Miglitol (BioDeep_00000405906)
Main id: BioDeep_00000002075
natural product
代谢物信息卡片
Miglitol
化学式: C8H17NO5 (207.1107)
中文名称: 米格列醇
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C(CO)N1C[C@@H]([C@H]([C@@H]([C@H]1CO)O)O)O
InChI: InChI=1S/C8H17NO5/c10-2-1-9-3-6(12)8(14)7(13)5(9)4-11/h5-8,10-14H,1-4H2/t5-,6+,7-,8-/m1/s1
描述信息
A - Alimentary tract and metabolism > A10 - Drugs used in diabetes > A10B - Blood glucose lowering drugs, excl. insulins > A10BF - Alpha glucosidase inhibitors
D007004 - Hypoglycemic Agents > D065089 - Glycoside Hydrolase Inhibitors
C471 - Enzyme Inhibitor > C2846 - Glucosidase Inhibitor
D004791 - Enzyme Inhibitors
同义名列表
数据库引用编号
18 个数据库交叉引用编号
- ChEBI: CHEBI:6935
- KEGG: C07708
- KEGG: C76308
- KEGGdrug: D00625
- PubChem: 441314
- DrugBank: DB00491
- ChEMBL: CHEMBL1561
- CAS: 1204250-58-7
- CAS: 72432-03-2
- MoNA: FiehnHILIC002105
- MoNA: FiehnHILIC001334
- MoNA: FiehnHILIC000532
- PubChem: 9910
- PDB-CCD: MIG
- NIKKAJI: J22.799D
- RefMet: Miglitol
- KNApSAcK: 6935
- LOTUS: LTS0233179
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
9 个相关的物种来源信息
- 2759 - Eukaryota: LTS0233179
- 43500 - Hintonia: LTS0233179
- 43501 - Hintonia latiflora: 10.1021/NP300869G
- 43501 - Hintonia latiflora: LTS0233179
- 3398 - Magnoliopsida: LTS0233179
- 24966 - Rubiaceae: LTS0233179
- 35493 - Streptophyta: LTS0233179
- 58023 - Tracheophyta: LTS0233179
- 33090 - Viridiplantae: LTS0233179
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Parsa Bazdar, Ali R Jalalvand, Vali Akbari, Reza Khodarahmi, Hector C Goicoechea. Resolving interactions of miglitol with normal and glycated human serum albumin by multivariate methods.
Analytical biochemistry.
2021 10; 630(?):114339. doi:
10.1016/j.ab.2021.114339. [PMID: 34411552] - Yasushi Honda, Anna Ozaki, Michihiro Iwaki, Takashi Kobayashi, Asako Nogami, Takaomi Kessoku, Yuji Ogawa, Wataru Tomeno, Kento Imajo, Masato Yoneda, Satoru Saito, Yoji Nagashima, Atsushi Nakajima. Protective effect of SGL5213, a potent intestinal sodium-glucose cotransporter 1 inhibitor, in nonalcoholic fatty liver disease in mice.
Journal of pharmacological sciences.
2021 Oct; 147(2):176-183. doi:
10.1016/j.jphs.2021.07.002. [PMID: 34384565] - Juan Yan, Xiao-Min Li, Yan-Xin Zhang, Su-Mei Xu, Wan-Li Liu, Jie Guo, Xiao-Lei Hu, Ting Zou, Yu-Ying Xu, Ping-Sheng Xu. Bioequivalence and Evaluation Parameters Based on the Pharmacodynamics of Miglitol in Healthy Volunteers.
Clinical pharmacology in drug development.
2021 06; 10(6):582-587. doi:
10.1002/cpdd.873. [PMID: 33058553] - Fumitaka Okajima, Hitoshi Sugihara, Naoya Emoto. Efficacy and Safety of Miglitol- or Repaglinide-Based Combination Therapy with Alogliptin for Drug-Naïve Patients with Type 2 Diabetes: An Open-Label, Single-Center, Parallel, Randomized Controlled Pilot Study.
Journal of Nippon Medical School = Nippon Ika Daigaku zasshi.
2021 Mar; 88(1):71-79. doi:
10.1272/jnms.jnms.2021_88-205. [PMID: 32475902] - Yu-Ying Xu, Su-Mei Xu, Xiao-Min Li, Dai Li, Juan Yan, Ping-Sheng Xu. Validation of the ADVIA Centaur® XP system for the determination of insulin and its application.
Analytical biochemistry.
2020 02; 591(?):113567. doi:
10.1016/j.ab.2019.113567. [PMID: 31881181] - Genki Naruse, Hiromitsu Kanamori, Akihiro Yoshida, Shingo Minatoguchi, Tomonori Kawaguchi, Masamitsu Iwasa, Yoshihisa Yamada, Atsushi Mikami, Masanori Kawasaki, Kazuhiko Nishigaki, Shinya Minatoguchi. The intestine responds to heart failure by enhanced mitochondrial fusion through glucagon-like peptide-1 signalling.
Cardiovascular research.
2019 Nov; 115(13):1873-1885. doi:
10.1093/cvr/cvz002. [PMID: 30629149] - Eun-Young Lee, Xilin Zhang, Junki Miyamoto, Ikuo Kimura, Tomoaki Taknaka, Kenichi Furusawa, Takahito Jomori, Kosuke Fujimoto, Satoshi Uematsu, Takashi Miki. Gut carbohydrate inhibits GIP secretion via a microbiota/SCFA/FFAR3 pathway.
The Journal of endocrinology.
2018 12; 239(3):267-276. doi:
10.1530/joe-18-0241. [PMID: 30400014] - Xiaodan Liu, Jianan Feng, Yan Li. Preparation of carbon-functionalized magnetic graphene/mesoporous silica composites for selective extraction of miglitol and voglibose in rat plasma.
Talanta.
2018 May; 182(?):405-413. doi:
10.1016/j.talanta.2018.01.079. [PMID: 29501171] - Yumi Kishida, Hirofumi Okubo, Haruya Ohno, Kenji Oki, Masayasu Yoneda. Effect of miglitol on the suppression of nonalcoholic steatohepatitis development and improvement of the gut environment in a rodent model.
Journal of gastroenterology.
2017 Nov; 52(11):1180-1191. doi:
10.1007/s00535-017-1331-4. [PMID: 28349245] - Bo-Wei Zhang, Yuan-Bin Sang, Wen-Long Sun, He-Shui Yu, Bai-Ping Ma, Zhi-Long Xiu, Yue-Sheng Dong. Combination of flavonoids from Oroxylum indicum seed extracts and acarbose improves the inhibition of postprandial blood glucose: In vivo and in vitro study.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2017 Jul; 91(?):890-898. doi:
10.1016/j.biopha.2017.04.080. [PMID: 28511342] - Marc Goetz, Anne Guivarćh, Jörg Hirsche, Martin Andreas Bauerfeind, María-Cruz González, Tae Kyung Hyun, Seung Hee Eom, Dominique Chriqui, Thomas Engelke, Dominik K Großkinsky, Thomas Roitsch. Metabolic Control of Tobacco Pollination by Sugars and Invertases.
Plant physiology.
2017 02; 173(2):984-997. doi:
10.1104/pp.16.01601. [PMID: 27923989] - Takeshi Osonoi, Miyoko Saito, Natsuyo Hariya, Moritaka Goto, Kazuki Mochizuki. Add-on therapy with anagliptin in Japanese patients with type-2 diabetes mellitus treated with metformin and miglitol can maintain higher concentrations of biologically active GLP-1/total GIP and a lower concentration of leptin.
Peptides.
2016 12; 86(?):118-125. doi:
10.1016/j.peptides.2016.10.011. [PMID: 27780736] - N Kasahara, H Fukase, Y Ohba, T Saito, K Miyata, S Iida, Y Takano, S Ikeda, M Harigai, K Terao. A Pharmacokinetic/Pharmacodynamic Drug-Drug Interaction Study of Tofogliflozin (a New SGLT2 Inhibitor) and Selected Anti-Type 2 Diabetes Mellitus Drugs.
Drug research.
2016 Feb; 66(2):74-81. doi:
10.1055/s-0035-1549967. [PMID: 26158794] - Sachie Hirose, Yasuyuki Iwahashi, Akane Seo, Michitaka Sumiyoshi, Tetsuya Takahashi, Yoshikazu Tamori. Concurrent Therapy with a Low-carbohydrate Diet and Miglitol Remarkably Improved the Postprandial Blood Glucose and Insulin Levels in a Patient with Reactive Hypoglycemia due to Late Dumping Syndrome.
Internal medicine (Tokyo, Japan).
2016; 55(9):1137-42. doi:
10.2169/internalmedicine.55.5655. [PMID: 27150868] - Eriko Shibata, Kazutaka Aoki, Kazuki Tajima, Masataka Taguri, Yasuo Terauchi. Comparison of efficacy and safety of taking miglitol dissolved in water during a meal and taking a miglitol tablet just before a meal in patients with type 2 diabetes.
Expert opinion on pharmacotherapy.
2016; 17(7):889-94. doi:
10.1517/14656566.2016.1159297. [PMID: 26918556] - George Chinedu Ezeji, Taiga Inoue, Gul Bahtiyar, Alan Sacerdote. Hallucinations associated with miglitol use in a patient with chronic kidney disease and hypothyroidism.
BMJ case reports.
2015 Feb; 2015(?):. doi:
10.1136/bcr-2014-207345. [PMID: 25666246] - Miyako Kishimoto, Mitsuhiko Noda. Additive effects of miglitol and anagliptin on insulin-treated type 2 diabetes mellitus: a case study.
Clinical drug investigation.
2015 Feb; 35(2):141-7. doi:
10.1007/s40261-014-0260-8. [PMID: 25511640] - Hiromichi Asamoto, Yasuhito Nobushi, Takahiko Oi, Kazuo Uchikura. Determination of Miglitol by Column-Switching Ion-Pair HPLC with Tris(2,2'-bipyridine)ruthenium(II)-Electrogenerated Chemiluminescence Detection.
Chemical & pharmaceutical bulletin.
2015; 63(6):476-80. doi:
10.1248/cpb.c14-00788. [PMID: 26027473] - Atsushi Mikada, Takuma Narita, Hiroki Yokoyama, Risa Yamashita, Yohei Horikawa, Katsushi Tsukiyama, Yuichiro Yamada. Effects of miglitol, sitagliptin, and initial combination therapy with both on plasma incretin responses to a mixed meal and visceral fat in over-weight Japanese patients with type 2 diabetes. "the MASTER randomized, controlled trial".
Diabetes research and clinical practice.
2014 Dec; 106(3):538-47. doi:
10.1016/j.diabres.2014.09.040. [PMID: 25451890] - Akiko Mizuno-Yasuhira, Kohnosuke Kinoshita, Shigeji Jingu, Jun-ichi Yamaguchi. A sensitive and selective method for the quantitative analysis of miglitol in rat plasma using unique solid-phase extraction coupled with liquid chromatography-tandem mass spectrometry.
Biomedical chromatography : BMC.
2014 Oct; 28(10):1423-9. doi:
10.1002/bmc.3185. [PMID: 24706526] - Natsuyo Hariya, Kazuki Mochizuki, Seiya Inoue, Miyoko Saito, Masahiro Fuchigami, Toshinao Goda, Takeshi Osonoi. Switching α-glucosidase inhibitors to miglitol reduced glucose fluctuations and circulating cardiovascular disease risk factors in type 2 diabetic Japanese patients.
Drugs in R&D.
2014 Sep; 14(3):177-84. doi:
10.1007/s40268-014-0055-7. [PMID: 25079671] - Akiko Mizuno-Yasuhira, Yasuhiro Nakai, Emi Gunji, Saeko Uchida, Teisuke Takahashi, Kohnosuke Kinoshita, Shigeji Jingu, Soichi Sakai, Yoshishige Samukawa, Jun-Ichi Yamaguchi. A Strategy for assessing potential drug-drug interactions of a concomitant agent against a drug absorbed via an intestinal transporter in humans.
Drug metabolism and disposition: the biological fate of chemicals.
2014 Sep; 42(9):1456-65. doi:
10.1124/dmd.114.058305. [PMID: 25005603] - Chihiro Imai, Miyoko Saito, Kazuki Mochizuki, Masahiro Fuchigami, Toshinao Goda, Takeshi Osonoi. Cotreatment with the α-glucosidase inhibitor miglitol and DPP-4 inhibitor sitagliptin improves glycemic control and reduces the expressions of CVD risk factors in type 2 diabetic Japanese patients.
Metabolism: clinical and experimental.
2014 Jun; 63(6):746-53. doi:
10.1016/j.metabol.2013.12.014. [PMID: 24559582] - Jun Shirakawa, Yuko Murohashi, Noriko Okazaki, Shunsuke Yamazaki, Tetsuya Tamura, Tomoko Okuyama, Yu Togashi, Yasuo Terauchi. Using miglitol at 30 min before meal is effective in hyperinsulinemic hypoglycemia after a total gastrectomy.
Endocrine journal.
2014; 61(11):1115-23. doi:
10.1507/endocrj.ej14-0290. [PMID: 25142087] - Hyun-Gyu Choi, Ji-Young Jeon, Yong-Jin Im, Yunjeong Kim, Haejong Jang, Seungwoo Kang, Kyeong Ho Kim, Soo-Wan Chae, Sun Young Lee, Min-Gul Kim. Pharmacokinetic comparisons between two formulations containing 100 mg of miglitol in healthy male Korean volunteers: a randomized, open-label, single-dose, two-period, two-sequence crossover bioequivalence study.
International journal of clinical pharmacology and therapeutics.
2014 Jan; 52(1):55-63. doi:
10.5414/cp201994. [PMID: 24290415] - Kazutaka Aoki, Hiroshi Kamiyama, Kiyomi Masuda, Kazunari Kamiko, Yoshihiko Noguchi, Kazuki Tajima, Yasuo Terauchi. Effects of miglitol, vildagliptin, or their combination on serum insulin and peptide YY levels and plasma glucose, cholecystokinin, ghrelin, and obestatin levels.
Endocrine journal.
2014; 61(3):249-56. doi:
10.1507/endocrj.ej13-0399. [PMID: 24389993] - Keita Ishibashi, Akemi Hara, Yoshio Fujitani, Toyoyoshi Uchida, Koji Komiya, Motoyuki Tamaki, Hiroko Abe, Takeshi Ogihara, Akio Kanazawa, Ryuzo Kawamori, Hirotaka Watada. Beneficial effects of vildagliptin combined with miglitol on glucose tolerance and islet morphology in diet-controlled db/db mice.
Biochemical and biophysical research communications.
2013 Nov; 440(4):570-5. doi:
10.1016/j.bbrc.2013.09.110. [PMID: 24103756] - Michio Shimabukuro, Moritake Higa, Ken Yamakawa, Hiroaki Masuzaki, Masataka Sata. Miglitol, α-glycosidase inhibitor, reduces visceral fat accumulation and cardiovascular risk factors in subjects with the metabolic syndrome: a randomized comparable study.
International journal of cardiology.
2013 Sep; 167(5):2108-13. doi:
10.1016/j.ijcard.2012.05.109. [PMID: 22721642] - Fuminori Tatsumi, Mitsuru Hashiramoto, Hidenori Hirukawa, Tomohiko Kimura, Masashi Shimoda, Kazuhito Tawaramoto, Yukiko Kanda-Kimura, Takatoshi Anno, Fumiko Kawasaki, Tomoatsu Mune, Michihiro Matsuki, Kohei Kaku. Concomitant use of miglitol and mitiglinide as initial combination therapy in type 2 diabetes mellitus.
Diabetes research and clinical practice.
2013 Jul; 101(1):35-44. doi:
10.1016/j.diabres.2013.04.007. [PMID: 23711593] - Atul Shrivastava, Upma Chaturvedi, Shiv Vardan Singh, Jitendra Kumar Saxena, Gitika Bhatia. Lipid lowering and antioxidant effect of miglitol in triton treated hyperlipidemic and high fat diet induced obese rats.
Lipids.
2013 Jun; 48(6):597-607. doi:
10.1007/s11745-012-3753-3. [PMID: 23334955] - Yoji Hamada, Hiroshi Nagasaki, Masahiro Fuchigami, Shinji Furuta, Yusuke Seino, Jiro Nakamura, Yutaka Oiso. The alpha-glucosidase inhibitor miglitol affects bile acid metabolism and ameliorates obesity and insulin resistance in diabetic mice.
Metabolism: clinical and experimental.
2013 May; 62(5):734-42. doi:
10.1016/j.metabol.2012.10.015. [PMID: 23194643] - Kenta Okada, Hiroaki Yagyu, Kazuhiko Kotani, Hisataka Yamazaki, Kazufumi Ozaki, Manabu Takahashi, Shuichi Nagashima, Jun-Ichi Osuga, Shun Ishibashi. Effects of miglitol versus sitagliptin on postprandial glucose and lipoprotein metabolism in patients with type 2 diabetes mellitus.
Endocrine journal.
2013; 60(7):913-22. doi:
10.1507/endocrj.ej13-0019. [PMID: 23574730] - Miyako Kishimoto, Mitsuhiko Noda. Effect of the addition of sitagliptin and miglitol on insulin-treated type 2 diabetes.
Diabetes therapy : research, treatment and education of diabetes and related disorders.
2012 Nov; 3(1):11. doi:
10.1007/s13300-012-0011-x. [PMID: 23055336] - K S Kesavanarayanan, S Sathiya, V Ranju, A G Sunil, R Ilavarasan, C Saravana Babu, S Kavimani, D Prathiba. In vitro cytotoxic, antioxidative and alpha-glucosidase inhibitory potential of a herbal mixture comprised of Allium sativum and Lagerstroemia speciosa.
European review for medical and pharmacological sciences.
2012 Jul; 16 Suppl 3(?):58-68. doi:
. [PMID: 22957419] - Tomoko Kimura, Jinya Suzuki, Mai Ichikawa, Michiko Imagawa, Satsuki Sato, Miki Fujii, Yasuo Zenimaru, Satoru Inaba, Sadao Takahashi, Tadashi Konoshita, Isamu Miyamori. Differential effects of α-glucosidase inhibitors on postprandial plasma glucose and lipid profile in patients with type 2 diabetes under control with insulin lispro mix 50/50.
Diabetes technology & therapeutics.
2012 Jul; 14(7):545-51. doi:
10.1089/dia.2012.0015. [PMID: 22519736] - Kazutaka Aoki, Hiroshi Kamiyama, Kouichiro Yoshimura, Makoto Shibuya, Kiyomi Masuda, Yasuo Terauchi. Miglitol administered before breakfast increased plasma active glucagon-like peptide-1 (GLP-1) levels after lunch in patients with type 2 diabetes treated with sitagliptin.
Acta diabetologica.
2012 Jun; 49(3):225-30. doi:
10.1007/s00592-011-0322-9. [PMID: 21898126] - Ruchita V Kumar, Vivek Ranjan Sinha. Newer insights into the drug delivery approaches of α-glucosidase inhibitors.
Expert opinion on drug delivery.
2012 Apr; 9(4):403-16. doi:
10.1517/17425247.2012.663080. [PMID: 22364261] - T Narita, H Yokoyama, R Yamashita, T Sato, M Hosoba, T Morii, H Fujita, K Tsukiyama, Y Yamada. Comparisons of the effects of 12-week administration of miglitol and voglibose on the responses of plasma incretins after a mixed meal in Japanese type 2 diabetic patients.
Diabetes, obesity & metabolism.
2012 Mar; 14(3):283-7. doi:
10.1111/j.1463-1326.2011.01526.x. [PMID: 22051162] - Takuo Emoto, Takahiro Sawada, Megumi Hashimoto, Hiroko Kageyama, Daisuke Terashita, Taiji Mizoguchi, Takao Mizuguchi, Yoshiki Motodi, Masamichi Iwasaki, Kazuki Taira, Hiroshi Okamoto, Yosuke Matsuo, Sushi-ku Kim, Akira Takarada, Mitsuhiro Yokoyama. Effect of 3-month repeated administration of miglitol on vascular endothelial function in patients with diabetes mellitus and coronary artery disease.
The American journal of cardiology.
2012 Jan; 109(1):42-6. doi:
10.1016/j.amjcard.2011.08.005. [PMID: 21944671] - Nalinee Poolsup, Naeti Suksomboon, Wanwaree Setwiwattanakul. Efficacy of various antidiabetic agents as add-on treatments to metformin in type 2 diabetes mellitus: systematic review and meta-analysis.
ISRN endocrinology.
2012; 2012(?):798146. doi:
10.5402/2012/798146. [PMID: 22619731] - Man-Wo Tsang. The management of type 2 diabetic patients with hypoglycaemic agents.
ISRN endocrinology.
2012; 2012(?):478120. doi:
10.5402/2012/478120. [PMID: 22645689] - Miyako Kishimoto, Mitsuhiko Noda. A pilot study of the efficacy of miglitol and sitagliptin for type 2 diabetes with a continuous glucose monitoring system and incretin-related markers.
Cardiovascular diabetology.
2011 Dec; 10(?):115. doi:
10.1186/1475-2840-10-115. [PMID: 22189184] - Kosuke Fukao, Kazunori Shimada, Makoto Hiki, Takashi Kiyanagi, Kuniaki Hirose, Atsumi Kume, Hiromichi Ohsaka, Rie Matsumori, Takeshi Kurata, Tetsuro Miyazaki, Hiroyuki Daida. Effects of calcium channel blockers on glucose tolerance, inflammatory state, and circulating progenitor cells in non-diabetic patients with essential hypertension: a comparative study between azelnidipine and amlodipine on glucose tolerance and endothelial function--a crossover trial (AGENT).
Cardiovascular diabetology.
2011 Sep; 10(?):79. doi:
10.1186/1475-2840-10-79. [PMID: 21906391] - Masamitsu Iwasa, Yoshihisa Yamada, Hiroyuki Kobayashi, Shinji Yasuda, Itta Kawamura, Shohei Sumi, Takeru Shiraki, Takahiko Yamaki, Hiroaki Ushikoshi, Arihiro Hattori, Takuma Aoyama, Kazuhiko Nishigaki, Genzou Takemura, Hisayoshi Fujiwara, Shinya Minatoguchi. Both stimulation of GLP-1 receptors and inhibition of glycogenolysis additively contribute to a protective effect of oral miglitol against ischaemia-reperfusion injury in rabbits.
British journal of pharmacology.
2011 Sep; 164(1):119-31. doi:
10.1111/j.1476-5381.2011.01357.x. [PMID: 21426318] - Mangesh C Deshpande, Vobalaboina Venkateswarlu, Arunkumar H Mantri, Sandeep T Gadewar. Targeting enteral endocrinal L-cells with dietary carbohydrates, by increasing the availability of miglitol in the intestinal lumen, leads to multi-fold enhancement of plasma glucagon-like peptide-1 levels in non-diabetic canines.
Drug development and industrial pharmacy.
2011 May; 37(5):506-17. doi:
10.3109/03639045.2010.526123. [PMID: 21126213] - Rajeev Jain, Ojitkumar Lukram, Ashish Dwivedi. Ultra-performance liquid chromatography electrospray ionization-tandem mass spectrometry method for the estimation of miglitol in human plasma using metformin as the internal standard.
Drug testing and analysis.
2011 Apr; 3(4):255-62. doi:
10.1002/dta.226. [PMID: 21500369] - Ji-Hye Kim, Min-Jung Kang, Ha-Neul Choi, Soo-Mi Jeong, Young-Min Lee, Jung-In Kim. Quercetin attenuates fasting and postprandial hyperglycemia in animal models of diabetes mellitus.
Nutrition research and practice.
2011 Apr; 5(2):107-11. doi:
10.4162/nrp.2011.5.2.107. [PMID: 21556223] - Assiamira Ferrara, James D Lewis, Charles P Quesenberry, Tiffany Peng, Brian L Strom, Stephen K Van Den Eeden, Samantha F Ehrlich, Laurel A Habel. Cohort study of pioglitazone and cancer incidence in patients with diabetes.
Diabetes care.
2011 Apr; 34(4):923-9. doi:
10.2337/dc10-1067. [PMID: 21447664] - Eiji Kutoh. Sitagliptin is effective and safe as add-on to insulin in patients with absolute insulin deficiency: a case series.
Journal of medical case reports.
2011 Mar; 5(?):117. doi:
10.1186/1752-1947-5-117. [PMID: 21443773] - Marilyn L Barrett, Jay K Udani. A proprietary alpha-amylase inhibitor from white bean (Phaseolus vulgaris): a review of clinical studies on weight loss and glycemic control.
Nutrition journal.
2011 Mar; 10(?):24. doi:
10.1186/1475-2891-10-24. [PMID: 21414227] - Masami Nemoto, Naoko Tajima, Ryuzo Kawamori. Efficacy of combined use of miglitol in Type 2 diabetes patients receiving insulin therapy-placebo-controlled double-blind comparative study.
Acta diabetologica.
2011 Mar; 48(1):15-20. doi:
10.1007/s00592-010-0206-4. [PMID: 20617348] - Sheng-Hwu Hsieh, Kuang-Chung Shih, Chien-Wen Chou, Chih-Hsun Chu. Evaluation of the efficacy and tolerability of miglitol in Chinese patients with type 2 diabetes mellitus inadequately controlled by diet and sulfonylureas.
Acta diabetologica.
2011 Mar; 48(1):71-7. doi:
10.1007/s00592-010-0220-6. [PMID: 20963449] - Annick A N M Royakkers, Johanna C Korevaar, Jeroen D E van Suijlen, Lieuwe S Hofstra, Michael A Kuiper, Peter E Spronk, Marcus J Schultz, Catherine S C Bouman. Serum and urine cystatin C are poor biomarkers for acute kidney injury and renal replacement therapy.
Intensive care medicine.
2011 Mar; 37(3):493-501. doi:
10.1007/s00134-010-2087-y. [PMID: 21153403] - Sung-Hoon Jo, Kyoung-Soo Ha, Kyoung-Sik Moon, Ok-Hwan Lee, Hae-Dong Jang, Young-In Kwon. In vitro and in vivo anti-hyperglycemic effects of Omija (Schizandra chinensis) fruit.
International journal of molecular sciences.
2011 Feb; 12(2):1359-70. doi:
10.3390/ijms12021359. [PMID: 21541063] - Takashi Uzu, Hiroki Yokoyama, Hirofumi Itoh, Daisuke Koya, Atsushi Nakagawa, Makoto Nishizawa, Hiroshi Maegawa, Yukiyo Yokomaku, Shin-Ichi Araki, Atsuko Abiko, Masakazu Haneda. Elevated serum levels of interleukin-18 in patients with overt diabetic nephropathy: effects of miglitol.
Clinical and experimental nephrology.
2011 Feb; 15(1):58-63. doi:
10.1007/s10157-010-0343-7. [PMID: 20824296] - Sudha P, Smita S Zinjarde, Shobha Y Bhargava, Ameeta R Kumar. Potent α-amylase inhibitory activity of Indian Ayurvedic medicinal plants.
BMC complementary and alternative medicine.
2011 Jan; 11(?):5. doi:
10.1186/1472-6882-11-5. [PMID: 21251279] - Shosaku Nomura, Seitaro Omoto, Takashi Yokoi, Shinya Fujita, Ryotaro Ozasa, Noritaka Eguchi, Akira Shouzu. Effects of miglitol in platelet-derived microparticle, adiponectin, and selectin level in patients with type 2 diabetes mellitus.
International journal of general medicine.
2011; 4(?):539-45. doi:
10.2147/ijgm.s22115. [PMID: 21845063] - Etsuko Nagai, Tomoyuki Katsuno, Jun-Ichiro Miyagawa, Kosuke Konishi, Masayuki Miuchi, Fumihiro Ochi, Yoshiki Kusunoki, Masaru Tokuda, Kazuki Murai, Tomoya Hamaguchi, Mitsuyoshi Namba. Effects of miglitol in combination with intensive insulin therapy on blood glucose control with special reference to incretin responses in type 1 diabetes mellitus.
Endocrine journal.
2011; 58(10):869-77. doi:
10.1507/endocrj.k11e-129. [PMID: 21869539] - Kalpana Kalaivanan, Kodukkur Vishwanthan Pugalendi. Antihyperglycemic effect of the alcoholic seed extract of Swietenia macrophylla on streptozotocin-diabetic rats.
Pharmacognosy research.
2011 Jan; 3(1):67-71. doi:
10.4103/0974-8490.79119. [PMID: 21731399] - Sun-Ho Kim, Sung-Hoon Jo, Young-In Kwon, Jae-Kwan Hwang. Effects of onion (Allium cepa L.) extract administration on intestinal α-glucosidases activities and spikes in postprandial blood glucose levels in SD rats model.
International journal of molecular sciences.
2011; 12(6):3757-69. doi:
10.3390/ijms12063757. [PMID: 21747704] - Min-Jung Kang, Ji-Hye Kim, Ha-Neul Choi, Myoung-Jin Kim, Jung-Hee Han, Jai-Heon Lee, Jung-In Kim. Hypoglycemic effects of Welsh onion in an animal model of diabetes mellitus.
Nutrition research and practice.
2010 Dec; 4(6):486-91. doi:
10.4162/nrp.2010.4.6.486. [PMID: 21286406] - Makoto Hiki, Kazunori Shimada, Takashi Kiyanagi, Kosuke Fukao, Kuniaki Hirose, Hiromichi Ohsaka, Yoshifumi Fukushima, Atsumi Kume, Rie Matsumori, Katsuhiko Sumiyoshi, Tetsuro Miyazaki, Hirotoshi Ohmura, Takeshi Kurata, Takashi Miida, Hiroyuki Daida. Single administration of alpha-glucosidase inhibitors on endothelial function and incretin secretion in diabetic patients with coronary artery disease - Juntendo University trial: effects of miglitol on endothelial vascular reactivity in type 2 diabetic patients with coronary heart disease (J-MACH) -.
Circulation journal : official journal of the Japanese Circulation Society.
2010 Jul; 74(7):1471-8. doi:
10.1253/circj.cj-10-0013. [PMID: 20519875] - S S Engel, D E Williams-Herman, G T Golm, R J Clay, S V Machotka, K D Kaufman, B J Goldstein. Sitagliptin: review of preclinical and clinical data regarding incidence of pancreatitis.
International journal of clinical practice.
2010 Jun; 64(7):984-90. doi:
10.1111/j.1742-1241.2010.02382.x. [PMID: 20412332] - Sonia A Tucci, Emma J Boyland, Jason Cg Halford. The role of lipid and carbohydrate digestive enzyme inhibitors in the management of obesity: a review of current and emerging therapeutic agents.
Diabetes, metabolic syndrome and obesity : targets and therapy.
2010 May; 3(?):125-43. doi:
10.2147/dmsott.s7005. [PMID: 21437083] - Lyann Sim, Kumarasamy Jayakanthan, Sankar Mohan, Ravindranath Nasi, Blair D Johnston, B Mario Pinto, David R Rose. New glucosidase inhibitors from an ayurvedic herbal treatment for type 2 diabetes: structures and inhibition of human intestinal maltase-glucoamylase with compounds from Salacia reticulata.
Biochemistry.
2010 Jan; 49(3):443-51. doi:
10.1021/bi9016457. [PMID: 20039683] - Kazutaka Aoki, Takashi Miyazaki, Jo Nagakura, Kazuki Orime, Yu Togashi, Yasuo Terauchi. Effects of pre-meal versus post-meal administration of miglitol on plasma glucagon-like peptide-1 and glucosedependent insulinotropic polypeptide levels in healthy men.
Endocrine journal.
2010; 57(8):673-7. doi:
10.1507/endocrj.k10e-064. [PMID: 20519807] - Kazutaka Aoki, Kiyomi Masuda, Takashi Miyazaki, Yu Togashi, Yasuo Terauchi. Effects of miglitol, sitagliptin or their combination on plasma glucose, insulin and incretin levels in non-diabetic men.
Endocrine journal.
2010; 57(8):667-72. doi:
10.1507/endocrj.k10e-103. [PMID: 20519806] - Hajime Haimoto, Tae Sasakabe, Hiroyuki Umegaki, Kenji Wakai. Acute metabolic responses to a high-carbohydrate meal in outpatients with type 2 diabetes treated with a low-carbohydrate diet: a crossover meal tolerance study.
Nutrition & metabolism.
2009 Dec; 6(?):52. doi:
10.1186/1743-7075-6-52. [PMID: 20040075] - Mangesh C Deshpande, Vobalaboina Venkateswarlu, Ravi K Babu, Ravi K Trivedi. Design and evaluation of oral bioadhesive controlled release formulations of miglitol, intended for prolonged inhibition of intestinal alpha-glucosidases and enhancement of plasma glucagon like peptide-1 levels.
International journal of pharmaceutics.
2009 Oct; 380(1-2):16-24. doi:
10.1016/j.ijpharm.2009.06.024. [PMID: 19563873] - Manthena V S Varma, Bo Feng, R Scott Obach, Matthew D Troutman, Jonathan Chupka, Howard R Miller, Ayman El-Kattan. Physicochemical determinants of human renal clearance.
Journal of medicinal chemistry.
2009 Aug; 52(15):4844-52. doi:
10.1021/jm900403j. [PMID: 19445515] - Nanae Fukaya, Kazuki Mochizuki, Masaya Shimada, Toshinao Goda. The alpha-glucosidase inhibitor miglitol decreases glucose fluctuations and gene expression of inflammatory cytokines induced by hyperglycemia in peripheral leukocytes.
Nutrition (Burbank, Los Angeles County, Calif.).
2009 Jun; 25(6):657-67. doi:
10.1016/j.nut.2008.11.015. [PMID: 19216056] - A Hirata, M Igarashi, H Iwai, M Tominaga. Effect of miglitol, an alpha-glucosidase inhibitor, on atherogenic outcomes in balloon-injured diabetic rats.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.
2009 Mar; 41(3):213-20. doi:
10.1055/s-0028-1105919. [PMID: 19085811] - Jérôme Guitton, Sylvie Coste, Nathalie Guffon-Fouilhoux, Sabine Cohen, Monique Manchon, Marc Guillaumont. Rapid quantification of miglustat in human plasma and cerebrospinal fluid by liquid chromatography coupled with tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2009 Jan; 877(3):149-54. doi:
10.1016/j.jchromb.2008.11.040. [PMID: 19095507] - Hiroki Yokoyama, Teruo Inoue, Koichi Node. Effect of insulin-unstimulated diabetic therapy with miglitol on serum cystatin C level and its clinical significance.
Diabetes research and clinical practice.
2009 Jan; 83(1):77-82. doi:
10.1016/j.diabres.2008.09.049. [PMID: 19027977] - Masayuki Arakawa, Chie Ebato, Tomoya Mita, Yoshio Fujitani, Tomoaki Shimizu, Hirotaka Watada, Ryuzo Kawamori, Takahisa Hirose. Miglitol suppresses the postprandial increase in interleukin 6 and enhances active glucagon-like peptide 1 secretion in viscerally obese subjects.
Metabolism: clinical and experimental.
2008 Sep; 57(9):1299-306. doi:
10.1016/j.metabol.2008.04.027. [PMID: 18702958] - K Aoki, S Nakajima, U Nezu, K Shinoda, Y Terauchi. Comparison of pre- vs. postmeal administration of miglitol for 3 months in type 2 diabetic patients.
Diabetes, obesity & metabolism.
2008 Sep; 10(10):970-2. doi:
10.1111/j.1463-1326.2008.00960.x. [PMID: 18721256] - R Scott Obach, Franco Lombardo, Nigel J Waters. Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Drug metabolism and disposition: the biological fate of chemicals.
2008 Jul; 36(7):1385-405. doi:
10.1124/dmd.108.020479. [PMID: 18426954] - Jeongsu Nam, Hyunju Choi. Effect of butanol fraction from Cassia tora L. seeds on glycemic control and insulin secretion in diabetic rats.
Nutrition research and practice.
2008; 2(4):240-6. doi:
10.4162/nrp.2008.2.4.240. [PMID: 20016725] - Kazutaka Aoki, Hideaki Kato, Yasuo Terauchi. Divided-dose administration of miglitol just before and 15 minutes after the start of a meal smoothes postprandial plasma glucose excursions and serum insulin responses in healthy men.
Endocrine journal.
2007 Dec; 54(6):1009-14. doi:
10.1507/endocrj.k07-018. [PMID: 18048991] - Hiroki Yokoyama, Sakiko Kannno, Ikue Ishimura, Koichi Node. Miglitol increases the adiponectin level and decreases urinary albumin excretion in patients with type 2 diabetes mellitus.
Metabolism: clinical and experimental.
2007 Nov; 56(11):1458-63. doi:
10.1016/j.metabol.2007.06.010. [PMID: 17950094] - Kazutaka Aoki, Akinobu Nakamura, Satoshi Ito, Uru Nezu, Tomoyuki Iwasaki, Mayumi Takahashi, Mari Kimura, Yasuo Terauchi. Administration of miglitol until 30 min after the start of a meal is effective in type 2 diabetic patients.
Diabetes research and clinical practice.
2007 Oct; 78(1):30-3. doi:
10.1016/j.diabres.2007.01.072. [PMID: 17493703] - Toshinao Goda, Kazuhito Suruga, Akiko Komori, Sachi Kuranuki, Kazuki Mochizuki, Yumi Makita, Toshihiko Kumazawa. Effects of miglitol, an alpha-glucosidase inhibitor, on glycaemic status and histopathological changes in islets in non-obese, non-insulin-dependent diabetic Goto-Kakizaki rats.
The British journal of nutrition.
2007 Oct; 98(4):702-10. doi:
10.1017/s0007114507742678. [PMID: 17537288] - Tomoya Mita, Aiko Otsuka, Kosuke Azuma, Toyoyoshi Uchida, Takeshi Ogihara, Yoshio Fujitani, Takahisa Hirose, Masako Mitsumata, Ryuzo Kawamori, Hirotaka Watada. Swings in blood glucose levels accelerate atherogenesis in apolipoprotein E-deficient mice.
Biochemical and biophysical research communications.
2007 Jul; 358(3):679-85. doi:
10.1016/j.bbrc.2007.04.118. [PMID: 17506980] - K P Singh, I Periyandavar, Girish C Rajadhyaksha, S Jayaram, Ashok B Mishra, Satish Kinagi, Akhilesh Sharma, Vidyagauri P Baliga. Evaluation of the efficacy, safety and tolerability of miglitol in adult Indian patients with uncomplicated type 2 diabetes mellitus.
Journal of the Indian Medical Association.
2007 Jun; 105(6):344, 346, 350. doi:
. [PMID: 18232183] - Francisco Castaneda, Antje Burse, Wilhelm Boland, Rolf K-H Kinne. Thioglycosides as inhibitors of hSGLT1 and hSGLT2: potential therapeutic agents for the control of hyperglycemia in diabetes.
International journal of medical sciences.
2007 May; 4(3):131-9. doi:
10.7150/ijms.4.131. [PMID: 17505558] - Xin Li, Yingwu Wang, Jiang Wang, J Paul Fawcett, Limei Zhao, Jingkai Gu. Determination of miglitol in human plasma by liquid chromatography/tandem mass spectrometry.
Rapid communications in mass spectrometry : RCM.
2007; 21(2):247-51. doi:
10.1002/rcm.2822. [PMID: 17171777] - Ji-Yeon Hwang, Jian Zhang, Min-Jung Kang, Soo-Kyung Lee, Hyun-A Kim, Jong-Jin Kim, Jung-In Kim. Hypoglycemic and hypolipidemic effects of Saururus chinensis Baill in streptozotocin-induced diabetic rats.
Nutrition research and practice.
2007; 1(2):100-4. doi:
10.4162/nrp.2007.1.2.100. [PMID: 20535394] - E Wright, J L Scism-Bacon, L C Glass. Oxidative stress in type 2 diabetes: the role of fasting and postprandial glycaemia.
International journal of clinical practice.
2006 Mar; 60(3):308-14. doi:
10.1111/j.1368-5031.2006.00825.x. [PMID: 16494646] - Ramakrishna V S Nirogi, Vishwottam N Kandikere, Manoj Shukla, Koteshwara Mudigonda, Santosh Maurya, Ravikumar Boosi, Anjaneyulu Yerramilli. Liquid chromatographic tandem mass spectrometry method for the quantification of miglitol in human plasma.
Arzneimittel-Forschung.
2006; 56(5):328-36. doi:
10.1055/s-0031-1296730. [PMID: 16821643] - Mark C Granberry, Vivian A Fonseca. Cardiovascular risk factors associated with insulin resistance: effects of oral antidiabetic agents.
American journal of cardiovascular drugs : drugs, devices, and other interventions.
2005; 5(3):201-9. doi:
10.2165/00129784-200505030-00006. [PMID: 15901207] - Floris A van de Laar, Peter L Lucassen, Reinier P Akkermans, Eloy H van de Lisdonk, Guy E Rutten, Chris van Weel. Alpha-glucosidase inhibitors for patients with type 2 diabetes: results from a Cochrane systematic review and meta-analysis.
Diabetes care.
2005 Jan; 28(1):154-63. doi:
10.2337/diacare.28.1.154. [PMID: 15616251] - J B Buse, M H Tan, M J Prince, P P Erickson. The effects of oral anti-hyperglycaemic medications on serum lipid profiles in patients with type 2 diabetes.
Diabetes, obesity & metabolism.
2004 Mar; 6(2):133-56. doi:
10.1111/j.1462-8902.2004.00325.x. [PMID: 14746579] - D A de Luis Román, E del Pozo García, R Aller, E Romero Bobillo, R Conde Valentín. [Usefulness of miglitol in patients with diabetes mellitus type 2 and insufficient control of the blood glucose].
Revista clinica espanola.
2004 Jan; 204(1):32-4. doi:
10.1157/13056791. [PMID: 14746760] - A Lee, P Patrick, J Wishart, M Horowitz, J E Morley. The effects of miglitol on glucagon-like peptide-1 secretion and appetite sensations in obese type 2 diabetics.
Diabetes, obesity & metabolism.
2002 Sep; 4(5):329-35. doi:
10.1046/j.1463-1326.2002.00219.x. [PMID: 12190996] - M L Drent, A T M Tollefsen, F H J A van Heusden, E B M Hoenderdos, J J C Jonker, E A van der Veen. Dose-dependent efficacy of miglitol, an alpha-glucosidase inhibitor, in type 2 diabetic patients on diet alone: results of a 24-week double-blind placebo-controlled study.
Diabetes, nutrition & metabolism.
2002 Jun; 15(3):152-9. doi:
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Nutrition, metabolism, and cardiovascular diseases : NMCD.
2002 Apr; 12(2):98-107. doi:
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Journal of natural products.
2002 Feb; 65(2):198-202. doi:
10.1021/np010360f. [PMID: 11858756] - L Van Gaal, M Maislos, G Schernthaner, J Rybka, P Segal. Miglitol combined with metformin improves glycaemic control in type 2 diabetes.
Diabetes, obesity & metabolism.
2001 Oct; 3(5):326-31. doi:
10.1046/j.1463-1326.2001.00141.x. [PMID: 11703422] - J R Gavin. Pathophysiologic mechanisms of postprandial hyperglycemia.
The American journal of cardiology.
2001 Sep; 88(6A):4H-8H. doi:
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