digallate (BioDeep_00000004719)

 

Secondary id: BioDeep_00000859761, BioDeep_00001868699

human metabolite PANOMIX_OTCML-2023


代谢物信息卡片


Benzoic acid,3,4-dihydroxy-5-[(3,4,5-trihydroxybenzoyl)oxy]-

化学式: C14H10O9 (322.0325)
中文名称: 二没食子酸
谱图信息: 最多检出来源 Viridiplantae(otcml) 22.66%

分子结构信息

SMILES: C1=C(C=C(C(=C1O)O)O)C(=O)OC2=CC(=CC(=C2O)O)C(=O)O
InChI: InChI=1S/C14H10O9/c15-7-2-6(3-8(16)11(7)18)14(22)23-10-4-5(13(20)21)1-9(17)12(10)19/h1-4,15-19H,(H,20,21)

描述信息

D004791 - Enzyme Inhibitors > D019384 - Nucleic Acid Synthesis Inhibitors

同义名列表

4 个代谢物同义名

Benzoic acid,3,4-dihydroxy-5-[(3,4,5-trihydroxybenzoyl)oxy]-; Digallic acid; digallate; Digallate



数据库引用编号

13 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

14 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 10 ACE2, AIMP2, BCL2, CASP3, CASP8, DHFR, FABP4, MAPK8, PPARG, XDH
Endosome membrane 1 CLCN5
Endoplasmic reticulum membrane 1 BCL2
Nucleus 10 AIMP2, BCL2, CASP3, CASP8, DNTT, FABP4, GABPA, MAPK8, PARP1, PPARG
cytosol 13 AIMP2, ANO6, BCL2, CASP3, CASP8, CLCN5, DHFR, DNTT, FABP4, MAPK8, PARP1, PPARG, XDH
nuclear body 1 PARP1
nucleoplasm 8 ANO1, CASP3, CASP8, DNTT, GABPA, MAPK8, PARP1, PPARG
RNA polymerase II transcription regulator complex 1 PPARG
Cell membrane 5 ACE2, ADGRL3, ANO1, ANO6, CLCN5
lamellipodium 1 CASP8
Cell projection, axon 1 ADGRL3
Multi-pass membrane protein 4 ADGRL3, ANO1, ANO6, CLCN5
Golgi apparatus membrane 1 CLCN5
Synapse 1 MAPK8
cell junction 1 ADGRL3
cell surface 3 ACE2, ADIPOQ, ANO6
glutamatergic synapse 2 ADGRL3, CASP3
Golgi apparatus 1 CLCN5
Golgi membrane 2 CLCN5, INS
lysosomal membrane 1 CLCN5
neuronal cell body 1 CASP3
synaptic vesicle 1 CLCN5
Cytoplasm, cytosol 2 AIMP2, PARP1
Presynapse 1 ANO1
plasma membrane 5 ACE2, ADGRL3, ANO1, ANO6, CLCN5
Membrane 8 ACE2, ADGRL3, AIMP2, ANO1, ANO6, BCL2, CLCN5, PARP1
apical plasma membrane 2 ACE2, ANO1
axon 2 ADGRL3, MAPK8
extracellular exosome 4 ACE2, ANO1, ANO6, FABP4
endoplasmic reticulum 2 ADIPOQ, BCL2
extracellular space 5 ACE2, ADIPOQ, INS, PNLIP, XDH
perinuclear region of cytoplasm 1 PPARG
mitochondrion 4 BCL2, CASP8, DHFR, PARP1
protein-containing complex 3 BCL2, CASP8, PARP1
intracellular membrane-bounded organelle 1 PPARG
postsynaptic density 1 CASP3
Single-pass type I membrane protein 1 ACE2
Secreted 4 ACE2, ADIPOQ, INS, PNLIP
extracellular region 4 ACE2, ADIPOQ, INS, PNLIP
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 2 BCL2, CASP8
transcription regulator complex 1 PARP1
Cell projection, cilium 1 ACE2
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
nucleolus 1 PARP1
Early endosome 1 CLCN5
apical part of cell 1 CLCN5
cell-cell junction 1 ADGRL3
Apical cell membrane 2 ACE2, ANO1
Cell projection, lamellipodium 1 CASP8
Membrane raft 1 ACE2
pore complex 1 BCL2
Peroxisome 1 XDH
collagen trimer 1 ADIPOQ
sarcoplasmic reticulum 1 XDH
collagen-containing extracellular matrix 1 ADIPOQ
receptor complex 1 PPARG
cilium 1 ACE2
chromatin 3 GABPA, PARP1, PPARG
cell projection 1 ANO1
Chromosome 1 PARP1
cytoskeleton 1 CASP8
brush border membrane 1 ACE2
Nucleus, nucleolus 1 PARP1
nuclear replication fork 1 PARP1
chromosome, telomeric region 1 PARP1
site of double-strand break 1 PARP1
nuclear envelope 1 PARP1
endosome lumen 1 INS
Lipid droplet 1 FABP4
chloride channel complex 2 ANO1, ANO6
specific granule membrane 1 ANO6
tertiary granule membrane 1 ANO6
euchromatin 1 DNTT
cell body 1 CASP8
myelin sheath 1 BCL2
secretory granule lumen 1 INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 2 ACE2, INS
nuclear matrix 1 DNTT
endocytic vesicle membrane 1 ACE2
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
protein-DNA complex 1 PARP1
basal dendrite 1 MAPK8
CD95 death-inducing signaling complex 1 CASP8
death-inducing signaling complex 2 CASP3, CASP8
ripoptosome 1 CASP8
aminoacyl-tRNA synthetase multienzyme complex 1 AIMP2
site of DNA damage 1 PARP1
[Poly [ADP-ribose] polymerase 1, processed N-terminus]: Chromosome 1 PARP1
[Poly [ADP-ribose] polymerase 1, processed C-terminus]: Cytoplasm 1 PARP1
BAD-BCL-2 complex 1 BCL2
[Processed angiotensin-converting enzyme 2]: Secreted 1 ACE2
[Isoform 2]: Apical cell membrane 1 ACE2


文献列表

  • Mebarka Imane Benguechoua, Khedidja Benarous, Ziyad Benahmed, Sarah Boukhalkhal, Artur M S Silva, Mohamed Yousfi. Quinic and Digallic acids from Pistacia atlantica Desf. Leaves Extracts as Potent Dual Effect Inhibitors against main Protease and RNA-dependent RNA Polymerase of SARS-CoV-2. Current computer-aided drug design. 2022; 18(4):307-317. doi: 10.2174/1573409918666220616121449. [PMID: 35713136]
  • Jie Zang, Shangzhi Ma, Cuizhe Wang, Gang Guo, Liangxue Zhou, Xing Tian, Mengying Lv, Jun Zhang, Bo Han. Screening for active constituents in Turkish galls against ulcerative colitis by mass spectrometry guided preparative chromatography strategy: in silico, in vitro and in vivo study. Food & function. 2018 Oct; 9(10):5124-5138. doi: 10.1039/c8fo01439f. [PMID: 30256363]
  • Takayuki Suzuki, Jun Suzuki, Shigekazu Nagata. Functional swapping between transmembrane proteins TMEM16A and TMEM16F. The Journal of biological chemistry. 2014 Mar; 289(11):7438-47. doi: 10.1074/jbc.m113.542324. [PMID: 24478309]
  • Wissem Bhouri, Ines Skandrani, Mohamed Ben Sghair, Marie-Geneviève Djoux Franca, Kamel Ghedira, Leila Chekir Ghedira. Digallic acid from Pistascia lentiscus fruits induces apoptosis and enhances antioxidant activities. Phytotherapy research : PTR. 2012 Mar; 26(3):387-91. doi: 10.1002/ptr.3540. [PMID: 21780210]
  • Manar M Salem, Frederick H Davidorf, Mohamed H Abdel-Rahman. In vitro anti-uveal melanoma activity of phenolic compounds from the Egyptian medicinal plant Acacia nilotica. Fitoterapia. 2011 Dec; 82(8):1279-84. doi: 10.1016/j.fitote.2011.08.020. [PMID: 21903153]
  • Arumugam Rajavelu, Zumrad Tulyasheva, Rakesh Jaiswal, Albert Jeltsch, Nikolai Kuhnert. The inhibition of the mammalian DNA methyltransferase 3a (Dnmt3a) by dietary black tea and coffee polyphenols. BMC biochemistry. 2011 Apr; 12(?):16. doi: 10.1186/1471-2091-12-16. [PMID: 21510884]
  • Hobeom Lee, Ji Yun Lee, Moo Hyun Suh, Sang-Soo Sim, Min-Won Lee, Chang Jong Kim. Hydrolysable tannins depress cardiac papillary muscle contraction and propranolol-induced negative inotropism. Fitoterapia. 2010 Oct; 81(7):820-5. doi: 10.1016/j.fitote.2010.05.002. [PMID: 20466042]
  • C T Ranjith-Kumar, Yvonne Lai, Robert T Sarisky, C Cheng Kao. Green tea catechin, epigallocatechin gallate, suppresses signaling by the dsRNA innate immune receptor RIG-I. PloS one. 2010 Sep; 5(9):e12878. doi: 10.1371/journal.pone.0012878. [PMID: 20877565]
  • Wissem Bhouri, Safa Derbel, Ines Skandrani, Jihed Boubaker, Ines Bouhlel, Mohamed B Sghaier, Soumaya Kilani, Anne M Mariotte, Marie G Dijoux-Franca, Kamel Ghedira, Leila Chekir-Ghedira. Study of genotoxic, antigenotoxic and antioxidant activities of the digallic acid isolated from Pistacia lentiscus fruits. Toxicology in vitro : an international journal published in association with BIBRA. 2010 Mar; 24(2):509-15. doi: 10.1016/j.tiv.2009.06.024. [PMID: 19563883]
  • Kanti Bhooshan Pandey, Syed Ibrahim Rizvi. Plant polyphenols as dietary antioxidants in human health and disease. Oxidative medicine and cellular longevity. 2009 Nov; 2(5):270-8. doi: 10.4161/oxim.2.5.9498. [PMID: 20716914]
  • Lucas Actis-Goretta, Leo J Romanczyk, Carla A Rodriguez, Catherine Kwik-Uribe, Carl L Keen. Cytotoxic effects of digalloyl dimer procyanidins in human cancer cell lines. The Journal of nutritional biochemistry. 2008 Dec; 19(12):797-808. doi: 10.1016/j.jnutbio.2007.10.004. [PMID: 18440795]
  • Jeong-Youn Jo, Elvira Gonzalez de Mejia, Mary Ann Lila. Effects of grape cell culture extracts on human topoisomerase II catalytic activity and characterization of active fractions. Journal of agricultural and food chemistry. 2005 Apr; 53(7):2489-98. doi: 10.1021/jf048524w. [PMID: 15796584]
  • M Luczkiewicz, W Cisowski, P Kaiser, R Ochocka, A Piotrowski. Comparative analysis of phenolic acids in mistletoe plants from various hosts. Acta poloniae pharmaceutica. 2001 Sep; 58(5):373-9. doi: . [PMID: 11876445]