Benzyl alcohol (BioDeep_00000004267)

 

Secondary id: BioDeep_00000400010, BioDeep_00000413330, BioDeep_00000860470

human metabolite PANOMIX_OTCML-2023 blood metabolite natural product BioNovoGene_Lab2019 Volatile Flavor Compounds


代谢物信息卡片


Hydroxymethylpolystyrene resin

化学式: C7H8O (108.0575118)
中文名称: 羟基甲基聚苯乙烯树脂, 苄醇, 苄醇-环-13C6, 苯甲醇
谱图信息: 最多检出来源 Homo sapiens(blood) 0.04%

分子结构信息

SMILES: C1=CC=C(C=C1)CO
InChI: InChI=1S/C7H8O/c8-6-7-4-2-1-3-5-7/h1-5,8H,6H2

描述信息

Benzyl alcohol is a colorless liquid with a sharp burning taste and slight odor. It is used as a local anesthetic and to reduce pain associated with Lidocaine injection. Also, it is used in the manufacture of other benzyl compounds, as a pharmaceutical aid, and in perfumery and flavoring. Benzyl Alcohol is an aromatic alcohol used in a wide variety of cosmetic formulations as a fragrance component, preservative, solvent, and viscosity-decreasing agent. Benzyl alcohol is metabolized to Benzoic Acid, which reacts with glycine and excreted as hippuric acid in the human body. Acceptable daily intakes were established by the World Health Organization at 5 mg/kg for Benzyl alcohol. No adverse effects of benzyl alcohol have been seen in chronic exposure animal studies using rats and mice. Effects of Benzyl Alcohol in chronic exposure animal studies are limited to reduced feed intake and reduced growth. Some differences have been noted in one reproductive toxicity study using mice, but these were limited to lower maternal body weights and decreased mean litter weights. Another study also noted that fetal weight was decreased compared to controls, but a third study showed no differences between control and benzyl alcohol-treated groups. Benzyl alcohol has been associated with an increased number of resorptions and malformations in hamsters, but there have been no reproductive or developmental toxicity findings in studies using mice and rats. Genotoxicity tests for benzyl alcohol are mostly negative, but there were some assays that were positive. Carcinogenicity studies, however, were negative. Clinical data indicates that benzyl alcohol can produce nonimmunologic contact urticaria and nonimmunologic immediate contact reactions, characterized by the appearance of wheals, erythema, and pruritis. 5\\\\% benzyl alcohol can elicit a reaction. Benzyl alcohol is not a sensitizer at 10\\\\%. Benzyl alcohol could be used safely at concentrations up to 5\\\\%, but that manufacturers should consider the nonimmunologic phenomena when using benzyl alcohol in cosmetic formulations designed for infants and children. Additionally, Benzyl alcohol is considered safe up to 10\\\\% for use in hair dyes. The limited body exposure, the duration of use, and the frequency of use are considered in concluding that the nonimmunologic reactions would not be a concern. Because of the wide variety of product types in which benzyl alcohol may be used, it is likely that inhalation may be a route of exposure. The available safety tests are not considered sufficient to support the safety of benzyl alcohol in formulations where inhalation is a route of exposure. Inhalation toxicity data are needed to complete the safety assessment of benzyl alcohol where inhalation can occur. (PMID:11766131).
Constituent of jasmine and other ethereal oils, both free and as estersand is also present in cherry, orange juice, mandarin peel oil, guava fruit, feijoa fruit, pineapple, leek, cinnamon, cloves, mustard, fermented tea, basil and red sage. Flavouring ingredient
P - Antiparasitic products, insecticides and repellents > P03 - Ectoparasiticides, incl. scabicides, insecticides and repellents > P03A - Ectoparasiticides, incl. scabicides
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D000777 - Anesthetics
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
C254 - Anti-Infective Agent > C28394 - Topical Anti-Infective Agent
COVID info from PDB, Protein Data Bank
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
Benzyl alcohol is an aromatic alcohol, a colorless liquid with a mild aromatic odor.
Benzyl alcohol is an aromatic alcohol, a colorless liquid with a mild aromatic odor.

同义名列表

46 个代谢物同义名

Hydroxymethylpolystyrene resin; Aromatic primary alcohol; .alpha.-hydroxytoluene; (Hydroxymethyl)benzene; Hydroxymethylbenzene; Phenylmethyl alcohol; Alcoholum benzylicum; alpha-Hydroxytoluene; Alcool benzylique; Phenylcarbinolum; Aromatic alcohol; Caswell no. 081F; Methanol benzene; .alpha.-toluenol; Α-hydroxytoluene; a-Hydroxytoluene; Benzylic alcohol; Benzenecarbinol; Benzoyl alcohol; Benzenemethanol; Alcohol, benzyl; Benzenmethanol; Benzal alcohol; alpha-Toluenol; Hydroxytoluene; Benzyl-alcohol; Phenolcarbinol; Phenylcarbinol; phenylmethanol; benzyl alcohol; Benzyl alkohol; Sunmorl BK 20; BenzylAlcohol; Benzylalkohol; Enzylalcohol; Euxyl K 100; Benzylicum; a-Toluenol; Α-toluenol; Bentalol; Ulesfia; Itch-X; TB 13g; MBN; Benzyl Alcohol; Benzyl alcohol



数据库引用编号

31 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(7)

PlantCyc(5)

代谢反应

368 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(12)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(347)

COVID-19 Disease Map(0)

PathBank(9)

PharmGKB(0)

460 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Javier Sáez-Sáez, Lachlan Jake Munro, Iben Møller-Hansen, Douglas B Kell, Irina Borodina. Identification of transporters involved in aromatic compounds tolerance through screening of transporter deletion libraries. Microbial biotechnology. 2024 Apr; 17(4):e14460. doi: 10.1111/1751-7915.14460. [PMID: 38635191]
  • Hadeel Alobeedallah, Bruce Cornell, Mohammed Ghazal, Hans Coster. The Effect of Benzyl Alcohol on the Voltage-Current Characteristics of Tethered Lipid Bilayers. The Journal of membrane biology. 2023 Sep; ?(?):. doi: 10.1007/s00232-023-00291-z. [PMID: 37728833]
  • Abid Bashir, Malik Muzafar Manzoor, Tanveer Ahmad, Sadaqat Farooq, Phalisteen Sultan, Ajai P Gupta, Syed Riyaz-Ul-Hassan. Endophytic fungal community of Rosa damascena Mill. as a promising source of indigenous biostimulants: Elucidating its spatial distribution, chemical diversity, and ecological functions. Microbiological research. 2023 Aug; 276(?):127479. doi: 10.1016/j.micres.2023.127479. [PMID: 37639964]
  • Yichao Ge, Yihan Ma, Meilu Zhao, Jihua Wei, Xiaodan Wu, Zunjing Zhang, Han Yang, Houxing Lei, Bin Wu. Exploring gabosine and chlorogentisyl alcohol derivatives from a marine-derived fungus as EcGUS inhibitors with informatic assisted approaches. European journal of medicinal chemistry. 2022 Nov; 242(?):114699. doi: 10.1016/j.ejmech.2022.114699. [PMID: 36001934]
  • Ho Viet Khoa, Koji Mikami. Membrane-Fluidization-Dependent and -Independent Pathways Are Involved in Heat-Stress-Inducible Gene Expression in the Marine Red Alga Neopyropia yezoensis. Cells. 2022 04; 11(9):. doi: 10.3390/cells11091486. [PMID: 35563791]
  • Fangyan He, Chenjing Ma, Jin Feng, Xiufang Li, Shuangli Xia, Qing Lin, Rong Dai. Angiogenesis effects of 4-methoxy benzyl alcohol on cerebral ischemia-reperfusion injury via regulation of VEGF-Ang/Tie2 balance. Canadian journal of physiology and pharmacology. 2021 Dec; 99(12):1253-1263. doi: 10.1139/cjpp-2021-0118. [PMID: 34283928]
  • Kirill S Mironov, Elena V Kupriyanova, Maria Shumskaya, Dmitry A Los. Alcohol stress on cyanobacterial membranes: New insights revealed by transcriptomics. Gene. 2021 Jan; 764(?):145055. doi: 10.1016/j.gene.2020.145055. [PMID: 32882332]
  • Paola Terrazas, Efrain Salamanca, Marcelo Dávila, Sophie Manner, Alberto Giménez, And Olov Sterner. SAR:s for the Antiparasitic Plant Metabolite Pulchrol. 1. The Benzyl Alcohol Functionality. Molecules (Basel, Switzerland). 2020 Jul; 25(13):. doi: 10.3390/molecules25133058. [PMID: 32635469]
  • Aldo Tava, Elisa Biazzi, Domenico Ronga, Pinarosa Avato. Identification of the Volatile Components of Galium verum L. and Cruciata leavipes Opiz from the Western Italian Alps. Molecules (Basel, Switzerland). 2020 May; 25(10):. doi: 10.3390/molecules25102333. [PMID: 32429453]
  • Fereshteh Hosseini-Eshbala, Alireza Sedrpoushan, Bernhard Breit, Farajollah Mohanazadeh, Hojat Veisi. Ionic-liquid-modified CMK-3 as a support for the immobilization of molybdate ions (MoO42-): Heterogeneous nanocatalyst for selective oxidation of sulfides and benzylic alcohols. Materials science & engineering. C, Materials for biological applications. 2020 May; 110(?):110577. doi: 10.1016/j.msec.2019.110577. [PMID: 32204056]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Tatsuru Hayashi, Hiroshi Tsuchikawa, Yuichi Umegawa, Michio Murata. Small structural alterations greatly influence the membrane affinity of lipophilic ligands: Membrane interactions of bafilomycin A1 and its desmethyl derivative bearing 19F-labeling. Bioorganic & medicinal chemistry. 2019 04; 27(8):1677-1682. doi: 10.1016/j.bmc.2019.03.017. [PMID: 30878192]
  • Ting Ding, Tingting Li, Jianrong Li. Identification of natural product compounds as quorum sensing inhibitors in Pseudomonas fluorescens P07 through virtual screening. Bioorganic & medicinal chemistry. 2018 08; 26(14):4088-4099. doi: 10.1016/j.bmc.2018.06.039. [PMID: 30100021]
  • Feng Jin, Ji Wang, Joe M Regenstein, Fengjun Wang. Effect of Roasting Temperatures on the Properties of Bitter Apricot (Armeniaca sibirica L.) Kernel Oil. Journal of oleo science. 2018 Jul; 67(7):813-822. doi: 10.5650/jos.ess17212. [PMID: 29877221]
  • Rajesh Katara, Sameer Sachdeva, Dipak K Majumdar. Aceclofenac oil drops: characterization and evaluation against ocular inflammation. Pharmaceutical development and technology. 2018 Mar; 23(3):240-246. doi: 10.1080/10837450.2017.1337794. [PMID: 28565934]
  • Mei-Huei Lin, Young-Chau Liu, Shyun-Yeu Liu, Fang-Chi Chen, Pei-Jung Yang, Guan-Hua Li, Pang-Yen Liu, Ching-Yu Yen. Clathrin-mediated endocytosis is required for ANE 30-100K-induced autophagy. Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology. 2018 Jan; 47(1):25-31. doi: 10.1111/jop.12593. [PMID: 28520088]
  • Lixin Wang, Peter Nick. Cold sensing in grapevine-Which signals are upstream of the microtubular 'thermometer'. Plant, cell & environment. 2017 Nov; 40(11):2844-2857. doi: 10.1111/pce.13066. [PMID: 28898434]
  • Seoyoung Son, George J Moroney, Peter J Butler. β1-Integrin-Mediated Adhesion Is Lipid-Bilayer Dependent. Biophysical journal. 2017 Sep; 113(5):1080-1092. doi: 10.1016/j.bpj.2017.07.010. [PMID: 28877491]
  • D M Suckling, A M El-Sayed. Caterpillar-Induced Plant Volatiles Attract Adult Tortricidae. Journal of chemical ecology. 2017 May; 43(5):487-492. doi: 10.1007/s10886-017-0847-7. [PMID: 28477139]
  • Nan Zhang, Lei Zhang, Linyin Feng, Lei Yao. The anxiolytic effect of essential oil of Cananga odorata exposure on mice and determination of its major active constituents. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2016 Dec; 23(14):1727-1734. doi: 10.1016/j.phymed.2016.10.017. [PMID: 27912874]
  • Hadeel Alobeedallah, Bruce Cornell, Hans Coster. The Effect of Benzyl Alcohol on the Dielectric Structure of Lipid Bilayers. The Journal of membrane biology. 2016 12; 249(6):833-844. doi: 10.1007/s00232-016-9934-x. [PMID: 27803961]
  • ". Drugs for head lice. The Medical letter on drugs and therapeutics. 2016 Nov; 58(1508):150-152. doi: ". [PMID: 27849194]
  • Lingtian Zhang, Katsuhisa Kurogi, Ming-Yih Liu, Alaina M Schnapp, Frederick E Williams, Yoichi Sakakibara, Masahito Suiko, Ming-Cheh Liu. Sulfation of benzyl alcohol by the human cytosolic sulfotransferases (SULTs): a systematic analysis. Journal of applied toxicology : JAT. 2016 09; 36(9):1090-4. doi: 10.1002/jat.3268. [PMID: 26663444]
  • Juan Palacios-Ortega, Sara García-Linares, Mia Åstrand, Md Abdullah Al Sazzad, José G Gavilanes, Álvaro Martínez-del-Pozo, J Peter Slotte. Regulation of Sticholysin II-Induced Pore Formation by Lipid Bilayer Composition, Phase State, and Interfacial Properties. Langmuir : the ACS journal of surfaces and colloids. 2016 Apr; 32(14):3476-84. doi: 10.1021/acs.langmuir.6b00082. [PMID: 27003246]
  • Raween Kalicharan, Mohsin El Amrani, Peter Schot, Herman Vromans. Pharmacokinetics in Elderly Women of Benzyl Alcohol From an Oil Depot. Journal of pharmaceutical sciences. 2016 Apr; 105(4):1519-25. doi: 10.1016/j.xphs.2016.01.022. [PMID: 27019966]
  • Museer A Lone, Aaron E Atkinson, Christine A Hodge, Stéphanie Cottier, Fernando Martínez-Montañés, Shelley Maithel, Laurent Mène-Saffrané, Charles N Cole, Roger Schneiter. Yeast Integral Membrane Proteins Apq12, Brl1, and Brr6 Form a Complex Important for Regulation of Membrane Homeostasis and Nuclear Pore Complex Biogenesis. Eukaryotic cell. 2015 Dec; 14(12):1217-27. doi: 10.1128/ec.00101-15. [PMID: 26432634]
  • Gregg M Griffenhagen, Marlis L Rezende, Daniel L Gustafson, Ryan J Hansen, Paul J Lunghofer, Khursheed R Mama. Pharmacokinetics and pharmacodynamics of propofol with or without 2\% benzyl alcohol following a single induction dose administered intravenously in cats. Veterinary anaesthesia and analgesia. 2015 Sep; 42(5):472-83. doi: 10.1111/vaa.12233. [PMID: 25327817]
  • Přemysl Pejchar, Jan Martinec. Aluminum ions alter the function of non-specific phospholipase C through the changes in plasma membrane physical properties. Plant signaling & behavior. 2015; 10(6):e1031938. doi: 10.1080/15592324.2015.1031938. [PMID: 26024014]
  • Bo Liu, Shaoying Lu, Ying-li Hu, Xiaoling Liao, Mingxing Ouyang, Yingxiao Wang. RhoA and membrane fluidity mediates the spatially polarized Src/FAK activation in response to shear stress. Scientific reports. 2014 Nov; 4(?):7008. doi: 10.1038/srep07008. [PMID: 25387906]
  • M J Yapura, R J Mapletoft, R A Pierson, J Singh, G P Adams. Effect of vehicle and route of administration of letrozole on ovarian function in a bovine model. Reproduction, fertility, and development. 2014 Oct; 26(8):1198-205. doi: 10.1071/rd13100. [PMID: 24176391]
  • Kyra J Barnes, Andrew Rowland, Thomas M Polasek, John O Miners. Inhibition of human drug-metabolising cytochrome P450 and UDP-glucuronosyltransferase enzyme activities in vitro by uremic toxins. European journal of clinical pharmacology. 2014 Sep; 70(9):1097-106. doi: 10.1007/s00228-014-1709-7. [PMID: 24954688]
  • Ariaki Murata, Ulrich H Engelhardt, Peter Fleischmann, Keita Yamada, Naohiro Yoshida, Dieter Juchelka, Andreas Hilkert, Toshiyuki Ohnishi, Naoharu Watanabe, Peter Winterhalter. Purification and gas chromatography-combustion-isotope ratio mass spectrometry of aroma compounds from green tea products and comparison to bulk analysis. Journal of agricultural and food chemistry. 2013 Nov; 61(47):11321-5. doi: 10.1021/jf403605a. [PMID: 24206364]
  • Raúl Muñoz, Theo S O Souza, Lina Glittmann, Rebeca Pérez, Guillermo Quijano. Biological anoxic treatment of O₂-free VOC emissions from the petrochemical industry: a proof of concept study. Journal of hazardous materials. 2013 Sep; 260(?):442-50. doi: 10.1016/j.jhazmat.2013.05.051. [PMID: 23811365]
  • Qiong Liu, Fei Qiao, Ahmed Ismail, Xiaoli Chang, Peter Nick. The plant cytoskeleton controls regulatory volume increase. Biochimica et biophysica acta. 2013 Sep; 1828(9):2111-20. doi: 10.1016/j.bbamem.2013.04.027. [PMID: 23660128]
  • Joshua Pezet, Joseph Elkinton, Sara Gomez, E Alexa McKenzie, Michael Lavine, Evan Preisser. Hemlock woolly adelgid and elongate hemlock scale induce changes in foliar and twig volatiles of eastern hemlock. Journal of chemical ecology. 2013 Aug; 39(8):1090-100. doi: 10.1007/s10886-013-0300-5. [PMID: 23900803]
  • Erdenechimeg Selenge, Toshihiro Murata, Kyoko Kobayashi, Javzan Batkhuu, Fumihiko Yoshizaki. Flavone tetraglycosides and benzyl alcohol glycosides from the Mongolian medicinal plant Dracocephalum ruyschiana. Journal of natural products. 2013 Feb; 76(2):186-93. doi: 10.1021/np300609u. [PMID: 23356964]
  • Aaron L Acton, Cristina Fante, Brian Flatley, Stefano Burattini, Ian W Hamley, Zuowei Wang, Francesca Greco, Wayne Hayes. Janus PEG-based dendrimers for use in combination therapy: controlled multi-drug loading and sequential release. Biomacromolecules. 2013 Feb; 14(2):564-74. doi: 10.1021/bm301881h. [PMID: 23305104]
  • Alistair Paterson, Angzzas Kassim, Susan McCallum, Mary Woodhead, Kay Smith, Dzeti Zait, Julie Graham. Environmental and seasonal influences on red raspberry flavour volatiles and identification of quantitative trait loci (QTL) and candidate genes. TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik. 2013 Jan; 126(1):33-48. doi: 10.1007/s00122-012-1957-9. [PMID: 22890807]
  • Jana Krtková, Lenka Havelková, Anna Křepelová, Radovan Fišer, Stanislav Vosolsobě, Zuzana Novotná, Jan Martinec, Kateřina Schwarzerová. Loss of membrane fluidity and endocytosis inhibition are involved in rapid aluminum-induced root growth cessation in Arabidopsis thaliana. Plant physiology and biochemistry : PPB. 2012 Nov; 60(?):88-97. doi: 10.1016/j.plaphy.2012.07.030. [PMID: 22922108]
  • D M Suckling, A M Twidle, A R Gibb, L M Manning, V J Mitchell, T E S Sullivan, S L Wee, A M El-Sayed. Volatiles from apple trees infested with light brown apple moth larvae attract the parasitoid Dolichogenidia tasmanica. Journal of agricultural and food chemistry. 2012 Sep; 60(38):9562-6. doi: 10.1021/jf302874g. [PMID: 22950817]
  • Philip E Otienoburu, Babak Ebrahimi, P Larry Phelan, Woodbridge A Foster. Analysis and optimization of a synthetic milkweed floral attractant for mosquitoes. Journal of chemical ecology. 2012 Jul; 38(7):873-81. doi: 10.1007/s10886-012-0150-6. [PMID: 22711028]
  • Ahmed M Saveer, Sophie H Kromann, Göran Birgersson, Marie Bengtsson, Tobias Lindblom, Anna Balkenius, Bill S Hansson, Peter Witzgall, Paul G Becher, Rickard Ignell. Floral to green: mating switches moth olfactory coding and preference. Proceedings. Biological sciences. 2012 Jun; 279(1737):2314-22. doi: 10.1098/rspb.2011.2710. [PMID: 22319127]
  • Hisashi Omura, Nanako Yanai, Keiichi Honda. Sexual dimorphism in scent substances and cuticular lipids of adult Papilio protenor butterflies. Zeitschrift fur Naturforschung. C, Journal of biosciences. 2012 May; 67(5-6):331-41. doi: 10.1515/znc-2012-5-614. [PMID: 22888540]
  • Colleen K Lambertz, Christopher J Johnson, Paul G Montgomery, James R Maxwell, Stefanie J Fry. Toxicity of topical lidocaine applied to the breasts to reduce discomfort during screening mammography. Journal of anaesthesiology, clinical pharmacology. 2012 Apr; 28(2):200-4. doi: 10.4103/0970-9185.94859. [PMID: 22557743]
  • Eric G Dennis, Robert A Keyzers, Curtis M Kalua, Suzanne M Maffei, Emily L Nicholson, Paul K Boss. Grape contribution to wine aroma: production of hexyl acetate, octyl acetate, and benzyl acetate during yeast fermentation is dependent upon precursors in the must. Journal of agricultural and food chemistry. 2012 Mar; 60(10):2638-46. doi: 10.1021/jf2042517. [PMID: 22332880]
  • Wosen Aman, Shaymaa Mousa, Gamal Shiha, Shaker A Mousa. Current status and future directions in the management of chronic hepatitis C. Virology journal. 2012 Mar; 9(?):57. doi: 10.1186/1743-422x-9-57. [PMID: 22385500]
  • Yang Zhou, Hong Wang, Ruili Yang, Hui Huang, Yuanming Sun, Yudong Shen, Hongtao Lei, Hong Gao. Effects of Litchi chinensis fruit isolates on prostaglandin E(2) and nitric oxide production in J774 murine macrophage cells. BMC complementary and alternative medicine. 2012 Mar; 12(?):12. doi: 10.1186/1472-6882-12-12. [PMID: 22380404]
  • Kyung Hye Seo, Ningning Zhuang, Cong Chen, Jae-Young Song, Hyung-Lyun Kang, Kwang-Ho Rhee, Kon Ho Lee. Unusual NADPH conformation in the crystal structure of a cinnamyl alcohol dehydrogenase from Helicobacter pylori in complex with NADP(H) and substrate docking analysis. FEBS letters. 2012 Feb; 586(4):337-43. doi: 10.1016/j.febslet.2012.01.020. [PMID: 22269576]
  • Hari S Muddana, Homer H Chiang, Peter J Butler. Tuning membrane phase separation using nonlipid amphiphiles. Biophysical journal. 2012 Feb; 102(3):489-97. doi: 10.1016/j.bpj.2011.12.033. [PMID: 22325271]
  • Daniela Küllenberg, Lenka A Taylor, Michael Schneider, Ulrich Massing. Health effects of dietary phospholipids. Lipids in health and disease. 2012 Jan; 11(?):3. doi: 10.1186/1476-511x-11-3. [PMID: 22221489]
  • Mokhtar Guerfel, Mohamed Ben Mansour, Youssef Ouni, Flamini Guido, Dalenda Boujnah, Mokhtar Zarrouk. Triacylglycerols composition and volatile compounds of virgin olive oil from Chemlali cultivar: comparison among different planting densities. TheScientificWorldJournal. 2012; 2012(?):354019. doi: 10.1100/2012/354019. [PMID: 22629139]
  • Martin Pareja, Erika Qvarfordt, Ben Webster, Patrick Mayon, John Pickett, Michael Birkett, Robert Glinwood. Herbivory by a Phloem-feeding insect inhibits floral volatile production. PloS one. 2012; 7(2):e31971. doi: 10.1371/journal.pone.0031971. [PMID: 22384116]
  • Yu Ling, Chunyu Zhang, Tong Chen, Huaiqing Hao, Peng Liu, Ray A Bressan, Paul M Hasegawa, Jing Bo Jin, Jinxing Lin. Mutation in SUMO E3 ligase, SIZ1, disrupts the mature female gametophyte in Arabidopsis. PloS one. 2012; 7(1):e29470. doi: 10.1371/journal.pone.0029470. [PMID: 22253727]
  • Catherine E Morris, Pierre-Alexandre Boucher, Béla Joós. Left-shifted nav channels in injured bilayer: primary targets for neuroprotective nav antagonists?. Frontiers in pharmacology. 2012; 3(?):19. doi: 10.3389/fphar.2012.00019. [PMID: 22375118]
  • Hasan Kirmizibekmez, Etil Ariburnu, Milena Masullo, Michela Festa, Anna Capasso, Erdem Yesilada, Sonia Piacente. Iridoid, phenylethanoid and flavonoid glycosides from Sideritis trojana. Fitoterapia. 2012 Jan; 83(1):130-6. doi: 10.1016/j.fitote.2011.10.003. [PMID: 22024633]
  • Manmohan Singhal, Niraj Kansara. Cassia tora Linn Cream Inhibits Ultraviolet-B-Induced Psoriasis in Rats. ISRN dermatology. 2012; 2012(?):346510. doi: 10.5402/2012/346510. [PMID: 22536527]
  • Laura Dindia, Josh Murray, Erin Faught, Tracy L Davis, Zoya Leonenko, Mathilakath M Vijayan. Novel nongenomic signaling by glucocorticoid may involve changes to liver membrane order in rainbow trout. PloS one. 2012; 7(10):e46859. doi: 10.1371/journal.pone.0046859. [PMID: 23056491]
  • Gideon Hen, Sara Yosefi, Dmitry Shinder, Adi Or, Sivan Mygdal, Reba Condiotti, Eithan Galun, Amir Bor, Dalit Sela-Donenfeld, Miriam Friedman-Einat. Gene transfer to chicks using lentiviral vectors administered via the embryonic chorioallantoic membrane. PloS one. 2012; 7(5):e36531. doi: 10.1371/journal.pone.0036531. [PMID: 22606269]
  • H-P Chang, M-L Wang, C-Y Hsu, M-E Liu, M-H Chan, Y-H Chen. Suppression of inflammation-associated factors by indole-3-carbinol in mice fed high-fat diets and in isolated, co-cultured macrophages and adipocytes. International journal of obesity (2005). 2011 Dec; 35(12):1530-8. doi: 10.1038/ijo.2011.12. [PMID: 21343904]
  • Sergey A Staroverov, Vladimir A Sidorkin, Alexander S Fomin, Sergey Yu Shchyogolev, Lev A Dykman. Biodynamic parameters of micellar diminazene in sheep erythrocytes and blood plasma. Journal of veterinary science. 2011 Dec; 12(4):303-7. doi: 10.4142/jvs.2011.12.4.303. [PMID: 22122895]
  • Ana M Fortes, Patricia Agudelo-Romero, Marta S Silva, Kashif Ali, Lisete Sousa, Federica Maltese, Young H Choi, Jerome Grimplet, José M Martinez-Zapater, Robert Verpoorte, Maria S Pais. Transcript and metabolite analysis in Trincadeira cultivar reveals novel information regarding the dynamics of grape ripening. BMC plant biology. 2011 Nov; 11(?):149. doi: 10.1186/1471-2229-11-149. [PMID: 22047180]
  • Jennifer M Friederichs, Suman Ghosh, Christine J Smoyer, Scott McCroskey, Brandon D Miller, Kyle J Weaver, Kym M Delventhal, Jay Unruh, Brian D Slaughter, Sue L Jaspersen. The SUN protein Mps3 is required for spindle pole body insertion into the nuclear membrane and nuclear envelope homeostasis. PLoS genetics. 2011 Nov; 7(11):e1002365. doi: 10.1371/journal.pgen.1002365. [PMID: 22125491]
  • Maria Graça Miguel, Maria Dulce Antunes. Is propolis safe as an alternative medicine?. Journal of pharmacy & bioallied sciences. 2011 Oct; 3(4):479-95. doi: 10.4103/0975-7406.90101. [PMID: 22219581]
  • Nora C Lawo, Georg J F Weingart, Rainer Schuhmacher, Astrid Forneck. The volatile metabolome of grapevine roots: first insights into the metabolic response upon phylloxera attack. Plant physiology and biochemistry : PPB. 2011 Sep; 49(9):1059-63. doi: 10.1016/j.plaphy.2011.06.008. [PMID: 21764593]
  • Fahima M Hashem, Dalia S Shaker, Mohamed Khalid Ghorab, Mohamed Nasr, Aliaa Ismail. Formulation, characterization, and clinical evaluation of microemulsion containing clotrimazole for topical delivery. AAPS PharmSciTech. 2011 Sep; 12(3):879-86. doi: 10.1208/s12249-011-9653-7. [PMID: 21725708]
  • Stephen C Barker, Phillip M Altman. An ex vivo, assessor blind, randomised, parallel group, comparative efficacy trial of the ovicidal activity of three pediculicides after a single application--melaleuca oil and lavender oil, eucalyptus oil and lemon tea tree oil, and a 'suffocation' pediculicide. BMC dermatology. 2011 Aug; 11(?):14. doi: 10.1186/1471-5945-11-14. [PMID: 21864348]
  • Carsten Schwan, Thilo Nölke, Anna S Kruppke, Daniel M Schubert, Alexander E Lang, Klaus Aktories. Cholesterol- and sphingolipid-rich microdomains are essential for microtubule-based membrane protrusions induced by Clostridium difficile transferase (CDT). The Journal of biological chemistry. 2011 Aug; 286(33):29356-29365. doi: 10.1074/jbc.m111.261925. [PMID: 21705797]
  • Coralia V Garcia, Siew-Young Quek, Ralph J Stevenson, Robert A Winz. Characterization of the bound volatile extract from baby kiwi (Actinidia arguta). Journal of agricultural and food chemistry. 2011 Aug; 59(15):8358-65. doi: 10.1021/jf201469c. [PMID: 21702480]
  • Rakesh Kumar, Nandini Sharma, Naina Sharma, Abhishek Sharma, Arun K Sinha. Metal-free activation of H₂O₂ by synergic effect of ionic liquid and microwave: chemoselective oxidation of benzylic alcohols to carbonyls and unexpected formation of anthraquinone in aqueous condition. Molecular diversity. 2011 Aug; 15(3):687-95. doi: 10.1007/s11030-010-9292-z. [PMID: 21113797]
  • Xiaoyan Zhang, Jonathan Hurng, Debra L Rateri, Alan Daugherty, Geert W Schmid-Schönbein, Hainsworth Y Shin. Membrane cholesterol modulates the fluid shear stress response of polymorphonuclear leukocytes via its effects on membrane fluidity. American journal of physiology. Cell physiology. 2011 Aug; 301(2):C451-60. doi: 10.1152/ajpcell.00458.2010. [PMID: 21525434]
  • Marica Orioli, Giulio Vistoli, Luca Regazzoni, Alessandro Pedretti, Annunziata Lapolla, Giuseppe Rossoni, Renato Canevotti, Luca Gamberoni, Massimo Previtali, Marina Carini, Giancarlo Aldini. Design, synthesis, ADME properties, and pharmacological activities of β-alanyl-D-histidine (D-carnosine) prodrugs with improved bioavailability. ChemMedChem. 2011 Jul; 6(7):1269-82. doi: 10.1002/cmdc.201100042. [PMID: 21634010]
  • Leonhard Jaitz, Bernhard Mueller, Gunda Koellensperger, Daniela Huber, Eva Oburger, Markus Puschenreiter, Stephan Hann. LC-MS analysis of low molecular weight organic acids derived from root exudation. Analytical and bioanalytical chemistry. 2011 Jun; 400(8):2587-96. doi: 10.1007/s00216-010-4090-0. [PMID: 20711769]
  • Fariza Hadjaz, Soizic Besret, Françoise Martin-Nizard, Saïd Yous, Sébastien Dilly, Nicolas Lebegue, Philippe Chavatte, Patrick Duriez, Pascal Berthelot, Pascal Carato. Antioxydant activity of β-carboline derivatives in the LDL oxidation model. European journal of medicinal chemistry. 2011 Jun; 46(6):2575-85. doi: 10.1016/j.ejmech.2011.03.048. [PMID: 21497423]
  • Lindsey K Tuominen, Virgil E Johnson, Chung-Jui Tsai. Differential phylogenetic expansions in BAHD acyltransferases across five angiosperm taxa and evidence of divergent expression among Populus paralogues. BMC genomics. 2011 May; 12(?):236. doi: 10.1186/1471-2164-12-236. [PMID: 21569431]
  • Rachel Berry, Louise Harewood, Liming Pei, Malcolm Fisher, David Brownstein, Allyson Ross, William A Alaynick, Julie Moss, Nicholas D Hastie, Peter Hohenstein, Jamie A Davies, Ronald M Evans, David R FitzPatrick. Esrrg functions in early branch generation of the ureteric bud and is essential for normal development of the renal papilla. Human molecular genetics. 2011 Mar; 20(5):917-26. doi: 10.1093/hmg/ddq530. [PMID: 21138943]
  • Ill-Min Chung, Hyung-In Moon. Immunotoxicity activity of 1,2,4-trimethoxybenzene from the Paulownia coreana Uyeki. against Aedes aegypti L. Immunopharmacology and immunotoxicology. 2011 Mar; 33(1):97-9. doi: 10.3109/08923973.2010.482591. [PMID: 20476845]
  • Luis Morales-Quintana, Lida Fuentes, Carlos Gaete-Eastman, Raúl Herrera, María Alejandra Moya-León. Structural characterization and substrate specificity of VpAAT1 protein related to ester biosynthesis in mountain papaya fruit. Journal of molecular graphics & modelling. 2011 Feb; 29(5):635-42. doi: 10.1016/j.jmgm.2010.11.011. [PMID: 21146433]
  • Zhi Zheng, So-Young Park, Min Lee, Sohee Phark, Nam Hee Won, Hyung-Sik Kang, Donggeun Sul. Effects of benzo(a)pyrene on the expression of heat shock proteins, pro-inflammatory cytokines and antioxidant enzymes in hepatic tumors induced by rat hepatoma N1-S1 cells. Journal of Korean medical science. 2011 Feb; 26(2):222-30. doi: 10.3346/jkms.2011.26.2.222. [PMID: 21286013]
  • Marc Tebruegge, Anastasia Pantazidou, Nigel Curtis. What's bugging you? An update on the treatment of head lice infestation. Archives of disease in childhood. Education and practice edition. 2011 Feb; 96(1):2-8. doi: 10.1136/adc.2009.178038. [PMID: 20688849]
  • Etsuko Tsuda, Haibing Yang, Takeshi Nishimura, Yukiko Uehara, Tatsuya Sakai, Masahiko Furutani, Tomokazu Koshiba, Masakazu Hirose, Hiroshi Nozaki, Angus S Murphy, Ken-ichiro Hayashi. Alkoxy-auxins are selective inhibitors of auxin transport mediated by PIN, ABCB, and AUX1 transporters. The Journal of biological chemistry. 2011 Jan; 286(3):2354-64. doi: 10.1074/jbc.m110.171165. [PMID: 21084292]
  • Thomas Louveau, Celine Leitao, Sol Green, Cyril Hamiaux, Benoît van der Rest, Odile Dechy-Cabaret, Ross G Atkinson, Christian Chervin. Predicting the substrate specificity of a glycosyltransferase implicated in the production of phenolic volatiles in tomato fruit. The FEBS journal. 2011 Jan; 278(2):390-400. doi: 10.1111/j.1742-4658.2010.07962.x. [PMID: 21166996]
  • Ghassan Z Abdullah, Muthanna F Abdulkarim, Ibrahim M Salman, Omar Z Ameer, Mun F Yam, Ahmed F Mutee, Mallikarjun Chitneni, Elrashid S Mahdi, Mahiran Basri, Munavvar A Sattar, Azmin M Noor. In vitro permeation and in vivo anti-inflammatory and analgesic properties of nanoscaled emulsions containing ibuprofen for topical delivery. International journal of nanomedicine. 2011; 6(?):387-96. doi: 10.2147/ijn.s14667. [PMID: 21499428]
  • Sajida Abdureyim, Nurmuhammat Amat, Anwar Umar, Halmurat Upur, Benedicte Berke, Nicholas Moore. Anti-inflammatory, immunomodulatory, and heme oxygenase-1 inhibitory activities of ravan napas, a formulation of uighur traditional medicine, in a rat model of allergic asthma. Evidence-based complementary and alternative medicine : eCAM. 2011; 2011(?):. doi: 10.1155/2011/725926. [PMID: 20953388]
  • Imre Gombos, Tim Crul, Stefano Piotto, Burcin Güngör, Zsolt Török, Gábor Balogh, Mária Péter, J Peter Slotte, Federica Campana, Ana-Maria Pilbat, Akos Hunya, Noémi Tóth, Zsuzsanna Literati-Nagy, László Vígh, Attila Glatz, Mario Brameshuber, Gerhard J Schütz, Andrea Hevener, Mark A Febbraio, Ibolya Horváth, László Vígh. Membrane-lipid therapy in operation: the HSP co-inducer BGP-15 activates stress signal transduction pathways by remodeling plasma membrane rafts. PloS one. 2011; 6(12):e28818. doi: 10.1371/journal.pone.0028818. [PMID: 22174906]
  • Sundarapandian Thangapandian, Shalini John, Yuno Lee, Songmi Kim, Keun Woo Lee. Dynamic structure-based pharmacophore model development: a new and effective addition in the histone deacetylase 8 (HDAC8) inhibitor discovery. International journal of molecular sciences. 2011; 12(12):9440-62. doi: 10.3390/ijms12129440. [PMID: 22272142]
  • Hiroki Kakuta. [Challenge of creating single-agents for the treatment of type 1 and 2 diabetes by targeting retinoid X receptor]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 2011; 131(6):917-23. doi: 10.1248/yakushi.131.917. [PMID: 21628978]
  • Helen L Rose, Caroline A Dewey, Morgan S Ely, Sarah L Willoughby, Tanya M Parsons, Victoria Cox, Phillippa M Spencer, Simon A Weller. Comparison of eight methods for the extraction of Bacillus atrophaeus spore DNA from eleven common interferents and a common swab. PloS one. 2011; 6(7):e22668. doi: 10.1371/journal.pone.0022668. [PMID: 21818364]
  • Jun Tabata, Consuelo M De Moraes, Mark C Mescher. Olfactory cues from plants infected by powdery mildew guide foraging by a mycophagous ladybird beetle. PloS one. 2011; 6(8):e23799. doi: 10.1371/journal.pone.0023799. [PMID: 21876772]
  • Christy E Manyi-Loh, Roland N Ndip, Anna M Clarke. Volatile compounds in honey: a review on their involvement in aroma, botanical origin determination and potential biomedical activities. International journal of molecular sciences. 2011; 12(12):9514-32. doi: 10.3390/ijms12129514. [PMID: 22272147]
  • Oliver Fiehn, W Timothy Garvey, John W Newman, Kerry H Lok, Charles L Hoppel, Sean H Adams. Plasma metabolomic profiles reflective of glucose homeostasis in non-diabetic and type 2 diabetic obese African-American women. PloS one. 2010 Dec; 5(12):e15234. doi: 10.1371/journal.pone.0015234. [PMID: 21170321]
  • Sung-Jae Lee, Hyung-In Moon. Immunotoxicity activity of the major essential oil of Filipendula glaberrima against Aedes aegypti L. Immunopharmacology and immunotoxicology. 2010 Dec; 32(4):617-9. doi: 10.3109/08923971003652983. [PMID: 20175741]
  • Idrian García-García, Carlos A González-Delgado, Carmen M Valenzuela-Silva, Alina Díaz-Machado, Marisol Cruz-Díaz, Hugo Nodarse-Cuní, Orlando Pérez-Pérez, Cimara H Bermúdez-Badell, Joel Ferrero-Bibilonia, Rolando Páez-Meireles, Iraldo Bello-Rivero, Fidel R Castro-Odio, Pedro A López-Saura. Pharmacokinetic and pharmacodynamic comparison of two "pegylated" interferon alpha-2 formulations in healthy male volunteers: a randomized, crossover, double-blind study. BMC pharmacology. 2010 Nov; 10(?):15. doi: 10.1186/1471-2210-10-15. [PMID: 21092287]
  • Pere Domingo, Javier Torres-Torronteras, Virginia Pomar, Marta Giralt, Joan Carles Domingo, Maria Del Mar Gutierrez, José M Gallego-Escuredo, Maria Gracia Mateo, Pedro Cano-Soldado, Irene Fernandez, Marçal Pastor-Anglada, Francesc Vidal, Francesc Villarroya, Antoni Andreu, Ramon Marti. Uridine metabolism in HIV-1-infected patients: effect of infection, of antiretroviral therapy and of HIV-1/ART-associated lipodystrophy syndrome. PloS one. 2010 Nov; 5(11):e13896. doi: 10.1371/journal.pone.0013896. [PMID: 21085568]
  • Josip Mastelić, Ivica Blažević, Ivan Kosalec. Chemical composition and antimicrobial activity of volatiles from Degenia velebitica, a European stenoendemic plant of the Brassicaceae family. Chemistry & biodiversity. 2010 Nov; 7(11):2755-65. doi: 10.1002/cbdv.201000053. [PMID: 21072775]
  • Elena Zaitseva, Sung-Tae Yang, Kamran Melikov, Sergei Pourmal, Leonid V Chernomordik. Dengue virus ensures its fusion in late endosomes using compartment-specific lipids. PLoS pathogens. 2010 Oct; 6(10):e1001131. doi: 10.1371/journal.ppat.1001131. [PMID: 20949067]
  • Laura K Cole, René L Jacobs, Dennis E Vance. Tamoxifen induces triacylglycerol accumulation in the mouse liver by activation of fatty acid synthesis. Hepatology (Baltimore, Md.). 2010 Oct; 52(4):1258-65. doi: 10.1002/hep.23813. [PMID: 20658461]
  • Eman Al-Sayed, Olli Martiskainen, Małgorzata Bobrowska-Hägerstrand, Jari Sinkkonen, Kid Törnquist, Kalevi Pihlaja, Nahla Ayoub, Abdel-Nasser Singab. Phenolic compounds from Eucalyptus gomphocephala with potential cytotoxic and antioxidant activities. Natural product communications. 2010 Oct; 5(10):1639-42. doi: ". [PMID: 21121264]
  • Patcharee Pripdeevech, Ekachai Chukeatirote. Chemical compositions, antifungal and antioxidant activities of essential oil and various extracts of Melodorum fruticosum L. flowers. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2010 Oct; 48(10):2754-8. doi: 10.1016/j.fct.2010.07.002. [PMID: 20621150]
  • Kiranmayee Rao, Bhuvaneswari Ch, Lakshmi M Narasu, Archana Giri. Antibacterial activity of Alpinia galanga (L) Willd crude extracts. Applied biochemistry and biotechnology. 2010 Oct; 162(3):871-84. doi: 10.1007/s12010-009-8900-9. [PMID: 20387130]