Dactinomycin (BioDeep_00000406210)

   

natural product Chemicals and Drugs Antibiotics


代谢物信息卡片


actinomycin D

化学式: C62H86N12O16 (1254.6284436)
中文名称: 放线菌素D
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1C(C(=O)NC(C(=O)N2CCCC2C(=O)N(CC(=O)N(C(C(=O)O1)C(C)C)C)C)C(C)C)NC(=O)C3=C4C(=C(C=C3)C)OC5=C(C(=O)C(=C(C5=N4)C(=O)NC6C(OC(=O)C(N(C(=O)CN(C(=O)C7CCCN7C(=O)C(NC6=O)C(C)C)C)C)C(C)C)C)N)C
InChI: InChI=1S/C62H86N12O16/c1-27(2)42-59(84)73-23-17-19-36(73)57(82)69(13)25-38(75)71(15)48(29(5)6)61(86)88-33(11)44(55(80)65-42)67-53(78)35-22-21-31(9)51-46(35)64-47-40(41(63)50(77)32(10)52(47)90-51)54(79)68-45-34(12)89-62(87)49(30(7)8)72(16)39(76)26-70(14)58(83)37-20-18-24-74(37)60(85)43(28(3)4)66-56(45)81/h21-22,27-30,33-34,36-37,42-45,48-49H,17-20,23-26,63H2,1-16H3,(H,65,80)(H,66,81)(H,67,78)(H,68,79)

描述信息

L - Antineoplastic and immunomodulating agents > L01 - Antineoplastic agents > L01D - Cytotoxic antibiotics and related substances > L01DA - Actinomycines
C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C259 - Antineoplastic Antibiotic
C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C2842 - DNA Binding Agent
D004791 - Enzyme Inhibitors > D019384 - Nucleic Acid Synthesis Inhibitors
D004791 - Enzyme Inhibitors > D011500 - Protein Synthesis Inhibitors
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents
D000970 - Antineoplastic Agents

同义名列表

2 个代谢物同义名

actinomycin D; Dactinomycin



相关代谢途径

Reactome(0)

BioCyc(1)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

11 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Ting Liu, Tianqi Xu, Chen Hu, Dayuan Sun, Guangxiong Zhou. Hemiactinomycin, an undescribed intermediate of actinomycin biosynthesis from an actinomycetes strain Streptomyces antibioticus H41-55. Natural product research. 2024 May; 38(9):1577-1582. doi: 10.1080/14786419.2022.2161541. [PMID: 36564053]
  • Liangliang Gao, Meiling Huang, Qin Xiong, Yan Liang, Lanfang Mi, Yueming Jiang, Jun Zhang. Antibacterial Mechanism, Control Efficiency, and Nontarget Toxicity Evaluation of Actinomycin X2 against Xanthomonas citri Subsp. citri. Journal of agricultural and food chemistry. 2024 Mar; 72(9):4788-4800. doi: 10.1021/acs.jafc.3c08600. [PMID: 38377546]
  • Yuan Zhang, Hao Li, Fang Wang, Chang Liu, Gadi V P Reddy, Hu Li, Zhihong Li, Yucheng Sun, Zihua Zhao. Discovery of a new highly pathogenic toxin involved in insect sepsis. Microbiology spectrum. 2023 Dec; 11(6):e0142223. doi: 10.1128/spectrum.01422-23. [PMID: 37787562]
  • Sherif Rashad, Shane R Byrne, Daisuke Saigusa, Jingdong Xiang, Yuan Zhou, Liyin Zhang, Thomas J Begley, Teiji Tominaga, Kuniyasu Niizuma. Codon Usage and mRNA Stability are Translational Determinants of Cellular Response to Canonical Ferroptosis Inducers. Neuroscience. 2022 10; 501(?):103-130. doi: 10.1016/j.neuroscience.2022.08.009. [PMID: 35987429]
  • Ngoc Tung Quach, Thi Hanh Nguyen Vu, Thi Lien Bui, Anh Tuan Pham, Thi Thu An Nguyen, Thi Thanh Xuan Le, Thi Thu Thuy Ta, Pravin Dudhagara, Quyet-Tien Phi. Genome-Guided Investigation Provides New Insights into Secondary Metabolites of Streptomyces parvulus SX6 from Aegiceras corniculatum. Polish journal of microbiology. 2022 Sep; 71(3):381-394. doi: 10.33073/pjm-2022-034. [PMID: 36185028]
  • Yashbir Singh, Naidu Subbarao, Abhinav Jaimini, Quincy A Hathaway, Amina Kunovac, Bradley Erickson, Vishnu Swarup, Himanshu Narayan Singh. Genome-wide expression reveals potential biomarkers in breast cancer bone metastasis. Journal of integrative bioinformatics. 2022 Sep; 19(3):. doi: 10.1515/jib-2021-0041. [PMID: 35388653]
  • Kanddy Chin Yee Loo, Yueh Ni Lim, Doreen Kher Lee Kiu, Wee Wee Sim. Gestational trophoblastic neoplasm in a patient with end-stage renal failure (ESRF): the challenges and lessons learnt. BMJ case reports. 2022 May; 15(5):. doi: 10.1136/bcr-2022-249474. [PMID: 35584862]
  • William Mifsud, Rhoikos Furtwängler, Christian Vokuhl, Ellen D'Hooghe, Kathy Pritchard-Jones, Norbert Graf, Gordan M Vujanić. Treatment of patients with stage I focal anaplastic and diffuse anaplastic Wilms tumour: A report from the SIOP-WT-2001 GPOH and UK-CCLG studies. European journal of cancer (Oxford, England : 1990). 2022 05; 166(?):1-7. doi: 10.1016/j.ejca.2022.01.036. [PMID: 35255331]
  • Peter F Ehrlich, Brett Tornwall, Murali M Chintagumpala, Yueh-Yun Chi, Fredric A Hoffer, Elizabeth J Perlman, John A Kalapurakal, Anne Warwick, Robert C Shamberger, Geetika Khanna, Thomas E Hamilton, Kenneth W Gow, Arnold C Paulino, Eric J Gratias, Elizabeth A Mullen, James I Geller, Conrad V Fernandez, Jeffrey S Dome. Kidney Preservation and Wilms Tumor Development in Children with Diffuse Hyperplastic Perilobar Nephroblastomatosis: A Report from the Children's Oncology Group Study AREN0534. Annals of surgical oncology. 2022 May; 29(5):3252-3261. doi: 10.1245/s10434-021-11266-6. [PMID: 35072864]
  • Alissa Groenendijk, Harm van Tinteren, Yilin Jiang, Ronald R de Krijger, Gordan M Vujanic, Jan Godzinski, Christian Rübe, Jens-Peter Schenk, Carlo Morosi, Kathy Pritchard-Jones, Reem Al-Saadi, Sucheta J Vaidya, Arnauld C Verschuur, Gema L Ramírez-Villar, Norbert Graf, Beatriz de Camargo, Jarno Drost, Daniela Perotti, Marry M van den Heuvel-Eibrink, Jesper Brok, Filippo Spreafico, Annelies M C Mavinkurve-Groothuis. Outcome of SIOP patients with low- or intermediate-risk Wilms tumour relapsing after initial vincristine and actinomycin-D therapy only - the SIOP 93-01 and 2001 protocols. European journal of cancer (Oxford, England : 1990). 2022 03; 163(?):88-97. doi: 10.1016/j.ejca.2021.12.014. [PMID: 35042071]
  • Yanxue Zhao, Lei Wang, Xuwu Sun, Yiqun Bao, Hao Liu, Yanxue Zhao. Inhibition of ribosome biogenesis by actinomycin D affects Arabidopsis root development. Biochemical and biophysical research communications. 2022 01; 588(?):61-67. doi: 10.1016/j.bbrc.2021.12.030. [PMID: 34952471]
  • Prakriti Roy, Sophie E van Peer, Martin M de Witte, Godelieve A M Tytgat, Henrike E Karim-Kos, Martine van Grotel, Cees P van de Ven, Annelies M C Mavinkurve-Groothuis, Johannes H M Merks, Roland P Kuiper, Janna A Hol, Geert O R Janssens, Ronald R de Krijger, Marjolijn C J Jongmans, Jarno Drost, Alida F W van der Steeg, Annemieke S Littooij, Marc H W A Wijnen, Harm van Tinteren, Marry M van den Heuvel-Eibrink. Characteristics and outcome of children with renal tumors in the Netherlands: The first five-year's experience of national centralization. PloS one. 2022; 17(1):e0261729. doi: 10.1371/journal.pone.0261729. [PMID: 35025887]
  • Noriko Yamaguchi, Yoshinobu Hamada, Risa Inagaki, Kohei Nemoto, Hideyuki Yoshitomi, Satoshi Takakura. Successful salvage treatment with paclitaxel, ifosfamide, and cisplatin in a patient with methotrexate-resistant gestational trophoblastic neoplasia who developed hypersensitivity reaction to etoposide. The journal of obstetrics and gynaecology research. 2021 Oct; 47(10):3737-3741. doi: 10.1111/jog.14945. [PMID: 34278664]
  • Noushin Miralaei, Ahmad Majd, Kamran Ghaedi, Maryam Peymani, Masoomeh Safaei. Integrated pan-cancer of AURKA expression and drug sensitivity analysis reveals increased expression of AURKA is responsible for drug resistance. Cancer medicine. 2021 09; 10(18):6428-6441. doi: 10.1002/cam4.4161. [PMID: 34337875]
  • Vanessa Sok, Alec Z Jacinto, Natalie Peng, Mohamed Eldemerdash, Lysa Le, Philip D Tran, Li Feng Feng, Jigisha R Patel, Michael Gi, Jane C Ammon, Christopher H So. G protein coupled receptor kinase 5 modifies the nucleolar stress response activated by actinomycin D. Biochemistry and cell biology = Biochimie et biologie cellulaire. 2021 08; 99(4):508-518. doi: 10.1139/bcb-2020-0480. [PMID: 33507833]
  • Kamal A Qureshi, Avinash D Bholay, Pankaj K Rai, Hamdoon A Mohammed, Riaz A Khan, Faizul Azam, Mariusz Jaremko, Abdul-Hamid Emwas, Piotr Stefanowicz, Mateusz Waliczek, Monika Kijewska, Ehab A Ragab, Medhat Rehan, Gamal O Elhassan, Md Jamir Anwar, Dinesh K Prajapati. Isolation, characterization, anti-MRSA evaluation, and in-silico multi-target anti-microbial validations of actinomycin X2 and actinomycin D produced by novel Streptomyces smyrnaeus UKAQ_23. Scientific reports. 2021 07; 11(1):14539. doi: 10.1038/s41598-021-93285-7. [PMID: 34267232]
  • Arlley Cleverson Belo da Silva, Jurandir Piassi Passos, Roney Cesar Signorini Filho, Antonio Braga, Rosiane Mattar, Sue Yazaki Sun. Uterine Rescue in High-Risk Gestational Trophoblastic Neoplasia Treated with EMA-CO by Uterine Arteries Embolization due to Arteriovenous Malformations. Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia. 2021 Apr; 43(4):323-328. doi: 10.1055/s-0041-1725054. [PMID: 33979893]
  • Hironao Nakayama, Masako Nakahara, Erina Matsugi, Midori Soda, Tomoka Hattori, Koki Hara, Ayuki Usami, Chiaki Kusumoto, Shigeki Higashiyama, Kiyoyuki Kitaichi. Protective Effect of Ferulic Acid against Hydrogen Peroxide Induced Apoptosis in PC12 Cells. Molecules (Basel, Switzerland). 2020 Dec; 26(1):. doi: 10.3390/molecules26010090. [PMID: 33379243]
  • Dandan Wang, Xiaoxiao Yang, Yuanli Chen, Ke Gong, Maoyun Yu, Yongyao Gao, Ximei Wu, Huaqing Hu, Chenzhong Liao, Jihong Han, Yajun Duan. Ascorbic acid enhances low-density lipoprotein receptor expression by suppressing proprotein convertase subtilisin/kexin 9 expression. The Journal of biological chemistry. 2020 11; 295(47):15870-15882. doi: 10.1074/jbc.ra120.015623. [PMID: 32913121]
  • Risa Maenaka, Shuji Tani, Yasufumi Hikichi, Kenji Kai. Actinomycins inhibit the production of the siderophore pyoverdines in the plant pathogen Pseudomonas cichorii SPC9018. Bioscience, biotechnology, and biochemistry. 2020 Oct; 84(10):1975-1985. doi: 10.1080/09168451.2020.1785839. [PMID: 32594848]
  • Leonardo Jose Silva, Eduardo José Crevelin, Danilo Tosta Souza, Gileno Vieira Lacerda-Júnior, Valeria Maia de Oliveira, Ana Lucia Tasca Gois Ruiz, Luiz Henrique Rosa, Luiz Alberto Beraldo Moraes, Itamar Soares Melo. Actinobacteria from Antarctica as a source for anticancer discovery. Scientific reports. 2020 08; 10(1):13870. doi: 10.1038/s41598-020-69786-2. [PMID: 32807803]
  • Fu-Juan Jia, Zhuo Han, Jia-Hui Ma, Shi-Qing Jiang, Xing-Ming Zhao, Hang Ruan, Wei-Dong Xie, Xia Li. Involvement of Reactive Oxygen Species in the Hepatorenal Toxicity of Actinomycin V In Vitro and In Vivo. Marine drugs. 2020 Aug; 18(8):. doi: 10.3390/md18080428. [PMID: 32824227]
  • Xiaodong Wu, Jiale Qin, Tao Shen, Weidong Fei, Lili Chen, Xing Xie, Weiguo Lu. The 16-year experience in treating low-risk gestational trophoblastic neoplasia patients with failed primary methotrexate chemotherapy. Journal of gynecologic oncology. 2020 Jul; 31(4):e36. doi: 10.3802/jgo.2020.31.e36. [PMID: 32026657]
  • Danielle B Chau, Anna L Beavis, Brigitte M Ronnett, Erik Jenson, Christopher D Gocke, Jean Anderson, Amanda Nickles Fader, Rebecca Stone. Genetically Related Choriocarcinoma Developing 5 Yr After a Complete Hydatidiform Mole and Simulating a Cornual Ectopic Pregnancy. International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists. 2020 Jul; 39(4):367-372. doi: 10.1097/pgp.0000000000000607. [PMID: 31033803]
  • Abril Carbajal-García, Jorge Reyes-García, María F Casas-Hernández, Edgar Flores-Soto, Verónica Díaz-Hernández, Héctor Solís-Chagoyán, Bettina Sommer, Luis M Montaño. Testosterone augments β2 adrenergic receptor genomic transcription increasing salbutamol relaxation in airway smooth muscle. Molecular and cellular endocrinology. 2020 06; 510(?):110801. doi: 10.1016/j.mce.2020.110801. [PMID: 32278021]
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  • Claudia Pasqualini, Rhoikos Furtwängler, Harm van Tinteren, Roberto A P Teixeira, Tomas Acha, Lisa Howell, Gordan Vujanic, Jan Godzinski, Patrick Melchior, Anne M Smets, Aurore Coulomb-L'Hermine, Hervé Brisse, Kathy Pritchard-Jones, Christophe Bergeron, Beatriz de Camargo, Marry M van den Heuvel-Eibrink, Norbert Graf, Arnauld C Verschuur. Outcome of patients with stage IV high-risk Wilms tumour treated according to the SIOP2001 protocol: A report of the SIOP Renal Tumour Study Group. European journal of cancer (Oxford, England : 1990). 2020 03; 128(?):38-46. doi: 10.1016/j.ejca.2020.01.001. [PMID: 32109849]
  • Raquel Dávila Fajardo, Marry M van den Heuvel-Eibrink, Harm van Tinteren, Filippo Spreafico, Thomas Acha, Christophe Bergeron, Beatriz de Camargo, Foppe Oldenburger, Christian Rübe, Takaharu Oue, Christian Vokuhl, Ronald R de Krijger, Gordan Vujanic, Neil Sebire, Aurore Coulomb-L'Hermine, Paola Collini, Lorenza Gandola, Kathy Pritchard-Jones, Norbert Graf, Geert O Janssens, Martine van Grotel. Is radiotherapy required in first-line treatment of stage I diffuse anaplastic Wilms tumor? A report of SIOP-RTSG, AIEOP, JWiTS, and UKCCSG. Pediatric blood & cancer. 2020 02; 67(2):e28039. doi: 10.1002/pbc.28039. [PMID: 31625685]
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  • Wenchu Ye, Ruqin Lin, Xiaoxuan Chen, Jiongjie Chen, Ruohong Chen, Xuan Xie, Yiqun Deng, Jikai Wen. T-2 toxin upregulates the expression of human cytochrome P450 1A1 (CYP1A1) by enhancing NRF1 and Sp1 interaction. Toxicology letters. 2019 Oct; 315(?):77-86. doi: 10.1016/j.toxlet.2019.08.021. [PMID: 31470059]
  • Anne Mahringer, Alexandra Bernd, David S Miller, Gert Fricker. Aryl hydrocarbon receptor ligands increase ABC transporter activity and protein expression in killifish (Fundulus heteroclitus) renal proximal tubules. Biological chemistry. 2019 09; 400(10):1335-1345. doi: 10.1515/hsz-2018-0425. [PMID: 30913027]
  • Su Jung Park, Sam Seok Cho, Kyu Min Kim, Ji Hye Yang, Jae Hoon Kim, Eun Hee Jeong, Jin Won Yang, Chang Yeob Han, Sae Kwang Ku, Il Je Cho, Sung Hwan Ki. Protective effect of sestrin2 against iron overload and ferroptosis-induced liver injury. Toxicology and applied pharmacology. 2019 09; 379(?):114665. doi: 10.1016/j.taap.2019.114665. [PMID: 31323261]
  • Sandhya Chandrakar, Ashwini Kumar Gupta. Actinomycin-Producing Endophytic Streptomyces parvulus Associated with Root of Aloe vera and Optimization of Conditions for Antibiotic Production. Probiotics and antimicrobial proteins. 2019 09; 11(3):1055-1069. doi: 10.1007/s12602-018-9451-6. [PMID: 30058033]
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