dimercaptosuccinic acid increase lead-induced inhibition of delta-aminolevulinate dehydratase in vitro and ex vivo. Toxicology in vitro : an international journal published in association with BIBRA. 2006 Apr; 20(3):317-23. doi: 10.1016/j.tiv.2005.08.006. [PMID: 16168622]
  • M-P Perriol, D Devos, J-F Hurtevent, V Tiffreau, F Saulnier, A Destee, L Defebvre. [A case of neuropathy mimicking Guillain-Barré syndrome after arsenic intoxication]. Revue neurologique. 2006 Mar; 162(3):374-7. doi: 10.1016/s0035-3787(06)75025-1. [PMID: 16585894]
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  • Akira Namera, Mikio Yashiki. [Practical analysis of toxic substances useful for clinical toxicology--14--arsenics]. Chudoku kenkyu : Chudoku Kenkyukai jun kikanshi = The Japanese journal of toxicology. 2005 Apr; 18(2):157-60. doi: NULL. [PMID: 16045178]
  • Hideaki Shimada, Masaaki Nagano, Takayuki Funakoshi, Yorishige Imamura. Effects of chelating agents on distribution and excretion of terbium in mice. Toxicology mechanisms and methods. 2005; 15(3):181-4. doi: 10.1080/15376520590945595. [PMID: 20021081]
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