5,10-Methenyl-tetrahydrofolate (BioDeep_00000004430)

 

Secondary id: BioDeep_00000019503


代谢物信息卡片


5,10-Methenyl-tetrahydrofolate

化学式: C20H22N7O6+ (456.1631)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 13.62%

分子结构信息

SMILES: C1C2CN(C=[N+]2C3=C(N1)N=C(NC3=O)N)C4=CC=C(C=C4)C(=O)NC(CCC(=O)O)C(=O)O
InChI: InChI=1S/C20H21N7O6/c21-20-24-16-15(18(31)25-20)27-9-26(8-12(27)7-22-16)11-3-1-10(2-4-11)17(30)23-13(19(32)33)5-6-14(28)29/h1-4,9,12-13H,5-8H2,(H6-,21,22,23,24,25,28,29,30,31,32,33)/p+1/t12?,13-/m0/s1

描述信息

同义名列表

1 个代谢物同义名

5,10-Methenyl-tetrahydrofolate



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

4 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(4)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 11 CRY2, DHFR, GCH1, HDC, MTHFD1, MTHFS, MTR, NR5A2, SHMT1, SLC25A32, TYMS
Nucleus 7 CRY2, GCH1, GGH, HDC, NR5A2, SHMT1, TYMS
cytosol 13 COMT, CRY2, DHFR, GCH1, HAL, HDC, MTHFD1, MTHFD1L, MTHFR, MTHFS, MTR, SHMT1, TYMS
dendrite 1 COMT
nucleoplasm 4 GCH1, GLDC, NR5A2, SHMT1
RNA polymerase II transcription regulator complex 1 NR5A2
Cell membrane 2 COMT, SLC19A1
Multi-pass membrane protein 2 SLC19A1, SLC25A32
Synapse 1 COMT
mitochondrial inner membrane 2 SLC25A32, TYMS
Lysosome 1 GGH
plasma membrane 4 COMT, GLDC, SLC19A1, TCN2
Membrane 6 COMT, HDC, MTHFD1, MTHFD1L, SLC19A1, SLC25A32
apical plasma membrane 1 SLC19A1
axon 1 COMT
basolateral plasma membrane 1 SLC19A1
extracellular exosome 4 COMT, GGH, MTHFD1, SHMT1
extracellular space 2 GGH, TCN2
lysosomal lumen 1 TCN2
mitochondrion 10 CRY2, DHFR, GCH1, GLDC, MTHFD1, MTHFD1L, MTHFS, SHMT1, SLC25A32, TYMS
protein-containing complex 1 GCH1
intracellular membrane-bounded organelle 2 COMT, SLC25A32
Secreted 2 NPW, TCN2
extracellular region 4 CRY2, GGH, NPW, TCN2
Mitochondrion matrix 1 TYMS
mitochondrial matrix 4 GLDC, MTHFD1L, MTHFS, TYMS
Extracellular side 1 COMT
nuclear membrane 1 GCH1
external side of plasma membrane 1 TCN2
cytoplasmic vesicle 1 GCH1
Single-pass type II membrane protein 1 COMT
Apical cell membrane 1 SLC19A1
Mitochondrion inner membrane 2 SLC25A32, TYMS
nuclear speck 1 CRY2
chromatin 1 NR5A2
Secreted, extracellular space 1 GGH
brush border membrane 1 SLC19A1
Basolateral cell membrane 1 SLC19A1
Melanosome 1 GGH
specific granule lumen 1 GGH
tertiary granule lumen 1 GGH
azurophil granule lumen 1 GGH
Vacuole 1 GGH
Cry-Per complex 1 CRY2
neuron projection terminus 1 GCH1
[Isoform Soluble]: Cytoplasm 1 COMT
[Isoform Membrane-bound]: Cell membrane 1 COMT
glycine cleavage complex 1 GLDC


文献列表

  • Tanja Göbel, Stefan Reisbacher, Alfred Batschauer, Richard Pokorny. Flavin Adenine Dinucleotide and N5 ,N10 -Methenyltetrahydrofolate are the in planta Cofactors of Arabidopsis thaliana Cryptochrome 3. Photochemistry and photobiology. 2017 01; 93(1):355-362. doi: 10.1111/php.12622. [PMID: 27463507]
  • Christine M Pfeiffer, Maya R Sternberg, Zia Fazili, David A Lacher, Mindy Zhang, Clifford L Johnson, Heather C Hamner, Regan L Bailey, Jeanne I Rader, Sedigheh Yamini, R J Berry, Elizabeth A Yetley. Folate status and concentrations of serum folate forms in the US population: National Health and Nutrition Examination Survey 2011-2. The British journal of nutrition. 2015 Jun; 113(12):1965-77. doi: 10.1017/s0007114515001142. [PMID: 25917925]
  • Patrick Scheerer, Fan Zhang, Jacqueline Kalms, David von Stetten, Norbert Krauß, Inga Oberpichler, Tilman Lamparter. The class III cyclobutane pyrimidine dimer photolyase structure reveals a new antenna chromophore binding site and alternative photoreduction pathways. The Journal of biological chemistry. 2015 May; 290(18):11504-14. doi: 10.1074/jbc.m115.637868. [PMID: 25784552]
  • Zia Fazili, Ralph D Whitehead, Neelima Paladugula, Christine M Pfeiffer. A high-throughput LC-MS/MS method suitable for population biomonitoring measures five serum folate vitamers and one oxidation product. Analytical and bioanalytical chemistry. 2013 May; 405(13):4549-60. doi: 10.1007/s00216-013-6854-9. [PMID: 23462981]
  • Mara L Becker, Leon van Haandel, Roger Gaedigk, Bradley Thomas, Mark F Hoeltzel, Andrew Lasky, Hongying Dai, John Stobaugh, James S Leeder. Red blood cell folate concentrations and polyglutamate distribution in juvenile arthritis: predictors of folate variability. Pharmacogenetics and genomics. 2012 Apr; 22(4):236-46. doi: 10.1097/fpc.0b013e3283500202. [PMID: 22344247]
  • Julia Moldt, Richard Pokorny, Christian Orth, Uwe Linne, Yann Geisselbrecht, Mohamed A Marahiel, Lars-Oliver Essen, Alfred Batschauer. Photoreduction of the folate cofactor in members of the photolyase family. The Journal of biological chemistry. 2009 Aug; 284(32):21670-83. doi: 10.1074/jbc.m109.018697. [PMID: 19531478]
  • Aymeric Goyer, Eva Collakova, Rocío Díaz de la Garza, Eoin P Quinlivan, Jerry Williamson, Jesse F Gregory, Yair Shachar-Hill, Andrew D Hanson. 5-Formyltetrahydrofolate is an inhibitory but well tolerated metabolite in Arabidopsis leaves. The Journal of biological chemistry. 2005 Jul; 280(28):26137-42. doi: 10.1074/jbc.m503106200. [PMID: 15888445]
  • J E Baggott, T Tamura. Bioactivity of orally administered unnatural isomers, [6R]-5-formyltetrahydrofolate and [6S]-5,10-methenyltetrahydrofolate, in humans. Biochimica et biophysica acta. 1999 Oct; 1472(1-2):323-32. doi: 10.1016/s0304-4165(99)00135-x. [PMID: 10572954]
  • R Ghosh, S Biswas, S Roy. An apyrase from Mimosa pudica contains N5,N10-methenyl tetrahydrofolate and is stimulated by light. European journal of biochemistry. 1998 Dec; 258(3):1009-13. doi: 10.1046/j.1432-1327.1998.2581009.x. [PMID: 9990319]
  • J A Houghton, L G Williams, S K Loftin, P J Cheshire, C L Morton, P J Houghton, A Dayan, J Jolivet. Factors that influence the therapeutic activity of 5-fluorouracil [6RS]leucovorin combinations in colon adenocarcinoma xenografts. Cancer chemotherapy and pharmacology. 1992; 30(6):423-32. doi: 10.1007/bf00685592. [PMID: 1394798]
  • J L Johnson, S Hamm-Alvarez, G Payne, G B Sancar, K V Rajagopalan, A Sancar. Identification of the second chromophore of Escherichia coli and yeast DNA photolyases as 5,10-methenyltetrahydrofolate. Proceedings of the National Academy of Sciences of the United States of America. 1988 Apr; 85(7):2046-50. doi: 10.1073/pnas.85.7.2046. [PMID: 2895469]