S-Adenosylmethioninamine (BioDeep_00000004587)

 

Secondary id: BioDeep_00001869253

human metabolite Endogenous blood metabolite natural product


代谢物信息卡片


{[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl}(3-aminopropyl)methylsulfanium

化学式: C14H23N6O3S+ (355.1552)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 24.82%

分子结构信息

SMILES: C[S+](CCCN)CC1C(C(C(O1)N2C=NC3=C(N=CN=C32)N)O)O
InChI: InChI=1S/C14H23N6O3S/c1-24(4-2-3-15)5-8-10(21)11(22)14(23-8)20-7-19-9-12(16)17-6-18-13(9)20/h6-8,10-11,14,21-22H,2-5,15H2,1H3,(H2,16,17,18)/q+1/t8-,10-,11-,14-,24?/m1/s1

描述信息

S-Adenosylmethioninamine is a biological sulfonium compound known as the major biological methyl donor. It is also a donor of methylene groups, amino groups, ribosyl groups and aminopropyl groups (PMID 15130560). S-Adenosylmethioninamine is a prodcut of enzyme adenosylmethionine decarboxylase [EC 4.1.1.50] in methionine metabolism pathway (KEGG). [HMDB]
S-Adenosylmethioninamine is a biological sulfonium compound known as the major biological methyl donor. It is also a donor of methylene groups, amino groups, ribosyl groups and aminopropyl groups (PMID 15130560). S-Adenosylmethioninamine is a prodcut of enzyme adenosylmethionine decarboxylase [EC 4.1.1.50] in methionine metabolism pathway (KEGG).

同义名列表

39 个代谢物同义名

{[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl}(3-aminopropyl)methylsulfanium; [1-(Adenin-9-yl)-1,5-dideoxy-beta-D-ribofuranos-5-yl](3-aminopropyl)(methyl)sulphonium; [1-(Adenin-9-yl)-1,5-dideoxy-beta-D-ribofuranos-5-yl](3-aminopropyl)(methyl)sulfonium; [1-(Adenin-9-yl)-1,5-dideoxy-β-D-ribofuranos-5-yl](3-aminopropyl)(methyl)sulphonium; [1-(Adenin-9-yl)-1,5-dideoxy-b-D-ribofuranos-5-yl](3-aminopropyl)(methyl)sulphonium; [1-(Adenin-9-yl)-1,5-dideoxy-β-D-ribofuranos-5-yl](3-aminopropyl)(methyl)sulfonium; [1-(Adenin-9-yl)-1,5-dideoxy-b-D-ribofuranos-5-yl](3-aminopropyl)(methyl)sulfonium; (5-Deoxy-5-adenosyl)(3-aminopropyl)methylsulphonium cation; (5-Deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium cation; (5-Deoxy-5-adenosyl)(3-aminopropyl) methylsulfonium salt; (5-Deoxy-5-adenosyl)(3-aminopropyl)methylsulphonium salt; (5-Deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt; 5’-[(3-aminopropyl)methylsulfonio]-5’-deoxyadenosine; (5-Deoxy-5-adenosyl)(3-aminopropyl)methylsulphonium; 5-[(3-Aminopropyl)methylsulfonio]-5-deoxyadenosine; (5-Deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium; S-5-Deoxyadenosyl-(5)-3-methylthiopropylamine; (-)-S-Adenosyl-(5’)-3-methylthiopropylamine; (-)-S-Adenosyl-(5)-3-methylthiopropylamine; S-Adenosyl 3-(methylsulphanyl)propylamine; S-Adenosyl 3-(methylsulfanyl)propylamine; S-Adenosyl-(5’)-3-methylthiopropylamine; S-Adenosyl-(5)-3-methylthiopropylamine; S-Adenosyl(5)-3-methylthiopropylamine; S-Adenosyl 3-(methylthio)propylamine; Decarboxylated S-adenosylmethionine; S-Adenosyl-3-methylthiopropylamine; S-Methyl-S-adenosyl homocysteamine; S-Methyl-S-adenosylhomocysteamine; S-Methyladenosylhomocysteamine; S-Adenosyl-L-methioninamine; S-Adenosyl-L-methionamine; S--Adenosylmethioninamine; S-Adenosylmethioninamine; S-Adenosylmethionamine; Decarboxylated adomet; Decarboxylated sam; Decarboxy-adomet; dAdoMet



数据库引用编号

17 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(2)

PlantCyc(0)

代谢反应

369 个相关的代谢反应过程信息。

Reactome(9)

BioCyc(11)

WikiPathways(1)

Plant Reactome(312)

INOH(1)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(35)

PharmGKB(0)

10 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 7 CRK, CRKL, GAPDH, PDPK1, PTK2, RHOA, TXN
Peripheral membrane protein 1 PTK2
Endosome membrane 1 INSR
Endoplasmic reticulum membrane 1 RHOA
Nucleus 6 CRK, GAPDH, PDPK1, PTK2, RHOA, TXN
cytosol 11 AMD1, CRK, CRKL, GAPDH, KCNN4, PDPK1, PTK2, PXN, RHOA, SMS, TXN
centrosome 1 PTK2
nucleoplasm 2 CRKL, TXN
Cell membrane 5 CRK, INSR, KCNN4, PTK2, RHOA
Lipid-anchor 1 RHOA
Cytoplasmic side 2 PTK2, RHOA
Cleavage furrow 1 RHOA
lamellipodium 2 PXN, RHOA
ruffle membrane 2 KCNN4, RHOA
Multi-pass membrane protein 1 KCNN4
cell cortex 3 PTK2, PXN, RHOA
cell junction 1 RHOA
glutamatergic synapse 1 RHOA
Golgi membrane 1 INS
neuromuscular junction 2 CRK, CRKL
neuronal cell body 1 KCNN4
postsynapse 1 RHOA
Cytoplasm, cytosol 1 GAPDH
Lysosome 1 INSR
endosome 1 RHOA
plasma membrane 8 CRK, GAPDH, INSR, KCNN4, PDPK1, PTK2, PXN, RHOA
Membrane 4 CRK, GAPDH, INSR, KCNN4
axon 1 INSR
caveola 1 INSR
extracellular exosome 6 CRK, GAPDH, INSR, RHOA, SMS, TXN
extracellular space 1 INS
perinuclear region of cytoplasm 2 GAPDH, PTK2
protein-containing complex 2 CRK, CRKL
intracellular membrane-bounded organelle 2 GAPDH, PTK2
postsynaptic density 1 PDPK1
Single-pass type I membrane protein 1 INSR
Secreted 2 INS, TXN
extracellular region 2 INS, TXN
cytoplasmic side of plasma membrane 1 RHOA
neuronal cell body membrane 1 INSR
anchoring junction 1 PTK2
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 PTK2
nuclear membrane 1 GAPDH
external side of plasma membrane 1 INSR
actin cytoskeleton 1 CRK
dendritic spine 2 PTK2, RHOA
cytoplasmic vesicle 1 PDPK1
microtubule cytoskeleton 1 GAPDH
midbody 1 RHOA
cell-cell junction 1 PXN
vesicle 3 GAPDH, KCNN4, RHOA
Cell projection, lamellipodium 1 RHOA
Cell projection, ruffle membrane 1 KCNN4
Cytoplasm, perinuclear region 2 GAPDH, PTK2
Cell junction, focal adhesion 2 PTK2, PXN
Cytoplasm, cytoskeleton 3 GAPDH, PTK2, PXN
focal adhesion 4 PDPK1, PTK2, PXN, RHOA
Late endosome 1 INSR
receptor complex 1 INSR
neuron projection 1 KCNN4
ciliary basal body 1 PTK2
microtubule associated complex 1 PXN
cell projection 2 PDPK1, PTK2
cell periphery 1 RHOA
cytoskeleton 4 GAPDH, PTK2, PXN, RHOA
Cytoplasm, cytoskeleton, cilium basal body 1 PTK2
Cytoplasm, cell cortex 3 PTK2, PXN, RHOA
endosome lumen 1 INS
Lipid droplet 1 GAPDH
Cell projection, dendrite 1 RHOA
stress fiber 2 PTK2, PXN
voltage-gated potassium channel complex 1 KCNN4
secretory granule lumen 1 INS
secretory granule membrane 1 RHOA
Golgi lumen 1 INS
endoplasmic reticulum lumen 1 INS
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
ribonucleoprotein complex 1 GAPDH
ficolin-1-rich granule membrane 1 RHOA
apical junction complex 1 RHOA
dendrite membrane 1 INSR
GAIT complex 1 GAPDH
extrinsic component of postsynaptic membrane 1 CRKL
insulin receptor complex 1 INSR


文献列表

  • Venkateswara R Chintapalli, Mohammed Al Bratty, Dominika Korzekwa, David G Watson, Julian A T Dow. Mapping an atlas of tissue-specific Drosophila melanogaster metabolomes by high resolution mass spectrometry. PloS one. 2013; 8(10):e78066. doi: 10.1371/journal.pone.0078066. [PMID: 24205093]
  • T K Smith, L Lindqvist, L Alakuijala, T O Eloranta. Effects of dietary polyamine precursors on the metabolism and tissue concentrations of amino acids in the rat. Annals of nutrition & metabolism. 1989; 33(3):143-52. doi: 10.1159/000177531. [PMID: 2802527]
  • N Claverie, J L Pasquali, P S Mamont, C Danzin, M Weil-Bousson, M Siat. Immunosuppressive effects of (2R,5R)-6-heptyne-2,5-diamine, an inhibitor of polyamine synthesis: II. Beneficial effects on the development of a lupus-like disease in MRL-lpr/lpr mice. Clinical and experimental immunology. 1988 May; 72(2):293-8. doi: NULL. [PMID: 3409547]
  • K D Haegele, T A Splinter, J C Romijn, P J Schechter, A Sjoerdsma. Decarboxylated-S-adenosylmethionine excretion: a biochemical marker of ornithine decarboxylase inhibition by alpha-difluoromethylornithine. Cancer research. 1987 Feb; 47(3):890-5. doi: . [PMID: 3100028]
  • J Wagner, Y Hirth, N Claverie, C Danzin. A sensitive high-performance liquid chromatographic procedure with fluorometric detection for the analysis of decarboxylated S-adenosylmethionine and analogs in urine samples. Analytical biochemistry. 1986 May; 154(2):604-17. doi: 10.1016/0003-2697(86)90036-9. [PMID: 3728970]
  • H S Ballard, A J Marcus. Platelet aggregation in portal cirrhosis. Archives of internal medicine. 1976 Mar; 136(3):316-9. doi: . [PMID: 4041]
  • . . . . doi: . [PMID: 9073064]