Questin (BioDeep_00000004691)

 

Secondary id: BioDeep_00000399729

PANOMIX_OTCML-2023 Marine Natural Products natural product


代谢物信息卡片


1,6-dihydroxy-3-methyl-8-(methyloxy)anthracene-9,10-dione

化学式: C16H12O5 (284.0685)
中文名称: 曲酸
谱图信息: 最多检出来源 Viridiplantae(plant) 17.65%

Reviewed

Last reviewed on 2024-10-08.

Cite this Page

Questin. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/questin (retrieved 2025-02-04) (BioDeep RN: BioDeep_00000004691). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: c1c(cc2c(c1OC)C(=O)c1c(C2=O)cc(cc1O)C)O
InChI: InChI=1S/C16H12O5/c1-7-3-9-13(11(18)4-7)16(20)14-10(15(9)19)5-8(17)6-12(14)21-2/h3-6,17-18H,1-2H3

描述信息

Questin is an antibacterial agent isolated from marine Aspergillus flavipes. Questin exhibits antibacterial activity against V. harveyi, V. anguillarum, V. cholerae, and V. parahemolyticus with MIC values of 31.25 μg/mL, 62.5 μg/mL, 62.5 μg/mL, and 125 μg/mL[1].
Questin is an antibacterial agent isolated from marine Aspergillus flavipes. Questin exhibits antibacterial activity against V. harveyi, V. anguillarum, V. cholerae, and V. parahemolyticus with MIC values of 31.25 μg/mL, 62.5 μg/mL, 62.5 μg/mL, and 125 μg/mL[1].

同义名列表

13 个代谢物同义名

Questin; 1,6-dihydroxy-3-methyl-8-(methyloxy)anthracene-9,10-dione; 9,10-Anthracenedione, 1,6-dihydroxy-8-methoxy-3-methyl-; 1,6-dihydroxy-8-methoxy-3-methyl-anthracene-9,10-dione; 1,6-dihydroxy-8-methoxy-3-methylanthracene-9,10-dione; 3,8-dihydroxy-1-methoxy-6-methylanthracene-9,10-dione; 1,6-dihydroxy-8-methoxy-3-methyl-9,10-anthraquinone; emodin-8-methyl ether; CHEBI:16200; 3774-64-9; C01448; Methylemodine; Questin



数据库引用编号

14 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

64 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 4 ACE, AIMP2, MTRNR2L4, PPARG
Endosome membrane 2 BACE1, NTRK1
Nucleus 2 AIMP2, PPARG
cytosol 2 AIMP2, PPARG
dendrite 2 BACE1, NTRK1
trans-Golgi network 1 BACE1
nucleoplasm 1 PPARG
RNA polymerase II transcription regulator complex 1 PPARG
Cell membrane 3 ACE, BACE1, NTRK1
Cell projection, axon 1 BACE1
Early endosome membrane 1 NTRK1
cell surface 2 BACE1, NTRK1
Golgi apparatus 1 BACE1
lysosomal membrane 1 EGF
neuronal cell body 2 BACE1, NTRK1
synaptic vesicle 1 BACE1
Cytoplasm, cytosol 1 AIMP2
Lysosome 3 ACE, BACE1, SGSH
endosome 2 ACE, BACE1
plasma membrane 5 ACE, BACE1, BCHE, EGF, NTRK1
Membrane 5 ACE, AIMP2, BACE1, EGF, NTRK1
axon 2 BACE1, NTRK1
extracellular exosome 3 ACE, EGF, SGSH
endoplasmic reticulum 1 BACE1
extracellular space 4 ACE, BCHE, EGF, IL6
lysosomal lumen 1 SGSH
perinuclear region of cytoplasm 1 PPARG
mitochondrion 1 NTRK1
protein-containing complex 1 NTRK1
intracellular membrane-bounded organelle 1 PPARG
Single-pass type I membrane protein 3 ACE, BACE1, NTRK1
Secreted 4 ACE, BCHE, IL6, MTRNR2L4
extracellular region 5 ACE, BCHE, EGF, IL6, MTRNR2L4
hippocampal mossy fiber to CA3 synapse 1 BACE1
external side of plasma membrane 1 ACE
multivesicular body 1 BACE1
Early endosome 2 BACE1, NTRK1
recycling endosome 1 BACE1
Membrane raft 1 BACE1
Late endosome 2 BACE1, NTRK1
receptor complex 2 NTRK1, PPARG
chromatin 1 PPARG
Late endosome membrane 1 NTRK1
brush border membrane 1 ACE
Golgi apparatus, trans-Golgi network 1 BACE1
blood microparticle 1 BCHE
sperm midpiece 1 ACE
Recycling endosome membrane 1 NTRK1
Endomembrane system 1 BACE1
Cytoplasmic vesicle membrane 1 BACE1
Cell projection, dendrite 1 BACE1
basal plasma membrane 1 ACE
endoplasmic reticulum lumen 3 BACE1, BCHE, IL6
platelet alpha granule lumen 1 EGF
nuclear envelope lumen 1 BCHE
clathrin-coated endocytic vesicle membrane 1 EGF
aminoacyl-tRNA synthetase multienzyme complex 1 AIMP2
interleukin-6 receptor complex 1 IL6
[Angiotensin-converting enzyme, soluble form]: Secreted 1 ACE
[Isoform Testis-specific]: Cell membrane 1 ACE
Golgi-associated vesicle lumen 1 BACE1


文献列表

  • Chong Yu, Shuang Lin, Xiaorui Ma, Jie Zhang, Caixia Wu, Ben Ma, Haifeng Wang, Yuehu Pei. 7-Hydroxy questin, a new anthraquinone from a wetland fungus Aspergillus flavipes PJ03-11. Natural product research. 2022 Nov; 36(21):5484-5489. doi: 10.1080/14786419.2021.2017927. [PMID: 34949143]
  • Xiaojia Liu, Jianzhong Shen, Kui Zhu. Antibacterial activities of plant-derived xanthones. RSC medicinal chemistry. 2022 Feb; 13(2):107-116. doi: 10.1039/d1md00351h. [PMID: 35308024]
  • Yang Yang, Yong-Ming Yan, Wei Wei, Jie Luo, Lan-Sheng Zhang, Xiao-Jiang Zhou, Peng-Cheng Wang, Yong-Xun Yang, Yong-Xian Cheng. Anthraquinone derivatives from Rumex plants and endophytic Aspergillus fumigatus and their effects on diabetic nephropathy. Bioorganic & medicinal chemistry letters. 2013 Jul; 23(13):3905-9. doi: 10.1016/j.bmcl.2013.04.059. [PMID: 23683594]
  • Yeung-Beom Park, Seon-Bong Kim. Isolation and identification of antitumor promoters from the seeds of Cassia tora. Journal of microbiology and biotechnology. 2011 Oct; 21(10):1043-8. doi: 10.4014/jmb.1103.03040. [PMID: 22031028]
  • Ziming Lv, Qingjian Zhang, Ruoyun Chen, Dequan Yu. [Alkaloids and anthraquinones from branches and leaves of uvaria kurzii]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2011 May; 36(9):1190-2. doi: . [PMID: 21842647]
  • Khair Zaman, Mohammad Rafiullah Khan, Mumtaz Ali, Derek J Maitland. New anthraquinone dimer from the root bark of Cassia artemisioides (Gaudich. Ex. DC) Randell. Journal of Asian natural products research. 2011 Jan; 13(1):62-7. doi: 10.1080/10286020.2010.534081. [PMID: 21253951]
  • Dong-Li Li, Xiao-Ming Li, Bin-Gui Wang. Natural anthraquinone derivatives from a marine mangrove plant-derived endophytic fungus Eurotium rubrum: structural elucidation and DPPH radical scavenging activity. Journal of microbiology and biotechnology. 2009 Jul; 19(7):675-80. doi: . [PMID: 19652514]
  • Sung-Gyu Choi, Jiin Kim, Nack-Do Sung, Kwang-Hee Son, Hyae-Gyeong Cheon, Kwang-Rok Kim, Byoung-Mog Kwon. Anthraquinones, Cdc25B phosphatase inhibitors, isolated from the roots of Polygonum multiflorum Thunb. Natural product research. 2007 May; 21(6):487-93. doi: 10.1080/14786410601012265. [PMID: 17497420]
  • H Fujimoto, T Fujimaki, E Okuyama, M Yamazaki. Immunomodulatory constituents from an ascomycete, Microascus tardifaciens. Chemical & pharmaceutical bulletin. 1999 Oct; 47(10):1426-32. doi: 10.1248/cpb.47.1426. [PMID: 10553639]
  • Z Ji, X T Liang. [Studies on the chemical constituents of the root of Actinidia chinensis Planch]. Yao xue xue bao = Acta pharmaceutica Sinica. 1985 Oct; 20(10):778-81. doi: ". [PMID: 3835786]