quetiapine (BioDeep_00000406004)

Main id: BioDeep_00000002535

 

natural product


代谢物信息卡片


quetiapine

化学式: C21H25N3O2S (383.1667)
中文名称: 喹硫平
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: c1ccc2c(c1)C(=Nc1ccccc1S2)N1CCN(CC1)CCOCCO
InChI: InChI=1S/C21H25N3O2S/c25-14-16-26-15-13-23-9-11-24(12-10-23)21-17-5-1-3-7-19(17)27-20-8-4-2-6-18(20)22-21/h1-8,25H,9-16H2

描述信息

N - Nervous system > N05 - Psycholeptics > N05A - Antipsychotics > N05AH - Diazepines, oxazepines, thiazepines and oxepines
D002492 - Central Nervous System Depressants > D014149 - Tranquilizing Agents > D014150 - Antipsychotic Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D000928 - Antidepressive Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
C78272 - Agent Affecting Nervous System > C66885 - Serotonin Antagonist
C78272 - Agent Affecting Nervous System > C29710 - Antipsychotic Agent
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
Quetiapine (ICI204636) is a 5-HT receptors agonist with a pEC50 of 4.77 for human 5-HT1A receptor. Quetiapine is a dopamine receptor antagonist with a pIC50 of 6.33 for human D2 receptor. Quetiapine has moderate to high affinity for the human D2, HT1A, 5-HT2A, 5-HT2C receptor with pKis of 7.25, 5.74, 7.54, 5.55. Antidepressant and anxiolytic effects[1].

同义名列表

3 个代谢物同义名

quetiapine; ICI204636; Quetiapine



数据库引用编号

17 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 5 ABCB1, CYP2C19, CYP2D6, CYP3A4, MVD
Peripheral membrane protein 2 CYP1B1, MBP
Endoplasmic reticulum membrane 6 CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, CYP3A5
Nucleus 1 MBP
cytosol 5 AVP, COMT, LEP, MBP, MVD
dendrite 6 AVP, COMT, DRD2, HTR1A, HTR2A, HTR2C
Cell membrane 8 ABCB1, COMT, DRD2, HTR1A, HTR2A, HTR2C, SLC6A2, TNF
Cytoplasmic side 1 MBP
Cell projection, axon 1 HTR2A
Multi-pass membrane protein 6 ABCB1, DRD2, HTR1A, HTR2A, HTR2C, SLC6A2
Golgi apparatus membrane 1 DRD2
Synapse 5 COMT, DRD2, HTR1A, HTR2C, MBP
cell surface 4 ABCB1, MBP, SLC6A2, TNF
dendritic shaft 1 HTR2A
glutamatergic synapse 2 DRD2, HTR2A
Golgi membrane 2 DRD2, INS
neuronal cell body 3 HTR2A, MBP, TNF
presynaptic membrane 3 DRD2, HTR2A, SLC6A2
Presynapse 1 HTR2A
acrosomal vesicle 1 DRD2
plasma membrane 10 ABCB1, COMT, CYP2C19, DRD2, HTR1A, HTR2A, HTR2C, MBP, SLC6A2, TNF
synaptic vesicle membrane 2 DRD2, SLC6A2
Membrane 7 ABCB1, COMT, CYP1B1, CYP2D6, CYP3A4, CYP3A5, SLC6A2
apical plasma membrane 1 ABCB1
axon 4 COMT, DRD2, HTR2A, SLC6A2
caveola 1 HTR2A
extracellular exosome 3 ABCB1, COMT, MBP
endoplasmic reticulum 1 CYP2D6
extracellular space 5 AVP, IL6, INS, LEP, TNF
mitochondrion 2 CYP1B1, CYP2D6
protein-containing complex 1 MBP
intracellular membrane-bounded organelle 7 COMT, CYP1A2, CYP1B1, CYP2C19, CYP2D6, CYP3A4, CYP3A5
Microsome membrane 5 CYP1A2, CYP1B1, CYP2D6, CYP3A4, CYP3A5
Secreted 4 AVP, IL6, INS, LEP
extracellular region 6 AVP, IL6, INS, LEP, MBP, TNF
Single-pass membrane protein 1 CYP2D6
neuronal cell body membrane 1 SLC6A2
Extracellular side 1 COMT
ciliary membrane 1 DRD2
external side of plasma membrane 1 TNF
dendritic spine 1 DRD2
perikaryon 1 DRD2
cytoplasmic vesicle 1 HTR2A
recycling endosome 1 TNF
Single-pass type II membrane protein 2 COMT, TNF
postsynaptic membrane 2 DRD2, HTR2A
Apical cell membrane 1 ABCB1
Membrane raft 1 TNF
GABA-ergic synapse 1 DRD2
collagen-containing extracellular matrix 1 MBP
secretory granule 1 AVP
lateral plasma membrane 1 DRD2
cilium 1 DRD2
phagocytic cup 1 TNF
cell periphery 1 MBP
[Isoform 3]: Nucleus 1 MBP
non-motile cilium 1 DRD2
sperm flagellum 1 DRD2
endosome lumen 1 INS
Membrane, caveola 1 HTR2A
cell body fiber 1 HTR2A
Cell projection, dendrite 2 HTR1A, HTR2A
myelin sheath 1 MBP
ficolin-1-rich granule lumen 1 MBP
secretory granule lumen 1 INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 2 IL6, INS
axon terminus 1 DRD2
endocytic vesicle 1 DRD2
transport vesicle 2 INS, MBP
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
neuronal dense core vesicle 1 AVP
neurofilament 1 HTR2A
clathrin-coated endocytic vesicle membrane 1 AVP
external side of apical plasma membrane 1 ABCB1
dopaminergic synapse 1 DRD2
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
compact myelin 1 MBP
internode region of axon 1 MBP
interleukin-6 receptor complex 1 IL6
[Bone marrow proteoglycan]: Secreted 1 MBP
G protein-coupled receptor complex 1 DRD2
[Isoform Soluble]: Cytoplasm 1 COMT
[Isoform Membrane-bound]: Cell membrane 1 COMT
G protein-coupled serotonin receptor complex 2 HTR2A, HTR2C
Myelin membrane 1 MBP
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Yeran Hwang, Ju-Tae Sohn. Effect of lipid emulsion on neuropsychiatric drug-induced toxicity: A narrative review. Medicine. 2024 Mar; 103(11):e37612. doi: 10.1097/md.0000000000037612. [PMID: 38489675]
  • Bruna Bernar Dias, Fernando Carreño, Victória Etges Helfer, Laura Ben Olivo, Keli Jaqueline Staudt, Karina Paese, Fabiano Barreto, Fabíola Schons Meyer, Ana Paula Herrmann, Sílvia Stanisçuaski Guterres, Stela Maris Kuze Rates, Bibiana Verlindo de Araújo, Iñaki F Trocóniz, Teresa Dalla Costa. Pharmacokinetic/pharmacodynamic modeling of cortical dopamine concentrations after quetiapine lipid core nanocapsules administration to schizophrenia phenotyped rats. CPT: pharmacometrics & systems pharmacology. 2024 Jan; ?(?):. doi: 10.1002/psp4.13107. [PMID: 38282365]
  • Meihua Lin, Yu Zhang, Duo Lv, Nana Xu, Xi Yang, Xueling Liu, Caixia Yan, Meijia Wu, Jiejing Kai, Shaohua Hu, Qingwei Zhao. The impact of CYP3A5*3 on oral quetiapine: A population pharmacokinetic model in Chinese bipolar disorder patients. Journal of affective disorders. 2024 Jan; 351(?):309-313. doi: 10.1016/j.jad.2024.01.170. [PMID: 38262522]
  • Lin Yang, Jinyuan Zhang, Jing Yu, Ze Yu, Xin Hao, Fei Gao, Chunhua Zhou. Predicting plasma concentration of quetiapine in patients with depression using machine learning techniques based on real-world evidence. Expert review of clinical pharmacology. 2023 Jul; 16(8):741-750. doi: 10.1080/17512433.2023.2238604. [PMID: 37466101]
  • Yupei Hao, Jinyuan Zhang, Chunhua Zhou, Lin Yang, Ze Yu, Xin Hao, Xiaolu Pang, Jing Yu. A Machine Learning Model For Predicting Blood Concentration of Quetiapine in Patients With Schizophrenia and Depression Based on Real-World Data. British journal of clinical pharmacology. 2023 Apr; ?(?):. doi: 10.1111/bcp.15734. [PMID: 37005382]
  • Mikkel Højlund, Henrik Støvring, Kjeld Andersen, Christoph U Correll, Jesper Hallas. Impact of low-dose quetiapine-use on glycosylated hemoglobin, triglyceride and cholesterol levels. Acta psychiatrica Scandinavica. 2023 01; 147(1):105-116. doi: 10.1111/acps.13515. [PMID: 36281759]
  • He Xu, Ge Liu, Jixing Gong, Ying Zhang, Shanshan Gu, Zhongjun Wan, Pengcheng Yang, Yage Nie, Yinghan Wang, Zhan-Peng Huang, Guanzheng Luo, Zhongyan Chen, Donghui Zhang, Nan Cao. Investigating and Resolving Cardiotoxicity Induced by COVID-19 Treatments using Human Pluripotent Stem Cell-Derived Cardiomyocytes and Engineered Heart Tissues. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2022 10; 9(30):e2203388. doi: 10.1002/advs.202203388. [PMID: 36055796]
  • Reeha Sharon, Theis Lange, Mia Aakjær, Sarah Brøgger Kristiansen, Morten Baltzer Houlind, Morten Andersen. Incidence of hospital contacts with acute kidney injury after initiation of second-generation antipsychotics in older adults: a Danish population-based cohort study. European journal of clinical pharmacology. 2022 Aug; 78(8):1341-1349. doi: 10.1007/s00228-022-03339-6. [PMID: 35639132]
  • Arnim Johannes Gaebler, Michelle Finner-Prével, Sarah Lammertz, Sabrina Schaffrath, Patrick Eisner, Felix Stöhr, Erik Röcher, Lina Winkler, Peter Kaleta, Laura Lenzen, Marc Augustin, Jana Hovancakova, Lara Schwemmer, Eva Stormanns, Fatih Keskin, Frederik Hendricks, Michael Paulzen, Gerhard Gründer, Frank Schneider, Klaus Mathiak. The negative impact of vitamin D on antipsychotic drug exposure may counteract its potential benefits in schizophrenia. British journal of clinical pharmacology. 2022 07; 88(7):3193-3200. doi: 10.1111/bcp.15223. [PMID: 35380747]
  • Seema Zargar, Tanveer A Wani, Nawaf A Alsaif, Arwa Ishaq A Khayyat. A Comprehensive Investigation of Interactions between Antipsychotic Drug Quetiapine and Human Serum Albumin Using Multi-Spectroscopic, Biochemical, and Molecular Modeling Approaches. Molecules (Basel, Switzerland). 2022 Apr; 27(8):. doi: 10.3390/molecules27082589. [PMID: 35458787]
  • Jennifer Fontaine, Evelyn Chin, Jean-François Provencher, Anthony Rainone, Dana Wazzan, Carmella Roy, Soham Rej, Marie Lordkipanidze, Vincent Dagenais-Beaulé. Assessing cardiometabolic parameter monitoring in inpatients taking a second-generation antipsychotic: The CAMI-SGA study - a cross-sectional study. BMJ open. 2022 04; 12(4):e055454. doi: 10.1136/bmjopen-2021-055454. [PMID: 35414553]
  • Maya Kuperberg, Ole Köhler-Forsberg, Alec P Shannon, Nevita George, Sophie Greenebaum, Charles L Bowden, Joseph R Calabrese, Michael Thase, Richard C Shelton, Melvin McInnis, Thilo Deckersbach, Mauricio Tohen, James H Kocsis, Terence A Ketter, Edward S Friedman, Dan V Iosifescu, Michael J Ostacher, Louisa G Sylvia, Susan L McElroy, Andrew A Nierenberg. Cardiometabolic risk markers during mood-stabilizing treatment: Correlation with drug-specific effects, depressive symptoms and treatment response. Journal of affective disorders. 2022 03; 300(?):41-49. doi: 10.1016/j.jad.2021.12.047. [PMID: 34952123]
  • Cintia R Prokopez, Romina Farinola, Miguel Vallejos, Lorena S Lopredo, Luciano E Sfriso, Luciana C Chiapella, Claudio Arce, Ricardo M Corral, Manuel J Cuesta, Martín Alomo. Olanzapine, risperidone and quetiapine: Do these atypical antipsychotics have a protective effect for SARS-CoV-2?. Schizophrenia research. 2022 03; 241(?):140-141. doi: 10.1016/j.schres.2022.01.035. [PMID: 35123336]
  • Y Zhang, F Teng, L L Liu, X L Cai, N Zhang, G Q Li. [Acute respiratory distress syndrome caused by quetiapine poisoning: a case report]. Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases. 2022 Feb; 40(2):145-148. doi: 10.3760/cma.j.cn121094-20210203-00078. [PMID: 35255585]
  • Tai-Ling Liu, Li-Shan Fang, Jing-Ru Liou, Jia-Shan Dai, Yen-Ling Chen. Determination of quetiapine and its metabolites in plasma by field-enhanced sample stacking. Journal of food and drug analysis. 2021 12; 29(4):709-716. doi: 10.38212/2224-6614.3378. [PMID: 35649137]
  • Ditte Rudå, Karsten Gjessing Jensen, Marie Stentebjerg Decara, Dea Gowers Klauber, Birgitte Fagerlund, Jens Richardt Møllegaard, Kristian Linnet, Thomas Werge, Christoph U Correll, Anders Fink-Jensen, Gesche Jürgens, Anne Katrine Pagsberg. CYP2D6 Genotyping and Antipsychotic-Associated Extrapyramidal Adverse Effects in a Randomized Trial of Aripiprazole Versus Quetiapine Extended Release in Children and Adolescents, Aged 12-17 Years, With First Episode Psychosis. Journal of clinical psychopharmacology. 2021 Nov; 41(6):667-672. doi: 10.1097/jcp.0000000000001490. [PMID: 34735099]
  • Jayantee Kalita, Vijay Kumar, Vasudev Parashar, Usha K Misra. Neuropsychiatric Manifestations of Wilson Disease: Correlation with MRI and Glutamate Excitotoxicity. Molecular neurobiology. 2021 Nov; 58(11):6020-6031. doi: 10.1007/s12035-021-02525-4. [PMID: 34435331]
  • Céline Dubath, Marianna Piras, Mehdi Gholam, Nermine Laaboub, Claire Grosu, Othman Sentissi, Franziska Gamma, Alessandra Solida, Armin von Gunten, Philippe Conus, Chin B Eap. Effect of Quetiapine, from Low to High Dose, on Weight and Metabolic Traits: Results from a Prospective Cohort Study. Pharmacopsychiatry. 2021 Nov; 54(6):279-286. doi: 10.1055/a-1525-2820. [PMID: 34388836]
  • Mohsen Khosravi. Letter to the editor: Quetiapine safety in ICU delirium management among SARS-CoV-2-infected patients. Journal of psychosomatic research. 2021 10; 149(?):110598. doi: 10.1016/j.jpsychores.2021.110598. [PMID: 34411965]
  • Beatriz Torroba Sanz, Elena Mendez Martínez, Elena Cacho Asenjo, Irene Aquerreta Gonzalez. Permanent renal sequelae secondary to drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome induced by quetiapine. European journal of hospital pharmacy : science and practice. 2021 09; 28(5):285-288. doi: 10.1136/ejhpharm-2019-002149. [PMID: 34426483]
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  • Katerina Ragazou, Rallis Lougkovois, Vassiliki Katseli, Christos Kokkinos. Fully Integrated 3D-Printed Electronic Device for the On-Field Determination of Antipsychotic Drug Quetiapine. Sensors (Basel, Switzerland). 2021 Jul; 21(14):. doi: 10.3390/s21144753. [PMID: 34300495]
  • Luis Fernando Zavala-Jonguitud, Carla Cristina Pérez-García. Delirium triggered by COVID-19 vaccine in an elderly patient. Geriatrics & gerontology international. 2021 Jun; 21(6):540. doi: 10.1111/ggi.14163. [PMID: 33829614]
  • Kouji Fukuyama, Motohiro Okada. Effects of Atypical Antipsychotics, Clozapine, Quetiapine and Brexpiprazole on Astroglial Transmission Associated with Connexin43. International journal of molecular sciences. 2021 May; 22(11):. doi: 10.3390/ijms22115623. [PMID: 34070699]
  • Kazuhito Nomura, Sonoko Sakawaki, Eiji Sakawaki, Ayumu Yamaoka, Wakiko Aisaka, Hiroyuki Okamoto, Yoshihiro Takeyama, Shuji Uemura, Eichi Narimatsu. Successful diagnosis and treatment of pulmonary aspergillosis-related malignant catatonia using propofol and quetiapine: A case report. Medicine. 2021 May; 100(19):e25967. doi: 10.1097/md.0000000000025967. [PMID: 34106671]
  • Liang Zheng, Shiwei Tang, Rui Tang, Miao Xu, Xuehua Jiang, Ling Wang. Dose Adjustment of Quetiapine and Aripiprazole for Pregnant Women Using Physiologically Based Pharmacokinetic Modeling and Simulation. Clinical pharmacokinetics. 2021 05; 60(5):623-635. doi: 10.1007/s40262-020-00962-3. [PMID: 33251573]
  • Miki Takahashi, Akihito Deguchi, Hiromu Nishihara, Mea Asou, Tomohiko Asakawa, Makoto Araki. Quetiapine-induced thrombotic microangiopathy in a patient on maintenance dialysis. CEN case reports. 2021 05; 10(2):159-164. doi: 10.1007/s13730-020-00536-z. [PMID: 32981026]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
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  • Burak Çakır, Şermin Yalın Sapmaz, Hasan Kandemir. Use of Antipsychotics: The Experiences, Views, and Monitoring Practices of Child and Adolescent Psychiatrists in Turkey. Journal of child and adolescent psychopharmacology. 2021 02; 31(1):73-78. doi: 10.1089/cap.2020.0078. [PMID: 32614261]
  • Shweta Agarwal, S L HariKumar, Poonam Negi, Navneet Upadhyay, Rajeev Garg. Quetiapine Fumarate Loaded Nanostructured Lipid Carrier for Enhancing Oral Bioavailability: Design, Development and Pharmacokinetic Assessment. Current drug delivery. 2021; 18(2):184-198. doi: 10.2174/1567201817999200728135119. [PMID: 32723273]
  • John Kendrick, Ruth Stow, Neil Ibbotson, Georgina Adjin-Tettey, Beverley Murphy, Glynn Bailey, James Miller, Hans Helleberg, Mette Finderup Grove, Kirstine Øvlisen, Jesper Juhl Hansen. A novel welfare and scientific approach to conducting dog metabolism studies allowing dogs to be pair housed. Laboratory animals. 2020 Dec; 54(6):588-598. doi: 10.1177/0023677220905330. [PMID: 32063096]
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  • Joseph W Lowdon, Kasper Eersels, Rocio Arreguin-Campos, Manlio Caldara, Benjamin Heidt, Renato Rogosic, Kathia L Jimenez-Monroy, Thomas J Cleij, Hanne Diliën, Bart van Grinsven. A Molecularly Imprinted Polymer-based Dye Displacement Assay for the Rapid Visual Detection of Amphetamine in Urine. Molecules (Basel, Switzerland). 2020 Nov; 25(22):. doi: 10.3390/molecules25225222. [PMID: 33182534]
  • Cui-Hong Zhou, Shan-Shan Xue, Fen Xue, Ling Liu, Jun-Chang Liu, Quan-Rui Ma, Jun-Hui Qin, Qing-Rong Tan, Hua-Ning Wang, Zheng-Wu Peng. The impact of quetiapine on the brain lipidome in a cuprizone-induced mouse model of schizophrenia. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2020 Nov; 131(?):110707. doi: 10.1016/j.biopha.2020.110707. [PMID: 32905942]
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  • Fernando Carreño, Victória Etges Helfer, Keli Jaqueline Staudt, Laura Bem Olivo, Fabiano Barreto, Ana Paula Herrmann, Stela Maris Kuze Rates, Teresa Dalla Costa. Quantification of neurotransmitters in microdialysate samples following quetiapine dosing to schizophrenia phenotyped rats using a validated LC-MS/MS method. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2020 Oct; 1155(?):122282. doi: 10.1016/j.jchromb.2020.122282. [PMID: 32771966]
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  • Risa Fukushi, Yuki Nomura, Masataka Katashima, Kanji Komatsu, Yuichiro Sato, Akitsugu Takada. Approach to Evaluating QT Prolongation of Quetiapine Fumarate in Late Stage of Clinical Development Using Concentration-QTc Modeling and Simulation in Japanese Patients With Bipolar Disorder. Clinical therapeutics. 2020 08; 42(8):1483-1493.e1. doi: 10.1016/j.clinthera.2020.06.002. [PMID: 32792252]
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