nalbuphine (BioDeep_00000405953)
Main id: BioDeep_00000002835
代谢物信息卡片
nalbuphine
化学式: C21H27NO4 (357.19399820000007)
中文名称: 纳布啡
谱图信息:
最多检出来源 Homo sapiens(blood) 6.25%
分子结构信息
SMILES: C(C1)CC1CN(C6)C(C4)C(O)(C5)C(C6)(C(C(O)C5)2)c(c34)c(c(O)cc3)O2
InChI: InChI=1S/C21H27NO4/c23-14-5-4-13-10-16-21(25)7-6-15(24)19-20(21,17(13)18(14)26-19)8-9-22(16)11-12-2-1-3-12/h4-5,12,15-16,19,23-25H,1-3,6-11H2/t15-,16+,19-,20-,21+/m0/s1
描述信息
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D009294 - Narcotics
D002492 - Central Nervous System Depressants > D009294 - Narcotics > D053610 - Opiate Alkaloids
N - Nervous system > N02 - Analgesics > N02A - Opioids > N02AF - Morphinan derivatives
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
C78272 - Agent Affecting Nervous System > C67413 - Opioid Receptor Agonist
D002491 - Central Nervous System Agents > D000700 - Analgesics
同义名列表
1 个代谢物同义名
数据库引用编号
18 个数据库交叉引用编号
- ChEBI: CHEBI:7454
- KEGG: C07251
- KEGGdrug: D08246
- PubChem: 5311304
- DrugBank: DB00844
- ChEMBL: CHEMBL895
- MeSH: Nalbuphine
- CAS: 20594-83-6
- MoNA: WA001518
- MoNA: WA001517
- MoNA: WA001516
- MoNA: WA001515
- MoNA: WA001514
- MoNA: FiehnHILIC002167
- MoNA: FiehnHILIC000599
- PubChem: 9460
- NIKKAJI: J14.212C
- RefMet: Nalbuphine
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Shylo R Johnson, Christine K Ellis, Chad K Wickham, Molly R Selleck, Amy T Gilbert. Comparison of Ketamine-Xylazine, Butorphanol-Azaperone-Medetomidine, and Nalbuphine-Medetomidine-Azaperone for Raccoon (Procyon Lotor) Immobilization.
Journal of wildlife diseases.
2023 Nov; ?(?):. doi:
10.7589/jwd-d-23-00060. [PMID: 37924235] - Wei Shi, Jing Dong, Jian-Feng Chen, Hai Yu. A meta-analysis showing the quantitative evidence base of perineural nalbuphine for wound pain from upper-limb orthopaedic trauma surgery.
International wound journal.
2023 May; 20(5):1476-1490. doi:
10.1111/iwj.14002. [PMID: 36330591] - Meng-Si Luo. Nalbuphine reduces the incidence of emergence agitation in children undergoing adenotonsillectomy.
Journal of clinical anesthesia.
2023 Apr; 87(?):111115. doi:
10.1016/j.jclinane.2023.111115. [PMID: 37018929] - Bingxu Ren, Jiannan Zhang, Xiaohu Yang, Dapeng Sun, Duanyang Sheng, Qiang Fang, Zhonghua Ji. Co-Administration of nalbuphine to improve morphine tolerance in mice with bone cancer pain.
Molecular pain.
2023 Jan; 19(?):17448069231178741. doi:
10.1177/17448069231178741. [PMID: 37226458] - Chenran Wang, Shen Sun, Jing Jiao, Xinhua Yu, Shaoqiang Huang. Effects of nalbuphine on the cardiotoxicity of ropivacaine in rats.
Fundamental & clinical pharmacology.
2022 Oct; 36(5):811-817. doi:
10.1111/fcp.12778. [PMID: 35373856] - Dijiao Ruan, Yuanyuan Wang, Sisi Li, Chao Zhang, Wenwen Zheng, Cong Yu. Nalbuphine alleviates inflammation by down-regulating NF-κB in an acute inflammatory visceral pain rat model.
BMC pharmacology & toxicology.
2022 06; 23(1):34. doi:
10.1186/s40360-022-00573-7. [PMID: 35642022] - Jing Dong, Yi-Feng Ren, Meng-Ling Wei, Xin Ye, Xiao-Yun Peng, Long-Fei Zhang, Fang Li, Wei Shi. Re-evaluating the clinical efficacy of intrathecal nalbuphine: Based on minimal clinically important difference and statistical threshold correction.
Pain practice : the official journal of World Institute of Pain.
2022 04; 22(4):497-499. doi:
10.1111/papr.13104. [PMID: 35178877] - Mahmoud Agami, Rasha A Shaalan, Saied F Belal, Marwa A A Ragab. LC-MS bioanalysis of targeted nasal galantamine bound chitosan nanoparticles in rats' brain homogenate and plasma.
Analytical and bioanalytical chemistry.
2021 Aug; 413(20):5181-5191. doi:
10.1007/s00216-021-03487-1. [PMID: 34173038] - Kun He, Wei Ji, Hengli Zhao, Yilin Wei, Shaomei Yang, Qing Wen. Pharmacokinetic comparison of nalbuphine with single injection and patient-controlled analgesia mimic method in healthy Chinese volunteers.
Journal of clinical pharmacy and therapeutics.
2021 Aug; 46(4):1166-1172. doi:
10.1111/jcpt.13421. [PMID: 33942343] - Xingfeng Sun, Qun Zhou, Min Zhou, Rong Cao, Zuolei Chen, Songjiang Tang, Shaoqiang Huang. The Effect of Epidural Nalbuphine Combined With Ropivacaine on Epidural Analgesia During Labor: A Multicenter, Randomized, Double-blind, Controlled Study.
The Clinical journal of pain.
2021 06; 37(6):437-442. doi:
10.1097/ajp.0000000000000928. [PMID: 33758132] - Shang-Wen Lin, Yan-Jye Shyong, Ping-Chung Kuo, Jui-Chen Tsai. Topical application of sebacoyl dinalbuphine ester-loaded nanostructured lipid carriers alleviate pruritus in scratching mouse model.
International journal of pharmaceutics.
2021 May; 600(?):120400. doi:
10.1016/j.ijpharm.2021.120400. [PMID: 33636328] - Kushagra Khanna, Nitin Sharma, Sonalika Rawat, Nazia Khan, Ritu Karwasra, Nazeer Hasan, Abhishek Kumar, Gaurav Kumar Jain, Dhruv Kumar Nishad, Sakshum Khanna, Harvinder Popli, Aseem Bhatnagar. Intranasal solid lipid nanoparticles for management of pain: A full factorial design approach, characterization & Gamma Scintigraphy.
Chemistry and physics of lipids.
2021 05; 236(?):105060. doi:
10.1016/j.chemphyslip.2021.105060. [PMID: 33582127] - Michael Voronkov, Georgiy Nikonov, Roman Naumov, John Abernethy, Levon Isakulyan. NB-33, a bioreversible opioid derivative of Nalbuphine, shows enhanced pharmacodynamics.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2021 Apr; 159(?):105734. doi:
10.1016/j.ejps.2021.105734. [PMID: 33515698] - Jia-Wei Chen, Lin Tian, Le Zhang, Jian-Ying Hu, Shao-Qiang Huang, Jing Jiao. Nalbuphine on postoperative gastrointestinal tract dysfunction after laparoscopic surgery for gynaecological malignancies: A randomized controlled trial.
Clinical and experimental pharmacology & physiology.
2021 02; 48(2):170-176. doi:
10.1111/1440-1681.13421. [PMID: 33063882] - Yifeng Ren, Hong Liu, Yuting Wang, Xi Fu, Fengming You. Efficacy of Nalbuphine as an Adjuvant to Ropivacaine in Ultrasound-guided Supraclavicular Brachial Block: A Prospective Randomized Controlled Study.
The Clinical journal of pain.
2021 02; 37(2):158-159. doi:
10.1097/ajp.0000000000000899. [PMID: 33165020] - Lining Wu, Junma Yu, Qiuyue Wang, Yao Lu. Effects of nalbuphine on the cardioprotective effect of morphine in rats.
International journal of cardiology.
2021 01; 322(?):207-210. doi:
10.1016/j.ijcard.2020.08.064. [PMID: 32828962] - Changcheng Jiang, Wenji Xie, Huijuan Xie, Wenqin Xie, Zhenming Kang, Naizhen Liu. Nalbuphine Exhibited a Better Adjuvant Than Dexmedetomidine in Supraclavicular Brachial Plexus Block in Youths.
Clinical neuropharmacology.
2020 Sep; 43(5):134-138. doi:
10.1097/wnf.0000000000000410. [PMID: 32947423] - Yajing Dong, Zhi Liang, Zhe Xu, Wei Hao, Dandan Wang, Shuping Huo, Huayu Zhao. Effects of dezocine, morphine and nalbuphine on electropain threshold, temperature pain threshold and cardiac function in rats with myocardial ischemia.
Annals of palliative medicine.
2020 Jul; 9(4):1556-1563. doi:
10.21037/apm-19-460. [PMID: 32762221] - Meng Ying Xi, Si Si Li, Chao Zhang, Lin Zhang, Tao Wang, Cong Yu. Nalbuphine for Analgesia After Orthognathic Surgery and Its Effect on Postoperative Inflammatory and Oxidative Stress: A Randomized Double-Blind Controlled Trial.
Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons.
2020 Apr; 78(4):528-537. doi:
10.1016/j.joms.2019.10.017. [PMID: 31785250] - Mona E El Sharkasy, M Walash, F Belal, M M Salim. Conventional and first derivative synchronous spectrofluorimetric methods for the simultaneous determination of cisatracurium and nalbuphine in biological fluids.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2020 Mar; 228(?):117841. doi:
10.1016/j.saa.2019.117841. [PMID: 31784219] - Ren-Jong Liang, Yin-Ning Shih, Yen-Lun Chen, Wei-Yang Liu, Wan-Ling Yang, Shih-Yu Lee, Hong-Jaan Wang. A dual system platform for drug metabolism: Nalbuphine as a model compound.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2020 Jan; 141(?):105093. doi:
10.1016/j.ejps.2019.105093. [PMID: 31648049] - Mansour Sobeh, Samar Rezq, Omar M Sabry, Mohamed A O Abdelfattah, Mohamed A El Raey, Walaa A El-Kashak, Assem M El-Shazly, Mona F Mahmoud, Michael Wink. Albizia anthelmintica: HPLC-MS/MS profiling and in vivo anti-inflammatory, pain killing and antipyretic activities of its leaf extract.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2019 Jul; 115(?):108882. doi:
10.1016/j.biopha.2019.108882. [PMID: 31029001] - Pamela D Reiter, Amy C Clevenger. Nalbuphine Reduces Opioid-Associated Urinary Retention in Pediatric Patients.
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies.
2019 05; 20(5):e240-e244. doi:
10.1097/pcc.0000000000001920. [PMID: 31013261] - Abdisamad M Ibrahim, Zainab Obaidi, Gordon Ruan, Dorcas Adaramola, Sharon Onguti. Nalbuphine for Opioid-Induced Urine Retention.
Annals of internal medicine.
2018 12; 169(12):894-895. doi:
10.7326/l18-0387. [PMID: 30178006] - Radomir Reszke, Jacek C Szepietowski. End-Stage Renal Disease Chronic Itch and Its Management.
Dermatologic clinics.
2018 Jul; 36(3):277-292. doi:
10.1016/j.det.2018.02.007. [PMID: 29929599] - F Belal, F Ibrahim, Z A Sheribah, H Alaa. New spectrophotometric/chemometric assisted methods for the simultaneous determination of imatinib, gemifloxacin, nalbuphine and naproxen in pharmaceutical formulations and human urine.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2018 Jun; 198(?):51-60. doi:
10.1016/j.saa.2018.02.048. [PMID: 29518680] - Lisa L Wolfe, Pauline Nol, Matthew P McCollum, Travis Mays, Morgan E Wehtje, William R Lance, Mark C Fisher, Michael W Miller. Tissue Residue Levels after Immobilization of Rocky Mountain Elk ( Cervus elaphus nelsoni) using a Combination of Nalbuphine, Medetomidine, and Azaperone Antagonized with Naltrexone, Atipamezole, and Tolazoline.
Journal of wildlife diseases.
2018 04; 54(2):362-365. doi:
10.7589/2017-06-132. [PMID: 29148888] - Brenda L Kick, Pan Shu, Bo Wen, Duxin Sun, Douglas K Taylor. Pharmacokinetic Profiles of Nalbuphine after Intraperitoneal and Subcutaneous Administration to C57BL/6 Mice.
Journal of the American Association for Laboratory Animal Science : JAALAS.
2017 Sep; 56(5):534-538. doi:
NULL. [PMID: 28903824] - Lisa L Wolfe, Mary E Wood, Pauline Nol, Matthew P McCollum, Mark C Fisher, William R Lance. THE EFFICACY OF NALBUPHINE, MEDETOMIDINE, AND AZAPERONE IN IMMOBILIZING AMERICAN BISON (BISON BISON).
Journal of wildlife diseases.
2017 04; 53(2):304-310. doi:
10.7589/2016-05-107. [PMID: 28051569] - Lisa F Potts, Eun S Park, Jong-Min Woo, Bhagya L Dyavar Shetty, Arun Singh, Steven P Braithwaite, Michael Voronkov, Stella M Papa, M Maral Mouradian. Dual κ-agonist/μ-antagonist opioid receptor modulation reduces levodopa-induced dyskinesia and corrects dysregulated striatal changes in the nonhuman primate model of Parkinson disease.
Annals of neurology.
2015 Jun; 77(6):930-41. doi:
10.1002/ana.24375. [PMID: 25820831] - Amale Hawi, Harry Alcorn, Jolene Berg, Carey Hines, Howard Hait, Thomas Sciascia. Pharmacokinetics of nalbuphine hydrochloride extended release tablets in hemodialysis patients with exploratory effect on pruritus.
BMC nephrology.
2015 Apr; 16(?):47. doi:
10.1186/s12882-015-0043-3. [PMID: 25885112] - Hong-Jaan Wang, Cheng-Huei Hsiong, Shung-Tai Ho, Min-Jen Lin, Tung-Yuan Shih, Pei-Wei Huang, Oliver Yoa-Pu Hu. Commonly used excipients modulate UDP-glucuronosyltransferase 2b7 activity to improve nalbuphine oral bioavailability in humans.
Pharmaceutical research.
2014 Jul; 31(7):1676-88. doi:
10.1007/s11095-013-1272-4. [PMID: 24526241] - J F Coetzee, K F Lechtenberg, M L Stock, B Kukanich. Pharmacokinetics and effect of intravenous nalbuphine in weaned Holstein calves after surgical castration.
Journal of veterinary pharmacology and therapeutics.
2014 Apr; 37(2):169-77. doi:
10.1111/jvp.12077. [PMID: 23931676] - Pei-Wei Huang, Hung-Ta Liu, Cheng-Huei Hsiong, Li-Heng Pao, Chih-Cherng Lu, Shung-Tai Ho, Oliver Yoa-Pu Hu. Simultaneous determination of nalbuphine and its prodrug sebacoly dinalbuphine ester in human plasma by ultra-performance liquid chromatography-tandem mass spectrometry and its application to pharmacokinetic study in humans.
Biomedical chromatography : BMC.
2013 Jul; 27(7):831-7. doi:
10.1002/bmc.2867. [PMID: 23460034] - Laizuman Nahar, Fatema Nasrin, Ronok Zahan, Md Ashik Mosaddik. Anti-nociceptive and anti-inflammatory activities of Wrightia arborea.
Pakistan journal of biological sciences : PJBS.
2013 May; 16(10):485-90. doi:
10.3923/pjbs.2013.485.490. [PMID: 24498815] - David Sanchez-Migallon Guzman, Butch KuKanich, Timothy D Heath, Lisa A Krugner-Higby, Steven A Barker, Carolyn S Brown, Joanne R Paul-Murphy. Pharmacokinetics of long-acting nalbuphine decanoate after intramuscular administration to Hispaniolan Amazon parrots (Amazona ventralis).
American journal of veterinary research.
2013 Feb; 74(2):191-5. doi:
10.2460/ajvr.74.2.191. [PMID: 23363341] - Li-Jing Cai, Jun Zhang, Xiu-Mei Wang, R H Zhu, Jian Yang, Qi-Zhi Zhang, W X Peng. Validated LC-MS/MS assay for the quantitative determination of nalbuphine in human plasma and its application to a pharmacokinetic study.
Biomedical chromatography : BMC.
2011 Dec; 25(12):1308-14. doi:
10.1002/bmc.1601. [PMID: 21337353] - Yasuto Kido, Pär Matsson, Kathleen M Giacomini. Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2.
Journal of medicinal chemistry.
2011 Jul; 54(13):4548-58. doi:
10.1021/jm2001629. [PMID: 21599003] - Dominique L Keller, David Sanchez-Migallon Guzman, Julia M Klauer, Butch KuKanich, Steven A Barker, Julia Rodríguez-Ramos Fernández, Joanne R Paul-Murphy. Pharmacokinetics of nalbuphine hydrochloride after intravenous and intramuscular administration to Hispaniolan Amazon parrots (Amazona ventralis).
American journal of veterinary research.
2011 Jun; 72(6):741-5. doi:
10.2460/ajvr.72.6.741. [PMID: 21627518] - C Dadure, S Bringuier, O Mathieu, O Raux, A Rochette, N Canaud, W Javitary, X Capdevila. [Continuous epidural block versus continuous psoas compartment block for postoperative analgesia after major hip or femoral surgery in children: a prospective comparative randomized study].
Annales francaises d'anesthesie et de reanimation.
2010 Sep; 29(9):610-5. doi:
10.1016/j.annfar.2010.05.033. [PMID: 20634030] - Joy Allee, Joseph D Tobias. Perioperative care of a child with non-ketotic hyperglycinemia.
Saudi journal of anaesthesia.
2010 Sep; 4(3):197-201. doi:
10.4103/1658-354x.71578. [PMID: 21189859] - Cynthia A Wong. Advances in labor analgesia.
International journal of women's health.
2010 Aug; 1(?):139-54. doi:
10.2147/ijwh.s4553. [PMID: 21072284] - David Calderón Guzmán, Norma Labra Ruiz, Ernestina Hernández García, Hugo Juárez Olguín. Levels of 5-hydroxyindol acetic acid and lipid peroxidation in brain after administration of marijuana and nalbuphine in male and female rat.
Proceedings of the Western Pharmacology Society.
2010; 53(?):20-5. doi:
. [PMID: 22128445] - Manthena V S Varma, Bo Feng, R Scott Obach, Matthew D Troutman, Jonathan Chupka, Howard R Miller, Ayman El-Kattan. Physicochemical determinants of human renal clearance.
Journal of medicinal chemistry.
2009 Aug; 52(15):4844-52. doi:
10.1021/jm900403j. [PMID: 19445515] - E J Cobos, J M Entrena, F R Nieto, C M Cendán, E Del Pozo. Pharmacology and therapeutic potential of sigma(1) receptor ligands.
Current neuropharmacology.
2008 Dec; 6(4):344-66. doi:
10.2174/157015908787386113. [PMID: 19587856] - R Scott Obach, Franco Lombardo, Nigel J Waters. Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Drug metabolism and disposition: the biological fate of chemicals.
2008 Jul; 36(7):1385-405. doi:
10.1124/dmd.108.020479. [PMID: 18426954] - Bharti Sapra, Subheet Jain, A K Tiwary. Percutaneous permeation enhancement by terpenes: mechanistic view.
The AAPS journal.
2008; 10(1):120-32. doi:
10.1208/s12248-008-9012-0. [PMID: 18446512] - Nathalie V Goletiani, Jack H Mendelson, Michelle B Sholar, Arthur J Siegel, Alicja Skupny, Nancy K Mello. Effects of nalbuphine on anterior pituitary and adrenal hormones and subjective responses in male cocaine abusers.
Pharmacology, biochemistry, and behavior.
2007 Apr; 86(4):667-77. doi:
10.1016/j.pbb.2007.02.012. [PMID: 17391744] - F Klinzig, E Vinner, C Brassart, E Houdain, L Humbert, M Lhermitte. Hair analysis by LC-MS as evidence of nalbuphine abuse by a nurse.
Journal of analytical toxicology.
2007 Jan; 31(1):62-5. doi:
10.1093/jat/31.1.62. [PMID: 17389085] - Jhi-Joung Wang, K C Sung, Oliver Yoa-Pu Hu, Chih-Hui Yeh, Jia-You Fang. Submicron lipid emulsion as a drug delivery system for nalbuphine and its prodrugs.
Journal of controlled release : official journal of the Controlled Release Society.
2006 Oct; 115(2):140-9. doi:
10.1016/j.jconrel.2006.07.023. [PMID: 16959357] - Parham Gharagozlou, Ezzat Hashemi, Timothy M DeLorey, J David Clark, Jelveh Lameh. Pharmacological profiles of opioid ligands at kappa opioid receptors.
BMC pharmacology.
2006 Jan; 6(?):3. doi:
10.1186/1471-2210-6-3. [PMID: 16433932] - Wenfang B Fang, David M Andrenyak, David E Moody, Elie S Nuwayser. Determination of nalmefene by high-performance liquid chromatography-electrospray ionization-tandem mass spectrometry.
Journal of analytical toxicology.
2005 Apr; 29(3):169-74. doi:
10.1093/jat/29.3.169. [PMID: 15842759] - Li-Heng Pao, Cheng-Huei Hsiong, Oliver Yoa-Pu Hu, Jhi-Jung Wang, Shung-Tai Ho. In vitro and in vivo evaluation of the metabolism and pharmacokinetics of sebacoyl dinalbuphine.
Drug metabolism and disposition: the biological fate of chemicals.
2005 Mar; 33(3):395-402. doi:
10.1124/dmd.104.002451. [PMID: 15608131] - Nancy K Mello, Jack H Mendelson, Michelle B Sholar, Maria Jaszyna-Gasior, Nathalie Goletiani, Arthur J Siegel. Effects of the mixed mu/kappa opioid nalbuphine on cocaine-induced changes in subjective and cardiovascular responses in men.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.
2005 Mar; 30(3):618-32. doi:
10.1038/sj.npp.1300631. [PMID: 15602503] - Shiou-Lan Chen, Eagle Yi-Kung Huang, Lok-Hi Chow, Pao-Luh Tao. Dextromethorphan differentially affects opioid antinociception in rats.
British journal of pharmacology.
2005 Feb; 144(3):400-4. doi:
10.1038/sj.bjp.0706086. [PMID: 15655510] - L M Malavasi, H Augustsson, M Jensen-Waern, G Nyman. The effect of transdermal delivery of fentanyl on activity in growing pigs.
Acta veterinaria Scandinavica.
2005; 46(3):149-57. doi:
10.1186/1751-0147-46-149. [PMID: 16261927] - Heesun Chung. Role of drug testing as an early warning programme: the experience of the Republic of Korea.
Bulletin on narcotics.
2005; 57(1-2):231-48. doi:
NULL. [PMID: 21338024] - Pekka Suomalainen, Christoffer Johans, Tim Söderlund, Paavo K J Kinnunen. Surface activity profiling of drugs applied to the prediction of blood-brain barrier permeability.
Journal of medicinal chemistry.
2004 Mar; 47(7):1783-8. doi:
10.1021/jm0309001. [PMID: 15027870] - Fang-I Liu, J H Kuo, K C Sung, Oliver Y P Hu. Biodegradable polymeric microspheres for nalbuphine prodrug controlled delivery: in vitro characterization and in vivo pharmacokinetic studies.
International journal of pharmaceutics.
2003 May; 257(1-2):23-31. doi:
10.1016/s0378-5173(03)00110-8. [PMID: 12711158] - Parham Gharagozlou, Hasan Demirci, J David Clark, Jelveh Lameh. Activation profiles of opioid ligands in HEK cells expressing delta opioid receptors.
BMC neuroscience.
2002 Nov; 3(?):19. doi:
10.1186/1471-2202-3-19. [PMID: 12437765] - Alaa El-Ghoneimi, Christian Deffarges, Regis Hankard, Fontan Jean-Eudes, Yves Aigrain, Evelyne Jacqz-Aigrain. Intravesical morphine analgesia is not effective after bladder surgery in children: results of a randomied double-blind study.
The Journal of urology.
2002 Aug; 168(2):694-7. doi:
NULL. [PMID: 12131352] - Musa Sesay, Vincent Dousset, Dominique Liguoro, Fabienne Péhourcq, Jean-Marie Caillé, Pierre Maurette. Intraosseous lidocaine provides effective analgesia for percutaneous vertebroplasty of osteoporotic fractures.
Canadian journal of anaesthesia = Journal canadien d'anesthesie.
2002 Feb; 49(2):137-43. doi:
10.1007/bf03020485. [PMID: 11823390] - S Y Yen, K C Sung, J J Wang, O Yoa-Pu Hu. Controlled release of nalbuphine propionate from biodegradable microspheres: in vitro and in vivo studies.
International journal of pharmaceutics.
2001 Jun; 220(1-2):91-9. doi:
10.1016/s0378-5173(01)00649-4. [PMID: 11376971] - L H Pao, C H Hsiong, O Y Hu, S T Ho. High-performance liquid chromatographic method for the simultaneous determination of nalbuphine and its prodrug, sebacoyl dinalbuphine ester, in dog plasma and application to pharmacokinetic studies in dogs.
Journal of chromatography. B, Biomedical sciences and applications.
2000 Sep; 746(2):241-7. doi:
10.1016/s0378-4347(00)00326-1. [PMID: 11076077] - K C Sung, J Y Fang, O Y Hu. Delivery of nalbuphine and its prodrugs across skin by passive diffusion and iontophoresis.
Journal of controlled release : official journal of the Controlled Release Society.
2000 Jun; 67(1):1-8. doi:
10.1016/s0168-3659(99)00269-2. [PMID: 10773323] - J A Vivian, M B DeYoung, T L Sumpter, J R Traynor, J W Lewis, J H Woods. kappa-Opioid receptor effects of butorphanol in rhesus monkeys.
The Journal of pharmacology and experimental therapeutics.
1999 Jul; 290(1):259-65. doi:
NULL. [PMID: 10381785] - Y Nishida, I Sugimoto, H Morita, H Murakami, H Hosomi, V S Bishop. Suppression of renal sympathetic nerve activity during portal vein infusion of hypertonic saline.
The American journal of physiology.
1998 01; 274(1):R97-103. doi:
10.1152/ajpregu.1998.274.1.r97. [PMID: 9458904] - E Nicolle, S Veitl, C Guimier, G Bessard. Modified method of nalbuphine determination in plasma: validation and application to pharmacokinetics of the rectal route.
Journal of chromatography. B, Biomedical sciences and applications.
1997 Mar; 690(1-2):89-97. doi:
10.1016/s0378-4347(96)00369-6. [PMID: 9106032] - F de Cazanove, J M Kinowski, M Audran, A Rochette, F Bressolle. Determination of nalbuphine in human plasma by high-performance liquid chromatography with electrochemical detection. Application to a pharmacokinetic study.
Journal of chromatography. B, Biomedical sciences and applications.
1997 Mar; 690(1-2):203-10. doi:
10.1016/s0378-4347(96)00374-x. [PMID: 9106045] - G Bessard, J P Alibeu, M Cartal, E Nicolle, F Serre Debeauvais, P Devillier. Pharmacokinetics of intrarectal nalbuphine in children undergoing general anaesthesia.
Fundamental & clinical pharmacology.
1997; 11(2):133-7. doi:
10.1111/j.1472-8206.1997.tb00180.x. [PMID: 9107559] - S T Ho, J J Wang, O Y Hu, P S Chiang, S C Lee. Determination of nalbuphine by high-performance liquid chromatography with ultraviolet detection: application to human and rabbit pharmacokinetic studies.
Journal of chromatography. B, Biomedical applications.
1996 Apr; 678(2):289-96. doi:
10.1016/0378-4347(95)00477-7. [PMID: 8738033] - E Nicolle, P Devillier, B Delanoy, C Durand, G Bessard. Therapeutic monitoring of nalbuphine: transplacental transfer and estimated pharmacokinetics in the neonate.
European journal of clinical pharmacology.
1996; 49(6):485-9. doi:
10.1007/bf00195935. [PMID: 8706774] - S T Ho, J J Wang, O Y Hu, T M Hu. The effect of aging on the pharmacokinetics of nalbuphine in rabbits.
Biopharmaceutics & drug disposition.
1995 Nov; 16(8):695-703. doi:
10.1002/bdd.2510160808. [PMID: 8573688] - A Doenicke, J Moss, W Lorenz, R Hoernecke. Intravenous morphine and nalbuphine increase histamine and catecholamine release without accompanying hemodynamic changes.
Clinical pharmacology and therapeutics.
1995 Jul; 58(1):81-9. doi:
10.1016/0009-9236(95)90075-6. [PMID: 7543038] - Y C Yoo, H S Chung, I S Kim, W T Jin, M K Kim. Determination of nalbuphine in drug abusers' urine.
Journal of analytical toxicology.
1995 Mar; 19(2):120-3. doi:
10.1093/jat/19.2.120. [PMID: 7769781] - E Nicolle, S Michaut, F Serre-Debeauvais, G Bessard. Rapid and sensitive high-performance liquid chromatographic assay for nalbuphine in plasma.
Journal of chromatography. B, Biomedical applications.
1995 Jan; 663(1):111-7. doi:
10.1016/0378-4347(94)00437-a. [PMID: 7704197] - M Hoehe, T Duka. Opiates increase plasma catecholamines in humans.
Psychoneuroendocrinology.
1993; 18(2):141-8. doi:
10.1016/0306-4530(93)90065-s. [PMID: 8388112] - P Kintz, A Tracqui, P Mangin. Determination of nalbuphine using high-performance liquid chromatography coupled to photodiode-array detection and gas chromatography coupled to mass spectrometry.
Journal of chromatography.
1992 Aug; 579(1):172-6. doi:
10.1016/0378-4347(92)80376-2. [PMID: 1447345] - W Dick, W Lorenz, D Heintz, H Sitter, A Doenicke. [Histamine release during induction of combination anesthesia using nalbuphine or fentanyl. Modulation of the reaction by premedication with promethazine/pethidine].
Der Anaesthesist.
1992; 41(5):239-47. doi:
NULL. [PMID: 1377455] - B M Weiss, E R Schmid, R I Gattiker. Comparison of nalbuphine and fentanyl anesthesia for coronary artery bypass surgery. Hemodynamics, hormonal response, and postoperative respiratory depression.
Anesthesia and analgesia.
1991 Nov; 73(5):521-9. doi:
10.1213/00000539-199111000-00002. [PMID: 1952130] - A D Baxter, S Langanière, B Samson, I J McGilveray, K Hull. A dose-response study of nalbuphine for post-thoracotomy epidural analgesia.
Canadian journal of anaesthesia = Journal canadien d'anesthesie.
1991 Mar; 38(2):175-82. doi:
10.1007/bf03008140. [PMID: 2021986] - Y Q Xu, H J Fang, Y X Xu, H J Duan, Y Wu. [Studies on the analysis of anileridine, levorphanol, nalbuphine and ethamivan in urine].
Yao xue xue bao = Acta pharmaceutica Sinica.
1991; 26(8):606-10. doi:
. [PMID: 1805523] - P A Flecknell, J H Liles. The effects of surgical procedures, halothane anaesthesia and nalbuphine on locomotor activity and food and water consumption in rats.
Laboratory animals.
1991 Jan; 25(1):50-60. doi:
10.1258/002367791780808239. [PMID: 2010976] - C A Mills, J W Flacke, W E Flacke, B C Bloor, M D Liu. Narcotic reversal in hypercapnic dogs: comparison of naloxone and nalbuphine.
Canadian journal of anaesthesia = Journal canadien d'anesthesie.
1990 Mar; 37(2):238-44. doi:
10.1007/bf03005476. [PMID: 2311152] - NULL. [Cumulative pharmacokinetics and clinical effects of nalbuphine in patients in the postoperative phase. An open multicenter study].
Arzneimittel-Forschung.
1989 Jun; 39(6):724-7. doi:
NULL. [PMID: 2673253] - V O Fuentes. Effect of naloxone, nalbuphine, progesterone and pregnant mare's serum gonadotrophin on the sexual behaviour of ewes.
The Veterinary record.
1989 Mar; 124(11):274-6. doi:
10.1136/vr.124.11.274. [PMID: 2523615] - G Pandèle, Y Nivoche, J Marty, J M Desmonts. [Comparison of nalbuphine and pentazocine in the treatment of postoperative pain by self-administration].
Annales francaises d'anesthesie et de reanimation.
1989; 8(2):85-9. doi:
10.1016/s0750-7658(89)80157-1. [PMID: 2660640] - N Wetzelsberger, P W Lücker, W Erking. Internally standardized method for the determination of nalbuphine in human plasma by means of high performance liquid chromatography with electrochemical coulometric detection.
Arzneimittel-Forschung.
1988 Dec; 38(12):1768-71. doi:
NULL. [PMID: 3245848] - J C Harrelson, Y J Wong. Species variation in the disposition of nalbuphine and its acetylsalicylate ester analogue.
Xenobiotica; the fate of foreign compounds in biological systems.
1988 Nov; 18(11):1239-47. doi:
10.3109/00498258809042247. [PMID: 3245223] - A Wischnik, N Wetzelsberger, P W Lücker. [Elimination of nalbuphine in human milk].
Arzneimittel-Forschung.
1988 Oct; 38(10):1496-8. doi:
NULL. [PMID: 3196391] - S M Muldoon, J E McKenzie, F J Collins. Pressor effect of nalbuphine in hemorrhagic shock is dependent on the sympathoadrenal system.
Circulatory shock.
1988 Sep; 26(1):89-98. doi:
. [PMID: 2847883] - U Saarialho-Kere. Psychomotor, respiratory and neuroendocrinological effects of nalbuphine and haloperidol, alone and in combination, in healthy subjects.
British journal of clinical pharmacology.
1988 Jul; 26(1):79-87. doi:
10.1111/j.1365-2125.1988.tb03367.x. [PMID: 3060191] - L M Dubé, N Beaudoin, M Lalande, I J McGilveray. Determination of nalbuphine by high-performance liquid chromatography with electrochemical detection: application to clinical samples from postoperative patients.
Journal of chromatography.
1988 May; 427(1):113-20. doi:
10.1016/0378-4347(88)80109-9. [PMID: 3410891] - R S Jaffe, C C Moldenhauer, C C Hug, D C Finlayson, V Tobia, M E Kopel. Nalbuphine antagonism of fentanyl-induced ventilatory depression: a randomized trial.
Anesthesiology.
1988 Feb; 68(2):254-60. doi:
10.1097/00000542-198802000-00012. [PMID: 3277486] - A R Aitkenhead, E S Lin, K J Achola. The pharmacokinetics of oral and intravenous nalbuphine in healthy volunteers.
British journal of clinical pharmacology.
1988 Feb; 25(2):264-8. doi:
10.1111/j.1365-2125.1988.tb03300.x. [PMID: 3358889] - M W Lo, W L Schary, C C Whitney. The disposition and bioavailability of intravenous and oral nalbuphine in healthy volunteers.
Journal of clinical pharmacology.
1987 Nov; 27(11):866-73. doi:
10.1002/j.1552-4604.1987.tb05581.x. [PMID: 3429694] - G C Pugh, G B Drummond. A dose-response study with nalbuphine hydrochloride for pain in patients after upper abdominal surgery.
British journal of anaesthesia.
1987 Nov; 59(11):1356-63. doi:
10.1093/bja/59.11.1356. [PMID: 3689610] - E K Zsigmond, A P Winnie, S M Raza, X Y Wang, E Barabas. Nalbuphine as an analgesic component in balanced anesthesia for cardiac surgery.
Anesthesia and analgesia.
1987 Nov; 66(11):1155-64. doi:
NULL. [PMID: 3499096] - E K Zsigmond, Z Durrani, E Barabas, X Y Wang, L Tran. Endocrine and hemodynamic effects of antagonism of fentanyl-induced respiratory depression by nalbuphine.
Anesthesia and analgesia.
1987 May; 66(5):421-6. doi:
10.1213/00000539-198705000-00009. [PMID: 3578849]