CDP-glycerol (BioDeep_00000004438)

 

Secondary id: BioDeep_00001870213

human metabolite Endogenous


代谢物信息卡片


[({[(2R,3S,4R,5R)-3,4-dihydroxy-5-(2-hydroxy-4-imino-1,4-dihydropyrimidin-1-yl)oxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](2,3-dihydroxypropoxy)phosphinic acid

化学式: C12H21N3O13P2 (477.055)
中文名称:
谱图信息: 最多检出来源 Viridiplantae(plant) 26.9%

分子结构信息

SMILES: C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCC(CO)O)O)O
InChI: InChI=1S/C12H21N3O13P2/c13-8-1-2-15(12(20)14-8)11-10(19)9(18)7(27-11)5-26-30(23,24)28-29(21,22)25-4-6(17)3-16/h1-2,6-7,9-11,16-19H,3-5H2,(H,21,22)(H,23,24)(H2,13,14,20)/t6?,7-,9-,10-,11-/m1/s1

描述信息

Cdp-glycerol is a member of the class of compounds known as cdp-glycerols. Cdp-glycerols are glycerolipids with a cytidine diphosphate attached to the oxygen O1 or O2 of the glycerol part. Cdp-glycerol is slightly soluble (in water) and a moderately acidic compound (based on its pKa). Cdp-glycerol can be found in a number of food items such as pummelo, elderberry, mugwort, and american butterfish, which makes cdp-glycerol a potential biomarker for the consumption of these food products.
Cdp-glycerol is part of the Purine metabolism, and Glycerophospholipid metabolism pathways. It is a substrate for: Manganese-dependent ADP-ribose/CDP-alcohol diphosphatase.

同义名列表

6 个代谢物同义名

[({[(2R,3S,4R,5R)-3,4-dihydroxy-5-(2-hydroxy-4-imino-1,4-dihydropyrimidin-1-yl)oxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](2,3-dihydroxypropoxy)phosphinic acid; Cytidine diphosphate glycerol, (R)-isomer; Cytidine diphosphate glycerol; CDP Glycerols; CDP-glycerol; cdpglycerol



数据库引用编号

14 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 9 DAG1, FDPS, FKRP, FKTN, GGPS1, GK, ITPR3, PCYT2, XPNPEP3
Peripheral membrane protein 1 PCYT1A
Endoplasmic reticulum membrane 3 ITPR3, PCYT1A, PCYT2
Nucleus 5 ERH, FKTN, GK, PCYT1A, PLCZ1
cytosol 8 DAG1, FDPS, FKRP, GGPS1, GK, PCYT1A, PLCZ1, XPNPEP3
nucleoplasm 6 DAG1, FDPS, FKRP, GGPS1, ITPR3, PLCZ1
Cell membrane 1 CNTN2
lamellipodium 1 DAG1
Multi-pass membrane protein 2 ITPR3, TPRA1
Golgi apparatus membrane 2 FKRP, FKTN
Synapse 1 CNTN2
cell surface 1 CNTN2
glutamatergic synapse 1 DAG1
Golgi apparatus 2 FKRP, FKTN
Golgi membrane 2 FKRP, FKTN
neuronal cell body 2 CNTN2, ITPR3
sarcolemma 2 DAG1, FKRP
Cytoplasm, cytosol 2 GK, PCYT1A
plasma membrane 4 CNTN2, DAG1, ITPR3, TPRA1
Membrane 7 DAG1, FDPS, FKRP, FKTN, ITPR3, PCYT1A, TPRA1
axon 1 CNTN2
basolateral plasma membrane 1 DAG1
brush border 1 ITPR3
extracellular exosome 3 DAG1, GK, LYZ
endoplasmic reticulum 3 FKTN, ITPR3, PCYT1A
extracellular space 5 DAG1, FKRP, FKTN, LYZ, PNLIP
perinuclear region of cytoplasm 2 GGPS1, PLCZ1
adherens junction 1 DAG1
mitochondrion 3 CLPP, GK, XPNPEP3
intracellular membrane-bounded organelle 1 DAG1
filopodium 1 DAG1
pronucleus 1 PLCZ1
Secreted 2 FKRP, PNLIP
extracellular region 3 DAG1, LYZ, PNLIP
Mitochondrion outer membrane 1 GK
Single-pass membrane protein 1 GK
mitochondrial outer membrane 1 GK
Mitochondrion matrix 1 CLPP
mitochondrial matrix 2 CLPP, FDPS
external side of plasma membrane 1 DAG1
Z disc 1 GGPS1
nucleolus 2 ITPR3, PLCZ1
midbody 1 ERH
apical part of cell 1 ITPR3
Single-pass type II membrane protein 2 FKRP, FKTN
postsynaptic membrane 2 CNTN2, DAG1
Cell membrane, sarcolemma 2 DAG1, FKRP
Cytoplasm, perinuclear region 2 GGPS1, PLCZ1
focal adhesion 1 DAG1
GABA-ergic synapse 1 DAG1
cis-Golgi network 1 FKTN
Peroxisome 1 FDPS
basement membrane 1 DAG1
sarcoplasmic reticulum 1 ITPR3
collagen-containing extracellular matrix 1 DAG1
nuclear outer membrane 1 ITPR3
Postsynaptic cell membrane 1 DAG1
receptor complex 1 ITPR3
cytoskeleton 1 DAG1
[Isoform 1]: Mitochondrion 1 XPNPEP3
Lipid-anchor, GPI-anchor 1 CNTN2
nuclear envelope 1 PCYT1A
Nucleus, nucleoplasm 1 DAG1
axon initial segment 1 CNTN2
side of membrane 1 CNTN2
myelin sheath 1 CNTN2
Cytoplasm, myofibril, sarcomere, Z line 1 GGPS1
[Isoform 4]: Cytoplasm, cytosol 1 GK
plasma membrane raft 1 DAG1
secretory granule membrane 1 ITPR3
Golgi lumen 1 DAG1
endoplasmic reticulum lumen 1 DAG1
specific granule lumen 1 LYZ
tertiary granule lumen 1 LYZ
node of Ranvier 2 CNTN2, DAG1
azurophil granule lumen 1 LYZ
methylosome 1 ERH
[Isoform 2]: Cytoplasm 1 XPNPEP3
platelet dense tubular network membrane 1 ITPR3
costamere 1 DAG1
dystrophin-associated glycoprotein complex 1 DAG1
Cytoplasmic vesicle, secretory vesicle membrane 1 ITPR3
Rough endoplasmic reticulum 1 FKRP
contractile ring 1 DAG1
postsynaptic cytosol 1 DAG1
nuclear periphery 1 DAG1
endopeptidase Clp complex 1 CLPP
transport vesicle membrane 1 ITPR3
sperm head 1 PLCZ1
photoreceptor ribbon synapse 1 DAG1
juxtaparanode region of axon 1 CNTN2
cytoplasmic side of endoplasmic reticulum membrane 1 ITPR3
[Isoform 3]: Mitochondrion outer membrane 1 GK
glycogen granule 1 PCYT1A
[Beta-dystroglycan]: Cell membrane 1 DAG1
dystroglycan complex 1 DAG1
skeletal muscle myofibril 1 FKRP


文献列表

  • Andrew L Lovering, Leo Y-C Lin, Edward W Sewell, Thomas Spreter, Eric D Brown, Natalie C J Strynadka. Structure of the bacterial teichoic acid polymerase TagF provides insights into membrane association and catalysis. Nature structural & molecular biology. 2010 May; 17(5):582-9. doi: 10.1038/nsmb.1819. [PMID: 20400947]
  • Edward W C Sewell, Mark P Pereira, Eric D Brown. The wall teichoic acid polymerase TagF is non-processive in vitro and amenable to study using steady state kinetic analysis. The Journal of biological chemistry. 2009 Aug; 284(32):21132-8. doi: 10.1074/jbc.m109.010215. [PMID: 19520862]
  • Jeffrey W Schertzer, Eric D Brown. Use of CDP-glycerol as an alternate acceptor for the teichoic acid polymerase reveals that membrane association regulates polymer length. Journal of bacteriology. 2008 Nov; 190(21):6940-7. doi: 10.1128/jb.00851-08. [PMID: 18723614]