Guanosine 3',5'-bis(diphosphate) (BioDeep_00000004623)

 

Secondary id: BioDeep_00001869091

human metabolite


代谢物信息卡片


{[hydroxy({[(2R,3S,4R,5R)-4-hydroxy-2-({[hydroxy(phosphonooxy)phosphoryl]oxy}methyl)-5-(6-hydroxy-2-imino-3,9-dihydro-2H-purin-9-yl)oxolan-3-yl]oxy})phosphoryl]oxy}phosphonic acid

化学式: C10H17N5O17P4 (602.9569952)
中文名称:
谱图信息: 最多检出来源 Viridiplantae(plant) 22.73%

分子结构信息

SMILES: C1=NC2=C(N1C3C(C(C(O3)COP(=O)(O)OP(=O)(O)O)OP(=O)(O)OP(=O)(O)O)O)N=C(NC2=O)N
InChI: InChI=1S/C10H17N5O17P4/c11-10-13-7-4(8(17)14-10)12-2-15(7)9-5(16)6(30-36(26,27)32-34(21,22)23)3(29-9)1-28-35(24,25)31-33(18,19)20/h2-3,5-6,9,16H,1H2,(H,24,25)(H,26,27)(H2,18,19,20)(H2,21,22,23)(H3,11,13,14,17)/t3-,5-,6-,9-/m1/s1

描述信息

Guanosine 3,5-bis(diphosphate) is part of the Purine metabolism pathway. It is a substrate for: Guanosine-3,5-bis(diphosphate) 3-pyrophosphohydrolase MESH1.

同义名列表

20 个代谢物同义名

{[hydroxy({[(2R,3S,4R,5R)-4-hydroxy-2-({[hydroxy(phosphonooxy)phosphoryl]oxy}methyl)-5-(6-hydroxy-2-imino-3,9-dihydro-2H-purin-9-yl)oxolan-3-yl]oxy})phosphoryl]oxy}phosphonic acid; {hydroxy[(2R,3S,4R,5R)-4-hydroxy-2-({[hydroxy(phosphonooxy)phosphoryl]oxy}methyl)-5-(6-hydroxy-2-imino-3H-purin-9-yl)oxolan-3-yl]oxyphosphoryl}oxyphosphonic acid; Guanosine 3-diphosphoric acid 5-diphosphoric acid; Guanosine 5-diphosphoric acid,3-diphosphoric acid; 3-Diphosphate, guanosine 5-diphosphate; 5-Diphosphate 3-diphosphate, guanosine; 3-Diphosphate 5-diphosphate, guanosine; 5-Diphosphate, guanosine 3-diphosphate; Guanosine 5-diphosphate,3-diphosphate; Guanosine 3-diphosphate 5-diphosphate; Guanosine 3 diphosphate 5 diphosphate; Guanosine 5-diphosphate 3-diphosphate; Guanosine 5 diphosphate 3 diphosphate; Guanosine 3,5-bis(diphosphoric acid); GUANOSINE-5,3-tetraphosphoric acid; Guanosine 3,5-bis(diphosphate); GUANOSINE-5,3-tetraphosphATE; Tetraphosphate, guanosine; Guanosine tetraphosphate; ppGpp



数据库引用编号

18 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(1)

代谢反应

8 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(1)

Plant Reactome(0)

INOH(0)

PlantCyc(1)

COVID-19 Disease Map(0)

PathBank(6)

PharmGKB(0)

3 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Sena Turkan, Milena Kulasek, Agnieszka Zienkiewicz, Agnieszka Mierek-Adamska, Edyta Skrzypek, Marzena Warchoł, Aleksandra Szydłowska-Czerniak, Julia Bartoli, Ben Field, Grażyna B Dąbrowska. Guanosine tetraphosphate (ppGpp) is a new player in Brassica napus L. seed development. Food chemistry. 2024 Mar; 436(?):137648. doi: 10.1016/j.foodchem.2023.137648. [PMID: 37852071]
  • Masataka Inazu, Takanari Nemoto, Yuto Omata, Sae Suzuki, Sumire Ono, Yuri Kanno, Mitsunori Seo, Akira Oikawa, Shinji Masuda. Complete loss of RelA and SpoT homologs in Arabidopsis reveals the importance of the plastidial stringent response in the interplay between chloroplast metabolism and plant defense response. Plant & cell physiology. 2023 Oct; ?(?):. doi: 10.1093/pcp/pcad136. [PMID: 37925598]
  • Yang Song, Xiangli Zhang, Zixuan Zhang, Xuping Shentu, Xiaoping Yu. Physiology and Transcriptional Analysis of ppGpp-Related Regulatory Effects in Streptomyces diastatochromogenes 1628. Microbiology spectrum. 2023 Feb; 11(1):e0120022. doi: 10.1128/spectrum.01200-22. [PMID: 36475882]
  • Marwa Mehrez, Shanna Romand, Ben Field. New perspectives on the molecular mechanisms of stress signalling by the nucleotide guanosine tetraphosphate (ppGpp), an emerging regulator of photosynthesis in plants and algae. The New phytologist. 2023 02; 237(4):1086-1099. doi: 10.1111/nph.18604. [PMID: 36349398]
  • Seddik Harchouni, Samantha England, Julien Vieu, Shanna Romand, Aicha Aouane, Sylvie Citerne, Bertrand Legeret, Jean Alric, Yonghua Li-Beisson, Benoît Menand, Benjamin Field. Guanosine tetraphosphate (ppGpp) accumulation inhibits chloroplast gene expression and promotes super grana formation in the moss Physcomitrium (Physcomitrella) patens. The New phytologist. 2022 10; 236(1):86-98. doi: 10.1111/nph.18320. [PMID: 35715975]
  • Kaihong Bai, Na Jiang, Xing Chen, Xiaoli Xu, Jianqiang Li, Laixin Luo. RNA-Seq Analysis Discovers the Critical Role of Rel in ppGpp Synthesis, Pathogenicity, and the VBNC State of Clavibacter michiganensis. Phytopathology. 2022 Sep; 112(9):1844-1858. doi: 10.1094/phyto-01-22-0023-r. [PMID: 35341314]
  • Kazuhiro Ito, Doshun Ito, Mina Goto, Sae Suzuki, Shinji Masuda, Koh Iba, Kensuke Kusumi. Regulation of ppGpp Synthesis and Its Impact on Chloroplast Biogenesis during Early Leaf Development in Rice. Plant & cell physiology. 2022 Jul; 63(7):919-931. doi: 10.1093/pcp/pcac053. [PMID: 35428891]
  • Hanwen Li, Jinqiang Nian, Shuang Fang, Meng Guo, Xiahe Huang, Fengxia Zhang, Qing Wang, Jian Zhang, Jiaoteng Bai, Guojun Dong, Peiyong Xin, Xianzhi Xie, Fan Chen, Guodong Wang, Yingchun Wang, Qian Qian, Jianru Zuo, Jinfang Chu, Xiaohui Ma. Regulation of nitrogen starvation responses by the alarmone (p)ppGpp in rice. Journal of genetics and genomics = Yi chuan xue bao. 2022 05; 49(5):469-480. doi: 10.1016/j.jgg.2022.02.006. [PMID: 35189402]
  • Shanna Romand, Hela Abdelkefi, Cécile Lecampion, Mohamed Belaroussi, Melanie Dussenne, Brigitte Ksas, Sylvie Citerne, Jose Caius, Stefano D'Alessandro, Hatem Fakhfakh, Stefano Caffarri, Michel Havaux, Ben Field. A guanosine tetraphosphate (ppGpp) mediated brake on photosynthesis is required for acclimation to nitrogen limitation in Arabidopsis. eLife. 2022 02; 11(?):. doi: 10.7554/elife.75041. [PMID: 35156611]
  • Mina Goto, Akira Oikawa, Shinji Masuda. Metabolic changes contributing to large biomass production in the Arabidopsis ppGpp-accumulating mutant under nitrogen deficiency. Planta. 2022 Jan; 255(2):48. doi: 10.1007/s00425-022-03835-0. [PMID: 35079894]
  • Kaihong Bai, Huayu Yan, Xing Chen, Qingyang Lyu, Na Jiang, Jianqiang Li, Laixin Luo. The Role of RelA and SpoT on ppGpp Production, Stress Response, Growth Regulation, and Pathogenicity in Xanthomonas campestris pv. campestris. Microbiology spectrum. 2021 12; 9(3):e0205721. doi: 10.1128/spectrum.02057-21. [PMID: 34935430]
  • Klaudyna Krause, Agnieszka Pyrczak-Felczykowska, Monika Karczewska, Magdalena Narajczyk, Anna Herman-Antosiewicz, Agnieszka Szalewska-Pałasz, Dariusz Nowicki. Dietary Isothiocyanates, Sulforaphane and 2-Phenethyl Isothiocyanate, Effectively Impair Vibrio cholerae Virulence. International journal of molecular sciences. 2021 Sep; 22(19):. doi: 10.3390/ijms221910187. [PMID: 34638525]
  • Kaihong Bai, Xing Chen, Na Jiang, Qingyang Lyu, Jianqiang Li, Laixin Luo. Extraction and detection of guanosine 5'-diphosphate-3'-diphosphate in amino acid starvation cells of Clavibacter michiganensis. Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]. 2021 Sep; 52(3):1573-1580. doi: 10.1007/s42770-021-00488-1. [PMID: 33837930]
  • Bing Wang, Vladimir Svetlov, Yuri I Wolf, Eugene V Koonin, Evgeny Nudler, Irina Artsimovitch. Allosteric Activation of SARS-CoV-2 RNA-Dependent RNA Polymerase by Remdesivir Triphosphate and Other Phosphorylated Nucleotides. mBio. 2021 06; 12(3):e0142321. doi: 10.1128/mbio.01423-21. [PMID: 34154407]
  • Luisana Avilan, Regine Lebrun, Carine Puppo, Sylvie Citerne, Stephane Cuiné, Yonghua Li-Beisson, Benoît Menand, Ben Field, Brigitte Gontero. ppGpp influences protein protection, growth and photosynthesis in Phaeodactylum tricornutum. The New phytologist. 2021 05; 230(4):1517-1532. doi: 10.1111/nph.17286. [PMID: 33595847]
  • Sophie E Irving, Naznin R Choudhury, Rebecca M Corrigan. The stringent response and physiological roles of (pp)pGpp in bacteria. Nature reviews. Microbiology. 2021 04; 19(4):256-271. doi: 10.1038/s41579-020-00470-y. [PMID: 33149273]
  • Zhouqi Cui, Ching-Hong Yang, Roshni R Kharadi, Xiaochen Yuan, George W Sundin, Lindsay R Triplett, Jie Wang, Quan Zeng. Cell-length heterogeneity: a population-level solution to growth/virulence trade-offs in the plant pathogen Dickeya dadantii. PLoS pathogens. 2019 08; 15(8):e1007703. doi: 10.1371/journal.ppat.1007703. [PMID: 31381590]
  • Corey Westfall, Ana Lidia Flores-Mireles, John Isaac Robinson, Aaron J L Lynch, Scott Hultgren, Jeffrey P Henderson, Petra Anne Levin. The Widely Used Antimicrobial Triclosan Induces High Levels of Antibiotic Tolerance In Vitro and Reduces Antibiotic Efficacy up to 100-Fold In Vivo. Antimicrobial agents and chemotherapy. 2019 05; 63(5):. doi: 10.1128/aac.02312-18. [PMID: 30782996]
  • Clément Patacq, Nicolas Chaudet, Fabien Létisse. Absolute Quantification of ppGpp and pppGpp by Double-Spike Isotope Dilution Ion Chromatography-High-Resolution Mass Spectrometry. Analytical chemistry. 2018 09; 90(18):10715-10723. doi: 10.1021/acs.analchem.8b00829. [PMID: 30110552]
  • Jennifer Patterson-West, Tamara D James, Llorenç Fernández-Coll, James R Iben, Kyung Moon, Leslie Knipling, Michael Cashel, Deborah M Hinton. The E. coli Global Regulator DksA Reduces Transcription during T4 Infection. Viruses. 2018 06; 10(6):. doi: 10.3390/v10060308. [PMID: 29882792]
  • Ben Field. Green magic: regulation of the chloroplast stress response by (p)ppGpp in plants and algae. Journal of experimental botany. 2018 05; 69(11):2797-2807. doi: 10.1093/jxb/erx485. [PMID: 29281108]
  • Hela Abdelkefi, Matteo Sugliani, Hang Ke, Seddik Harchouni, Ludivine Soubigou-Taconnat, Sylvie Citerne, Gregory Mouille, Hatem Fakhfakh, Christophe Robaglia, Ben Field. Guanosine tetraphosphate modulates salicylic acid signalling and the resistance of Arabidopsis thaliana to Turnip mosaic virus. Molecular plant pathology. 2018 03; 19(3):634-646. doi: 10.1111/mpp.12548. [PMID: 28220595]
  • Kasumi Takeuchi. GABA, A Primary Metabolite Controlled by the Gac/Rsm Regulatory Pathway, Favors a Planktonic Over a Biofilm Lifestyle in Pseudomonas protegens CHA0. Molecular plant-microbe interactions : MPMI. 2018 Feb; 31(2):274-282. doi: 10.1094/mpmi-05-17-0120-r. [PMID: 28990487]
  • Régis Hallez, Marie Delaby, Stefano Sanselicio, Patrick H Viollier. Hit the right spots: cell cycle control by phosphorylated guanosines in alphaproteobacteria. Nature reviews. Microbiology. 2017 03; 15(3):137-148. doi: 10.1038/nrmicro.2016.183. [PMID: 28138140]
  • Rachel D Hood, Sean A Higgins, Avi Flamholz, Robert J Nichols, David F Savage. The stringent response regulates adaptation to darkness in the cyanobacterium Synechococcus elongatus. Proceedings of the National Academy of Sciences of the United States of America. 2016 08; 113(33):E4867-76. doi: 10.1073/pnas.1524915113. [PMID: 27486247]
  • Wieland Steinchen, Gert Bange. The magic dance of the alarmones (p)ppGpp. Molecular microbiology. 2016 08; 101(4):531-44. doi: 10.1111/mmi.13412. [PMID: 27149325]
  • Matteo Sugliani, Hela Abdelkefi, Hang Ke, Emmanuelle Bouveret, Christophe Robaglia, Stefano Caffarri, Ben Field. An Ancient Bacterial Signaling Pathway Regulates Chloroplast Function to Influence Growth and Development in Arabidopsis. The Plant cell. 2016 Mar; 28(3):661-79. doi: 10.1105/tpc.16.00045. [PMID: 26908759]
  • Yuta Ihara, Shinji Masuda. Cytosolic ppGpp accumulation induces retarded plant growth and development. Plant signaling & behavior. 2016; 11(2):e1132966. doi: 10.1080/15592324.2015.1132966. [PMID: 26825398]
  • Tiyakhon Chatnaparat, Zhong Li, Schuyler S Korban, Youfu Zhao. The bacterial alarmone (p)ppGpp is required for virulence and controls cell size and survival of Pseudomonas syringae on plants. Environmental microbiology. 2015 Nov; 17(11):4253-70. doi: 10.1111/1462-2920.12744. [PMID: 25626964]
  • Wieland Steinchen, Jan S Schuhmacher, Florian Altegoer, Christopher D Fage, Vasundara Srinivasan, Uwe Linne, Mohamed A Marahiel, Gert Bange. Catalytic mechanism and allosteric regulation of an oligomeric (p)ppGpp synthetase by an alarmone. Proceedings of the National Academy of Sciences of the United States of America. 2015 Oct; 112(43):13348-53. doi: 10.1073/pnas.1505271112. [PMID: 26460002]
  • Maria V Yamburenko, Yan O Zubo, Thomas Börner. Abscisic acid affects transcription of chloroplast genes via protein phosphatase 2C-dependent activation of nuclear genes: repression by guanosine-3'-5'-bisdiphosphate and activation by sigma factor 5. The Plant journal : for cell and molecular biology. 2015 Jun; 82(6):1030-1041. doi: 10.1111/tpj.12876. [PMID: 25976841]
  • Yuta Ihara, Hiroyuki Ohta, Shinji Masuda. A highly sensitive quantification method for the accumulation of alarmone ppGpp in Arabidopsis thaliana using UPLC-ESI-qMS/MS. Journal of plant research. 2015 May; 128(3):511-8. doi: 10.1007/s10265-015-0711-1. [PMID: 25752614]
  • Veronica Ancona, Jae Hoon Lee, Tiyakhon Chatnaparat, Jinrok Oh, Jong-In Hong, Youfu Zhao. The bacterial alarmone (p)ppGpp activates the type III secretion system in Erwinia amylovora. Journal of bacteriology. 2015 Apr; 197(8):1433-43. doi: 10.1128/jb.02551-14. [PMID: 25666138]
  • Michio Sato, Tomohiro Takahashi, Kozo Ochi, Hideyuki Matsuura, Kensuke Nabeta, Kosaku Takahashi. Overexpression of RelA/SpoT homologs, PpRSH2a and PpRSH2b, induces the growth suppression of the moss Physcomitrella patens. Bioscience, biotechnology, and biochemistry. 2015; 79(1):36-44. doi: 10.1080/09168451.2014.952617. [PMID: 25228236]
  • Devon O Osbourne, Valerie W C Soo, Igor Konieczny, Thomas K Wood. Polyphosphate, cyclic AMP, guanosine tetraphosphate, and c-di-GMP reduce in vitro Lon activity. Bioengineered. 2014 Jul; 5(4):264-8. doi: 10.4161/bioe.29261. [PMID: 24874800]
  • Yuhta Nomura, Atsushi Izumi, Yoshinori Fukunaga, Kensuke Kusumi, Koh Iba, Seiya Watanabe, Yoichi Nakahira, Andreas P M Weber, Akira Nozawa, Yuzuru Tozawa. Diversity in guanosine 3',5'-bisdiphosphate (ppGpp) sensitivity among guanylate kinases of bacteria and plants. The Journal of biological chemistry. 2014 May; 289(22):15631-41. doi: 10.1074/jbc.m113.534768. [PMID: 24722991]
  • Yuhta Nomura, Akira Nozawa, Yuzuru Tozawa. Biochemical analyses of ppGpp effect on adenylosuccinate synthetases, key enzymes in purine biosynthesis in rice. Bioscience, biotechnology, and biochemistry. 2014; 78(6):1022-5. doi: 10.1080/09168451.2014.910103. [PMID: 25036129]
  • Vinoy K Ramachandran, Neil Shearer, Arthur Thompson. The primary transcriptome of Salmonella enterica Serovar Typhimurium and its dependence on ppGpp during late stationary phase. PloS one. 2014; 9(3):e92690. doi: 10.1371/journal.pone.0092690. [PMID: 24664308]
  • Steven D Bowden, Alison Eyres, Jade C S Chung, Rita E Monson, Arthur Thompson, George P C Salmond, David R Spring, Martin Welch. Virulence in Pectobacterium atrosepticum is regulated by a coincidence circuit involving quorum sensing and the stress alarmone, (p)ppGpp. Molecular microbiology. 2013 Nov; 90(3):457-71. doi: 10.1111/mmi.12369. [PMID: 23957692]
  • Kasumi Takeuchi, Kosumi Yamada, Dieter Haas. ppGpp controlled by the Gac/Rsm regulatory pathway sustains biocontrol activity in Pseudomonas fluorescens CHA0. Molecular plant-microbe interactions : MPMI. 2012 Nov; 25(11):1440-9. doi: 10.1094/mpmi-02-12-0034-r. [PMID: 23035953]
  • Usheer Kanjee, Koji Ogata, Walid A Houry. Direct binding targets of the stringent response alarmone (p)ppGpp. Molecular microbiology. 2012 Sep; 85(6):1029-43. doi: 10.1111/j.1365-2958.2012.08177.x. [PMID: 22812515]
  • Daisuke Ito, Takahiro Kato, Takanori Maruta, Masahiro Tamoi, Kazuya Yoshimura, Shigeru Shigeoka. Enzymatic and molecular characterization of Arabidopsis ppGpp pyrophosphohydrolase, AtNUDX26. Bioscience, biotechnology, and biochemistry. 2012; 76(12):2236-41. doi: 10.1271/bbb.120523. [PMID: 23221701]
  • Yuhta Nomura, Taito Takabayashi, Hiroshi Kuroda, Yasushi Yukawa, Kwanchanok Sattasuk, Mitsuru Akita, Akira Nozawa, Yuzuru Tozawa. ppGpp inhibits peptide elongation cycle of chloroplast translation system in vitro. Plant molecular biology. 2012 Jan; 78(1-2):185-96. doi: 10.1007/s11103-011-9858-x. [PMID: 22108865]
  • Julia V Bugrysheva, Henry P Godfrey, Ira Schwartz, Felipe C Cabello. Patterns and regulation of ribosomal RNA transcription in Borrelia burgdorferi. BMC microbiology. 2011 Jan; 11(?):17. doi: 10.1186/1471-2180-11-17. [PMID: 21251259]
  • Maarten Vercruysse, Maarten Fauvart, Ann Jans, Serge Beullens, Kristien Braeken, Lore Cloots, Kristof Engelen, Kathleen Marchal, Jan Michiels. Stress response regulators identified through genome-wide transcriptome analysis of the (p)ppGpp-dependent response in Rhizobium etli. Genome biology. 2011; 12(2):R17. doi: 10.1186/gb-2011-12-2-r17. [PMID: 21324192]
  • Michio Sato, Kosaku Takahashi, Yuka Ochiai, Takeshi Hosaka, Kozo Ochi, Kensuke Nabeta. Bacterial alarmone, guanosine 5'-diphosphate 3'-diphosphate (ppGpp), predominantly binds the beta' subunit of plastid-encoded plastid RNA polymerase in chloroplasts. Chembiochem : a European journal of chemical biology. 2009 May; 10(7):1227-33. doi: 10.1002/cbic.200800737. [PMID: 19308923]
  • Aurélia Battesti, Emmanuelle Bouveret. Bacteria possessing two RelA/SpoT-like proteins have evolved a specific stringent response involving the acyl carrier protein-SpoT interaction. Journal of bacteriology. 2009 Jan; 191(2):616-24. doi: 10.1128/jb.01195-08. [PMID: 18996989]
  • Kozo Ochi. From microbial differentiation to ribosome engineering. Bioscience, biotechnology, and biochemistry. 2007 Jun; 71(6):1373-86. doi: 10.1271/bbb.70007. [PMID: 17587668]
  • Marie Dozot, Rose-Anne Boigegrain, Rose-May Delrue, Régis Hallez, Safia Ouahrani-Bettache, Isabelle Danese, Jean-Jacques Letesson, Xavier De Bolle, Stephan Köhler. The stringent response mediator Rsh is required for Brucella melitensis and Brucella suis virulence, and for expression of the type IV secretion system virB. Cellular microbiology. 2006 Nov; 8(11):1791-802. doi: 10.1111/j.1462-5822.2006.00749.x. [PMID: 16803581]
  • Grazyna Dabrowska, Justyna Prusińska, Anna Goc. [Plant mechanism of an adaptive stress response homologous to bacterial stringent response]. Postepy biochemii. 2006; 52(1):94-100. doi: ". [PMID: 16869307]
  • Martine Moris, Kristien Braeken, Eric Schoeters, Christel Verreth, Serge Beullens, Jos Vanderleyden, Jan Michiels. Effective symbiosis between Rhizobium etli and Phaseolus vulgaris requires the alarmone ppGpp. Journal of bacteriology. 2005 Aug; 187(15):5460-9. doi: 10.1128/jb.187.15.5460-5469.2005. [PMID: 16030240]
  • Arturo Calderón-Flores, Gisela Du Pont, Alejandro Huerta-Saquero, Horacio Merchant-Larios, Luis Servín-González, Socorro Durán. The stringent response is required for amino acid and nitrate utilization, nod factor regulation, nodulation, and nitrogen fixation in Rhizobium etli. Journal of bacteriology. 2005 Aug; 187(15):5075-83. doi: 10.1128/jb.187.15.5075-5083.2005. [PMID: 16030199]
  • Kosaku Takahashi, Koji Kasai, Kozo Ochi. Identification of the bacterial alarmone guanosine 5'-diphosphate 3'-diphosphate (ppGpp) in plants. Proceedings of the National Academy of Sciences of the United States of America. 2004 Mar; 101(12):4320-4. doi: 10.1073/pnas.0308555101. [PMID: 15010537]
  • Robert M Givens, Mei-Hui Lin, Derek J Taylor, Undine Mechold, James O Berry, V James Hernandez. Inducible expression, enzymatic activity, and origin of higher plant homologues of bacterial RelA/SpoT stress proteins in Nicotiana tabacum. The Journal of biological chemistry. 2004 Feb; 279(9):7495-504. doi: 10.1074/jbc.m311573200. [PMID: 14660585]
  • Akiyo Yamada, Kouichi Tsutsumi, Shizufumi Tanimoto, Yoshihiro Ozeki. Plant RelA/SpoT homolog confers salt tolerance in Escherichia coli and Saccharomyces cerevisiae. Plant & cell physiology. 2003 Jan; 44(1):3-9. doi: 10.1093/pcp/pcg001. [PMID: 12552141]
  • Derek H Wells, Sharon R Long. The Sinorhizobium meliloti stringent response affects multiple aspects of symbiosis. Molecular microbiology. 2002 Mar; 43(5):1115-27. doi: 10.1046/j.1365-2958.2002.02826.x. [PMID: 11918800]
  • P M Riccillo, M M Collavino, D H Grasso, R England, F J de Bruijn, O M Aguilar. A guaB mutant strain of Rhizobium tropici CIAT899 pleiotropically defective in thermal tolerance and symbiosis. Molecular plant-microbe interactions : MPMI. 2000 Nov; 13(11):1228-36. doi: 10.1094/mpmi.2000.13.11.1228. [PMID: 11059489]
  • K Kvint, C Hosbond, A Farewell, O Nybroe, T Nyström. Emergency derepression: stringency allows RNA polymerase to override negative control by an active repressor. Molecular microbiology. 2000 Jan; 35(2):435-43. doi: 10.1046/j.1365-2958.2000.01714.x. [PMID: 10652104]
  • Michael P Spector, Concetta C DiRusso, Mark J Pallen, Francisco Garcia Del Portillo, Gordon Dougan, B Brett Finlay. The medium-/long-chain fatty acyl-CoA dehydrogenase (fadF) gene of Salmonella typhimurium is a phase 1 starvation-stress response (SSR) locus. Microbiology (Reading, England). 1999 Jan; 145 ( Pt 1)(?):15-31. doi: 10.1099/13500872-145-1-15. [PMID: 10206693]
  • J Eichel, Y Y Chang, D Riesenberg, J E Cronan. Effect of ppGpp on Escherichia coli cyclopropane fatty acid synthesis is mediated through the RpoS sigma factor (sigmaS). Journal of bacteriology. 1999 Jan; 181(2):572-6. doi: 10.1128/jb.181.2.572-576.1999. [PMID: 9882672]
  • P G Jones, M Inouye. The cold-shock response--a hot topic. Molecular microbiology. 1994 Mar; 11(5):811-8. doi: 10.1111/j.1365-2958.1994.tb00359.x. [PMID: 8022259]
  • E Strauch, E Takano, H A Baylis, M J Bibb. The stringent response in Streptomyces coelicolor A3(2). Molecular microbiology. 1991 Feb; 5(2):289-98. doi: 10.1111/j.1365-2958.1991.tb02109.x. [PMID: 1710311]
  • D Riesenberg. A radioimmunoassay for (p)ppGpp and its application to Streptomyces hygroscopicus. Journal of basic microbiology. 1985; 25(2):127-40. doi: 10.1002/jobm.3620250209. [PMID: 4009429]
  • J C Cameselle, M J Costas, M A Sillero, A Sillero. Bis-(5'-guanosyl) tetraphosphatase in rat tissues. The Biochemical journal. 1982 Feb; 201(2):405-10. doi: 10.1042/bj2010405. [PMID: 6282267]
  • Y Hamagishi, T Oki, H Tone, T Inui. A radioimmunoassay for guanosine-5'-diphosphate-3'-diphosphate and adenosine-5'-triphosphate-3'-diphosphate. Journal of biochemistry. 1980 Dec; 88(6):1785-92. doi: 10.1093/oxfordjournals.jbchem.a133153. [PMID: 6780546]
  • E E Ishiguro, W D Ramey. Inhibition of in vitro peptidoglycan biosynthesis in Escherichia coli by guanosine 5'-diphosphate 3'-diphosphate. Canadian journal of microbiology. 1980 Dec; 26(12):1514-8. doi: 10.1139/m80-253. [PMID: 7016279]
  • J Akinyanju, R J Smith. Accumulation of ppGpp and pppGpp during nitrogen deprivation of the cyanophyte Anabaena cylindrica. FEBS letters. 1979 Nov; 107(1):173-6. doi: 10.1016/0014-5793(79)80489-5. [PMID: 115718]
  • E E Ishiguro. Regulation of peptidoglycan biosynthesis in relA+ and relA- strains of Escherichia coli during diauxic growth on glucose and lactose. Canadian journal of microbiology. 1979 Oct; 25(10):1206-8. doi: 10.1139/m79-188. [PMID: 394820]
  • . . . . doi: . [PMID: 21815973]