Aminomalonic acid (BioDeep_00000415949)
Main id: BioDeep_00000004262
PANOMIX_OTCML-2023
代谢物信息卡片
化学式: C3H5NO4 (119.0219)
中文名称: 2-氨基-丙二酸
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C(C(=O)O)(C(=O)O)N
InChI: InChI=1S/C3H5NO4/c4-1(2(5)6)3(7)8/h1H,4H2,(H,5,6)(H,7,8)
描述信息
An amino dicarboxylic acid that is malonic acid in which one of the methylene hydrogens has been replaced by an amino group.
Aminomalonic acid is an amino endogenous metabolite, acts as a strong inhibitor of L-asparagine synthetase from Leukemia 5178Y/AR (Ki= 0.0023 M) and mouse pancreas (Ki= 0.0015 M) in vitro. Aminomalonic acid is a potential biomarker to discriminate between different stages of melanoma metastasis[1][2][3].
同义名列表
2 个代谢物同义名
数据库引用编号
19 个数据库交叉引用编号
- ChEBI: CHEBI:17475
- KEGG: C00872
- PubChem: 100714
- DrugBank: DB02289
- ChEMBL: CHEMBL1232731
- CAS: 1068-84-4
- MoNA: MoNA038292
- MoNA: MoNA037547
- MoNA: MoNA033188
- MoNA: MoNA033187
- MoNA: MoNA033185
- MetaboLights: MTBLC17475
- PubChem: 4129
- PDB-CCD: FGL
- 3DMET: B00195
- NIKKAJI: J556H
- RefMet: Aminomalonic acid
- medchemexpress: HY-112052
- KNApSAcK: 17475
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
- 569774 - 金线莲: -
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Ming-Yuan Xu, Pan Wang, Ying-Jian Sun, Lin Yang, Yi-Jun Wu. Identification of metabolite biomarkers in serum of rats exposed to chlorpyrifos and cadmium.
Scientific reports.
2020 03; 10(1):4999. doi:
10.1038/s41598-020-61982-4. [PMID: 32193438] - Jian-Jun Chen, Shun-Jie Bai, Wen-Wen Li, Chan-Juan Zhou, Peng Zheng, Liang Fang, Hai-Yang Wang, Yi-Yun Liu, Peng Xie. Urinary biomarker panel for diagnosing patients with depression and anxiety disorders.
Translational psychiatry.
2018 09; 8(1):192. doi:
10.1038/s41398-018-0245-0. [PMID: 30232320] - Dorottya Nagy-Szakal, Dinesh K Barupal, Bohyun Lee, Xiaoyu Che, Brent L Williams, Ellie J R Kahn, Joy E Ukaigwe, Lucinda Bateman, Nancy G Klimas, Anthony L Komaroff, Susan Levine, Jose G Montoya, Daniel L Peterson, Bruce Levin, Mady Hornig, Oliver Fiehn, W Ian Lipkin. Insights into myalgic encephalomyelitis/chronic fatigue syndrome phenotypes through comprehensive metabolomics.
Scientific reports.
2018 07; 8(1):10056. doi:
10.1038/s41598-018-28477-9. [PMID: 29968805] - Mahim I Qureshi, Michele Greco, Panagiotis A Vorkas, Elaine Holmes, Alun H Davies. Application of Metabolic Profiling to Abdominal Aortic Aneurysm Research.
Journal of proteome research.
2017 07; 16(7):2325-2332. doi:
10.1021/acs.jproteome.6b00894. [PMID: 28287739] - Gyu Song, Eleonora Napoli, Sarah Wong, Randi Hagerman, Siming Liu, Flora Tassone, Cecilia Giulivi. Altered redox mitochondrial biology in the neurodegenerative disorder fragile X-tremor/ataxia syndrome: use of antioxidants in precision medicine.
Molecular medicine (Cambridge, Mass.).
2016 Oct; 22(?):548-559. doi:
10.2119/molmed.2016.00122. [PMID: 27385396] - Francisco J Rupérez, Priscila Ramos-Mozo, Joanna Teul, Roxana Martinez-Pinna, Antonia Garcia, Myriam Malet-Martino, Emilio Camafeita, Juan Antonio Lopez, Carlos Pastor-Vargas, Jesús Egido, Stéphane Balayssac, Véronique Gilard, Coral Barbas, Jose Luis Martin-Ventura. Metabolomic study of plasma of patients with abdominal aortic aneurysm.
Analytical and bioanalytical chemistry.
2012 Jun; 403(6):1651-60. doi:
10.1007/s00216-012-5982-y. [PMID: 22543712] - Jiayu Tu, Jiye A, Guangji Wang, Hongmei Wen, Aiyun Wang, Liuqing Di, Bei Cao, Linsheng Liu. [Plasma metabonomics study of ischemic cerebral apoplexy rats treated with Tongsaimai pellets].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2012 Apr; 37(7):1028-33. doi:
. [PMID: 22792811] - Jing Wang, Zimin Yuan, Hongwei Kong, Yong Li, Xin Lu, Guowang Xu. [Exploring the mechanism of rhizoma coptidis in treating type II diabetes mellitus based on metabolomics by gas chromatography-mass spectrometry].
Se pu = Chinese journal of chromatography.
2012 Jan; 30(1):8-13. doi:
10.3724/sp.j.1123.2011.08039. [PMID: 22667084] - Joanna Teul, Antonia Garcia, José Tuñón, Jose Luis Martin-Ventura, Nieves Tarín, Lorenzo López Bescós, Jesús Egido, Coral Barbas, Francisco J Rupérez. Targeted and non-targeted metabolic time trajectory in plasma of patients after acute coronary syndrome.
Journal of pharmaceutical and biomedical analysis.
2011 Sep; 56(2):343-51. doi:
10.1016/j.jpba.2011.05.020. [PMID: 21696905] - Matej Orešič, Jing Tang, Tuulikki Seppänen-Laakso, Ismo Mattila, Suoma E Saarni, Samuli I Saarni, Jouko Lönnqvist, Marko Sysi-Aho, Tuulia Hyötyläinen, Jonna Perälä, Jaana Suvisaari. Metabolome in schizophrenia and other psychotic disorders: a general population-based study.
Genome medicine.
2011 Mar; 3(3):19. doi:
10.1186/gm233. [PMID: 21429189] - Nikolaos Psychogios, David D Hau, Jun Peng, An Chi Guo, Rupasri Mandal, Souhaila Bouatra, Igor Sinelnikov, Ramanarayan Krishnamurthy, Roman Eisner, Bijaya Gautam, Nelson Young, Jianguo Xia, Craig Knox, Edison Dong, Paul Huang, Zsuzsanna Hollander, Theresa L Pedersen, Steven R Smith, Fiona Bamforth, Russ Greiner, Bruce McManus, John W Newman, Theodore Goodfriend, David S Wishart. The human serum metabolome.
PloS one.
2011 Feb; 6(2):e16957. doi:
10.1371/journal.pone.0016957. [PMID: 21359215] - Ruyi Xue, Zhenxin Lin, Chunhui Deng, Ling Dong, Taotao Liu, Jiyao Wang, Xizhong Shen. A serum metabolomic investigation on hepatocellular carcinoma patients by chemical derivatization followed by gas chromatography/mass spectrometry.
Rapid communications in mass spectrometry : RCM.
2008 Oct; 22(19):3061-8. doi:
10.1002/rcm.3708. [PMID: 18767022] - You-Ying Mao, Jing-Qing Bai, Jiang-Hua Chen, Zhang-Fei Shou, Qiang He, Jian-Yong Wu, Ying Chen, Yi-Yu Cheng. A pilot study of GC/MS-based serum metabolic profiling of acute rejection in renal transplantation.
Transplant immunology.
2008 Apr; 19(1):74-80. doi:
10.1016/j.trim.2008.01.006. [PMID: 18346641] - H A Milman, R Muth, D A Cooney. Aminomalonic acid and its congeners as potential in vivo inhibitors of L-asparagine synthetase.
Enzyme.
1979; 24(1):36-47. doi:
10.1159/000458626. [PMID: 35346]
