ethylmorphine (BioDeep_00000408998)

Main id: BioDeep_00000002307

 

natural product


代谢物信息卡片


ethylmorphine

化学式: C19H23NO3 (313.1678)
中文名称: 甲基氯化镁
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCOc(c5)c(O4)c(c(c5)1)C(C2)(C34)C([H])(C=CC(O)3)C(N(C)C2)C1
InChI: InChI=1S/C19H23NO3/c1-3-22-15-7-4-11-10-13-12-5-6-14(21)18-19(12,8-9-20(13)2)16(11)17(15)23-18/h4-7,12-14,18,21H,3,8-10H2,1-2H3/t12-,13+,14-,18-,19-/m0/s1

描述信息

R - Respiratory system > R05 - Cough and cold preparations > R05D - Cough suppressants, excl. combinations with expectorants > R05DA - Opium alkaloids and derivatives
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D009294 - Narcotics
D002492 - Central Nervous System Depressants > D009294 - Narcotics > D053610 - Opiate Alkaloids
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
C78272 - Agent Affecting Nervous System > C67413 - Opioid Receptor Agonist
D019141 - Respiratory System Agents > D000996 - Antitussive Agents
D002491 - Central Nervous System Agents > D000700 - Analgesics
S - Sensory organs > S01 - Ophthalmologicals

同义名列表

2 个代谢物同义名

ethylmorphine; Ethylmorphine



数据库引用编号

18 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

12 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 10 AHRR, ALB, AXIN2, CAT, CYP2B6, CYP2C19, CYP2D6, CYP3A4, HPGDS, POMC
Peripheral membrane protein 3 CYP21A2, CYP2B6, HSD17B6
Endoplasmic reticulum membrane 8 CYP19A1, CYP1A2, CYP21A2, CYP2B6, CYP2C19, CYP2D6, CYP3A4, HSP90B1
Nucleus 4 AHRR, ALB, AXIN2, HSP90B1
cytosol 8 AHRR, ALB, AXIN2, CAT, GPT, GSR, HPGDS, HSP90B1
centrosome 2 ALB, AXIN2
nucleoplasm 2 AHRR, HPGDS
Cell membrane 1 OPRD1
Early endosome membrane 1 HSD17B6
Multi-pass membrane protein 3 CYP19A1, OPRD1, SLC45A2
Golgi apparatus 1 ALB
Golgi membrane 1 INS
presynaptic membrane 1 OPRD1
smooth endoplasmic reticulum 1 HSP90B1
plasma membrane 3 AXIN2, CYP2C19, OPRD1
synaptic vesicle membrane 1 OPRD1
Membrane 8 CAT, CYP19A1, CYP21A2, CYP2D6, CYP3A4, HSP90B1, OPRD1, SLC45A2
extracellular exosome 5 ALB, CAT, GPT, GSR, HSP90B1
Lumenal side 1 HSD17B6
endoplasmic reticulum 5 ALB, CYP19A1, CYP2D6, HSD17B6, HSP90B1
extracellular space 3 ALB, INS, POMC
perinuclear region of cytoplasm 1 HSP90B1
mitochondrion 3 CAT, CYP2D6, GSR
protein-containing complex 3 ALB, CAT, HSP90B1
intracellular membrane-bounded organelle 8 CAT, CYP1A2, CYP2B6, CYP2C19, CYP2D6, CYP3A4, HPGDS, HSD17B6
Microsome membrane 7 CYP19A1, CYP1A2, CYP21A2, CYP2B6, CYP2D6, CYP3A4, HSD17B6
Secreted 3 ALB, INS, POMC
extracellular region 5 ALB, CAT, HSP90B1, INS, POMC
Single-pass membrane protein 2 CYP21A2, CYP2D6
mitochondrial matrix 2 CAT, GSR
anchoring junction 1 ALB
external side of plasma membrane 1 GSR
beta-catenin destruction complex 1 AXIN2
Melanosome membrane 1 SLC45A2
midbody 1 HSP90B1
focal adhesion 2 CAT, HSP90B1
Peroxisome 1 CAT
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
collagen-containing extracellular matrix 1 HSP90B1
secretory granule 1 POMC
neuron projection 1 OPRD1
ciliary basal body 1 ALB
chromatin 1 AHRR
centriole 1 ALB
spindle pole 1 ALB
blood microparticle 1 ALB
endosome lumen 1 INS
aryl hydrocarbon receptor complex 1 AHRR
Melanosome 1 HSP90B1
sperm plasma membrane 1 HSP90B1
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 3 CAT, INS, POMC
Golgi lumen 1 INS
endoplasmic reticulum lumen 3 ALB, HSP90B1, INS
platelet alpha granule lumen 1 ALB
axon terminus 1 OPRD1
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
postsynaptic density membrane 1 OPRD1
neuronal dense core vesicle 1 OPRD1
Sarcoplasmic reticulum lumen 1 HSP90B1
dendrite membrane 1 OPRD1
endocytic vesicle lumen 1 HSP90B1
catalase complex 1 CAT
endoplasmic reticulum chaperone complex 1 HSP90B1
spine apparatus 1 OPRD1
ciliary transition fiber 1 ALB


文献列表

  • Aliaa Nabil ElMeshad, Khaled M Abdel-Haleem, Nabaweya A Abdel Gawad, Mohamed Ahmed El-Nabarawi, Nermin M Sheta. Core in Cup Ethylmorphine Hydrochloride Tablet for Dual Fast and Sustained Pain Relief: Formulation, Characterization, and Pharmacokinetic Study. AAPS PharmSciTech. 2020 Aug; 21(7):244. doi: 10.1208/s12249-020-01759-0. [PMID: 32856114]
  • Carla Alexandra Gouveia, Ana Oliveira, Sandra Pinho, Carlos Vasconcelos, Félix Carvalho, Roxana Falcão Moreira, Ricardo Jorge Dinis-Oliveira. Simultaneous quantification of morphine and cocaine in hair samples from drug addicts by GC-EI/MS. Biomedical chromatography : BMC. 2012 Aug; 26(8):1041-7. doi: 10.1002/bmc.2775. [PMID: 22753238]
  • Rumyana Simeonova, Vessela Vitcheva, Mitka Mitcheva. Effect of cytisine on some brain and hepatic biochemical parameters in spontaneously hypertensive rats. Interdisciplinary toxicology. 2010 Mar; 3(1):21-5. doi: 10.2478/v10102-010-0004-4. [PMID: 21217867]
  • Henrik Lövborg, Ingela Jacobsson, Staffan Hägg. [The effect of warfarin was potentiated by an antitussive. Cocillana-Etyfin increased the PK(INR) value]. Lakartidningen. 2009 Nov; 106(45):2968-9. doi: ". [PMID: 19998819]
  • M Gergov, P Nokua, E Vuori, I Ojanperä. Simultaneous screening and quantification of 25 opioid drugs in post-mortem blood and urine by liquid chromatography-tandem mass spectrometry. Forensic science international. 2009 Apr; 186(1-3):36-43. doi: 10.1016/j.forsciint.2009.01.013. [PMID: 19232849]
  • Thomas Berg, Elsa Lundanes, Asbjørg S Christophersen, Dag Helge Strand. Determination of opiates and cocaine in urine by high pH mobile phase reversed phase UPLC-MS/MS. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2009 Feb; 877(4):421-32. doi: 10.1016/j.jchromb.2008.12.052. [PMID: 19144579]
  • Veronica Santos, Karin Jannet Vera López, Luciana Moraes Santos, Mauricio Yonamine, Maria José Carvalho Carmona, Silvia Regina Cavani Jorge Santos. Determining plasma morphine levels using GC-MS after solid phase extraction to monitor drug levels in the postoperative period. Clinics (Sao Paulo, Brazil). 2008 Jun; 63(3):307-14. doi: 10.1590/s1807-59322008000300004. [PMID: 18568238]
  • A Wayne Jones, Anita Holmgren, Fredrik C Kugelberg. Driving under the influence of opiates: concentration relationships between morphine, codeine, 6-acetyl morphine, and ethyl morphine in blood. Journal of analytical toxicology. 2008 May; 32(4):265-72. doi: 10.1093/jat/32.4.265. [PMID: 18430293]
  • Jacqui L Adcock, Paul S Francis, Kent M Agg, Graham D Marshall, Neil W Barnett. A hybrid FIA/HPLC system incorporating monolithic column chromatography. Analytica chimica acta. 2007 Sep; 600(1-2):136-41. doi: 10.1016/j.aca.2007.03.048. [PMID: 17903475]
  • E Gustavsson, M Andersson, N Stephanson, O Beck. Validation of direct injection electrospray LC-MS/MS for confirmation of opiates in urine drug testing. Journal of mass spectrometry : JMS. 2007 Jul; 42(7):881-9. doi: 10.1002/jms.1219. [PMID: 17535017]
  • J-O Svensson, M Andersson, E Gustavsson, O Beck. Electrospray LC-MS method with solid-phase extraction for accurate determination of morphine-, codeine-, and ethylmorphine-glucuronides and 6-acetylmorphine in urine. Journal of analytical toxicology. 2007 Mar; 31(2):81-6. doi: 10.1093/jat/31.2.81. [PMID: 17536742]
  • Robert Kronstrand, Ingrid Nyström, Joakim Strandberg, Henrik Druid. Screening for drugs of abuse in hair with ion spray LC-MS-MS. Forensic science international. 2004 Oct; 145(2-3):183-90. doi: 10.1016/j.forsciint.2004.04.034. [PMID: 15451091]
  • V Cirimele, S Etienne, M Villain, B Ludes, P Kintz. Evaluation of the One-Step ELISA kit for the detection of buprenorphine in urine, blood, and hair specimens. Forensic science international. 2004 Jul; 143(2-3):153-6. doi: 10.1016/j.forsciint.2004.02.035. [PMID: 15240036]
  • Mia von Euler, Tomas Villén, Jan-Olof Svensson, Lars Ståhle. Interpretation of the presence of 6-monoacetylmorphine in the absence of morphine-3-glucuronide in urine samples: evidence of heroin abuse. Therapeutic drug monitoring. 2003 Oct; 25(5):645-8. doi: 10.1097/00007691-200310000-00015. [PMID: 14508389]
  • V Cirimele, P Kintz, S Lohner, B Ludes. Enzyme immunoassay validation for the detection of buprenorphine in urine. Journal of analytical toxicology. 2003 Mar; 27(2):103-5. doi: 10.1093/jat/27.2.103. [PMID: 12670004]
  • M Raynal, J D Bailly, G Benard, P Guerre. Effects of fumonisin B1 present in Fusarium moniliforme culture material on drug metabolising enzyme activities in ducks. Toxicology letters. 2001 May; 121(3):179-90. doi: 10.1016/s0378-4274(01)00338-1. [PMID: 11369472]
  • C Calléja, K Bigot, C Eeckhoutte, P Sibille, C Boulard, P Galtier. Comparison of hepatic and renal drug-metabolising enzyme activities in sheep given single or two-fold challenge infections with Fasciola hepatica. International journal for parasitology. 2000 Jul; 30(8):953-8. doi: 10.1016/s0020-7519(00)00070-9. [PMID: 10927086]
  • W Klinger, H Oelschläger, D Rothley, E Karge, A Seeling. Interaction of chlormezanone enantiomers with rat liver microsomes. European journal of drug metabolism and pharmacokinetics. 1999 Jan; 24(1):63-8. doi: 10.1007/bf03190012. [PMID: 10412893]
  • U D Kuhn, A Lupp, E Kostka, A Kühl, A Balogh, G Stein, C Fleck. Is there a beneficial effect of the calcium channel blocker diltiazem on cyclosporine A nephrotoxicity in rats?. Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie. 1998 Sep; 50(4-6):484-90. doi: 10.1016/s0940-2993(98)80038-9. [PMID: 9784027]
  • C Popa, O Beck, K Brodin. Morphine formation from ethylmorphine: implications for drugs-of-abuse testing in urine. Journal of analytical toxicology. 1998 Mar; 22(2):142-7. doi: 10.1093/jat/22.2.142. [PMID: 9547411]
  • K Hedenmalm, M Sundgren, K Granberg, O Spigset, R Dahlqvist. Urinary excretion of codeine, ethylmorphine, and their metabolites: relation to the CYP2D6 activity. Therapeutic drug monitoring. 1997 Dec; 19(6):643-9. doi: 10.1097/00007691-199712000-00007. [PMID: 9421105]
  • W Klinger, H Oelschläger, E Karge, D Rothley. Interaction of chlormezanone with rat liver microsomes and its degradation. European journal of drug metabolism and pharmacokinetics. 1997 Apr; 22(2):165-71. doi: 10.1007/bf03189801. [PMID: 9248786]
  • H Wilczek, J Presl, I Douda. [Laboratory indicators in drug addicts and tertiary prevention of narcotic dependence]. Casopis lekaru ceskych. 1995 Dec; 134(23):752-5. doi: NULL. [PMID: 8599816]
  • T A Aasmundstad, B Q Xu, I Johansson, A Ripel, A Bjørneboe, A S Christophersen, E Bodd, J Mørland. Biotransformation and pharmacokinetics of ethylmorphine after a single oral dose. British journal of clinical pharmacology. 1995 Jun; 39(6):611-20. doi: 10.1111/j.1365-2125.1995.tb05720.x. [PMID: 7654478]
  • P Edder, C Staub, J L Veuthey, I Pierroz, W Haerdi. Subcritical fluid extraction of opiates in hair of drug addicts. Journal of chromatography. B, Biomedical applications. 1994 Aug; 658(1):75-86. doi: 10.1016/0378-4347(94)00220-7. [PMID: 7952134]
  • M Krogh, A S Christophersen, K E Rasmussen. Automated sample preparation by on-line dialysis and trace enrichment. Analysis of morphine, 6-monoacetylmorphine, codeine, ethylmorphine and pholcodine in plasma and whole blood by capillary gas chromatography and capillary gas chromatography-mass spectrometry. Journal of chromatography. 1993 Nov; 621(1):41-8. doi: . [PMID: 8308086]
  • R F Witkamp, H J Kolker, S M Nijmeijer, J Noordhoek, A S van Miert. Selective changes in oxidative xenobiotic metabolism in vivo and in vitro after parenteral administration of recombinant bovine somatotrophin to rats. Research in veterinary science. 1993 Jul; 55(1):31-7. doi: 10.1016/0034-5288(93)90030-j. [PMID: 8378610]
  • A Rane, A R Modiri, E Gerdin. Ethylmorphine O-deethylation cosegregates with the debrisoquin genetic metabolic polymorphism. Clinical pharmacology and therapeutics. 1992 Sep; 52(3):257-64. doi: 10.1038/clpt.1992.139. [PMID: 1526082]
  • E Gerdin, A Rane. N-demethylation of ethylmorphine in pregnant and non-pregnant women and in men: an evaluation of the effects of sex steroids. British journal of clinical pharmacology. 1992 Sep; 34(3):250-5. doi: 10.1111/j.1365-2125.1992.tb04132.x. [PMID: 1389949]
  • E Sartori, M Delaforge. Specific drug binding to rat liver cytochrome P-450 isozymes induced by pregnenolone-16 alpha-carbonitrile and macrolide antibiotics. Implications for drug interactions. Chemico-biological interactions. 1990; 73(2-3):297-307. doi: 10.1016/0009-2797(90)90010-k. [PMID: 2107034]
  • M I Bushma, L B Zavodnik, P I Lukienko. [Effect of the diethylamide of nicotinic acid (cordiamine) on the hydroxylating function of the liver]. Farmakologiia i toksikologiia. 1989 Jul; 52(4):56-9. doi: NULL. [PMID: 2806530]
  • N P Skoulis, R C James, R D Harbison, S M Roberts. Depression of hepatic glutathione by opioid analgesic drugs in mice. Toxicology and applied pharmacology. 1989 Jun; 99(1):139-47. doi: 10.1016/0041-008x(89)90119-1. [PMID: 2471291]
  • W R Rush, S A Smith, J H Mulvey, D J Graham, M D Chaplin. Inhibition and induction of hepatic drug metabolism in rats and mice by nafimidone and its major metabolite nafimidone alcohol. Drug metabolism and disposition: the biological fate of chemicals. 1987 Jul; 15(4):571-8. doi: NULL. [PMID: 2888633]
  • S Borrello, T Galeotti, G Palombini, G Minotti. Restoration of hydroperoxide-dependent lipid peroxidation by 3-methylcholanthrene induction of cytochrome P-448 in hepatoma microsomes. FEBS letters. 1986 Dec; 209(2):305-10. doi: 10.1016/0014-5793(86)81132-2. [PMID: 3792550]
  • A G Maiche. Acute renal failure due to concomitant action of methotrexate and indomethacin. Lancet (London, England). 1986 Jun; 1(8494):1390. doi: 10.1016/s0140-6736(86)91706-x. [PMID: 2872506]
  • S Kuwahara, G J Mannering. Evidence for a predominantly NADH-dependent O-dealkylating system in rat hepatic microsomes. Biochemical pharmacology. 1985 Dec; 34(24):4215-28. doi: 10.1016/0006-2952(85)90276-x. [PMID: 3935115]
  • R F Butz, E C Jones, R M Welch, J W Findlay. Pharmacokinetics and O-dealkylation of morphine-3-alkyl ethers in the rat. A radioimmunoassay study. Drug metabolism and disposition: the biological fate of chemicals. 1983 Sep; 11(5):481-8. doi: . [PMID: 6138235]
  • G Svenneby, E Wedege, R L Karlsen. Pholcodine interference in the immunoassay for opiates in urine. Forensic science international. 1983 May; 21(3):223-6. doi: 10.1016/0379-0738(83)90126-3. [PMID: 6347841]
  • T H Arnold, J M Epps, H R Cook, M E Hamrick. Dantrolene sodium: urinary metabolites and hepatotoxicity. Research communications in chemical pathology and pharmacology. 1983 Mar; 39(3):381-98. doi: NULL. [PMID: 6856946]
  • S D Mercurio, A M Nemeth. Regulation of monooxygenation during development of chick embryo liver: role of cytochrome P-450 isozymes and NADPH. Developmental pharmacology and therapeutics. 1983; 6(2):94-109. doi: 10.1159/000457283. [PMID: 6861599]
  • J W Findlay, R F Butz, E C Jones. Relationships between immunogen structure and antisera specificity in the narcotic alkaloid series. Clinical chemistry. 1981 Sep; 27(9):1524-35. doi: NULL. [PMID: 7261330]
  • D W Schneck, J F Pritchard. The inhibitory effect of propranolol pretreatment on its own metabolism in the rat. The Journal of pharmacology and experimental therapeutics. 1981 Sep; 218(3):575-81. doi: NULL. [PMID: 6267246]
  • L I Sushko, P I Lukienko. [Effect of vitamin B1 deficiency on xenobiotic hydroxylation and lipid peroxidation in rat liver microsomes]. Farmakologiia i toksikologiia. 1981 Jan; 44(1):102-4. doi: ". [PMID: 7262290]
  • J L Plummer, B R Smith, H Sies, J R Bend. Chemical depletion of glutathione in vivo. Methods in enzymology. 1981; 77(?):50-9. doi: 10.1016/s0076-6879(81)77010-1. [PMID: 7035795]
  • J R Baldwin, D T Witiak, D R Feller. Disposition of clofibrate in the rat. Acute and chronic administration. Biochemical pharmacology. 1980 Dec; 29(23):3143-54. doi: 10.1016/0006-2952(80)90578-x. [PMID: 7447955]
  • M Kitada, N Yamaguchi, K Igarashi, S Hirose, H Kitagawa. Effects of polyamines on ethylmorphine N-demethylation in rat liver microsomes. Japanese journal of pharmacology. 1980 Oct; 30(5):579-86. doi: 10.1254/jjp.30.579. [PMID: 6782317]
  • S S Sofer, R A Wills, B J Van Wie. A model enzymic extracorporeal detoxification system. Artificial organs. 1979 May; 3(2):147-52. doi: 10.1111/j.1525-1594.1979.tb01029.x. [PMID: 43719]
  • G W Wolfe, R C Schnell. Annual differences in daily variations in hepatic drug metabolizing enzyme activity and plasma hormone levels in the rat. Pharmacology. 1979; 19(3):116-20. doi: 10.1159/000137298. [PMID: 574973]
  • G P Gegenava, V V Chistiakov. [Effect of morphine and its derivatives on the electric conductivity of artificial phospholipid membranes]. Biofizika. 1979 Jan; 24(1):67-71. doi: . [PMID: 435545]
  • D Friedburg, B Meissner. Fluorescein angiography of the corneal limbus--drug effects on capillary blood flow. Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie. Albrecht von Graefe's archive for clinical and experimental ophthalmology. 1978 Aug; 207(3):213-9. doi: 10.1007/bf00411055. [PMID: 309738]
  • S Szeberényi, E Pálosi, L Szporny. Effects of 3-trifluoromethyl-alpha-ethylbenzhydrol (RGH-3332), a new enzyme inducer, on the microsomal drug metabolism. Part I. Arzneimittel-Forschung. 1978; 28(4):663-8. doi: . [PMID: 581944]
  • W O Caster, L A Hoff, A E Wade. Effect of major nutrient substitutions on body weight gain, blood glucose and cholesterol levels, and the rate of drug metabolism in the liver. International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition. 1978; 48(1):54-61. doi: . [PMID: 632010]