Leukotriene C4 (BioDeep_00000410648)
Main id: BioDeep_00000003314
代谢物信息卡片
5S-hydroxy-6R-(S-glutathionyl),7E,9E,11Z,14Z-eicosatetraenoic acid
化学式: C30H47N3O9S (625.3033)
中文名称: 白三烯C4
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C(=O)(NCC(O)=O)[C@@H](NC(=O)CC[C@H](N)C(=O)O)CS[C@@H]([C@@H](O)CCCC(O)=O)/C=C/C=C/C=C\C/C=C\CCCCC
InChI: InChI=1S/C30H47N3O9S/c1-2-3-4-5-6-7-8-9-10-11-12-13-16-25(24(34)15-14-17-27(36)37)43-21-23(29(40)32-20-28(38)39)33-26(35)19-18-22(31)30(41)42/h6-7,9-13,16,22-25,34H,2-5,8,14-15,17-21,31H2,1H3,(H,32,40)(H,33,35)(H,36,37)(H,38,39)(H,41,42)/b7-6-,10-9-,12-11+,16-13+/t22-,23-,24-,25+/m0/s1
描述信息
A leukotriene that is (5S,7E,9E,11Z,14Z)-5-hydroxyicosa-7,9,11,14-tetraenoic acid in which a glutathionyl group is attached at position 6 via a sulfide linkage.
同义名列表
数据库引用编号
25 个数据库交叉引用编号
- ChEBI: CHEBI:16978
- KEGG: C02166
- PubChem: 5280493
- DrugBank: DB08855
- ChEMBL: CHEMBL451509
- LipidMAPS: LMFA03020003
- MeSH: Leukotriene C4
- CAS: 72025-60-6
- CAS: 10-34-4
- MoNA: HMDB0001198_ms_ms_1218221
- MoNA: HMDB0001198_ms_ms_1218220
- MoNA: HMDB0001198_ms_ms_1218215
- MoNA: HMDB0001198_ms_ms_1218216
- MoNA: HMDB0001198_ms_ms_1218223
- MoNA: HMDB0001198_ms_ms_1218219
- MoNA: HMDB0001198_ms_ms_1218217
- MoNA: HMDB0001198_ms_ms_1218222
- MoNA: HMDB0001198_ms_ms_1218218
- MetaboLights: MTBLC16978
- PubChem: 5241
- PDB-CCD: LTX
- 3DMET: B01543
- NIKKAJI: J263.860F
- RefMet: LTC4
- KNApSAcK: 16978
分类词条
相关代谢途径
Reactome(11)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
- 9606 - Homo sapiens: 10.1007/S11306-016-1051-4
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Yuanfeng Shen, Entezar Mehrabi Nasab, Fatemeh Hassanpour, Seyyed Shamsadin Athari. The Effects of Combined Therapeutic Protocol on Allergic Rhinitis Symptoms and Molecular Determinants.
Iranian journal of allergy, asthma, and immunology.
2022 Apr; 21(2):141-150. doi:
10.18502/ijaai.v21i2.9222. [PMID: 35490268] - Ko Fujimori, Saki Uno, Kyohei Kuroda, Chihiro Matsumoto, Toko Maehara. Leukotriene C4 synthase is a novel PPARγ target gene, and leukotriene C4 and D4 activate adipogenesis through cysteinyl LT1 receptors in adipocytes.
Biochimica et biophysica acta. Molecular cell research.
2022 03; 1869(3):119203. doi:
10.1016/j.bbamcr.2021.119203. [PMID: 34968576] - Remo Poto, Isabella Quinti, Gianni Marone, Maurizio Taglialatela, Amato de Paulis, Vincenzo Casolaro, Gilda Varricchi. IgG Autoantibodies Against IgE from Atopic Dermatitis Can Induce the Release of Cytokines and Proinflammatory Mediators from Basophils and Mast Cells.
Frontiers in immunology.
2022; 13(?):880412. doi:
10.3389/fimmu.2022.880412. [PMID: 35711458] - Tatsuro Nakamura. The roles of lipid mediators in type I hypersensitivity.
Journal of pharmacological sciences.
2021 Sep; 147(1):126-131. doi:
10.1016/j.jphs.2021.06.001. [PMID: 34294363] - Joseph H Butterfield, Ravinder J Singh. Divergent PGD2 and leukotriene C4 metabolite excretion following aspirin therapy: Ten patients with systemic mastocytosis.
Prostaglandins & other lipid mediators.
2021 08; 155(?):106563. doi:
10.1016/j.prostaglandins.2021.106563. [PMID: 34029712] - Junmei He, Zhongjie Han, Qurat Ul Ain Farooq, Chunhua Li. Study on functional sites in human multidrug resistance protein 1 (hMRP1).
Proteins.
2021 06; 89(6):659-670. doi:
10.1002/prot.26049. [PMID: 33469960] - Michele Biagioli, Adriana Carino, Silvia Marchianò, Rosalinda Roselli, Cristina Di Giorgio, Martina Bordoni, Chiara Fiorucci, Valentina Sepe, Paolo Conflitti, Vittorio Limongelli, Eleonora Distrutti, Monia Baldoni, Angela Zampella, Stefano Fiorucci. Identification of cysteinyl-leukotriene-receptor 1 antagonists as ligands for the bile acid receptor GPBAR1.
Biochemical pharmacology.
2020 07; 177(?):113987. doi:
10.1016/j.bcp.2020.113987. [PMID: 32330496] - Xiao Tang, David Fuchs, Shuai Tan, Mette Trauelsen, Thue W Schwartz, Craig E Wheelock, Nailin Li, Jesper Z Haeggström. Activation of metabolite receptor GPR91 promotes platelet aggregation and transcellular biosynthesis of leukotriene C4.
Journal of thrombosis and haemostasis : JTH.
2020 04; 18(4):976-984. doi:
10.1111/jth.14734. [PMID: 31930602] - Wei Fang, ChenHui Li, QingQing Wu, ZhaoMin Yao, Jie Wu, Peng Huang, DianLei Wang, ZeGeng Li. Metabolic profiling of chronic obstructive pulmonary disease model rats and the interventional effects of HuaTanJiangQi decoction using UHPLC-Q-TOF/MSE.
Journal of pharmaceutical and biomedical analysis.
2020 Feb; 180(?):113078. doi:
10.1016/j.jpba.2019.113078. [PMID: 31911286] - Beatriz Sastre, María Luz García-García, Cristina Calvo, Inmaculada Casas, José Manuel Rodrigo-Muñoz, José Antonio Cañas, Inés Mora, Victoria Del Pozo. Immune recovery following bronchiolitis is linked to a drop in cytokine and LTC4 levels.
Pediatric research.
2020 02; 87(3):581-587. doi:
10.1038/s41390-019-0606-2. [PMID: 31600771] - Zhiyong Wu, Chunli Chen, Qiaomei Zhang, Jiaxin Bao, Qianqian Fan, Rui Li, Muhammad Ishfaq, Jichang Li. Arachidonic acid metabolism is elevated in Mycoplasma gallisepticum and Escherichia coli co-infection and induces LTC4 in serum as the biomarker for detecting poultry respiratory disease.
Virulence.
2020 01; 11(1):730-738. doi:
10.1080/21505594.2020.1772653. [PMID: 32441188] - Gwenaëlle Conseil, May Arama-Chayoth, Yossi Tsfadia, Susan P C Cole. Structure-guided probing of the leukotriene C4 binding site in human multidrug resistance protein 1 (MRP1; ABCC1).
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2019 10; 33(10):10692-10704. doi:
10.1096/fj.201900140r. [PMID: 31268744] - A A Szczepańska, M Łupicka, A J Korzekwa. Do arachidonic acid metabolites affect apoptosis in bovine endometrial cells with silenced PPAR genes?.
Prostaglandins & other lipid mediators.
2019 08; 143(?):106336. doi:
10.1016/j.prostaglandins.2019.106336. [PMID: 31112752] - Ryota Uchida, Tomonori Egawa, Yoshio Fujita, Kazuyuki Furuta, Hiroaki Taguchi, Satoshi Tanaka, Keigo Nishida. Identification of the minimal region of peptide derived from ADP-ribosylation factor1 (ARF1) that inhibits IgE-mediated mast cell activation.
Molecular immunology.
2019 01; 105(?):32-37. doi:
10.1016/j.molimm.2018.11.002. [PMID: 30472514] - Yoshihide Kanaoka, K Frank Austen. Roles of cysteinyl leukotrienes and their receptors in immune cell-related functions.
Advances in immunology.
2019; 142(?):65-84. doi:
10.1016/bs.ai.2019.04.002. [PMID: 31296303] - Menachem Rubinstein, Efrat Dvash. Leukotrienes and kidney diseases.
Current opinion in nephrology and hypertension.
2018 01; 27(1):42-48. doi:
10.1097/mnh.0000000000000381. [PMID: 29059080] - Natália R T Amorim, Tatiana Luna-Gomes, Marcos Gama-Almeida, Glaucia Souza-Almeida, Claudio Canetti, Bruno L Diaz, Peter F Weller, Patricia Torres Bozza, Clarissa M Maya-Monteiro, Christianne Bandeira-Melo. Leptin Elicits LTC4 Synthesis by Eosinophils Mediated by Sequential Two-Step Autocrine Activation of CCR3 and PGD2 Receptors.
Frontiers in immunology.
2018; 9(?):2139. doi:
10.3389/fimmu.2018.02139. [PMID: 30298073] - Anuradha Rajamanickam, Saravanan Munisankar, Yukthi Bhootra, Chandra Kumar Dolla, Thomas B Nutman, Subash Babu. Elevated Systemic Levels of Eosinophil, Neutrophil, and Mast Cell Granular Proteins in Strongyloides Stercoralis Infection that Diminish following Treatment.
Frontiers in immunology.
2018; 9(?):207. doi:
10.3389/fimmu.2018.00207. [PMID: 29479356] - Kelly G Magalhães, Tatiana Luna-Gomes, Fabio Mesquita-Santos, Rafael Corrêa, Leonardo Santos Assunção, Georgia Correa Atella, Peter F Weller, Christianne Bandeira-Melo, Patricia T Bozza. Schistosomal Lipids Activate Human Eosinophils via Toll-Like Receptor 2 and PGD2 Receptors: 15-LO Role in Cytokine Secretion.
Frontiers in immunology.
2018; 9(?):3161. doi:
10.3389/fimmu.2018.03161. [PMID: 30740113] - Sean J Lund, Alex Portillo, Kellen Cavagnero, Rachel E Baum, Luay H Naji, Jana H Badrani, Amit Mehta, Michael Croft, David H Broide, Taylor A Doherty. Leukotriene C4 Potentiates IL-33-Induced Group 2 Innate Lymphoid Cell Activation and Lung Inflammation.
Journal of immunology (Baltimore, Md. : 1950).
2017 08; 199(3):1096-1104. doi:
10.4049/jimmunol.1601569. [PMID: 28667163] - Meihua Jin, Sungun Kim, Nan Qin, Xi Chen, Ning Ji, Sheng-An Tang, Dexin Kong, Eunkyung Lee, Hongquan Duan. 1,6-O,O-Diacetylbritannilactone suppresses activation of mast cell and airway hyper-responsiveness.
Immunopharmacology and immunotoxicology.
2017 Aug; 39(4):173-179. doi:
10.1080/08923973.2017.1318911. [PMID: 28447503] - Jong-Uk Lee, Hun Soo Chang, Hyeon Ju Lee, Da-Jeong Bae, Ji-Hye Son, Jong-Sook Park, Jae Sung Choi, Hun Gyu Hwang, Choon-Sik Park. Association of interleukin-25 levels with development of aspirin induced respiratory diseases.
Respiratory medicine.
2017 02; 123(?):71-78. doi:
10.1016/j.rmed.2016.11.020. [PMID: 28137499] - T A Mashkova, A B Mal'tsev, A I Nerovny, L S Bakulina. [The role of a leukotriene receptor antagonist in the restoration of the nasal breathing in the patients presenting with polypous rhinosinusitis].
Vestnik otorinolaringologii.
2017 ; 82(5):32-35. doi:
10.17116/otorino201782532-35. [PMID: 29072660] - L A Mys, A Yu Budko, N A Strutynska, V F Sagach. [PYRIDOXAL-5-PHOSPHATE RESTORES HYDROGEN SULFIDE SYNTHES AND REDOX STATE OF HEART AND BLOOD VESSELS TISSUE IN OLD ANIMALS].
Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994).
2017; 63(1):3-9. doi:
10.15407/fz63.01.003. [PMID: 29975822] - Dale R Bergren, Jimmie L Valentine. Anti-anaphylactic action of nordihydroguaiaretic acid in antigen sensitized guinea pigs.
Respiratory physiology & neurobiology.
2016 12; 234(?):26-31. doi:
10.1016/j.resp.2016.09.003. [PMID: 27595978] - Ana Lukic, Jie Ji, Helena Idborg, Bengt Samuelsson, Lena Palmberg, Susanne Gabrielsson, Olof Rådmark. Pulmonary epithelial cancer cells and their exosomes metabolize myeloid cell-derived leukotriene C4 to leukotriene D4.
Journal of lipid research.
2016 09; 57(9):1659-69. doi:
10.1194/jlr.m066910. [PMID: 27436590] - Gwan Ui Hong, Jai Youl Ro, Youin Bae, In-Ho Kwon, Gyeong-Hun Park, Young Hee Choi, Jeong-Hee Choi. Association of TG2 from mast cells and chronic spontaneous urticaria pathogenesis.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.
2016 09; 117(3):290-7. doi:
10.1016/j.anai.2016.06.026. [PMID: 27613463] - Shaoshan Mai, Qin He, Hong Wang, Xinyue Hu, Ying Luo, Yang Yang, Shengnan Kuang, Xiaoyan Tian, Jie Ma, Junqing Yang. 5-lipoxygenase activation is involved in the mechanisms of chronic hepatic injury in a rat model of chronic aluminum overload exposure.
Toxicology and applied pharmacology.
2016 08; 305(?):259-266. doi:
10.1016/j.taap.2016.06.029. [PMID: 27368151] - Sung Phil Kim, Sang Jong Lee, Seok Hyun Nam, Mendel Friedman. Elm Tree (Ulmus parvifolia) Bark Bioprocessed with Mycelia of Shiitake (Lentinus edodes) Mushrooms in Liquid Culture: Composition and Mechanism of Protection against Allergic Asthma in Mice.
Journal of agricultural and food chemistry.
2016 Feb; 64(4):773-84. doi:
10.1021/acs.jafc.5b04972. [PMID: 26807923] - X Li, O Kwon, D Y Kim, Y Taketomi, M Murakami, H W Chang. NecroX-5 suppresses IgE/Ag-stimulated anaphylaxis and mast cell activation by regulating the SHP-1-Syk signaling module.
Allergy.
2016 Feb; 71(2):198-209. doi:
10.1111/all.12786. [PMID: 26456627] - Michaela Neprasova, Dita Maixnerova, Jan Novak, Colin Reily, Bruce A Julian, Jan Boron, Petr Novotny, Miloslav Suchanek, Vladimir Tesar, Petr Kacer. Toward Noninvasive Diagnosis of IgA Nephropathy: A Pilot Urinary Metabolomic and Proteomic Study.
Disease markers.
2016; 2016(?):3650909. doi:
10.1155/2016/3650909. [PMID: 27799660] - Tianwu Guo, Jun Cai, Yanxia Peng, Lifang Zhang, Qiaofen Lan, Yanwen Chen, Huanjin Liao, Tong Xie, Ping Wu, Qingjun Pan. Protective Effect of an Antibody against Specific Extracellular Domain of TLR2 on Agonists-Driven Inflammatory and Allergic Response.
BioMed research international.
2016; 2016(?):9803846. doi:
10.1155/2016/9803846. [PMID: 27213155] - N V Bogdanovskaya, A V Kotsuruba, A V Golubenko. INDUCTION OF OXIDATIVE AND NITROSATIVE STRESS IN BOYS IN ADAPTING TO PHYSICAL STRESS DURING TRAINING AND COMPETITIVE PERIODS.
Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994).
2016 ; 62(2):47-56. doi:
10.15407/fz62.02.047. [PMID: 29537225] - Efrat Dvash, Michal Har-Tal, Sara Barak, Ofir Meir, Menachem Rubinstein. Leukotriene C4 is the major trigger of stress-induced oxidative DNA damage.
Nature communications.
2015 Dec; 6(?):10112. doi:
10.1038/ncomms10112. [PMID: 26656251] - Yvonne Hagenlocher, Kristina Kiessling, Michael Schäffer, Stephan C Bischoff, Axel Lorentz. Cinnamaldehyde is the main mediator of cinnamon extract in mast cell inhibition.
European journal of nutrition.
2015 Dec; 54(8):1297-309. doi:
10.1007/s00394-014-0810-0. [PMID: 25504111] - Lamiaa A Ahmed, Shohda A El-Maraghy, Sherine M Rizk. Role of the KATP channel in the protective effect of nicorandil on cyclophosphamide-induced lung and testicular toxicity in rats.
Scientific reports.
2015 Sep; 5(?):14043. doi:
10.1038/srep14043. [PMID: 26403947] - Young Min Ahn, Gwan Ui Hong, Sang Hoon Kim, Ho Jung Lee, Hey Sung Baek, Myung Nam Kim, Kui Young Park, Jai Youl Ro. Transglutaminase 2 expressed in mast cells recruited into skin or bone marrow induces the development of pediatric mastocytosis.
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology.
2015 Aug; 26(5):438-45. doi:
10.1111/pai.12403. [PMID: 25952500] - Yue Lu, Shuangfan Cai, Hongsheng Tan, Wenwei Fu, Hong Zhang, Hongxi Xu. Inhibitory effect of oblongifolin C on allergic inflammation through the suppression of mast cell activation.
Molecular and cellular biochemistry.
2015 Aug; 406(1-2):263-71. doi:
10.1007/s11010-015-2444-9. [PMID: 25968068] - Valérie Capra, Chiara Carnini, Maria Rosa Accomazzo, Antonio Di Gennaro, Marco Fiumicelli, Emanuele Borroni, Ivan Brivio, Carola Buccellati, Paolo Mangano, Silvia Carnevali, Gianenrico Rovati, Angelo Sala. Autocrine activity of cysteinyl leukotrienes in human vascular endothelial cells: Signaling through the CysLT₂ receptor.
Prostaglandins & other lipid mediators.
2015 Jul; 120(?):115-25. doi:
10.1016/j.prostaglandins.2015.03.007. [PMID: 25839425] - K K Piotrowska-Tomala, M M Bah, K Jankowska, K Lukasik, P Warmowski, A M Galvao, D J Skarzynski. Lipopolysaccharides, cytokines, and nitric oxide affect secretion of prostaglandins and leukotrienes by bovine mammary gland during experimentally induced mastitis in vivo and in vitro.
Domestic animal endocrinology.
2015 Jul; 52(?):90-9. doi:
10.1016/j.domaniend.2015.03.001. [PMID: 25935895] - Tao Liu, Denise Garofalo, Chunli Feng, Juying Lai, Howard Katz, Tanya M Laidlaw, Joshua A Boyce. Platelet-driven leukotriene C4-mediated airway inflammation in mice is aspirin-sensitive and depends on T prostanoid receptors.
Journal of immunology (Baltimore, Md. : 1950).
2015 Jun; 194(11):5061-8. doi:
10.4049/jimmunol.1402959. [PMID: 25904552] - Peimin Dai, Lijun Zhu, Xiaoshan Yang, Min Zhao, Jian Shi, Ying Wang, Linlin Lu, Zhongqiu Liu. Multidrug resistance-associated protein 2 is involved in the efflux of Aconitum alkaloids determined by MRP2-MDCKII cells.
Life sciences.
2015 Apr; 127(?):66-72. doi:
10.1016/j.lfs.2015.02.011. [PMID: 25744397] - Jia Xiao, Emily C Liong, Hai Huang, Wing On Tse, Kam Shing Lau, Jingfei Pan, Amin A Nanji, Man Lung Fung, Feiyue Xing, George L Tipoe. Cyclooxygenase-1 serves a vital hepato-protective function in chemically induced acute liver injury.
Toxicological sciences : an official journal of the Society of Toxicology.
2015 Feb; 143(2):430-40. doi:
10.1093/toxsci/kfu244. [PMID: 25432964] - Laura R R Ribeiro, Flávio V Loures, Eliseu F de Araújo, Cláudia Feriotti, Tânia A Costa, Carlos Henrique Serezani, Sonia Jancar, Vera L G Calich. Lipoxin Inhibits Fungal Uptake by Macrophages and Reduces the Severity of Acute Pulmonary Infection Caused by Paracoccidioides brasiliensis.
Mediators of inflammation.
2015; 2015(?):852574. doi:
10.1155/2015/852574. [PMID: 26635449] - A V Kotsuruba, R R Sharipov, B S Kopyak, V F Sagach. [BRAIN FOCAL ISCHEMIA-REPERFUSION CAUSES A DECREASED RESISTANCE OF ERYTHROCYTES FROM VENOUS BLOOD TO ACID HEMOLYSIS, WHICH IS PREVENTED BY ECDYSTERONE].
Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994).
2015; 61(5):3-10. doi:
10.15407/fz61.05.003. [PMID: 26845838] - Feng Tang, Feilong Chen, Xiao Ling, Yao Huang, Xiaomei Zheng, Qingfa Tang, Xiaomei Tan. Inhibitory effect of methyleugenol on IgE-mediated allergic inflammation in RBL-2H3 cells.
Mediators of inflammation.
2015; 2015(?):463530. doi:
10.1155/2015/463530. [PMID: 25960618] - Madeleine Rådinger, Bettina M Jensen, Emily Swindle, Alasdair M Gilfillan. Assay of mast cell mediators.
Methods in molecular biology (Clifton, N.J.).
2015; 1220(?):307-23. doi:
10.1007/978-1-4939-1568-2_19. [PMID: 25388259] - Ijaz Ahmad, Abdul Waheed, Nafisa Batool Tahir, Aisha Kalsoom Rais. Anti-inflammatory constituents from Perovskia atriplicifolia.
Pharmaceutical biology.
2015; 53(11):1628-31. doi:
10.3109/13880209.2014.997250. [PMID: 25856716] - Anna N Bukiya, Jacob McMillan, Jianxi Liu, Bangalore Shivakumar, Abby L Parrill, Alex M Dopico. Activation of calcium- and voltage-gated potassium channels of large conductance by leukotriene B4.
The Journal of biological chemistry.
2014 Dec; 289(51):35314-25. doi:
10.1074/jbc.m114.577825. [PMID: 25371198] - Andrea Dichlberger, Stefanie Schlager, Katariina Maaninka, Wolfgang J Schneider, Petri T Kovanen. Adipose triglyceride lipase regulates eicosanoid production in activated human mast cells.
Journal of lipid research.
2014 Dec; 55(12):2471-8. doi:
10.1194/jlr.m048553. [PMID: 25114172] - Susan P C Cole. Multidrug resistance protein 1 (MRP1, ABCC1), a 'multitasking' ATP-binding cassette (ABC) transporter.
The Journal of biological chemistry.
2014 Nov; 289(45):30880-8. doi:
10.1074/jbc.r114.609248. [PMID: 25281745] - Barbara Jana, Joanna Czarzasta, Jerzy Jaroszewski. Synthesis of leukotrienes in porcine uteri with endometritis induced by infection with Escherichia coli.
Reproduction, fertility, and development.
2014 Aug; 26(7):1007-16. doi:
10.1071/rd13191. [PMID: 23924575] - Sheng-An Tang, Hong Zhu, Nan Qin, Jing-Ya Zhou, Eunkyung Lee, De-Xin Kong, Mei-Hua Jin, Hong-Quan Duan. Anti-inflammatory terpenes from flowers of Inula japonica.
Planta medica.
2014 May; 80(7):583-9. doi:
10.1055/s-0034-1368353. [PMID: 24710901] - Xuexin Zhang, Wei Zhang, José C González-Cobos, Isaac Jardin, Christoph Romanin, Khalid Matrougui, Mohamed Trebak. Complex role of STIM1 in the activation of store-independent Orai1/3 channels.
The Journal of general physiology.
2014 Mar; 143(3):345-59. doi:
10.1085/jgp.201311084. [PMID: 24567509] - Yong-Bin Gao, Chun-Lei Wang, Ju-You Wu, Hong-Sheng Zhou, Xue-Ting Jiang, Jun Wu, Shao-Ling Zhang. Low temperature inhibits pollen tube growth by disruption of both tip-localized reactive oxygen species and endocytosis in Pyrus bretschneideri Rehd.
Plant physiology and biochemistry : PPB.
2014 Jan; 74(?):255-62. doi:
10.1016/j.plaphy.2013.11.018. [PMID: 24321875] - Hannah E Cummings, Tao Liu, Chunli Feng, Tanya M Laidlaw, Pamela B Conley, Yoshihide Kanaoka, Joshua A Boyce. Cutting edge: Leukotriene C4 activates mouse platelets in plasma exclusively through the type 2 cysteinyl leukotriene receptor.
Journal of immunology (Baltimore, Md. : 1950).
2013 Dec; 191(12):5807-10. doi:
10.4049/jimmunol.1302187. [PMID: 24244016] - Kamila Syslová, Adéla Böhmová, Elvan Demirbağ, Kateřina Šimková, Marek Kuzma, Daniela Pelclová, Vratislav Sedlák, Petr Čáp, Pavel Martásek, Petr Kačer. Immunomagnetic molecular probe with UHPLC-MS/MS: a promising way for reliable bronchial asthma diagnostics based on quantification of cysteinyl leukotrienes.
Journal of pharmaceutical and biomedical analysis.
2013 Jul; 81-82(?):108-17. doi:
10.1016/j.jpba.2013.03.026. [PMID: 23644905] - Xiao Dong, Xiaojin Ye, Nana Song, Jing Zhao, Beibing Di, Fen Peng, Chaoshu Tang, Wenhui Ding. Urotensin II promotes the production of LTC4 in rat aortic adventitial fibroblasts through NF-κB-5-LO pathway by p38 MAPK and ERK activations.
Heart and vessels.
2013 Jul; 28(4):514-23. doi:
10.1007/s00380-012-0291-0. [PMID: 23053343] - Hyo Won Jung, Jin Ki Jung, Yong-Ki Park. Comparison of the efficacy of KOB03, ketotifen, and montelukast in an experimental mouse model of allergic rhinitis.
International immunopharmacology.
2013 Jun; 16(2):254-60. doi:
10.1016/j.intimp.2013.04.011. [PMID: 23643816] - Yoshihiko Ikeno, Hirokuni Hirata, Masafumi Arima, Yumeko Hayashi, Mineaki Watanabe, Naruo Yoshida, Kazuyuki Chibana, Kumiya Sugiyama, Yasutsugu Fukushima, Ikuo Akutsu, Takeshi Fukuda. Wasp venom allergy: effect of anti-IgE antibody on wasp venom anaphylaxis in a mouse model.
Asian Pacific journal of allergy and immunology.
2013 Jun; 31(2):115-24. doi:
10.12932/ap0239.31.2.2013. [PMID: 23859410] - Minghui Zhou, Dongshu Du, Keqing Zhao, Chunquan Zheng. In vivo intranasal anti-CD23 treatment inhibits allergic responses in a murine model of allergic rhinitis.
Journal of molecular histology.
2013 Jun; 44(3):327-38. doi:
10.1007/s10735-013-9484-9. [PMID: 23377922] - Joon-Ho Keum, Ok-Hwa Kang, Sung-Bae Kim, Su-Hyun Mun, Yun-Soo Seo, Ma-Ryong Kim, Jung-Rae Rho, Young-Seob Lee, Chung-Berm Park, Young-Guk Kim, Yong-Il Kim, Sin-Hee Han, Dong-Yeul Kwon. The anti-inflammatory effect of Cheongseoikki-tang ethanol extract on allergic reactions mediated by bone marrow-derived mast cells.
Chinese journal of integrative medicine.
2013 May; 19(5):380-6. doi:
10.1007/s11655-013-1448-0. [PMID: 23494327] - Yoshihide Kanaoka, Akiko Maekawa, K Frank Austen. Identification of GPR99 protein as a potential third cysteinyl leukotriene receptor with a preference for leukotriene E4 ligand.
The Journal of biological chemistry.
2013 Apr; 288(16):10967-72. doi:
10.1074/jbc.c113.453704. [PMID: 23504326] - Jae-Myung Yoo, Eun Seok Park, Mee Ree Kim, Dai-Eun Sok. Inhibitory effect of N-Acyl dopamines on IgE-mediated allergic response in RBL-2H3 cells.
Lipids.
2013 Apr; 48(4):383-93. doi:
10.1007/s11745-013-3758-6. [PMID: 23377981] - Shabbir Ahmad, Damian Niegowski, Anders Wetterholm, Jesper Z Haeggström, Ralf Morgenstern, Agnes Rinaldo-Matthis. Catalytic characterization of human microsomal glutathione S-transferase 2: identification of rate-limiting steps.
Biochemistry.
2013 Mar; 52(10):1755-64. doi:
10.1021/bi3014104. [PMID: 23409838] - Sandra Lechowski, Katharina Feilhauer, Ludger Staib, Moïse Coëffier, Stephan C Bischoff, Axel Lorentz. Combined arginine and glutamine decrease release of de novo synthesized leukotrienes and expression of proinflammatory cytokines in activated human intestinal mast cells.
European journal of nutrition.
2013 Mar; 52(2):505-12. doi:
10.1007/s00394-012-0353-1. [PMID: 22527286] - Peter Meszaros, Karin Klappe, Annie van Dam, Pavlina T Ivanova, Stephen B Milne, David S Myers, H Alex Brown, Hjalmar Permentier, Dick Hoekstra, Jan W Kok. Long term myriocin treatment increases MRP1 transport activity.
The international journal of biochemistry & cell biology.
2013 Feb; 45(2):326-34. doi:
10.1016/j.biocel.2012.11.009. [PMID: 23178537] - Anna James, Kameran Daham, Linda Backman, Asa Brunnström, Tove Tingvall, Maria Kumlin, Charlotte Edenius, Sven-Erik Dahlén, Barbro Dahlén, Hans-Erik Claesson. The influence of aspirin on release of eoxin C4, leukotriene C4 and 15-HETE, in eosinophilic granulocytes isolated from patients with asthma.
International archives of allergy and immunology.
2013; 162(2):135-42. doi:
10.1159/000351422. [PMID: 23921438] - Gui-Hua Quan, Hee-Sung Chae, Hyuk Hwan Song, Kyoung-Seop Ahn, Hyeong-Kyu Lee, Young-Ho Kim, Sei-Ryang Oh, Young-Won Chin. Anti-allergic flavones from Arthraxon hispidus.
Chemical & pharmaceutical bulletin.
2013; 61(9):920-6. doi:
10.1248/cpb.c13-00239. [PMID: 23995356] - Wei Liu, Qian Feng, Ye Li, Ling Ye, Ming Hu, Zhongqiu Liu. Coupling of UDP-glucuronosyltransferases and multidrug resistance-associated proteins is responsible for the intestinal disposition and poor bioavailability of emodin.
Toxicology and applied pharmacology.
2012 Dec; 265(3):316-24. doi:
10.1016/j.taap.2012.08.032. [PMID: 22982073] - Fenfang Hong, Shulong Yang. Ischemic preconditioning decreased leukotriene C4 formation by depressing leukotriene C4 synthase expression and activity during hepatic I/R injury in rats.
The Journal of surgical research.
2012 Dec; 178(2):1015-21. doi:
10.1016/j.jss.2012.07.061. [PMID: 22921920] - Yue Lu, Ying Li, Chang-Seob Seo, Makoto Murakami, Jong-Keun Son, Hyeun Wook Chang. Saucerneol D inhibits eicosanoid generation and degranulation through suppression of Syk kinase in mast cells.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2012 Dec; 50(12):4382-8. doi:
10.1016/j.fct.2012.08.053. [PMID: 22982805] - Young Sun Han, Myung-Suk Kim, Jae-Kwan Hwang. Macelignan inhibits histamine release and inflammatory mediator production in activated rat basophilic leukemia mast cells.
Inflammation.
2012 Oct; 35(5):1723-31. doi:
10.1007/s10753-012-9490-1. [PMID: 22729280] - Lei Qin, Shui-Pang Tam, Roger G Deeley. Effect of multiple cysteine substitutions on the functionality of human multidrug resistance protein 1 expressed in human embryonic kidney 293 cells: identification of residues essential for function.
Drug metabolism and disposition: the biological fate of chemicals.
2012 Jul; 40(7):1403-13. doi:
10.1124/dmd.112.044867. [PMID: 22511347] - Heidi Kidron, Gloria Wissel, Nenad Manevski, Marika Häkli, Raimo A Ketola, Moshe Finel, Marjo Yliperttula, Henri Xhaard, Arto Urtti. Impact of probe compound in MRP2 vesicular transport assays.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2012 May; 46(1-2):100-5. doi:
10.1016/j.ejps.2012.02.016. [PMID: 22406294] - Surtaj H Iram, Susan P C Cole. Mutation of Glu521 or Glu535 in cytoplasmic loop 5 causes differential misfolding in multiple domains of multidrug and organic anion transporter MRP1 (ABCC1).
The Journal of biological chemistry.
2012 Mar; 287(10):7543-55. doi:
10.1074/jbc.m111.310409. [PMID: 22232552] - Ye Jin, Hyun Ok Yang, Jong Keun Son, Hyeun Wook Chang. Pinusolide isolated from Biota orientalis inhibits 5-lipoxygenase dependent leukotriene C4 generation by blocking c-Jun N-terminal kinase pathway in mast cells.
Biological & pharmaceutical bulletin.
2012; 35(8):1374-8. doi:
10.1248/bpb.b12-00271. [PMID: 22863941] - Daniela Pelclová, Zdenka Fenclová, Stepánka Vlcková, Jindriška Lebedová, Kamila Syslová, Ondrej Pecha, Jaromír Belácek, Tomáš Navrátil, Marek Kuzma, Petr Kacer. Leukotrienes B4, C4, D4 and E4 in the exhaled breath condensate (EBC), blood and urine in patients with pneumoconiosis.
Industrial health.
2012; 50(4):299-306. doi:
10.2486/indhealth.ms1274. [PMID: 22785421] - Megumi Furukawa, Mitsuko Makino, Emika Ohkoshi, Taketo Uchiyama, Yasuo Fujimoto. Terpenoids and phenethyl glucosides from Hyssopus cuspidatus (Labiatae).
Phytochemistry.
2011 Dec; 72(17):2244-52. doi:
10.1016/j.phytochem.2011.07.008. [PMID: 21893325] - Khozirah Shaari, Velan Suppaiah, Lam Kok Wai, Johnson Stanslas, Bimo Ario Tejo, Daud Ahmad Israf, Faridah Abas, Intan Safinar Ismail, Nor Hasifi Shuaib, Seema Zareen, Nordin Hj Lajis. Bioassay-guided identification of an anti-inflammatory prenylated acylphloroglucinol from Melicope ptelefolia and molecular insights into its interaction with 5-lipoxygenase.
Bioorganic & medicinal chemistry.
2011 Nov; 19(21):6340-7. doi:
10.1016/j.bmc.2011.09.001. [PMID: 21958738] - Meihua Jin, Yue Lu, Ju Hye Yang, Tae Hyung Jo, Young In Park, Chong-Kil Lee, Sang-Jo Park, Kun Ho Son, Hyeun Wook Chang. Anti-inflammatory activity of 6-hydroxy-2,7-dimethoxy-1,4-henanthraquinone from tuberous roots of yam (Dioscorea batatas) through inhibition of prostaglandin D₂ and leukotriene C₄ production in mouse bone marrow-derived mast cells.
Archives of pharmacal research.
2011 Sep; 34(9):1495-501. doi:
10.1007/s12272-011-0911-8. [PMID: 21975811] - H Hirata, M Arima, Y Fukushima, K Honda, K Sugiyama, T Tokuhisa, T Fukuda. Over-expression of the LTC4 synthase gene in mice reproduces human aspirin-induced asthma.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.
2011 Aug; 41(8):1133-42. doi:
10.1111/j.1365-2222.2011.03720.x. [PMID: 21429049] - Vandana Megaraj, Tianyong Zhao, Christian M Paumi, Phillip M Gerk, Richard B Kim, Mary Vore. Functional analysis of nonsynonymous single nucleotide polymorphisms of multidrug resistance-associated protein 2 (ABCC2).
Pharmacogenetics and genomics.
2011 Aug; 21(8):506-15. doi:
10.1097/fpc.0b013e328348c786. [PMID: 21691255] - Fadhil G Al-Amran, Najah R Hadi, Ali M Hashim. Leukotriene biosynthesis inhibition ameliorates acute lung injury following hemorrhagic shock in rats.
Journal of cardiothoracic surgery.
2011 Jun; 6(?):81. doi:
10.1186/1749-8090-6-81. [PMID: 21649921] - You-Chang Oh, Ok-Hwa Kang, Jang-Gi Choi, Obiang-Obounou Brice, Young-Seob Lee, Joon-Ho Keum, Sung-Bae Kim, Dong-Won Shin, Jinyeul Ma, Gi-Hoon Jeong, Dong-Yeul Kwon. Anti-allergic effects of sinomenine by inhibition of prostaglandin D₂ and leukotriene C₄ in mouse bone marrow-derived mast cells.
Immunopharmacology and immunotoxicology.
2011 Jun; 33(2):266-70. doi:
10.3109/08923973.2010.499914. [PMID: 21080779] - Jiao-Li Wang, Zhen-Yi Ren, Jun-Bo Xia, Sheng Huang, Ming-Hao Qi, Li-Min Wang, Jian Ye. [The mechanism of airway inflammation in eosinophilic bronchitis and cough variant asthma].
Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases.
2011 Jun; 34(6):433-7. doi:
. [PMID: 21781515] - Nguyen Dang Hung, Mee Ree Kim, Dai-Eun Sok. Oral administration of 2-docosahexaenoyl lysophosphatidylcholine displayed anti-inflammatory effects on zymosan A-induced peritonitis.
Inflammation.
2011 Jun; 34(3):147-60. doi:
10.1007/s10753-010-9218-z. [PMID: 20490641] - Adriana Vieira-de-Abreu, Andrea S Calheiros, Fabio P Mesquita-Santos, Elisabeth S Magalhães, Diego Mourão-Sá, Hugo C Castro-Faria-Neto, Marcelo T Bozza, Christianne Bandeira-Melo, Patricia T Bozza. Cross-talk between macrophage migration inhibitory factor and eotaxin in allergic eosinophil activation forms leukotriene C₄-synthesizing lipid bodies.
American journal of respiratory cell and molecular biology.
2011 Apr; 44(4):509-16. doi:
10.1165/rcmb.2010-0004oc. [PMID: 20539011] - F P Mesquita-Santos, I Bakker-Abreu, T Luna-Gomes, P T Bozza, B L Diaz, C Bandeira-Melo. Co-operative signalling through DP(1) and DP(2) prostanoid receptors is required to enhance leukotriene C(4) synthesis induced by prostaglandin D(2) in eosinophils.
British journal of pharmacology.
2011 Apr; 162(8):1674-85. doi:
10.1111/j.1476-5381.2010.01086.x. [PMID: 20973774] - Graham A Mackay, Alastair G Stewart. R2D(2) for C(4)Eo: an 'alliance' of PGD(2) receptors is required for LTC(4) production by human eosinophils.
British journal of pharmacology.
2011 Apr; 162(8):1671-3. doi:
10.1111/j.1476-5381.2011.01236.x. [PMID: 21426314] - Surtaj H Iram, Susan P C Cole. Expression and function of human MRP1 (ABCC1) is dependent on amino acids in cytoplasmic loop 5 and its interface with nucleotide binding domain 2.
The Journal of biological chemistry.
2011 Mar; 286(9):7202-13. doi:
10.1074/jbc.m110.166959. [PMID: 21177244] - Nguyen Dang Hung, Mee Ree Kim, Dai-Eun Sok. Mechanisms for anti-inflammatory effects of 1-[15(S)-hydroxyeicosapentaenoyl] lysophosphatidylcholine, administered intraperitoneally, in zymosan A-induced peritonitis.
British journal of pharmacology.
2011 Mar; 162(5):1119-35. doi:
10.1111/j.1476-5381.2010.01117.x. [PMID: 21091644] - Christy C Bridges, Lucy Joshee, Rudolfs K Zalups. MRP2 and the handling of mercuric ions in rats exposed acutely to inorganic and organic species of mercury.
Toxicology and applied pharmacology.
2011 Feb; 251(1):50-8. doi:
10.1016/j.taap.2010.11.015. [PMID: 21134393] - Ariane Brochu-Bourque, Steeve Véronneau, Marek Rola-Pleszczynski, Jana Stankova. Differential signaling defects associated with the M201V polymorphism in the cysteinyl leukotriene type 2 receptor.
The Journal of pharmacology and experimental therapeutics.
2011 Feb; 336(2):431-9. doi:
10.1124/jpet.110.172411. [PMID: 20966037] - Dong Yan, Rino Stocco, Nicole Sawyer, Michael E Nesheim, Mark Abramovitz, Colin D Funk. Differential signaling of cysteinyl leukotrienes and a novel cysteinyl leukotriene receptor 2 (CysLT₂) agonist, N-methyl-leukotriene C₄, in calcium reporter and β arrestin assays.
Molecular pharmacology.
2011 Feb; 79(2):270-8. doi:
10.1124/mol.110.069054. [PMID: 21078884] - Jonathon L Stickford, Timothy D Mickleborough, Alyce D Fly, Joel M Stager. Conjugated linoleic acid's lack of attenuation of hyperpnea-induced bronchoconstriction in asthmatic individuals in the short term.
International journal of sport nutrition and exercise metabolism.
2011 Feb; 21(1):40-7. doi:
10.1123/ijsnem.21.1.40. [PMID: 21411834] - Su Jeong Kim, Yue Lu, Okyun Kwon, Kyoung Hwangbo, Chang-Seob Seo, Seung Ho Lee, Cheorl-Ho Kim, Young-Chae Chang, Jong Keun Son, Hyeun Wook Chang. Manassantin A isolated from Saururus chinensis inhibits 5-lipoxygenase-dependent leukotriene C4 generation by blocking mitogen-activated protein kinase activation in mast cells.
Biological & pharmaceutical bulletin.
2011; 34(11):1769-72. doi:
10.1248/bpb.34.1769. [PMID: 22040894] - Zhejiu Quan, Youn Ju Lee, Ju Hye Yang, Yue Lu, Ying Li, Yeun-Kyung Lee, Meihua Jin, Jong-Yeon Kim, Joon Hyuk Choi, Jong Keun Son, Hyeun Wook Chang. Ethanol extracts of Saururus chinensis suppress ovalbumin-sensitization airway inflammation.
Journal of ethnopharmacology.
2010 Oct; 132(1):143-9. doi:
10.1016/j.jep.2010.08.002. [PMID: 20699114] - Masamichi Okubo, Hiroki Yamanaka, Kimiko Kobayashi, Tetsuo Fukuoka, Yi Dai, Koichi Noguchi. Expression of leukotriene receptors in the rat dorsal root ganglion and the effects on pain behaviors.
Molecular pain.
2010 Sep; 6(?):57. doi:
10.1186/1744-8069-6-57. [PMID: 20846451]
