Acetone (BioDeep_00000004334)

 

Secondary id: BioDeep_00000405460, BioDeep_00000863193

human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite


代谢物信息卡片


Dimethylformaldehyde

化学式: C3H6O (58.041862599999995)
中文名称: 丙酮
谱图信息: 最多检出来源 Macaca mulatta(otcml) 0.22%

分子结构信息

SMILES: CC(=O)C
InChI: InChI=1S/C3H6O/c1-3(2)4/h1-2H3

描述信息

Acetone, or propanone, is an organic compound with the formula (CH3)2CO. It is the simplest and smallest ketone. It is a colourless, highly volatile and flammable liquid with a characteristic pungent odour. Acetone is miscible with water and serves as an important organic solvent in its own right, in industry, home, and laboratory. Acetone is produced and disposed of in the human body through normal metabolic processes. It is normally present in blood and urine. People with diabetic ketoacidosis produce it in larger amounts. Acetone is not regarded as a waste product of metabolism. However, its physiological role in biochemical machinery is not clear. A model for the role of acetone metabolism is presented that orders the events occurring in acetonemia in sequence: in diabetic ketosis or starvation, ketone body production (b-hydroxy-butyrate, acetoacetate) provides fuel for vital organs (heart, brain, among others) raising the chance of survival of the metabolic catastrophe. However, when ketone body production exceeds the degrading capacity, the accumulating acetoacetic acid presents a new challenge to the pH regulatory system. Acetone production and its further degradation to C3 fragments fulfill two purposes: the maintenance of pH buffering capacity and provision of fuel for peripheral tissues. Since ketosis develops under serious metabolic circumstances, all the mechanisms that balance or moderate the effects of ketosis enhance the chance for survival. From this point of view, the theory that transportable C3 fragments can serve as additional nutrients is a novel view of acetone metabolism which introduces a new approach to the study of acetone degradation, especially in understanding its physiological function and the interrelationship between liver and peripheral tissues. (PMID 10580530). Acetone is typically derived from acetoacetate through the action of microbial acetoacetate decarboxylases found in gut microflora. In chemistry, acetone is the simplest representative of the ketones. Acetone is a colorless, mobile, flammable liquid readily soluble in water, ethanol, ether, etc., and itself serves as an important solvent. It is an irritant and inhalation may lead to hepatotoxic effects (causing liver damage). Acetone can be found in Clostridium (PMID:685531).
Solvent used in food processing as a colour diluent, flavour ingredient, etc.
D012997 - Solvents

同义名列表

17 个代谢物同义名

Dimethylformaldehyde; Pyroacetic ether; beta-Ketopropane; Dimethyl ketone; Dimethylketone; Dimethylcetone; Dimethylketon; b-Ketopropane; Methyl ketone; Β-ketopropane; propan-2-one; 2-Propanone; Propanone; Propanon; acetone; Azeton; Aceton



数据库引用编号

21 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(15)

PlantCyc(5)

代谢反应

145 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(21)

WikiPathways(3)

Plant Reactome(3)

INOH(0)

PlantCyc(111)

COVID-19 Disease Map(0)

PathBank(7)

PharmGKB(0)

71 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Rajasree Shanmuganathan, Sandhanasamy Devanesan, Goldie Oza, Ashutosh Sharma. Assessment of antimicrobial, antidiabetic, and anti-inflammatory properties of acetone extract of Aerva lanata (L.) by in-vitro approach and bioactive compounds characterization. Environmental research. 2024 May; 248(?):118348. doi: 10.1016/j.envres.2024.118348. [PMID: 38295976]
  • Nikhil Mehta, Rhea Ahuja, Neetu Bhari, Kaushal Verma. A comparison of parthenium 15\% in Indian Standard Series versus acetone extract 2\% of parthenium plant in diagnosing contact allergy to parthenium. Contact dermatitis. 2024 May; 90(5):538-540. doi: 10.1111/cod.14517. [PMID: 38316109]
  • Minna K Karjalainen, Savita Karthikeyan, Clare Oliver-Williams, Eeva Sliz, Elias Allara, Wing Tung Fung, Praveen Surendran, Weihua Zhang, Pekka Jousilahti, Kati Kristiansson, Veikko Salomaa, Matt Goodwin, David A Hughes, Michael Boehnke, Lilian Fernandes Silva, Xianyong Yin, Anubha Mahajan, Matt J Neville, Natalie R van Zuydam, Renée de Mutsert, Ruifang Li-Gao, Dennis O Mook-Kanamori, Ayse Demirkan, Jun Liu, Raymond Noordam, Stella Trompet, Zhengming Chen, Christiana Kartsonaki, Liming Li, Kuang Lin, Fiona A Hagenbeek, Jouke Jan Hottenga, René Pool, M Arfan Ikram, Joyce van Meurs, Toomas Haller, Yuri Milaneschi, Mika Kähönen, Pashupati P Mishra, Peter K Joshi, Erin Macdonald-Dunlop, Massimo Mangino, Jonas Zierer, Ilhan E Acar, Carel B Hoyng, Yara T E Lechanteur, Lude Franke, Alexander Kurilshikov, Alexandra Zhernakova, Marian Beekman, Erik B van den Akker, Ivana Kolcic, Ozren Polasek, Igor Rudan, Christian Gieger, Melanie Waldenberger, Folkert W Asselbergs, Caroline Hayward, Jingyuan Fu, Anneke I den Hollander, Cristina Menni, Tim D Spector, James F Wilson, Terho Lehtimäki, Olli T Raitakari, Brenda W J H Penninx, Tonu Esko, Robin G Walters, J Wouter Jukema, Naveed Sattar, Mohsen Ghanbari, Ko Willems van Dijk, Fredrik Karpe, Mark I McCarthy, Markku Laakso, Marjo-Riitta Järvelin, Nicholas J Timpson, Markus Perola, Jaspal S Kooner, John C Chambers, Cornelia van Duijn, P Eline Slagboom, Dorret I Boomsma, John Danesh, Mika Ala-Korpela, Adam S Butterworth, Johannes Kettunen. Genome-wide characterization of circulating metabolic biomarkers. Nature. 2024 Apr; 628(8006):130-138. doi: 10.1038/s41586-024-07148-y. [PMID: 38448586]
  • Özge Üst, Emine Yalçin, Kültiğin Çavuşoğlu, Burak Özkan. LC-MS/MS, GC-MS and molecular docking analysis for phytochemical fingerprint and bioactivity of Beta vulgaris L. Scientific reports. 2024 03; 14(1):7491. doi: 10.1038/s41598-024-58338-7. [PMID: 38553576]
  • Gatluak Goanar, Geremew Tafesse, Workineh Mengesha Fereja. In vitro antibacterial activity of fruit pulp extracts of Tamarindus indica against Staphylococcus aureus and Klebsiella pneumoniae. BMC complementary medicine and therapies. 2024 Mar; 24(1):127. doi: 10.1186/s12906-024-04404-6. [PMID: 38504277]
  • Jolanta Flieger, Natalia Żuk, Sylwia Pasieczna-Patkowska, Marcin Kuśmierz, Rafał Panek, Wojciech Franus, Jacek Baj, Grzegorz Buszewicz, Grzegorz Teresiński, Wojciech Płaziński. Selective Removal of Chlorophyll and Isolation of Lutein from Plant Extracts Using Magnetic Solid Phase Extraction with Iron Oxide Nanoparticles. International journal of molecular sciences. 2024 Mar; 25(6):. doi: 10.3390/ijms25063152. [PMID: 38542125]
  • İnan Dursun, İkranur Felek, Duygu Nur Çobanoğlu. Analyzing the Antioxidant Activity and Fatty Acid Composition of Monofloral Mullein (Verbascum sp.) Pollen Oil obtained via Various Extraction Techniques. Chemistry & biodiversity. 2024 Mar; 21(3):e202400117. doi: 10.1002/cbdv.202400117. [PMID: 38366982]
  • Rizwan Ahmad, Muhammad Riaz, Mohammed Aldholmi, Ahad Alsulays, Wala Alsulais, Deema Alaswad, Alhassan Ibrahim Almutawah, Hasan Zaki Al Nahab. Solanum pseudocapsicum vs Capsicum annum; comparative phenolics profiling using green ultrasonic extraction and UHPLC analysis. Ultrasonics sonochemistry. 2024 Feb; 103(?):106789. doi: 10.1016/j.ultsonch.2024.106789. [PMID: 38309047]
  • Supachai Changphuek, Thaneeya Chetiyanukornkul, Yaowatat Boongla. Simulation analysis of hazardous chemicals released from the furniture plant using ALOHA software. Environmental monitoring and assessment. 2024 Jan; 196(2):207. doi: 10.1007/s10661-024-12322-w. [PMID: 38280056]
  • Li Jiang, Chenxing Wang, Tingting Fan, Siyuan Lv, Si Pan, Peng Sun, Jie Zheng, Chuan Zhang, Fangmeng Liu, Geyu Lu. Mixed Potential Type Acetone Sensor with Ultralow Detection Limit for Diabetic Ketosis Breath Analysis. ACS sensors. 2024 Jan; 9(1):464-473. doi: 10.1021/acssensors.3c02253. [PMID: 38153408]
  • Giulia Coradello, Chiara Setti, Roberto Donno, Matilde Ghibaudi, Federico Catalano, Nicola Tirelli. A Quantitative Re-Assessment of Microencapsulation in (Pre-Treated) Yeast. Molecules (Basel, Switzerland). 2024 Jan; 29(2):. doi: 10.3390/molecules29020539. [PMID: 38276617]
  • Eirini Stini, Dimitrios Tsimogiannis, Vassiliki Oreopoulou. The Valorisation of Melissa officinalis Distillation By-Products for the Production of Polyphenol-Rich Formulations. Molecules (Basel, Switzerland). 2024 Jan; 29(2):. doi: 10.3390/molecules29020377. [PMID: 38257290]
  • Priyanka Mandal, Goutam Chandra. Casearia tomentosa fruit extracts exposed larvicidal activity and morphological alterations in Culex quinquefasciatus and Aedes albopictus under in vitro and semi field conditions. BMC research notes. 2024 Jan; 17(1):6. doi: 10.1186/s13104-023-06663-x. [PMID: 38167220]
  • Felipe Carlos de Macêdo Oliveira, Tatiana Moura Vasconcelos Holanda, Cristiane Fernandes de Assis, Francisco Humberto Xavier Júnior, Francisco Canindé de Sousa Júnior. Flours from Spondias mombin and Spondias tuberosa seeds: Physicochemical characterization, technological properties, and antioxidant, antibacterial, and antidiabetic activities. Journal of food science. 2024 Jan; 89(1):342-355. doi: 10.1111/1750-3841.16882. [PMID: 38126119]
  • Jazia Sriti, Wissem Aidi Wannes, Olfa Bachrouch, Jihed Aouini, Emna Boushih, Ferid Limam, Jouda Mediouni Ben Jemaa. Phenolic constitutents, antioxidant and repellent activities of coriander (Coriandrum sativum L.) fruits using different solvent extracts. International journal of environmental health research. 2024 Jan; 34(1):225-237. doi: 10.1080/09603123.2022.2143483. [PMID: 36369804]
  • Marijana Kosanić, Nevena Petrovic, Dragana Šeklić, Marko Živanović, Mihajlo Kokanović. Bioactivities and Medicinal Value of the Fruiting Body Extracts of Laetiporus sulphureus and Meripilus giganteus Polypore Mushrooms (Agaricomycetes). International journal of medicinal mushrooms. 2024; 26(1):17-26. doi: 10.1615/intjmedmushrooms.2023051297. [PMID: 38305259]
  • Zhijie Zheng, Mei Tian, Guozhou Liao, Guanghui Chen, Yanru Zhong, Yuan Yang, Guiying Wang. Evaluation of the effects of compound curing agents on the lipid profiles and volatile flavors in Nuodeng ham based on lipidomics and GC-IMS analysis. Food research international (Ottawa, Ont.). 2024 Jan; 176(?):113810. doi: 10.1016/j.foodres.2023.113810. [PMID: 38163715]
  • Godfrey O Mauti. Extracts of Jamun seeds inhibited the growth of human (Hep-2) cancer cells. Journal of cancer research and therapeutics. 2024 Jan; 20(1):189-192. doi: 10.4103/jcrt.jcrt_638_22. [PMID: 38554319]
  • Usama Mohammed Abu El-Ghiet, Abdullah Mohammed Salman Alhuraysi, Tarek Mohamed Yousry Elsheikh, Mohamed Abdel-Monem El-Sakhawy. Oviposition Deterrent Activity of Some Wild Plants for Adult Females of Chrysomya albiceps with Medical and Veterinary Importance. Pakistan journal of biological sciences : PJBS. 2024 Jan; 27(1):8-17. doi: 10.3923/pjbs.2024.8.17. [PMID: 38413393]
  • Mari Ogawa-Ohnishi, Yoshikatsu Matsubayashi. Extraction of Apoplastic Peptides for the Structural Elucidation of Mature Peptide Hormones in Arabidopsis. Methods in molecular biology (Clifton, N.J.). 2024; 2731(?):81-87. doi: 10.1007/978-1-0716-3511-7_6. [PMID: 38019427]
  • Mysoon Al-Ansari, Nora Dahmash Al-Dahmash, Paola Isabel Angulo-Bejarano, Hai-Anh Ha, Thai-Hang Nguyen-Thi. Phytochemical, bactericidal, antioxidant and anti-inflammatory properties of various extracts from Pongamia pinnata and functional groups characterization by FTIR and HPLC analyses. Environmental research. 2023 Dec; 245(?):118044. doi: 10.1016/j.envres.2023.118044. [PMID: 38157963]
  • Wanda Shekwa, Tsolanku Sidney Maliehe, Peter Masoko. Antimicrobial, antioxidant and cytotoxic activities of the leaf and stem extracts of Carissa bispinosa used for dental health care. BMC complementary medicine and therapies. 2023 Dec; 23(1):462. doi: 10.1186/s12906-023-04308-x. [PMID: 38102607]
  • Jelena Šuran, Božo Radić, Dilza Trevisan-Silva, Mario Cindrić, Amela Hozić. First Proteome Analysis of Poplar-Type Propolis. Plant foods for human nutrition (Dordrecht, Netherlands). 2023 Dec; ?(?):. doi: 10.1007/s11130-023-01127-w. [PMID: 38048032]
  • Hudson V V Tomé, Stephen L Clark, Brant C Jorgenson, Stefan Kimmel, Bettina Wenzel, Carmen Gimeno, John Porch, Michael R Patnaude, Kristin Schmidt, Line Deslandes, Daniel R Schmehl. Chronic larval and adult honey bee laboratory testing: Which dietary additive should be considered when a test substance is not solubilized in acetone?. Ecotoxicology and environmental safety. 2023 Dec; 268(?):115718. doi: 10.1016/j.ecoenv.2023.115718. [PMID: 38000305]
  • Tatapudi Kiran Kumar, Bandi Siva, Basani Kiranmai, Vidya Jyothi Alli, Surender Singh Jadav, Araveeti Madhusudana Reddy, Joël Boustie, Françoise Le Devehat, Ashok Kumar Tiwari, Katragadda Suresh Babu. Salazinic Acid and Norlobaridone from the Lichen Hypotrachyna cirrhata: Antioxidant Activity, α-Glucosidase Inhibitory and Molecular Docking Studies. Molecules (Basel, Switzerland). 2023 Nov; 28(23):. doi: 10.3390/molecules28237840. [PMID: 38067568]
  • Kalaivani Madhavaram Kuppusamy, Sivakumar Selvaraj, Pujithaa Singaravelu, Cordelia Mano John, Kalaiselvan Racheal, Keziaann Varghese, Dinesh Kaliyamoorthy, Elumalai Perumal, Krishnamoorthy Gunasekaran. Anti-microbial and anti-cancer efficacy of acetone extract of Rosa chinensis against resistant strain and lung cancer cell line. BMC complementary medicine and therapies. 2023 Nov; 23(1):406. doi: 10.1186/s12906-023-04222-2. [PMID: 37950173]
  • Altevir Rossato Viana, Isadora Nicola, Camila Franco, Patrícia Acosta Caetano, Eduardo Jacob-Lopes, Leila Queiroz Zepka, Daniel Santos, Erico Marlon Moraes Flores, Bruno Stefanello Vizzotto, Katianne Wolf, Aline Ferreira Ourique, Sergio Roberto Mortari, Cristiano Rodrigo Bohn Rhoden, Luciana Maria Fontanari Krause. Phytochemical characterization and toxicological activity attributed to the acetonic extract of South American Vassobia breviflora. Journal of toxicology and environmental health. Part A. 2023 Nov; 86(21):816-832. doi: 10.1080/15287394.2023.2254316. [PMID: 37667472]
  • Elena V Emelyanova. Micromycete Responses to Acetone: Electrochemical Express Evaluation of Acetone Metabolism. Applied biochemistry and biotechnology. 2023 Oct; 195(10):6359-6368. doi: 10.1007/s12010-023-04408-x. [PMID: 36867387]
  • Maryam Koopaie, Hanieh Karimi, Mohammad Sohrabi, Hooman Norouzi. Cytotoxic, anti-proliferative, and apoptotic evaluation of Ramalina sinensis (Ascomycota, Lecanoromycetes), lichenized fungus on oral squamous cell carcinoma cell line; in-vitro study. BMC complementary medicine and therapies. 2023 Aug; 23(1):296. doi: 10.1186/s12906-023-04118-1. [PMID: 37608377]
  • Alfredi A Moyo, Kishor S Jagadhane, Sneha R Bhosale, Devashree N Patil, Vinod B Shimpale, Prashant V Anbhule. Phytochemical Profiling, Antimicrobial, Antiproliferative and Apoptotic Effects of Stemodia viscosa Roxb. of Western Ghats Region, India. Chemistry & biodiversity. 2023 Aug; 20(8):e202300332. doi: 10.1002/cbdv.202300332. [PMID: 37461844]
  • Dimitri Wendgida Wangrawa, Félix Yaméogo, Aboubacar Sombié, Edward Esalimba, Eric Ochomo, Dov Borovsky, Athanase Badolo, Antoine Sanon. Methanol and acetone extracts from the leaves of selected aromatic plants affect survival of field collected Anopheles arabiensis (Diptera: Culicidae) from Kisumu, Kenya. Journal of medical entomology. 2023 Jul; ?(?):. doi: 10.1093/jme/tjad066. [PMID: 37478413]
  • Magdalena Kulinowska, Sławomir Dresler, Agnieszka Skalska-Kamińska, Agnieszka Hanaka, Maciej Strzemski. Methodological Aspects of Green Extraction of Usnic Acid Using Natural Deep Eutectic Solvents. Molecules (Basel, Switzerland). 2023 Jul; 28(14):. doi: 10.3390/molecules28145321. [PMID: 37513195]
  • Ting Li, Yifan Wang, Nannan Liu. Mosquito Adult Bioassays. Cold Spring Harbor protocols. 2023 07; 2023(7):.pdb.prot108041. doi: 10.1101/pdb.prot108041. [PMID: 36882289]
  • Yue Sun, Jia-Xin Feng, Zhong-Bao Wei, Hui Sun, Li Li, Jun-Yi Zhu, Guang-Qing Xia, Hao Zang. Phytochemical Analysis, Antioxidant Activities In Vitro and In Vivo, and Theoretical Calculation of Different Extracts of Euphorbia fischeriana. Molecules (Basel, Switzerland). 2023 Jul; 28(13):. doi: 10.3390/molecules28135172. [PMID: 37446834]
  • Hosakatte Niranjana Murthy, Guggalada Govardhana Yadav, Sathish Shekhappa Kadapatti, M Sandhya. Phytochemical Analysis, GC-MS Identification of Bioactive Compounds, and In Vitro Antioxidant Activities of Resin of Garcinia indica (Thouars) Choisy. Applied biochemistry and biotechnology. 2023 Jul; 195(7):4570-4582. doi: 10.1007/s12010-023-04343-x. [PMID: 36705843]
  • Yu Zhang, Xiaosan Wang, Xingguo Wang. Acyl migration of 2-monoacylglycerols rich in DHA: Effect of temperature and solvent medium. Food chemistry. 2023 Jun; 412(?):135501. doi: 10.1016/j.foodchem.2023.135501. [PMID: 36716621]
  • Xuehui Xu, Wei Han. Analysis of tetrabromobisphenol A and bisphenol A in plant sample-method optimization and identification of the derivatives. Environmental science and pollution research international. 2023 Jun; ?(?):. doi: 10.1007/s11356-023-28241-1. [PMID: 37335514]
  • Raghavakumari R Sunagar, Yadahally N Sreerama. Implication of solvent polarities on browntop millet (Urochloa ramosa) phenolic antioxidants and their ability to protect oxidative DNA damage and inhibit α-amylase and α-glucosidase enzymes. Food chemistry. 2023 Jun; 411(?):135474. doi: 10.1016/j.foodchem.2023.135474. [PMID: 36681026]
  • Ivana D Radojević, Mirjana Ž Grujović, Olivera Milošević-Djordjević, Jovana Tubić Vukajlović, Aleksandra Marković, Darko Grujičić, Andrija Ćirić, Gorica Djelić, Marina Topuzović, Ljiljana R Čomić. Putative application of Najas marina L. extracts as a source of bioactive compounds and their antioxidant, antimicrobial, antibiofilm, and genotoxic properties. Letters in applied microbiology. 2023 May; 76(5):. doi: 10.1093/lambio/ovad055. [PMID: 37158292]
  • Elisabetta Lambertini, Letizia Penolazzi, Maria Pina Notarangelo, Serena Fiorito, Francesco Epifano, Assunta Pandolfi, Roberta Piva. Pro‑differentiating compounds for human intervertebral disc cells are present in Violina pumpkin leaf extracts. International journal of molecular medicine. 2023 May; 51(5):. doi: 10.3892/ijmm.2023.5242. [PMID: 37026516]
  • Veysel Çomaklı, Rüya Sağlamtaş, Müslüm Kuzu, Yalçın Karagöz, Tuba Aydın, Ramazan Demirdağ. Enzyme Inhibition and Antioxidant Activities of Asparagus officinalis L. and Analysis of Its Phytochemical Content by LC/MS/MS. Chemistry & biodiversity. 2023 Apr; ?(?):e202201231. doi: 10.1002/cbdv.202201231. [PMID: 37096958]
  • Nadjet Mostefa, Noureddine Djebli, Pham Ngoc Khanh, Nguyen Xuan Ha, Hoang Thi Ngoc Anh, Vu Thi Ha, Tran Thu Huong, Dang Viet Anh, Nguyen Manh Cuong. Anti-Alzheimer's Activity of Polyphenolic Stilbene-Rich Acetone Fraction of the Oil-Removed Seeds of Passiflora edulis: in Vivo and in Silico Studies. Chemistry & biodiversity. 2023 Apr; ?(?):e202201051. doi: 10.1002/cbdv.202201051. [PMID: 37032441]
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  • Subrata Das, Ashikur Rahaman, Rajat Nath, Anupam Das Talukdar, Deepa Nath, Shamee Bhattacharjee, Deba Prasad Mandal, Manabendra Dutta Choudhury, Dipika Das, Gitishree Das, Jayanta Kumar Patra. Effect of acetone fraction of Ottelia alismoides on the G2/M cell cycle arrest and apoptosis in the human carcinoma cell lines. Journal of ethnopharmacology. 2023 Jan; 300(?):115729. doi: 10.1016/j.jep.2022.115729. [PMID: 36162544]
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