flufenamic acid (BioDeep_00000412945)

   


代谢物信息卡片


flufenamic acid

化学式: C14H10F3NO2 (281.0663596)
中文名称: 氟芬那酸
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC=C(C(=C1)C(=O)O)NC2=CC=CC(=C2)C(F)(F)F
InChI: InChI=1S/C14H10F3NO2/c15-14(16,17)9-4-3-5-10(8-9)18-12-7-2-1-6-11(12)13(19)20/h1-8,18H,(H,19,20)

描述信息

M - Musculo-skeletal system > M01 - Antiinflammatory and antirheumatic products > M01A - Antiinflammatory and antirheumatic products, non-steroids > M01AG - Fenamates
C78272 - Agent Affecting Nervous System > C241 - Analgesic Agent > C2198 - Nonnarcotic Analgesic
C471 - Enzyme Inhibitor > C1323 - Cyclooxygenase Inhibitor
D000893 - Anti-Inflammatory Agents
CONFIDENCE standard compound; INTERNAL_ID 367; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 5428; ORIGINAL_PRECURSOR_SCAN_NO 5423
CONFIDENCE standard compound; INTERNAL_ID 367; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 5418; ORIGINAL_PRECURSOR_SCAN_NO 5416
CONFIDENCE standard compound; INTERNAL_ID 367; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 5457; ORIGINAL_PRECURSOR_SCAN_NO 5455
CONFIDENCE standard compound; INTERNAL_ID 367; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 5442; ORIGINAL_PRECURSOR_SCAN_NO 5441
CONFIDENCE standard compound; INTERNAL_ID 367; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 5524; ORIGINAL_PRECURSOR_SCAN_NO 5519
CONFIDENCE standard compound; INTERNAL_ID 367; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 5447; ORIGINAL_PRECURSOR_SCAN_NO 5445
CONFIDENCE standard compound; INTERNAL_ID 367; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9133; ORIGINAL_PRECURSOR_SCAN_NO 9128
CONFIDENCE standard compound; INTERNAL_ID 367; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9153; ORIGINAL_PRECURSOR_SCAN_NO 9148
CONFIDENCE standard compound; INTERNAL_ID 367; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9175; ORIGINAL_PRECURSOR_SCAN_NO 9171
CONFIDENCE standard compound; INTERNAL_ID 367; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9182; ORIGINAL_PRECURSOR_SCAN_NO 9178
CONFIDENCE standard compound; INTERNAL_ID 367; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9162; ORIGINAL_PRECURSOR_SCAN_NO 9160
CONFIDENCE standard compound; INTERNAL_ID 367; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9196; ORIGINAL_PRECURSOR_SCAN_NO 9192
Flufenamic acid is a non-steroidal anti-inflammatory agent, inhibits cyclooxygenase (COX), activates AMPK, and also modulates ion channels, blocking chloride channels and L-type Ca2+ channels, modulating non-selective cation channels (NSC), activating K+ channels. Flufenamic acid binds to the central pocket of TEAD2 YBD and inhibits both TEAD function and TEAD-YAP-dependent processes, such as cell migration and proliferation.

同义名列表

1 个代谢物同义名

flufenamic acid



数据库引用编号

21 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Dominika Kapuścińska, Magdalena Narajczyk, Ivan Liakh, Bartosz Wielgomas, Anna Aksmann. Nabumetone and flufenamic acid pose a serious risk to aquatic plants: A study with Chlamydomonas reinhardtii as a model organism. Chemosphere. 2024 Feb; 349(?):140853. doi: 10.1016/j.chemosphere.2023.140853. [PMID: 38052310]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Takeshi Yokoyama, Mineyuki Mizuguchi. Transthyretin Amyloidogenesis Inhibitors: From Discovery to Current Developments. Journal of medicinal chemistry. 2020 12; 63(23):14228-14242. doi: 10.1021/acs.jmedchem.0c00934. [PMID: 32914975]
  • Sultan Alshehri, Syed Sarim Imam, Afzal Hussain, Abdul Malik Alyousef, Mohammad Altamimi, Bader Alsulays, Faiyaz Shakeel. Flufenamic Acid-Loaded Self-Nanoemulsifying Drug Delivery System for Oral Delivery: From Formulation Statistical Optimization to Preclinical Anti-Inflammatory Assessment. Journal of oleo science. 2020 Oct; 69(10):1257-1271. doi: 10.5650/jos.ess20070. [PMID: 32908093]
  • Lukáš Smolko, Romana Smolková, Erika Samoľová, Ibrahim Morgan, Mohamad Saoud, Goran N Kaluđerović. Two isostructural Co(II) flufenamato and niflumato complexes with bathocuproine: Analogues with a different cytotoxic activity. Journal of inorganic biochemistry. 2020 09; 210(?):111160. doi: 10.1016/j.jinorgbio.2020.111160. [PMID: 32717439]
  • Filitsa Dimiza, Marialena Lazou, Athanasios N Papadopoulos, Antonios G Hatzidimitriou, George Psomas. Manganese(II) coordination compounds of carboxylate non-steroidal anti-inflammatory drugs. Journal of inorganic biochemistry. 2020 02; 203(?):110906. doi: 10.1016/j.jinorgbio.2019.110906. [PMID: 31707332]
  • Wenchao Lu, Jun Wang, Yong Li, Hongru Tao, Huan Xiong, Fulin Lian, Jing Gao, Hongna Ma, Tian Lu, Dan Zhang, Xiaoqing Ye, Hong Ding, Liyan Yue, Yuanyuan Zhang, Huanyu Tang, Naixia Zhang, Yaxi Yang, Hualiang Jiang, Kaixian Chen, Bing Zhou, Cheng Luo. Discovery and biological evaluation of vinylsulfonamide derivatives as highly potent, covalent TEAD autopalmitoylation inhibitors. European journal of medicinal chemistry. 2019 Dec; 184(?):111767. doi: 10.1016/j.ejmech.2019.111767. [PMID: 31622854]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Satoshi Endo, Namiki Miyagi, Toshiyuki Matsunaga, Akira Ikari. Rabbit dehydrogenase/reductase SDR family member 11 (DHRS11): Its identity with acetohexamide reductase with broad substrate specificity and inhibitor sensitivity, different from human DHRS11. Chemico-biological interactions. 2019 May; 305(?):12-20. doi: 10.1016/j.cbi.2019.03.026. [PMID: 30926317]
  • Nagaraj P Shetti, Deepti S Nayak, Shweta J Malode, Raghava Reddy Kakarla, Shyam S Shukla, Tejraj M Aminabhavi. Sensors based on ruthenium-doped TiO2 nanoparticles loaded into multi-walled carbon nanotubes for the detection of flufenamic acid and mefenamic acid. Analytica chimica acta. 2019 Mar; 1051(?):58-72. doi: 10.1016/j.aca.2018.11.041. [PMID: 30661620]
  • R Smolková, V Zeleňák, L Smolko, D Sabolová, J Kuchár, R Gyepes. Novel Zn(II) complexes with non-steroidal anti-inflammatory ligand, flufenamic acid: Characterization, topoisomerase I inhibition activity, DNA and HSA binding studies. Journal of inorganic biochemistry. 2017 12; 177(?):143-158. doi: 10.1016/j.jinorgbio.2017.09.005. [PMID: 28963956]
  • Sara Drago, Roger Imboden, Philipp Schlatter, Mirabel Buylaert, Stephan Krähenbühl, Juergen Drewe. Pharmacokinetics of Transdermal Etofenamate and Diclofenac in Healthy Volunteers. Basic & clinical pharmacology & toxicology. 2017 Nov; 121(5):423-429. doi: 10.1111/bcpt.12818. [PMID: 28561421]
  • Hayato Iino, Makiko Fujii, Manami Fujino, Shizuka Kohara, Kaname Hashizaki, Hitomi Kira, Naoya Koizumi, Yoshiteru Watanabe, Naoki Utoguchi. Influence of Characteristics of Oily Vehicle on Skin Penetration of Ufenamate. Biological & pharmaceutical bulletin. 2017; 40(2):220-226. doi: 10.1248/bpb.b16-00817. [PMID: 28154263]
  • Alketa Tarushi, Philippos Kastanias, Catherine P Raptopoulou, Vassilis Psycharis, Dimitris P Kessissoglou, Athanasios N Papadopoulos, George Psomas. Zinc complexes of flufenamic acid: Characterization and biological evaluation. Journal of inorganic biochemistry. 2016 10; 163(?):332-345. doi: 10.1016/j.jinorgbio.2016.04.023. [PMID: 27155725]
  • Sofia Tsiliou, Lida-Aikaterini Kefala, Antonios G Hatzidimitriou, Dimitris P Kessissoglou, Franc Perdih, Athanasios N Papadopoulos, Iztok Turel, George Psomas. Cobalt(II) complexes with non-steroidal anti-inflammatory drugs and α-diimines. Journal of inorganic biochemistry. 2016 07; 160(?):125-39. doi: 10.1016/j.jinorgbio.2015.12.015. [PMID: 26775611]
  • Panagiotis Theodosis-Nobelos, Malamati Kourti, Antonios Gavalas, Eleni A Rekka. Amides of non-steroidal anti-inflammatory drugs with thiomorpholine can yield hypolipidemic agents with improved anti-inflammatory activity. Bioorganic & medicinal chemistry letters. 2016 Feb; 26(3):910-913. doi: 10.1016/j.bmcl.2015.12.063. [PMID: 26750253]
  • Lucie Zemanova, Jakub Hofman, Eva Novotna, Kamil Musilek, Tereza Lundova, Jana Havrankova, Anna Hostalkova, Jakub Chlebek, Lucie Cahlikova, Vladimír Wsol. Flavones Inhibit the Activity of AKR1B10, a Promising Therapeutic Target for Cancer Treatment. Journal of natural products. 2015 Nov; 78(11):2666-74. doi: 10.1021/acs.jnatprod.5b00616. [PMID: 26529431]
  • Panagiotis Theodosis-Nobelos, Malamati Kourti, Paraskevi Tziona, Panos N Kourounakis, Eleni A Rekka. Esters of some non-steroidal anti-inflammatory drugs with cinnamyl alcohol are potent lipoxygenase inhibitors with enhanced anti-inflammatory activity. Bioorganic & medicinal chemistry letters. 2015 Nov; 25(22):5028-31. doi: 10.1016/j.bmcl.2015.10.036. [PMID: 26494261]
  • Ulya Badilli, C Tuba Sengel-Turk, Arzu Onay-Besikci, Nilufer Tarimci. Development of etofenamate-loaded semisolid sln dispersions and evaluation of anti-inflammatory activity for topical application. Current drug delivery. 2015; 12(2):200-9. doi: 10.2174/1567201811666140613112721. [PMID: 24925321]
  • Madhumitha Rajagopal, Sheela V Thomas, Paru P Kathpalia, Yu Chen, Alan C Pao. Prostaglandin E2 induces chloride secretion through crosstalk between cAMP and calcium signaling in mouse inner medullary collecting duct cells. American journal of physiology. Cell physiology. 2014 Feb; 306(3):C263-78. doi: 10.1152/ajpcell.00381.2012. [PMID: 24284792]
  • Julia C Schwarz, Elisabeth Pagitsch, Claudia Valenta. Comparison of ATR-FTIR spectra of porcine vaginal and buccal mucosa with ear skin and penetration analysis of drug and vehicle components into pig ear. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2013 Dec; 50(5):595-600. doi: 10.1016/j.ejps.2012.12.020. [PMID: 23277290]
  • Charikleia Tolia, Athanassios N Papadopoulos, Catherine P Raptopoulou, Vassilis Psycharis, Claudio Garino, Luca Salassa, George Psomas. Copper(II) interacting with the non-steroidal antiinflammatory drug flufenamic acid: structure, antioxidant activity and binding to DNA and albumins. Journal of inorganic biochemistry. 2013 Jun; 123(?):53-65. doi: 10.1016/j.jinorgbio.2013.02.009. [PMID: 23528572]
  • Ruiliang Ge, Lei Hu, Yilin Tai, Feng Xue, Lei Yuan, Gongtian Wei, Yi Wang. Flufenamic acid promotes angiogenesis through AMPK activation. International journal of oncology. 2013 Jun; 42(6):1945-50. doi: 10.3892/ijo.2013.1891. [PMID: 23589027]
  • Mohamed-Yassine Amarouch, Ninda Syam, Hugues Abriel. Biochemical, single-channel, whole-cell patch clamp, and pharmacological analyses of endogenous TRPM4 channels in HEK293 cells. Neuroscience letters. 2013 Apr; 541(?):105-10. doi: 10.1016/j.neulet.2013.02.011. [PMID: 23428507]
  • Maria Domínguez-Luis, Ada Herrera-García, Maria Arce-Franco, Estefania Armas-González, Marta Rodríguez-Pardo, Fabian Lorenzo-Díaz, Manuel Feria, Susana Cadenas, Francisco Sánchez-Madrid, Federico Díaz-González. Superoxide anion mediates the L-selectin down-regulation induced by non-steroidal anti-inflammatory drugs in human neutrophils. Biochemical pharmacology. 2013 Jan; 85(2):245-56. doi: 10.1016/j.bcp.2012.10.024. [PMID: 23142710]
  • Julia C Schwarz, Angelika Weixelbaum, Elisabeth Pagitsch, Monika Löw, Guenter P Resch, Claudia Valenta. Nanocarriers for dermal drug delivery: influence of preparation method, carrier type and rheological properties. International journal of pharmaceutics. 2012 Nov; 437(1-2):83-8. doi: 10.1016/j.ijpharm.2012.08.003. [PMID: 22903049]
  • Eunyoung Kim, Byoungki Ahn, Keumhan Noh, Wonku Kang, Hye sun Gwak. Quantitative determination of aceclofenac and its three major metabolites in rat plasma by HPLC-MS/MS. Journal of separation science. 2012 Sep; 35(17):2219-22. doi: 10.1002/jssc.201200367. [PMID: 22807412]
  • Madhumitha Rajagopal, Paru P Kathpalia, Jonathan H Widdicombe, Alan C Pao. Differential effects of extracellular ATP on chloride transport in cortical collecting duct cells. American journal of physiology. Renal physiology. 2012 Aug; 303(4):F483-91. doi: 10.1152/ajprenal.00062.2012. [PMID: 22647633]
  • Julia C Schwarz, Victoria Klang, Magdalena Hoppel, Denise Mahrhauser, Claudia Valenta. Natural microemulsions: formulation design and skin interaction. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 2012 Aug; 81(3):557-62. doi: 10.1016/j.ejpb.2012.04.003. [PMID: 22561183]
  • R Salgado, R Marques, J P Noronha, G Carvalho, A Oehmen, M A M Reis. Assessing the removal of pharmaceuticals and personal care products in a full-scale activated sludge plant. Environmental science and pollution research international. 2012 Jun; 19(5):1818-27. doi: 10.1007/s11356-011-0693-z. [PMID: 22207237]
  • Romain Guinamard, Marc Paulais, Stéphane Lourdel, Jacques Teulon. A calcium-permeable non-selective cation channel in the thick ascending limb apical membrane of the mouse kidney. Biochimica et biophysica acta. 2012 May; 1818(5):1135-41. doi: 10.1016/j.bbamem.2011.12.024. [PMID: 22230350]
  • Sen Wang, Jongseok Lee, Jin Y Ro, Man-Kyo Chung. Warmth suppresses and desensitizes damage-sensing ion channel TRPA1. Molecular pain. 2012 Mar; 8(?):22. doi: 10.1186/1744-8069-8-22. [PMID: 22458587]
  • Shalini Ghosh, Sankar Jana, Nikhil Guchhait. Domain specific association of small fluorescent probe trans-3-(4-monomethylaminophenyl)-acrylonitrile (MMAPA) with bovine serum albumin (BSA) and its dissociation from protein binding sites by Ag nanoparticles: spectroscopic and molecular docking study. The journal of physical chemistry. B. 2012 Jan; 116(3):1155-63. doi: 10.1021/jp2094752. [PMID: 22126460]
  • Iti Som, Kashish Bhatia, Mohd Yasir. Status of surfactants as penetration enhancers in transdermal drug delivery. Journal of pharmacy & bioallied sciences. 2012 Jan; 4(1):2-9. doi: 10.4103/0975-7406.92724. [PMID: 22368393]
  • Jimmy Y C Chow, Christine Estrema, Tiffany Orneles, Xiao Dong, Kim E Barrett, Hui Dong. Calcium-sensing receptor modulates extracellular Ca(2+) entry via TRPC-encoded receptor-operated channels in human aortic smooth muscle cells. American journal of physiology. Cell physiology. 2011 Aug; 301(2):C461-8. doi: 10.1152/ajpcell.00389.2010. [PMID: 21562303]
  • Yonghyun Lee, In Ho Kim, Jeongyun Kim, Jeong-Hyun Yoon, Young Hee Shin, Yunjin Jung, Young Mi Kim. Evaluation of dextran-flufenamic acid ester as a polymeric colon-specific prodrug of flufenamic acid, an anti-inflammatory drug, for chronotherapy. Journal of drug targeting. 2011 Jun; 19(5):336-43. doi: 10.3109/1061186x.2010.499462. [PMID: 20615092]
  • Sungwook Choi, Jeffery W Kelly. A competition assay to identify amyloidogenesis inhibitors by monitoring the fluorescence emitted by the covalent attachment of a stilbene derivative to transthyretin. Bioorganic & medicinal chemistry. 2011 Feb; 19(4):1505-14. doi: 10.1016/j.bmc.2010.12.050. [PMID: 21273081]
  • E Benítez-Rangel, L García, M C Namorado, J L Reyes, A Guerrero-Hernández. Ion channel inhibitors block caspase activation by mechanisms other than restoring intracellular potassium concentration. Cell death & disease. 2011 Jan; 2(?):e113. doi: 10.1038/cddis.2010.93. [PMID: 21368885]
  • Tünde Molnár, László Héja, Zsuzsa Emri, Agnes Simon, Gabriella Nyitrai, Ildikó Pál, Julianna Kardos. Activation of astroglial calcium signaling by endogenous metabolites succinate and gamma-hydroxybutyrate in the nucleus accumbens. Frontiers in neuroenergetics. 2011; 3(?):7. doi: 10.3389/fnene.2011.00007. [PMID: 22180742]
  • Arne Naegel, Michael Heisig, Gabriel Wittum. Computational modeling of the skin barrier. Methods in molecular biology (Clifton, N.J.). 2011; 763(?):1-32. doi: 10.1007/978-1-61779-191-8_1. [PMID: 21874441]
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  • Suzanne Habjan, Robert J Vandenberg. Modulation of glutamate and glycine transporters by niflumic, flufenamic and mefenamic acids. Neurochemical research. 2009 Oct; 34(10):1738-47. doi: 10.1007/s11064-009-9983-y. [PMID: 19444608]
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