Buclizine (BioDeep_00000408907)

Main id: BioDeep_00000006601

 


代谢物信息卡片


Buclizine

化学式: C28H33ClN2 (432.2332)
中文名称: 布克立嗪
谱图信息: 最多检出来源 Homo sapiens(urine) 66.67%

分子结构信息

SMILES: C(C3)N(CCN(Cc(c4)ccc(c4)C(C)(C)C)3)C(c(c2)cccc2)c(c1)ccc(c1)Cl
InChI: InChI=1S/C28H33ClN2/c1-28(2,3)25-13-9-22(10-14-25)21-30-17-19-31(20-18-30)27(23-7-5-4-6-8-23)24-11-15-26(29)16-12-24/h4-16,27H,17-21H2,1-3H3

描述信息

R - Respiratory system > R06 - Antihistamines for systemic use > R06A - Antihistamines for systemic use > R06AE - Piperazine derivatives
D018377 - Neurotransmitter Agents > D018494 - Histamine Agents > D006633 - Histamine Antagonists
C308 - Immunotherapeutic Agent > C29578 - Histamine-1 Receptor Antagonist

同义名列表

2 个代谢物同义名

Buclizine; Buclizine



数据库引用编号

19 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 5 ANXA5, BCL2, PPARG, VDR, YAP1
Peripheral membrane protein 1 ANXA5
Endoplasmic reticulum membrane 1 BCL2
Nucleus 5 BCL2, PCNA, PPARG, VDR, YAP1
cytosol 5 ANXA5, BCL2, PPARG, VDR, YAP1
nuclear body 1 PCNA
centrosome 1 PCNA
nucleoplasm 4 PCNA, PPARG, VDR, YAP1
RNA polymerase II transcription regulator complex 2 PPARG, VDR
Cell membrane 1 YAP1
Early endosome membrane 1 WNT3A
cell junction 1 YAP1
cell surface 1 WNT3A
glutamatergic synapse 1 WNT3A
sarcolemma 1 ANXA5
Presynapse 1 WNT3A
plasma membrane 2 IGHE, WNT3A
Membrane 3 ANXA5, BCL2, YAP1
extracellular exosome 3 ANXA5, PCNA, WNT3A
endoplasmic reticulum 1 BCL2
extracellular space 2 IGHE, WNT3A
perinuclear region of cytoplasm 1 PPARG
Cell junction, tight junction 1 YAP1
bicellular tight junction 1 YAP1
mitochondrion 1 BCL2
protein-containing complex 1 BCL2
intracellular membrane-bounded organelle 1 PPARG
Single-pass type I membrane protein 1 IGHE
Secreted 1 WNT3A
extracellular region 3 ANXA5, IGHE, WNT3A
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 1 BCL2
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
external side of plasma membrane 1 ANXA5
Secreted, extracellular space, extracellular matrix 1 WNT3A
cell-cell junction 1 YAP1
pore complex 1 BCL2
focal adhesion 1 ANXA5
collagen-containing extracellular matrix 1 ANXA5
receptor complex 2 PPARG, VDR
Zymogen granule membrane 1 ANXA5
chromatin 3 PCNA, PPARG, VDR
IgE immunoglobulin complex 1 IGHE
nuclear replication fork 1 PCNA
chromosome, telomeric region 1 PCNA
[Isoform 2]: Cell membrane 1 IGHE
female germ cell nucleus 1 YAP1
replication fork 1 PCNA
myelin sheath 1 BCL2
Golgi lumen 1 WNT3A
endoplasmic reticulum lumen 1 WNT3A
male germ cell nucleus 1 PCNA
endocytic vesicle membrane 1 WNT3A
vesicle membrane 1 ANXA5
nuclear lamina 1 PCNA
Wnt-Frizzled-LRP5/6 complex 1 WNT3A
[Isoform 3]: Cell membrane 1 IGHE
cyclin-dependent protein kinase holoenzyme complex 1 PCNA
[Isoform 1]: Secreted 1 IGHE
IgE B cell receptor complex 1 IGHE
immunoglobulin complex, circulating 1 IGHE
endothelial microparticle 1 ANXA5
BAD-BCL-2 complex 1 BCL2
PCNA complex 1 PCNA
PCNA-p21 complex 1 PCNA
replisome 1 PCNA
TEAD-YAP complex 1 YAP1


文献列表

  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • M Saeed Arayne, Najma Sultana, Agha Zeeshan Mirza, Farhan Ahmed Siddiqui. Simultaneous determination of gliquidone, fexofenadine, buclizine, and levocetirizine in dosage formulation and human serum by RP-HPLC. Journal of chromatographic science. 2010 May; 48(5):382-5. doi: 10.1093/chromsci/48.5.382. [PMID: 20515533]
  • M Saeed Arayne, Najma Sultana, Farhan Ahmed Siddiqui. Quantitation of buclizine hydrochloride in pharmaceutical formulations and human serum by RP-HPLC. Pakistan journal of pharmaceutical sciences. 2006 Oct; 19(4):326-9. doi: . [PMID: 17105713]
  • H A Burgess, D M Merrington, W J Oliver, A Thomson, H J Rogers. The relative bioavailability of paracetamol after rectal administration of suppositories containing a mixture of paracetamol, codeine phosphate and buclizine hydrochloride in healthy volunteers. Current medical research and opinion. 1985; 9(9):634-41. doi: 10.1185/03007998509109645. [PMID: 3902377]