nefazodone (BioDeep_00000405955)
Main id: BioDeep_00000002094
Volatile Flavor Compounds
代谢物信息卡片
nefazodone
化学式: C25H32ClN5O2 (469.2244402)
中文名称: 奈法唑酮
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCC1=NN(C(=O)N1CCOC2=CC=CC=C2)CCCN3CCN(CC3)C4=CC(=CC=C4)Cl
InChI: InChI=1S/C25H32ClN5O2/c1-2-24-27-31(25(32)30(24)18-19-33-23-10-4-3-5-11-23)13-7-12-28-14-16-29(17-15-28)22-9-6-8-21(26)20-22/h3-6,8-11,20H,2,7,12-19H2,1H3
描述信息
D018377 - Neurotransmitter Agents > D014179 - Neurotransmitter Uptake Inhibitors > D000068760 - Serotonin and Noradrenaline Reuptake Inhibitors
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D000928 - Antidepressive Agents
D018377 - Neurotransmitter Agents > D018490 - Serotonin Agents > D012702 - Serotonin Antagonists
C78272 - Agent Affecting Nervous System > C265 - Antidepressant Agent
N - Nervous system > N06 - Psychoanaleptics > N06A - Antidepressants
D049990 - Membrane Transport Modulators
Nefazodone is an orally active phenylpiperazine antidepressant. Nefazodone can potently and selectively block postsynaptic 5-HT2A receptors, and moderately inhibit 5-HT and noradrenaline reuptake. Nefazodone can also relieve the adverse effects of stress on the the immune system of mice. Nefazodone has a high affinity for CYP3A4 isoenzyme, which indicates that it has certain risk of agent-agent interaction[1][2][3].
同义名列表
2 个代谢物同义名
数据库引用编号
14 个数据库交叉引用编号
- ChEBI: CHEBI:7494
- KEGG: C07256
- KEGGdrug: D08257
- PubChem: 4449
- DrugBank: DB01149
- ChEMBL: CHEMBL623
- CAS: 83366-66-9
- MoNA: FiehnHILIC002173
- MoNA: FiehnHILIC000604
- PubChem: 9465
- NIKKAJI: J33.097C
- RefMet: Nefazodone
- medchemexpress: HY-119209
- KNApSAcK: 7494
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
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1998 Nov; 55(11):1050-2. doi:
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1998 Oct; 718(1):77-85. doi:
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1998 Apr; 18(2):145-53. doi:
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British journal of clinical pharmacology.
1998 Mar; 45(3):318-21. doi:
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Journal of clinical psychopharmacology.
1998 Feb; 18(1):67-71. doi:
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American journal of kidney diseases : the official journal of the National Kidney Foundation.
1998 Feb; 31(2):320-3. doi:
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The Journal of pharmacology and experimental therapeutics.
1997 Dec; 283(3):1305-22. doi:
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1997 Oct; 33(4):260-75. doi:
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1997 Feb; 17(1):27-33. doi:
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British journal of clinical pharmacology.
1996 Nov; 42(5):573-81. doi:
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Annals of internal medicine.
1996 Sep; 125(5):424. doi:
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Journal of clinical psychopharmacology.
1996 Feb; 16(1):19-25. doi:
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Journal of clinical psychopharmacology.
1996 Feb; 16(1):26-34. doi:
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Journal of clinical pharmacology.
1996 Feb; 36(2):160-7. doi:
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The Journal of clinical psychiatry.
1996; 57 Suppl 2(?):31-8. doi:
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European journal of clinical pharmacology.
1996; 50(1-2):101-7. doi:
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British journal of clinical pharmacology.
1996 Jan; 41(1):21-7. doi:
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Drug metabolism and disposition: the biological fate of chemicals.
1996 Jan; 24(1):91-5. doi:
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Journal of clinical psychopharmacology.
1995 Dec; 15(6):399-408. doi:
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British journal of clinical pharmacology.
1995 Dec; 40(6):598-601. doi:
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Journal of clinical psychopharmacology.
1995 Dec; 15(6):409-16. doi:
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Journal of clinical pharmacology.
1995 Nov; 35(11):1109-18. doi:
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Clinical pharmacology and therapeutics.
1995 Oct; 58(4):390-8. doi:
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Journal of clinical psychopharmacology.
1995 Oct; 15(5):320-6. doi:
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Journal of clinical pharmacology.
1995 Oct; 35(10):974-84. doi:
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Journal of clinical pharmacology.
1995 Aug; 35(8):830-9. doi:
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British journal of clinical pharmacology.
1995 Aug; 40(2):161-5. doi:
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Journal of clinical pharmacology.
1995 Jul; 35(7):730-8. doi:
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Journal of clinical psychopharmacology.
1995 Feb; 15(1):30-40. doi:
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Life sciences.
1995; 57(24):PL373-80. doi:
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European journal of clinical pharmacology.
1995; 49(3):221-8. doi:
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